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| | Postgraduate Medicine: Current therapies for chronic hepatitis C |
 | | In the interim, pegylated interferon and ribavirin remain the cornerstone of therapy. | | | Most patients who receive combination therapy with pegylated interferon and ribavirin have an early reduction in HCV RNA levels. | | | This approach may be appropriate for nonresponding patients with advanced fibrosis or cirrhosis and is being evaluated in three large, multicenter trials. |
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http://www.postgradmed.com/issues/2003/07_03/1patel.htm
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| | PharmaCare - HCV Medication pegylated interferon (PEG-Intron) |
| | Overall, clinical studies have found that pegylated interferon used in combination with ribavirin (Rebetol®, Copegus®) is more effective than standard interferon in combination with ribavirin or pegylated interferon used alone. | | | This means that the pegylated interferon stays in the body longer and is able to fight off the HCV virus more effectively. | | | Therefore, standard interferon plus ribavirin may be an effective therapeutic option for individuals with genotypes 2 or 3. |
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http://www.stadtlander.com/content/hepc/clinical/pegylated.html
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| | News - Pegylated Interferon Induces Sustained Responses in Asymptomatic Patients With Hepatitis C Infection: Presented ... |
| | "Pegylated interferon leads to higher sustained viral response rates in symptomatic patients with acute HCV infections, but the treatment of asymptomatic HCV is not yet established," said Sanaa Kamal, MD, professor of medicine, Harvard University, Boston, Massachusetts. | | | Continuation of therapy for another 12 weeks raised the early virologic response rate in the interferon-ribavirin group to 74.2% and in the pegylated interferon group to 96.7%. | | | Patients in each of these groups were randomly assigned to 12 weeks of therapy with interferon alfa-2b plus ribavirin or once-weekly pegylated interferon alfa monotherapy. |
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http://www.docguide.com/news/content.nsf/news/8525697700573E1885256F400051DB27?OpenDocument&id=48DDE4A73E09A969852568880078C249&c=Hepatitis%20Other&count=10
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| | Combo to Pegalayted |
| | First of all, it is not clear that pegylated interferon alone will be significantly better than combination therapy, which is the combination of standard interferon (3X a week) and ribavirin. | | | I do advise some of my patients who have early levels of fibrosis on biopsy that there is little risk to waiting six to 12 months to see how these drugs continue to do in clinical trials and to see when they are likely to be released. | | | A second point I would make is that pegylated interferon is still a form of interferon and there are still considerable side effects. |
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http://www.medhelp.org/forums/hepatitis/messages/30189a.html
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| | Clinical Care Options for Hepatitis - Pegylated Interferon and Ribavirin: Also the Standard of Care for HIV-infected ... |
| | While future studies are ongoing to clarify these issues, it is now clear that pegylated interferon and ribavirin therapy is the treatment of choice for HIV/HCV-coinfected patients. | | | However, of the 5 instances occurring in persons taking pegylated interferon and ribavirin, 4 were in patients who should not have been enrolled in the study, because they had baseline Child-Pugh scores of more than 5. | | | Each study contributed one other finding that I believe is important with regard to the effectiveness of treatment. |
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http://clinicalcareoptions.com/hep/jopt/articles/article.asp?a=Chung-NEJM-2004-07&page=commentary
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| | Pegylated Interferon Health Web Links |
| | -- General George Patton Pegylated Interferon One of the symptoms of an approaching nervous breakdown is the belief that one's work is terribly important. | | | That is why most men dread it." (George Bernard Shaw) Working mothers are guinea pigs in a scientific experiment to show that sleep is not necessary to human life. | | | -- Chad A. Gamble, Escape, short story Pegylated Interferon "Murder is the very bed-rock of our social institutions." (Octave Mirbeau, The Torture Garden) It is possible to store the mind with a million facts and still be entirely uneducated. |
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http://www.internet-health-directory.com/Pharmacy_Drugs_and_Medications_P_Pegylated_Interferon.html
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| | News Review |
| | Combination therapy with pegylated interferon plus ribavirin for 24 to 48 weeks can result in eradication of the virus in about 50 percent of patients, he adds. | | | Most genotype 1 patients fail initial therapy of pegylated interferon and ribavirin and become non-responders. | | | Non-responders to previous hepatitis C therapy are the subjects of SciClone's two U.S. phase 3 clinical trials for ZADAXIN in combination therapy with pegylated interferon. |
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http://www.hcvadvocate.org/news/newsRev/2004/NewsRev-73.html
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| | Aidsmap Treatment for HIV/HCV coinfection: three major studies report at CROI |
