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| | World Intellectual Property Organization |
 | | Other peptidases may also be useful as the second peptidase, for example triaminopeptidase, which can utilize | | | The method of claim 12, wherein the MAP is a human MAP. | | | This inhibitor-detection method can utilize MAP or the second peptidase from any source. |
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http://www.wipo.int/ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=01/27242.010419&ELEMENT_SET=DECL
(4634 words)
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| | Tripeptidyl Peptidase II & Cholecystokinin -- Neurotransmitter.net |
| | The rate of [3H]pCCK8 uptake was not affected by CCK4, CCK5, D-Trp CCK8, BC 264, a potent and radioactivity was observed using [3H]pBC 264, a result which is not in favour of a cholecystokinin receptor-induced internalization mechanism. | | | These results show that the behavior of rats exposed to a novel external stimuli is highly sensitive to CCK8." [Abstract] | | | The potent and selective uptake mechanism characterized in this study could participate, in conjunction with extra and intracellular degradation of CCK8 by peptidases, in the interruption of cholecystokinin-conveyed messages in the brain." [Abstract] |
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http://www.neurotransmitter.net/tpp2.html
(10389 words)
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| | PEPB - peptidase B |
| | Three private polymorphisms, at the 2,3-diphosphoglycerate mutase, peptidase B, and purine nucleoside phosphorylase loci, have been observed, which may be useful in future studies of genetic relationships between Eskimos and other circumpolar populations. | | | About 2,000 newborn have been analyzed for ACP, GLO I, and UMPK; 1,000 of them were also analyzed for PepA and PepB, and 500 for PGM1 and PGM2. | | | This decreased ability to cleave these substrates is pepN-specific as there is no reduction in the ability to hydrolyse exopeptidase substrates in E. coli mutants lacking other peptidases, pepA, pepB or pepE. |
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http://www.ihop-net.org/UniPub/iHOP/gg/90931.html
(1123 words)
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| | SPC1 - Microsomal signal peptidase subunit 1 |
| | This extends the types of damage that are sensed by the spc1 MAPK pathway via atf1. | | | In the present study, we addressed this issue through analysis of the yeast homologs to SPC12 and SPC25, Spc1p and Spc2p. | | | Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct. |
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http://www.ihop-net.org/UniPub/iHOP/gg/33722.html
(375 words)
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| | Amazon.ca: Books: Proteinase and Peptidase Inhibition |
| | For researchers in medicinal chemistry, drug design, and structural development. | | | Look for books like Proteinase and Peptidase Inhibition by subject: | | | Use Your Account to view or change your orders |
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http://www.amazon.ca/exec/obidos/ASIN/0415273498
(201 words)
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| | DPP IV - Dipeptidyl Peptidase IV-Master regulatory enzyme |
| | See what parents and doctors say about our services | | | Effects of psychological stress on serum prolyl endopeptidase and dipeptidyl peptidase IV activity in humans: higher serum prolyl endopeptidase activity is related to stress-induced anxiety. | | | Morimoto C, Schlossman SF.The structure and function of CD26 in the T-cell immune response. |
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http://www.gpl4u.com/Peptidase.html
(459 words)
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| | Protease - Wikipedia, the free encyclopedia |
| | This may be an important method of regulation of peptidase activity. | | | The activity can be a destructive change abolishing a proteins function or digesting it to its principal components, it can be an activation of a function or it can be a signal in a signalling pathway. | | | The threonine and glutamic peptidases was not described until 1995 and 2004, respectively. |
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http://en.wikipedia.org/wiki/Peptidase
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| | Purification and characterization of an arginyl peptidase from the chloroplast stroma of pea seedlings. |
| | Only Arg-containing peptides were cleaved by the peptidase, and it was found most sensitive to the inhibitors 3,4-dichloroisocoumarin and antipain. | | | Purification and characterization of an arginyl peptidase from the chloroplast stroma of pea seedlings. | | | This peptidase could not cleave stromal or thylakoid proteins, suggesting that its activity is limited to later stages of the protein degradation process in chloroplasts, in which short peptides are further cleaved to ultimately yield free amino acids. |
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http://indycc1.agri.huji.ac.il/~zacha/purification.html
(188 words)
