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Topic: Phospholipid


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 Uniqema introduces Arlasilk™ Phospholipid PTM
Phospholipids are essential components of the human body and a natural for personal care products created to nourish, moisturize, cleanse and condition skin and hair.
Arlasilk Phospholipid PTM is ideal for most rinse-off formulations where gentle cleansing and conditioning is required.
Arlasilk Phospholipid PTM combines gentle cleansing, conditioning, emulsification and a distinctive sensory experience.
http://www.uniqema.com/press/news05053.htm   (724 words)

  
 Role of Electrostatic and Hydrophobic Interactions in Ca2+-Dependent Phospholipid Binding by the C2A-Domain From ...
Data shown are means ± SEM from a representative experiment performed in triplicate.
Foremost among the electrostatic interactions that promote phospholipid
our results provide further evidence for the role of the phospholipid
http://diabetes.diabetesjournals.org/cgi/content/full/51/suppl_1/S12   (3562 words)

  
 PLTP - phospholipid transfer protein
These studies demonstrate that PLTP plays a major role in facilitating the transfer of phospholipid between lipoproteins, and suggest that triglyceride is a significant modulator of intravascular phospholipid transport.
However, changes in apo A-I and A-II between these two time points were correlated with the corresponding change in PLTP activity.
Plasma phospholipid transfer protein activity in patients with low HDL and cardiovascular disease treated with simvastatin and niacin.
http://www.ihop-net.org/UniPub/iHOP/gi/91100.html   (4719 words)

  
 Cellular Phospholipid and Cholesterol Efflux in High-Density Lipoprotein Deficiency -- Marcil et al. 107 (10): 1366 -- ...
subjects (phospholipid and cholesterol efflux of <70% and
are expressed in mmol/L, and phospholipid and cholesterol efflux
There was a wide biological variability with considerable overlap
http://circ.ahajournals.org/cgi/content/full/107/10/1366   (3142 words)

  
 [No title]
Phospholipids naturally tend to assemble in this way, because the arrangement tends to satisfy the opposing tendencies of these amphipathic molecules.
The hydroxyl group is positioned where it can interact with the lower oxygens on the phospholipids.
For example, positioned between the phospholipids, the cholesterol prevents their interaction and possible crystallization.
http://courses.washington.edu/conj/membrane/bilayer.htm   (707 words)

  
 Human seminal plasma displays significant phospholipid transfer activity due to the presence of active phospholipid ...
Phospholipid transfer activity was determined as described in Materials and methods.
or NBD-PE liposomes (125 nmol of phospholipids), human HDL (100
to what extent PLTP contributes to the phospholipid transfer
http://molehr.oxfordjournals.org/cgi/content/full/9/8/457   (5165 words)

  
 Phospholipid derivatives of valproic acid and mixtures thereof - Patent 6313106
Therefore, the invention is not to be construed as restricted to the particularly described embodiments, rather the scope, spirit and concept of the invention will be more readily understood by reference to the claims which follow.
Despite continuous efforts in the field, it is still an unmet need to provide an anti-epileptic medication with improved pharmacokinetic properties and overall superior therapeutic index.
Dosing is dependent on the severity of the symptoms and on the responsiveness of the subject to the DP-VPA drug.
http://www.freepatentsonline.com/6313106.html   (6170 words)

  
 Sterol carrier protein-2 expression alters phospholipid content and fatty acyl composition in L-cell fibroblasts -- ...
and phospholipids (20), it more importantly enhances cholesterol
specifically in the Kennedy pathway affecting the other phospholipids.
to the other phospholipids and suggest that large changes in
http://www.jlr.org/cgi/content/full/41/5/788   (5459 words)

  
 Altered Phospholipid Composition and Aggregate Structure of Lung Surfactant Is Associated with Impaired Lung Function ...
Previous analysis of phospholipids in BALF from patients with
for compositional analysis of phospholipid and for surface tension
fractions (SA:LA) of BALF phospholipid for all patient groups,
http://ajrcmb.atsjournals.org/cgi/content/full/27/6/714   (4567 words)

  
 Maternal plasma phospholipid polyunsaturated fatty acids in pregnancy with and without gestational diabetes mellitus: ...
Plasma phospholipid (expressed as % by wt and mg/L) linolenic
The correlation coefficients for the association between mean
phospholipid DHA, as a metabolic response to impairment in fetal
http://www.ajcn.org/cgi/content/full/70/1/53   (4792 words)

  
 Anti-Phospholipid Antibodies (Lupus Anticoagulant)
Assessing the usefulness of anticardiolipin antibody assays: a cautious approach is suggested by high variation and limited consensus in multilaboratory testing.
Cardiolipin assay with the use of cardiolipin or other negatively charged phospholipids as antigens
Instead, it is associated with arterial and venous thrombosis occurring in 25-50% of patients who carry this protein.
http://www.thedoctorsdoctor.com/diseases/antiphospholipid_antibody.htm   (5584 words)

