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| | bio |
 | | In most mammalian species investigated the pinealocytes contain few granules that can be regarded as morphological correlated of secretory products, and the circadian behaviour of the few dense core vesicles present does not support the assumption that they contain melatonin. | | | A study of rat pinealocytes after electrical stimulation of the SCG by Beuss in 1985 reviewed that some pinealocytes did not appear to be influenced by SCG stimulation, a second group responded with enhanced electrical activity and in a third group electrical activity was depressed. | | | In fact, according to quantitative studies in the rat, 91.1% of the nerve fibres have a perivascular location, the remainder lying between pinealocytes (A.Meyer and L. Vollrath 1985). |
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http://www.chemie.uni-muenchen.de/ChemInsight/Deutsch/melatonin/bio.html
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| | Summaries 1997 |
| | In particular, these cultures permit experimental studies of the compartment of pinealocyte SLMVs which seem to make up a major secretory pathway for paracrine intrapineal communication. | | | The data show that anatomy is graded as highly relevant in the undergraduate medical curriculum by doctors at the end of their postgraduate training. | | | This may indicate that a substantial fraction of pinealocyte SLMVs by-passes the early endosomal-related recycling pathway of SLMVs. |
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http://www.mh-hannover.de/institute/anatomie2/sum1997.htm
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| | NEL, Effects of estradiol benzoate on the ultrastructure of the pinealocyte |
| | Estradiol administration to ovariectomized rats resulted in formation of less extensive lipid droplets, mitochondria and ribosomes compared to pinealocyte ultrastructure of both control and ovariectomized rats. | | | Extensiveness of rough endoplasmic reticulum in the pinealocytes of estradiol-administrated rats was similar to that in controls. | | | Effects of estradiol benzoate on the ultrastructure of the pinealocyte in the ovariectomized rat |
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http://www.nel.edu/23_56/NEL235602A03_Kus_Oner.htm
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| | NEL, The age-related quantitative ultrastructural changes in pinealocytes of gerbils. |
| | NEL, The age-related quantitative ultrastructural changes in pinealocytes of gerbils. | | | The age-related quantitative ultrastructural changes in pinealocytes of gerbils | | | Therefore, the aim of the present study was to examine the quantitative ultrastructure of pinealocytes of the gerbil in three different age groups. |
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http://www.nel.edu/20_6/nel20_6orig6_Swietoslawski.htm
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| | 1969 - 1989: Pineal Gland Abstracts. Fluoride Action Network Pesticide Project. |
| | This dual AII localization suggests that both neurons and blood vessels may be involved in the transport of AII to sensitive sites within the rat brain. | | | These loci, and particularly those within the cytoplasmic matrix, transform into acervuli by a further addition of hydroxyapatite crystals | | | The initial intracellular calcification sites occur in the cytoplasmic matrix, vacuoles, mitochondria and the endoplasmic reticulum of large clear pinealocytes. |
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http://www.fluoridealert.org/pesticides/pineal.up.to.1989.abstracts.htm
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| | ::: IJAO ::: |
| | The aim of this study was to assess cell viability and the function of rat pinealocytes encapsulated in APA capsules and offer experimental suggestions for pineal microencapsulation grafting to resist aging. | | | Microencapsulation and culture in vitro of rat pinealocytes | | | Pinealocytes were isolated and encapsulated in APA microencapsulation and cultured. |
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http://www.artificial-organs.com/index.asp?a=abstract&id=104E95E5-1502-4AE7-9989-67348D2
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| | UF : Molecular Cell Biology Program - Professor Details |
| | Improved understanding of this relationship is critical to the development and successful utilization of this type of therapy in the treatment of retinal disease. | | | Additional research interests include studies to understand the mechanisms underlying light entrainment of photoreceptor and pinealocyte circadian clocks. | | | Develop and test tetracycline-control systems for regulation of gene expression. |
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http://www.med.ufl.edu/anatomy/mcb/profdetail.cgi?name=semple-rowland_s
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| | Neonatal development of circadian rhythm in "synaptic" ribbon numbers in the rat pinealocyte. |
| | Neonatal development of circadian rhythm in "synaptic" ribbon numbers in the rat pinealocyte. | | | Populations of "synaptic" ribbons (SR) in pinealocytes of the rat pineal gland at various ages from the neonatal period through early adulthood were analyzed morphometrically. | | | Diurnal and nocturnal numbers of SR were small on day one but had increased dramatically by the end of the first week and beginning of the second week. |