| | Overall, 40% of coinfected patients treated with pegylated interferon/ribavirin achieved SVR, compared with 20% of those receiving pegylated interferon monotherapy and 12% of those receiving standard interferon/ribavirin (corresponding end-of-treatment response rates were 49%, 33%, and 14%). | | | Within the pegylated interferon arm, 80% with genotypes other than 1 showed an end-of-treatment response, compared with 29% of genotype 1 patients. | | | Eligible participants either had a CD4 count of at least 100 cells/mL, an HIV viral load less than 10,000 copies/mL, and stable antiretroviral therapy for at least 12 weeks, or else were antiretroviral naive and had a CD4 count of at least 300. |
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http://www.aidsmap.com/en/news/229840FE-4B61-4042-970E-D182D6AAEE48.asp
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| | Conference Reports |
| | Cost of treating genotype 1 patients with interferon (pegylated and non) an ribavirin was analyzed. | | | Some patients with a poor response to IFN achieve on-treatment virological responses to pegylated IFN/ribavirin, although relapse is not uncommon after the end of treatment. | | | Eradicating HCV in the majority of infected patients remains an elusive goal, particularly in previously treated patients who failed or relapsed following prior therapy. |
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http://www.hcvadvocate.org/news/reports/Day3.html
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| | Simple FactSheet: pegylated interferon (Pegasys, PEG-Intron) |
| | Pegylated interferon is made with special add-on parts that help the drug stay in the body longer. | | | Pegylated interferon can increase blood levels of pheothylline, an asthma medication. | | | Hoffman-LaRoche, the maker of Pegasys, and Schering-Plough, the maker of PEG-Intron, each have a patient assistance program for people having problems getting the drug. |
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http://www.aegis.com/factshts/network/simple/pifn.html
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| | Pegylated Interferon Alfa-2b Plus Ribavirin... |
| | This study focused on those with paired liver biopsies (the first biopsy was done within 12 months of starting therapy and the second biopsy was done after treatment) which were reviewed by a central liver pathologist. | | | By Mark Sulkowsky, MD Over the past 12 months, patients and clinicians have awaited information from clinical trials of long-acting, once-weekly pegylated interferons in combination with oral ribavirin. | | | This indicates the need for more research side-effect management related to both interferon and ribavirin. |
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http://www.hivandhepatitis.com/hep_c/news/111300a.html
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| | HepNet: Results of the Pegylated Interferon Trial |
| | Comparison of these preliminary data with data on interferon/ribavirin suggest that monotherapy with pegylated interferon will not be as effective as the current standard of care, combination therapy using interferon a-2b/ribavirin. | | | These trials demonstrate that pegylated interferon is more effective than interferon monotherapy. | | | Compared with standard interferon, pegylated interferon appears to be better tolerated, more convenient and, therefore may well have a role as therapy for those who cannot tolerate interferon a-2b/ribavirin or maintenance therapy. |
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http://www.hepnet.com/hepc/ddw00/lindsay.html
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| | Low-Dose Pegylated-Interferon in Early HIV to Reduce Viral Reservoir: pilot study |
| | At an Immune-Based Therapy oral session at Retrovirus German researchers presented this abstract for a pilot study on using pegylated interferon in a unique way as a treatment for HIV. | | | Study researchers reported that our study shows that application of pegylated interferon alfa 2b allows early control of HIV replication and a rapid decline of the viral reservoir while CD4-cell levels improved. | | | "Pegylated Interferon Alfa-2b: A New Therapeutic Option in the Treatment of Early-stage HIV Infection" |
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http://www.natap.org/2003/Retro/day35.htm
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| | Patent 6,362,162 |
| | Methods for treating treatment-naive as well as treatment-experienced patients having CML to achieve at least a partial cytogenetic response involving administering a therapeutically effective amount of pegylated interferon-alpha, e.g., pegylated interferon alpha-2b as monotherapy or in association with a therapeutically effective amount of Ara-C are disclosed. | | | The present invention provides an improved method of treating patients with CML-especially those in the chronic phase of CML. | | | A method of treating a patient having chronic myelogenous leukemia which comprises administering to such a patient a therapeutically effective dose of pegylated interferon alpha for a time period sufficient to effect at least a partial cytogenetic response. |
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http://www.pharmcast.com/Patents/Yr2002/Mar2002/032602/6362162_CML032602.htm
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| | Clinical Trial: Pegylated Interferon to Treat Chronic Hepatitis D |
| | The primary endpoint of therapy will be improvements in hepatic histology on liver biopsy done after 3 years of pegylated alpha interferon therapy. | | | All patients will fill out a health-related quality of life questionnaire. | | | Pegylated interferon is more effective than standard interferon in hepatitis C patients, with patients experiencing longer-term improvement. |
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http://clinicaltrials.gov/ct/show/NCT00023322?order=30
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| | The Body: New HCV Treatment Options Available |