  
 Oral Synthetic Phospholipid (DMPC) Raises High-Density Lipoprotein Cholesterol Levels, Improves High-Density ...
is a phospholipid that does not exist in nature and has been
monocyte chemotactic activity in response to oxidized phospholipids
On searching the literature, we also found no studies of phospholipids
http://circ.ahajournals.org/cgi/content/full/108/14/1735   (3500 words)

  
 Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding -- Sun ...
C variants with enhanced phospholipid- and calcium-binding ability
The samples were analyzed by Western blotting using the
useful for in vitro and in vivo experimentation on phospholipid
http://www.bloodjournal.org/cgi/content/full/101/6/2277   (6072 words)

  
 {beta}2-Glycoprotein I Promotes the Binding of Anionic Phospholipid Vesicles by Macrophages -- Thiagarajan et al. 19 ...
and internalization of anionic phospholipid vesicles by macrophages.
cell-bound phospholipid vesicles were analyzed by flow cytometry.
Collagen-induced exposure of anionic phospholipid in platelets and platelet-derived microparticles.
http://atvb.ahajournals.org/cgi/content/full/19/11/2807   (2674 words)

  
 Failure of the Expression of Phospholipid Hydroperoxide Glutathione Peroxidase in the Spermatozoa of Human Infertile ...
Failure of the Expression of Phospholipid Hydroperoxide Glutathione Peroxidase in the Spermatozoa of Human Infertile Males -- Imai et al.
Failure of the Expression of Phospholipid Hydroperoxide Glutathione Peroxidase in the Spermatozoa of Human Infertile Males
Spatiotemporal Changes of Levels of a Moonlighting Protein, Phospholipid Hydroperoxide Glutathione Peroxidase, in Subcellular Compartments During Spermatogenesis in the Rat Testis
http://www.biolreprod.org/cgi/content/abstract/64/2/674   (859 words)

  
 Phospholipids Handbook
The Phospholipids Handbook discusses the biochemistry and synthesis of phospholipid molecules; covers all important fields of phospholipid applications; addresss the more physiological aspects of research, such as biodegradation and lipid-related diseases; surveys the main preparative, purification, and characterization techniques useful in phospholipid manufacturing and research.
Isolation and Analysis of Phospholipids and Phospholipid Mixtures.
Lipid Polymorphism: Structure and Stability of Lyotropic Mesophases of Phospholipids.
http://www.chipsbooks.com/phosphol.htm   (150 words)

  
 Human Monoclonal Antiphospholipid Antibodies Disrupt the Annexin A5 Anticoagulant Crystal Shield on Phospholipid ...
to prevent oxidation of the forming planar phospholipid by repeated
A5, had no observable effect on the crystalline lattice structure.
annexin A5 lattice on phospholipid surfaces may be a pathophysiological
http://ajp.amjpathol.org/cgi/content/full/163/3/1193   (5027 words)

  
 [No title]
g., hammerhead ribozymes (described in Haselhoff and Gerlach (1988) Nature 334 : 585-591)) can be used to catalytically cleave human phospholipid scramblase-like
The human phospholipid scramblase gene herein described may play an important role in erythrocyte, platelet, lymphocyte and endothelium physiology and function.
activity of a human phospholipid scramblase-like protein"refers to an activity exerted by a human phospholipid scramblase-like protein, polypeptide, or nucleic acid molecule on a human phospholipid scramblase-like responsive cell as determined in vivo, or in vitro, according to standard assay techniques.
http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=01/64894.010907&ELEMENT_SET=DECL   (8652 words)

  
 Phospholipid-binding antibodies and recurrent pregnancy loss
But a non-anionic phospholipid, phosphatidylethanolamine, when present in an hexagonal phase, can also be an immunological target for Plb-Ab (14).
Proteins, namely prothrombin and ß2-glycoprotein 1, are now considered as essential cofactors for the generation of Plb-Ab (1,9,19,20), and other new cofactors such as protein S have been identified.
These proteins have phospholipid-binding capacities and when they form complexes with phospholipids, cryptic epitopes may appear, which could lead to the formation of autoantibodies such as Plb-Ab.
http://www.gfmer.ch/Books/Reproductive_health/Phospholipid.html   (2331 words)

  
 Chapter 2.1: Phospholipid/Cell Membrane
Below is an example of a simple phospholipid bilayer.
First would be a micelle which would like like a ball with the phospholipid heads on the outside and the tails pointing together like this or in the form of a lipid bilayer:
The head group has a 'special' region that changes between various phospholipids.
http://ccgb.umn.edu/~mwd/cell_www/chapter2/membrane.html   (579 words)