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http://www.arclab.org/medlineupdates/abstract_7190775.html
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| | Department of Physiology and Biophysics of Mount Sinai School of Medicine |
| | The variability from culture to culture in the amplitude and timing of the melatonin peak is minimal and this allows us to perform controlled experiments as we explore elements of the pineal photo-transduction pathways and their impact on melatonin synthesis. | | | This transgenic approach allows us to manipulate the level of expression of genes that may be involved in photo-transduction or circadian rhythmicity, either by over expressing them or their mutant counterparts or by reducing their expression through the use of specific ribozymes or antisense sequences. | | | Using these approaches we are able to assess the role of specific proteins in photo-transduction and circadian rhythmicity in cultures of pinealocytes. |
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http://directory.mssm.edu/faculty/facultyInfo.php?id=27436&deptid=94
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| | The presence of delta and mu-, but not kappa or ORL1 receptors in bovine pinealocytes |
| | Physicians have noted since antiquity that their patients complained of less pain and required fewer analgesics at night-time. | | | In this study, we have attempted to identify and characterize the nature and types 3 of opioid receptor in bovine pinealocyte membranes, using a radioligand binding technique with the selective radioligands [H-3]DAMGO, [H-3]DPDPE, [H-3]U69593 and [H-3]orphanin-FQ (OFQ) for identifying mu delta (mu)-, kappa (kappa)- and opioid receptor-like (ORL1) receptors, respectively. | | | These opioid receptors, by stimulating the activity of N-acetyltransferase, enhance the synthesis of melatonin. |
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http://www.st.mahidol.ac.th/research/ji2002/ji02_08.htm
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| | Evaluation of gingival and periodontal conditions following causal periodontal treatment in patients treated with ... |
| | Vasoactive intestinal peptide elevates pinealocyte intracellular calcium concentrations by enhancing influx: evidence for involvement of a cyclic GMP-dependent mechanism. | | | This should, perhaps, be taken into consideration when working with continuous ambulatory peritoneal dialysis (CAPD) patients to whom antihypertensive drugs are administered in large doses. | | | In the present study, we show that VIP (5-200 nM) treatment increased the intracellular calcium concentration ([Ca2+]i) in 64% of isolated individual pinealocytes; in comparison, norepinephrine (NE) elevated [Ca2+]i in 93% of the cells and produced more robust responses. |
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http://hairmillion.com/rx-online-info/diltiazem-online-rx/diltiazem-online-rx.844.html
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| | The incidence and severity of nifedipine-induced gingival overgrowth. SK&F 87516, a close analog of fenoldopam, is ... |
| | Beta-adrenergic regulation of cyclic GMP in rat pinealocytes. | | | Sugden D. Biomedical Sciences Division, King's College London, Kensington, London, U.K. Stimulation of rat pinealocyte cyclic GMP by beta-adrenergic agonists (in the presence of prazosin to block alpha 1-adrenoceptors) showed an identical potency order (isoproterenol greater than epinephrine = norepinephrine much greater than salbutamol greater than terbutaline) to the stimulation of pinealocyte cyclic AMP. | | | SKandF 87516, a close analog of fenoldopam, is a partial agonist at dopamine-1 and alpha-2 receptors and produces stimulation of 5-hydroxytryptamine-2 receptors in the cardiovascular system of the rat. |
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http://darwinpharmacy.com/ref-atenolol/atenolol-research-abs3.279.html
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| | Effects of advancing age on the ultrastructure of pinealocytes in the male white-footed mouse (Peromyscus leucopus). |
| | In contrast, no differences between these two age groups were noted in the areas of granular endoplasmic reticulum, vacuoles with flocculent content, lysosome-like bodies, or mitochondria. | | | These observations suggest a possible age-associated decrease in the neurosecretory-like (but not ependymal-like) secretory process in the pinealocyte of white-footed mice. | | | Nor were any changes between groups of mice apparent in pinealocyte nuclear or cytoplasmic areas, nuclear: cytoplasmic ratios, or the number of pinealocyte nuclei per unit area. |
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http://www.arclab.org/medlineupdates/abstract_7153722.html
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| | Mouse/Rat Pinealocytes |