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| | News - Serum Dipeptidyl Peptidase IV Activity May Reflect Therapy Efficacy |
| | Serum Dipeptidyl Peptidase IV Activity May Reflect Therapy Efficacy | | | News - Serum Dipeptidyl Peptidase IV Activity May Reflect Therapy Efficacy | | | In fact, this activity of dipeptidyl peptidase IV (DPP IV) may reflect the efficacy of interferon therapy, suggest these authors. |
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http://www.docguide.com/news/content.nsf/news/8525697700573E1885256A9C004DCFB0?OpenDocument&c=&count=10&id=48DDE4A73E09A969852568880078C249
(475 words)
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| | SPCS2 - Microsomal signal peptidase 25 kDa subunit |
| | SPCS2 is a homologue of At2g39960 (Probable microsomal signal peptidase 25 kDa subunit) from Arabidopsis thaliana. | | | SPCS2 is a homologue of CG1751 (Probable microsomal signal peptidase 25 kDa subunit) from Drosophila melanogaster. | | | SPCS2 is a homologue of Spcs2 (Microsomal signal peptidase 25 kDa subunit) from Mus musculus. |
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http://www.pdg.cnb.uam.es/UniPub/iHOP/gg/94961.html
(493 words)
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| | At3g05230 - signal peptidase subunit family protein |
| | At3g05230 is a homologue of CG5677 (Probable microsomal signal peptidase 22 kDa subunit) from Drosophila melanogaster. | | | At3g05230 is a homologue of 6530401D17Rik (Microsomal signal peptidase 23 kDa subunit) from Mus musculus. | | | At3g05230 is a homologue of SPC3 (Microsomal signal peptidase subunit 3) from Saccharomyces cerevisiae. |
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http://www.ihop-net.org/UniPub/iHOP/gg/5051.html
(119 words)
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| | Pfam 18.0 : Peptidase_M16_C |
| | The mitochondrial processing peptidase consists of two structurally related domains. | | | One is the active peptidase, whereas the other is inactive. | | | Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences. |
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http://pfam.wustl.edu/cgi-bin/getdesc?name=Peptidase_M16_C
(244 words)
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| | Kirkman's Peptidase Complete™ |
| | As a dietary supplement take 1 or more capsules with meals or as directed by a health care practitioner. | | | This unique blend of pure plant-based as well as fruit-based enzymes are utilized to provide digestive activity for a full range of proteins under the wide range of pH conditions, found in the intestinal tract. | | | DPP-IV is a type of peptidase enzyme that is commonly located on the epithelial brush boarders of the small intestine where it is specifically imbedded in the mucosal membrane of the lining of the intestinal tract. |
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http://www.kirkmanlabs.com/products/enzymes/peptidase/Peptidase_C_100_Spec248.html
(870 words)
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| | ARS Publication request: Isolation, Characterization and Mapping of the Bovine Signal Peptidase Subunit 18 Gene |
| | This example provides evidence that predictions based on human mapping data are not always correct and prudence should be exercised when comparative maps are generated in silico. | | | Therefore, signal peptidase may be a candidate gene affecting economically important traits in dairy cattle such as milk production and, specifically protein yield due to its essential role in the secretory process. | | | Technical Abstract: Signal peptidases are responsible for the removal of amino-terminal signal peptides from secretory and integral membrane proteins and are ubiquitous in nature. |
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http://www.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=119224
(380 words)
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| | Pfam 18.0 : Peptidase_S24 |
| | Notwithstanding their different evolutionary origins, there are similarities in the reaction mechanisms of several peptidases. | | | This signature is associated with serine peptidases belong to MEROPS peptidase families: S24 (LexA family, clan SF); S26A (signal peptidase I) and S26B (signalase). | | | In prokaryotes three types of SPases are known: type I (gene lepB) which is responsible for the processing of the majority of exported pre-proteins; type II (gene lsp) which only process lipoproteins, and a third type involved in the processing of pili subunits. |
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http://pfam.wustl.edu/cgi-bin/getdesc?name=Peptidase_S24
(698 words)
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| | Safety Evaluation of Amino Peptidase Enzyme Preparation derived from Aspergillus niger |
| | The no-observed-adverse-effect level (NOAEL) of the enzyme preparation in the subchronic toxicity study was 2000mg/kg body weight/day (equivalent to 1152 PHEA units/kg body weight/day). | | | It can be concluded that no safety concerns were identified in the studies conducted with this amino peptidase enzyme preparation derived from Aspergillus niger and produced under controlled fermentation conditions. | | | An amino peptidase enzyme preparation obtained from Aspergillus niger was subjected to a series of toxicological tests to document the safety for use as a processing aid for food. |