  
 Phospholipid - Wikipedia, the free encyclopedia
This allows it to form liposomes spontaneously, or small lipid vesicles, which can then be used to transport materials into living organisms and study diffusion rates into or out of a cell membrane.
There is only one type of phospholipid with a sphingosine backbone; sphingomyelin.
Phospholipids are a major component of all biological membranes, along with glycolipids and cholesterol.
http://en.wikipedia.org/wiki/Phospholipid   (583 words)

  
 Search Results for phospholipid - Encyclopædia Britannica
Although amino acids other than serine may occur in natural phospholipids, phosphatidyl serine is the most representative one.
One important role is the synthesis of phospholipids and cholesterol, which are major...
The formation of sn-glycerol-3-phosphate is the initial process in the biosynthesis of phospholipids.
http://www.britannica.com/search?query=phospholipid&submit=Find&source=MWTEXT   (356 words)

  
 Brain Phospholipid Composition in Schizophrenia Research - UAMS Radiology
The full study, which is funded by the National Institute of Mental Health, is currently in progress, and results are not yet available.
Analysis of phospholipid molecular species in brain by 31P NMR spectroscopy.
The results of this study will provide significant information concerning the role of brain phospholipids and fatty acids in schizophrenia.
http://www.uams.edu/radiology/info/research/phospholipid/results.asp   (192 words)

  
 Jackowski: Defining the biochemical mechanisms that regulate membrane phospholipid biosynthesis
The research program is focused on defining the biochemical mechanisms that regulate membrane phospholipid biosynthesis.
Having the appropriate molecular reagents is essential to investigating the role of pathway enzymes in signal transduction and intermediary metabolism.
The mechanism of action of antineoplastic phospholipids is also under investigation and our recent results link their efficacy in inducing apoptosis with their ability to inhibit membrane phospholipid biogenesis.
http://www.stjude.org/faculty/0,2512,407_2030_4391,00.html   (384 words)

  
 PHOSPHOLIPID
Approximate level of phospholipids in lecithin is 50%.
Phospholipids consist of a water-soluble head (a positively charged group), linked to two water-insoluble nonpolar tails.
Common types of phospholipids are: phosphatidylethanolamine, phosphatidylinositol, phosphatidic acid and phosphatidylcholine Phospholipids are also present in lecithin.
http://www.yotor.org/wiki/en/ph/Phospholipid.htm   (155 words)

  
 Phospholipids
Phospholipids are fat derivatives in which one fatty acid has been replaced by a phosphate group and one of several nitrogen-containing molecules.
These molecules form a phospholipid bilayer with their hydrophilic (polar) heads facing their aqueous surroundings (e.g., the cytosol) and their hydrophobic tails facing each other.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Phospholipids.html   (89 words)

  
 Biophysical Journal: Properties of a Self-Assembled Phospholipid Membrane Supported on Lipobeads
However, unless some input of energy is applied, such as by homogenization or Langmuir-Blodgett type processes, the lipid membrane formed on substrate surfaces may be heterogeneous, and their properties hard to predict.
Hydrogel-supported phospholipid membranes may be useful tools in both fundamental and applied research in protein biology, membrane biophysics, and biosensor technology.
The overall objective of our work was to make a hydrogel-supported phospholipid bilayer that models a cytoskeleton-supported cell membrane and provides a platform for studying membrane biology.
http://www.findarticles.com/p/articles/mi_qa3938/is_200407/ai_n9429033   (1324 words)

  
 Optimising testing for phospholipid antibodies -- Helbert et al. 54 (9): 693 -- Journal of Clinical Pathology
Phospholipid antibodies are associated with thrombosis in patients
Diagnosis of the anti phospholipid syndrome: proposal for use of laboratory tests.
Optimising testing for phospholipid antibodies -- Helbert et al.
http://jcp.bmjjournals.com/cgi/content/full/54/9/693   (2327 words)

  
 Impact of Nonspecific Binding to Microsomes and Phospholipid on the Inhibition of Cytochrome P4502D6: Implications for ...
to a large extent comprised of phospholipid, experiments were
The system chosen for study was the CYP2D6-mediated
as the concentration of microsomes (and hence phospholipid) is
http://dmd.aspetjournals.org/cgi/content/full/31/5/606   (3510 words)

  
 Ethylene-Mediated Phospholipid Catabolic Pathway in Glucose-Starved Carrot Suspension Cells -- Hyun Lee et al. 116 (1): ...
phospholipid catabolic pathway is part of the metabolic strategies
Ethylene-Mediated Phospholipid Catabolic Pathway in Glucose-Starved Carrot Suspension Cells -- Hyun Lee et al.
of the phospholipid degradation, suggesting that the observed
http://www.plantphysiol.org/cgi/content/abstract/116/1/223   (524 words)