| | Hasegawa, A., Kurumado, K., Mori, W.: Synaptic ribbon of the rat pinealocytes - numerical changes under physiological and ophthalmectomized conditions (in Japanese). | | | Hasegawa, A.: Age-related changes of mouse pinealocytes - electron microscopy and morphometry (in Japanese). | | | Electron microscopic feature of a synaptic ribbon of a rat pinealocyte in the vicinity of the plasma membrane (original x38,000) |
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http://members.aol.com/drhasegawa/mouse.htm
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| | Histol Histopathol, Vol 17, Martínez-Soriano et al. |
| | Morphological and physiological studies suggest a possible division of the pineal parenchyma into an external or "cortical" and another central or "medullar" layer. | | | Main results showed that nuclear volume of the cortical pinealocytes was greater than that of the medullar pinealocytes only during the photophases of winter new-moon days and spring full moon days, whereas in all the remaining situations, the greater nuclear sizes were found in the pinealocytes of the medullar layer. | | | We have studied the possible influence of the light/dark, seasonal and lunar cycles on the nuclear size of the pinealocytes of the rat in both the hypothetical "cortical" and "medullar" layers. |
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http://www.hh.um.es/Abstracts/Vol_17/17_1/17_1_205.htm
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| | David Klein - Section on Neuroendocrinology - Publications |
| | -and beta-adrenergic regulation of adenosine 3',5'-monophosphate and guanosine 3',5'- monophosphate in rat pinealocytes. | | | -alpha-adrenergic potentiation of vasoactive intestinal peptide stimulation of pinealocyte adenosine 3',5'-monophosphate. | | | Biochemical and Biophysical Research Communications 142 : 819-825. |
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http://dir2.nichd.nih.gov/nichd/ldn/SNE/Publications.htm
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| | Lin, H.S. The fine structure and transformation of centrioles in the rat pinealocyte. | | | Lin, H.S., Chen, I.L. Development of the ciliary complex and microtubules in the cells of rat subcommissural organ. | | | Lyser, K.M. An electron microscope study of centrioles in differentiating motor neuroblasts. |
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http://www.wadsworth.org/BMS/SCBlinks/cilium1.html
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| | Three-dimensional reconstruction of synaptic bodies |
| | 2.) Three-dimensional reconstruction of synaptic bodies in a field of a guinea-pig pinealocyte | | | See a scanned TEM picture of a field of synaptic bodies (311KB) | | | 1.) Animated 3D-reconstruction of synaptic bodies in a field of a guinea-pig pinealocyte of an animal kept under constant light |
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http://www.uni-mainz.de/~jastrow/SR3D.html
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| | [Pinealocyte functioning in stress during daytime in rats] |
| | Dream Pharmaceuticals Rx: prescription medication and drugs online | | | [Pinealocyte functioning in stress during daytime in rats] | | | Electrical stimulation of olfactory epithelium decreased the unit activity rate in the most active pinealocytes. |
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http://viagenbio.com/~melatonin/melatonin-research-abs.390.html
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| | Pinealocytes did not show b-FGF immunoreactivity at any time. | | | The techniques for the demonstration of reticulin fibers showed a higher development of connective septa in sympathectomized animals. | | | Cytoplasmic lipid droplets in the pinealocytes were markedly decreased in number and size in experimental rats. |
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http://www.ucm.es/info/ghm/pineal.htm
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| | The Pineal Gland |
| | Tumors of pinealocytes also occur and vary in their potential for malignant change. | | | These tumors are malignant and invasive and may be life-threatening. | | | Given the universal need for circadian rhythmicity in all animals, it is not surprising that the pineal, which has the ability to perceive these daily cycles, became closely associated with entrainment to twenty-four hour periods. |
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http://www4.ncsu.edu/~mdmarti2/pineal/pineal.html
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| | Inhibitory effects of amilorides on pinealocyte adenosine 3',5'- monophosphate and guanosine 3',5'-monophosphate ... |
| | Inhibitory effects of amilorides on pinealocyte adenosine 3',5'- monophosphate and guanosine 3',5'-monophosphate accumulation: possible involvement of postreceptor mechanisms | | | Inhibitory effects of amilorides on pinealocyte adenosine 3',5'- monophosphate and guanosine 3',5'-monophosphate accumulation: possible involvement of postreceptor mechanisms -- Ho et al. | | | In rat pinealocytes, alpha 1-adrenergic receptor activation increases |
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http://endo.endojournals.org/cgi/content/abstract/127/1/460
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| | Borchard Introduction |