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http://www.elsevier.com/cdweb/views/article.htt?jnl=02786915&iss=9-10&vol=36&pii=S027869159800041
(203 words)
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| | Evidence that “Vaginal Peptidase” Is a Bacterial Gene Product |
| | These studies reveal that “vaginal peptidase” is composed of a family of peptidase isozymes that originate from several bacterial species. | | | The characterization of “vaginal peptidase” as a tissue specific marker for vaginal debris is premature. | | | A peptidase has been described in vaginal samples, termed “vaginal peptidase.” This enzyme has been proposed as a tissue specific marker for vaginal debris. |
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http://www.astm.org/JOURNALS/FORENSIC/PAGES/886.htm
(145 words)
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| | E.C.3.4.21.89 Signal peptidase I. |
| | Comments: Unaffected by inhibitors of most serine peptidases. | | | The characteristics of the P1 and P3 residues are especially important in the specificity of leader peptidase. | | | E.C.3.4.21.89 Signal peptidase I. Reaction: Cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor. |
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http://www.biochem.ucl.ac.uk/bsm/enzymes/ec3/ec04/ec21/ec0089
(70 words)
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| | [No title] |
| | COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases | | | [NOU] COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases... |
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http://cmgm.stanford.edu/~merino/COGs/COG1989.html
(272 words)
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| | Factors Governing Nonoverlapping Substrate Specificity by Mitochondrial Inner Membrane Peptidase -- Luo et al. 278 (7): ... |
| | The crystal structure of only one type I SP, the leader peptidase from Escherichia coli, has been determined previously (20). | | | Mitochondrial targeting is achieved to a large extent by N-terminal presequences whose cleavage by mitochondrial peptidases | | | The abbreviations used are: MPP, mitochondrial processing peptidase; ER, endoplasmic reticulum; IMP, inner membrane protease; cyt, cytochrome; SP, signal peptidase; HA, hemagglutinin. |
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http://www.jbc.org/cgi/content/full/278/7/4943
(3461 words)
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| | (WO 01/27242) METHODS FOR IDENTIFYING INHIBITORS OF METHIONINE AMINOPEPTIDASES |
| | Reaction mixes, peptides, and kits which are useful for practicing the methods are also provided. | | | The methods utilize a peptide comprising an N-terminal methionine which can be cleaved from the peptide by MAP, and a C-terminal detection moiety which is released by a second peptidase only if the N-terminal methionine has been cleaved from the peptide. | | | When the peptide is combined with MAP and the second peptidase, the detection moiety is released, while the addition of a MAP inhibitor will inhibit the release of the detection moiety. |
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http://wipo.int/ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=01/27242.010419&...
(184 words)
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| | dipeptidyl peptidase IV - Press Release |
| | Basel, Switzerland, 29 April - Evidence that a new pharmacological strategy may be a useful treatment for type 2 diabetes is being published in the May issue of Diabetes Care. | | | Initial findings from a study in patients with type 2 diabetes show that inhibition of the enzyme dipeptidyl peptidase IV (DPP IV) improves glucose tolerance and insulin response to oral glucose in patients with type 2 diabetes. | | | Proof-of-concept published in 'Diabetes Care' could pave the way to development of new class of diabetes treatment |
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http://www.pharma.us.novartis.com/newsroom/pressReleases/releaseDetail.jsp?PRID=195
(914 words)
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| | Diabetes: Dipeptidyl peptidase IV-resistant [D-[Ala.sup.2... @ HighBeam Research |
| | One of the major drawbacks with the use of either GIP or GLP-1 as potential therapeutic agents is their short duration of action, due to enzymatic degradation in vivo. | | | (35.) Deacon CF, Knudsen LB, Madsen K, Wiberg FC, Jacobsen O, Holst JJ: Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity. | | | All inquiries regarding rights should be directed to the Gale Group. |
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http://www.highbeam.com/library/doc0.asp?DOCID=1G1:84209406&refid=holomed_1
(5705 words)
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| | Search Results |