  
 Membranes for Modern/Cell Biology
The structure shown here corresponds to the most ordered arrangement of the phospholipids, the so-called "crystal" phase.
See also Dr. Eric Martz' treatment of Lipid Bilayer Membranes to view GIFs of the crystal, gel and fluid models and for downloading the coordinates of each.
Similar displays of the gel and fluid phases show more disorder in the fatty acid tails of the phospholipid.
http://info.bio.cmu.edu/Courses/BiochemMols/BuildBlocks/Membrane.html   (322 words)

  
 Macromolecules on surface control mobility in phospholipid bilayers
CHAMPAIGN, Ill. -- Phospholipid bilayers serve as the framework in biological membranes in which other components are embedded.
To study lipid mobility, Granick and graduate student Liangfang Zhang first supported a bilayer made of a single type of phospholipid molecule on a planar substrate (separated from the substrate by a thin layer of water several nanometers thick, the lipid molecules were free to move around).
This simple bilayer mimicked the much more complex structure of a real cell membrane comprised of hundreds of different lipids and proteins.
http://www.eurekalert.org/pub_releases/2005-06/uoia-mos061505.php   (533 words)

  
 phospholipid - definition of phospholipid by the Free Online Dictionary, Thesaurus and Encyclopedia.
This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.
Any of various phosphorous-containing lipids, such as lecithin and cephalin, that are composed mainly of fatty acids, a phosphate group, and a simple organic molecule.
lecithin - a yellow phospholipid essential for the metabolism of fats; found in egg yolk and in many plant and animal cells; used commercially as an emulsifier
http://www.thefreedictionary.com/phospholipid   (186 words)

  
 Human protein: Q9NRY7 - Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2). EMBL ...
may mediate accelerated atp-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
Identification of three new members of the phospholipid scramblase gene family.
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.
http://harvester.embl.de/harvester/Q9NR/Q9NRY7.htm   (703 words)

  
 Amazon.com: Phospholipid Signaling Protocols (Methods in Molecular Biology): Books: Ian M. Bird
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Phospholipid Signaling Protocols (Methods in Molecular Biology) (Hardcover)
The minor inositol-containing membrane phospholipids, the phosphoinositides, play a central role in cell signal transduction.
http://www.amazon.com/exec/obidos/tg/detail/-/0896034917?v=glance   (385 words)

  
 Phospholipid Structure
This figure illustrates the basic structure of a phospholipid molecule, a primary constituent of a biological membrane.
This page was last updated on January 10, 1999.
http://tidepool.st.usm.edu/crswr/phospholipidstruct.html   (26 words)

  
 Drug Discovery & Development
Inositol phospholipids are a minor component of the plasma membrane important in signal transduction.
http://www.dddmag.com/scripts/Glossary.asp?RPTID=KWSRCH&SEARCHMETHOD=WORD&SEARCHWORD=Phospholipid   (168 words)

  
 Avanti Polar Lipids - The Phospholipid and Sphingolipid People
Avanti Polar Lipids - The Phospholipid and Sphingolipid People
http://www.avantilipids.com   (9 words)

  
 Calcium-sensitive Phospholipid Binding Properties of Normal and Mutant Ferlin C2 Domains -- Davis et al. 277 (25): ...
C2 domains for their ability to bind phospholipid in a calcium-sensitive
We found that C2A, the first C2 domain of dysferlin and
Calcium-sensitive Phospholipid Binding Properties of Normal and Mutant Ferlin C2 Domains -- Davis et al.
http://www.jbc.org/cgi/content/abstract/277/25/22883   (641 words)

  
 Drug Discovery & Development
A form of parallel synthesis used in combinatorial chemistry in which the reactions take place in a spatially organized array.
Arachidonic acid is released from cell membrane phospholipids, including phosphatidyl inositol, by phospholipases.
http://dddmag.com/scripts/Glossary.asp?...&SEARCHWORD=Phospholipid   (2449 words)

  
 LUPUS ANTICOAGULANTS/PHOSPHOLIPID-DEPENDENT ANTIBODIES
He found that about 20% of LA positive plasmas give discordant results.
Finn Wisloff compared LA results obtained with an aPTT, a PT and a RVVT using identical phospholipid composition, instrumentation and calculation of the results.
http://www.med.unc.edu/isth/SSC/01sscminutes/01lupus.html   (1627 words)

  
 GLOSSARY PQ
Lipids with a phosphate group in place of one of the three fatty acid chains.
Phospholipids have hydrophilic heads (glycerol and phosphate) and hydrophobic tails (the non-polar fatty acids).
Phospholipids are the building blocks of cellular membranes.
http://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookglossPQ.html   (3318 words)

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