| | The photoreceptor of the retina and the pinealocyte of the pineal gland are in a delicate balance in health and disease that is genetically regulated by gene expression monitored by the biological clock and environmentally regulated by the light/dark inputs to the signal transduction pathways. | | | The reader should note the open format led to many issues being discussed, within the context of the specific issues. |
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http://www.eyesightresearch.org/old/Borchard_Intro.htm
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| | Human Pineal Gland |
| | The phylogenesis of the pineal may be more interesting than Much Melatonin About Nothing. | | | Bulbous endings of human pinealocytes in contact with | | | AUTHOR'S NOTE : Although the specimens were taken at autopsy within 5 hours of death (mean 2.5 hours), the post mortem degeneration of membranous ultrastructures cannot be ignored in the electron micrographs of human materials. |
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http://members.aol.com/drhasegawa/pineal.htm
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| | Published Papers in English |
| | These findings may reflect the age-associated changes in the cytokinetic and metabolic activity of the pinealocyte nuclei. | | | However, the age distribution of individuals with PTF suggests that the intermediate filaments of human pinealocytes are more susceptible to early deterioration during aging than those of other cerebral neurons. | | | The identity of the PTF remains unclear in terms of their apparent similarity to the paired helical filaments observed previously in aged rats. |
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http://members.aol.com/drhasegawa/engpaper2.htm
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| | Endo Page 19 |
| | It is best identified by the distinctive dark globules known as brain sand that can be observed in the glands of older individuals. | | | There are two principal cell types in the pineal; the pinealocyte that is a highly modified neuronal cell and that secretes melatonin, and glial cells. |
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http://www.kumc.edu/instruction/medicine/anatomy/histoweb/endo/endo19.htm
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| | Dr Edward Howell |
| | -Adrenergic stimulation increases cAMP and melatonin production in ovine pinealocyte cultures. |
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http://www.rri.sari.ac.uk/divisions/appetite/molneuro/drug_res/howell.html
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| | A HARMOUCH AND OTHERS |
| | Moreover, we found that both alpha- and ß-adrenergic receptors are highly specific at both ages, since the binding of the specific radioligands used to their receptors could be displaced only by their corresponding agonists and antagonists. | | | , rather than to postreceptor-mediated mechanisms or changes in the characteristics of the ß-adrenergic receptors on the pinealocyte membrane. | | | In conclusion, the results presented suggest that the relative lack of sensitivity of rat pineal gland to ß-adrenergic receptor agonists early in the postnatal development may be explained by the low levels of membrane G |
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http://journals.endocrinology.org/joe/155/joe1550305.htm
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| | 2003: Pineal Gland Abstracts. Fluoride Action Network Pesticide Project. |
| | Pituitary adenylate-cyclase activating polypeptide (PACAP) is a neuropeptide originally isolated from the hypothalamus and located in many neuronal systems in both the central and peripheral nervous system. | | | Melatonin carried to the brain by the blood appears to be able to mediate the effects of photoperiod on reproduction, but it is unclear whether melatonin in CSF may fine-tune this response both in terms of timing and amplitude. | | | Membrane-bound melatonin receptors are found in many peripheral organs, including lymphoid glands and immune cells, from which melatonin receptor genes have been characterized and cloned. |
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http://www.fluoridealert.org/pesticides/pineal.2003.abstracts.htm
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| | an43 |
| | Light signals can shift the phase of the circadian oscillator of the biological clock for most animals. | | | In the avian pinealocyte, it was shown that the retinal protein pinopsin is a photoreceptor that resets the phase of the circadian pacemaker controlling the rhythmic production of melatonin D. Spawning of ascidians has been reported to be triggered by exposure to light following a period of darkness. |
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http://nsm.fullerton.edu/~lamberts/ascidian/an43.html
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| | Circumventricular organs |
| | The pineal is a diencephalic structure of the epithalamus. | | | At the ultrastructural level (Figure 2), other cellular components of the gland are more easily visualized. | | | It's principal cell type is the pinealocyte (Figure 1). |
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http://www.meddean.luc.edu/lumen/MedEd/Neuro/Circumventricular.html
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