| | Smith,A.M., Yan,H., Groves,N., Dalla Pozza,T. and Walker,M.J. Co-expression of the Bordetella pertussis leader peptidase I results in enhanced processing and expression of the pertussis toxin S1 subunit in Escherichia coli. | | | Residues 80 to 319 (E-value = 9.6e-45) place NG0343 in the Peptidase_S26 family which is described as Signal peptidase I (PF00461) | | | Residues 95-236 are 32% similar to a (SIGNAL PEPTIDASE I SPASE) protein domain (PD109753) which is seen in LEP_HELPY. |
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http://hpv-web.lanl.gov/cgi-bin/gene_id_search.cgi?dbname=ngon&gene_id=NG0343
(261 words)
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| | Search Results |
| | (1999) demonstrate tripeptidyl peptidase activity for this enzyme, though it lacks structural similarity to other known tripeptidyl peptidases. | | | Similarites are also seen to PG1528, PG0652, PG0897. | | | Residues 532 to 608 (E-value = 2.1e-06) place PG1196 in the Peptidase_S9 family which is described as Prolyl oligopeptidase family (PF00326) |
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http://hpv-web.lanl.gov/cgi-bin/gene_id_search.cgi?dbname=pgin&gene_id=PG1196
(424 words)
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| | Welcome to the Dalbey Page |
| | Paetzel, M., Strynadka, N.C.J., James, M.N.G. and Dalbey, R.E. "Crystallization and Preliminary X-Ray Analysis of a Soluble, Catalytically Active Form of Escherichia coli Type 1 Signal Peptidases", Proteolysis in Cell Function, 256-261. | | | Laws, J.K. and Dalbey, R.E. (1989), "Positive Charges in the Cytoplasmic Domain of Escherichia coli Leader Peptidase Prevent an Apolar Domain from Functioning as a Signal", EMBO J., 8, 2095-2099. | | | Dalbey, R.E. and von Heijne, G. "Signal Peptidase in Prokaryotes and Eukaryotes - A New Protease Family", Trends in Biochemical Sciences, 17, 474-478. |
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http://www.chemistry.ohio-state.edu/~dalbey/publications.html
(2189 words)
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| | peptidase - definition of peptidase by the Free Online Dictionary, Thesaurus and Encyclopedia. |
| | This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. | | | peptidase - any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis | | | peptidase - definition of peptidase by the Free Online Dictionary, Thesaurus and Encyclopedia. |
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http://www.thefreedictionary.com/peptidase
(180 words)
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| | Protein Traffic Signals |
| | The sequence recognized by the signal peptidase is complex, consisting of three regions: | | | Many peptidases consist of several polypeptides, thus requiring several genes to encode them. | | | Thylakoid proteins are first imported into the stroma and then transferred across the thylakoid membrane. |
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http://opbs.okstate.edu/~melcher/MG/MGW2/MG2543.html
(260 words)
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| | EC 3.4.19.3 |
| | The enzyme from bacterial sources is used in protein sequencing, and is the type example of peptidase family C15. | | | An improved purification method and some properties of the enzyme. | | | Patti, J.M., Schneider, A., Garza, N. and Boles, J.O. Isolation and characterization of pcp, a gene encoding a pyrrolidone carboxyl peptidase in Staphylococcus aureus. |
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http://www.chem.qmw.ac.uk/iubmb/enzyme/EC3/4/19/3.html
(181 words)
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| | New Dipeptidyl Peptidase II Inhibitor available from Peptides International |
| | This new tool is expected to be valuable for investigations of DPP II function. | | | Larger quantities available please contact our technical sales specialists to discuss your project needs.. | | | New Dipeptidyl Peptidase II Inhibitor available from Peptides International |
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http://www.pepnet.com/dppIIinhibitor.html
(115 words)
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| | Detailed annotation info for RP116 |
| | Bacterial leader peptidase I.; Phage-procoat-leader peptidase.; SPase I.; signal peptidase I [Rickettsia typhi str. | | | GO:0006508proteolysis and peptidolysisIEA; GO:0008236serine-type peptidase activityIEA; GO:0009004signal peptidase I activityIEA; GO:0016020membraneIEA; GO:0016787hydrolase activityIEA | | | signal peptidase I; Bacterial leader peptidase I.; Phage-procoat-leader peptidase.; SPase I. [Rickettsia typhi str. |
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http://megasun.bch.umontreal.ca/Software/Rprowasekii_GeneQuiz/html/RP116.html
(52 words)
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| | Protein gi2313695 |
| | lepP, probable signal peptidase I 802203:803051 forward MW:32952 | | | Sequence neighbours to Helicobacter pylori 26695 protein gi2313695, signal peptidase I (lepB) |
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http://www.sbc.su.se/PhylProM/HPYL/gi2313695.html
(20 words)
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