| | If you do take Videx with ribavirin, you should be monitored closely for Videx side effects, including pancreatitis, lactic acidosis and peripheral neuropathy. | | | They can include muscle aches, joint pains, anxiety and depression. | | | Interferon, an important HCV drug, is available in an improved, time-release form called pegylated interferon. |
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http://www.thebody.com/pw/hcv_treatment.html
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| | Clinical Care Options for HIV - Pegylated interferon superior to lamivudine for first-line hepatitis B treatment |
| | The addition of lamivudine to pegylated interferon did not improve the treatment outcome; a total of 27% achieved HBeAg seroconversion (P =.02). | | | However, seroconversion from positive to negative does indicate a better clinical prognosis. | | | The first treatment to be licensed for HBV treatment was interferon-alpha, but pegylated interferon was shown to be superior to interferon-alpha in a phase 2 study. |
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http://clinicalcareoptions.com/hiv/news/news_NAM_483.asp
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| | IngentaConnect Structure, Biology, and Therapeutic Implications of Pegylated Int... |
| | Keywords: hepatitic c; pegylated positional isomer; pegylated protein-based therapeutics; protein-polymer conjugate; pegylated interferon; interferon alpha-2b | | | This review will provide an overview of pegylation technology and pegylated protein-based drugs being used or investigated clinically. | | | Structure, Biology, and Therapeutic Implications of Pegylated Interferon Alpha-2b |
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http://www.ingentaconnect.com/content/ben/cpd/2002/00000008/00000024/art00003
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| | Clinical Trial: Pegylated Interferon and Ribavirin to Treat Chronic Hepatitis C with and without Kidney Disease |
| | Up to 100 with chronic hepatitis C will be enrolled in a study of the combination of pegylated alpha interferon and ribavirin for 48 weeks with the option of early discontinuation of therapy for patients who do not respond within 24 weeks of starting therapy. | | | Official Title: Combination of Pegylated Interferon and Ribavirin as Therapy for Patients with Chronic Hepatitis C with and without Renal Disease | | | Adult patients will be chosen who have chronic hepatitis C, HCV RNA in serum, HCV genotype 1 and liver histology showing chronic hepatitis C. Patients with advanced liver disease and clinical decompensation and patients who have received alpha interferon in the past will not be eligible. |
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http://www.clinicaltrials.gov/ct/show/NCT00028093?order=3
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| | CHEST: Pegylated interferon and ribavirin-induced interstitial pneumonitis with ARDS - selected reports |
| | Interstitial pneumonitis has been previously described as a complication of interferon-[alpha] therapy (1-6) but, to our knowledge, never has been reported with pegylated interferon-[[alpha].sub.2]b therapy following its approval by the US Food and Drug Administration in January 2001. | | | This ease suggests that interstitial pulmonary disease can occur with pegylated interferon-[[alpha].sub.2]b therapy. | | | A possible pulmonary allergic reaction to pegylated interferon-[[alpha].sub.2]b was suspected as the cause of his symptoms, and the patient therefore was started on therapy with methylprednisolone, 60 mg IV q8h. |
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http://www.findarticles.com/p/articles/mi_m0984/is_1_124/ai_106096410
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| | Forum on Hepatitis and HIV Coinfection: Pegylated Inteferon |
| | I know it's a new drug, but I don't know what it is or how it works. | | | Let me know what else you need to clarify.Next week I would be able to give you %and numbers after they are presented at DDW> | | | Forum on Hepatitis and HIV Coinfection: Pegylated Inteferon |
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http://www.thebody.com/Forums/AIDS/Hepatitis/Current/Q24192.qna
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| | News - Pegylated Interferon Alpha-2b Plus Ribavirin Provides Treatment Option for Patients with Hepatitis C Virus and ... |
| | The combination achieved an overall virologic response rate of 68 percent at 12 weeks, including a 90 percent response rate in patients who had genotype non-1, said Dr. Steven Flamm, a hepatologist at Northwestern University, in Chicago, Illinois, United States. | | | The patients were randomised to 1.0 or 1.5 µg/kg/week of pegylated interferon alpha-2b plus ribavirin 800 to 1400 mg/day. | | | Responses occurred in six of seven genotype non-1 patients in the reduced-dose group and all three such patients in the standard-dose group. |
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http://www.docguide.com/news/content.nsf/news/8525697700573E1885256C68004E1DF3
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| | Pegylated Liposomal Doxorubicin in the Treatment of Breast Cancer |
| | Liposomal formulations were developed to increase the therapeutic index of conventional doxorubicin. | | | Pegylated Liposomal Doxorubicin in the Treatment of Breast Cancer | | | Pegylated liposomal doxorubicin, the most widely studied liposomal doxorubicin formulation in breast cancer, has been evaluated in > 20 clinical trials. |
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http://www.electronicipc.com/journalEZ/detail.cfm?code=39560010040503
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| | Biodistribution and pharmacokinetics of111In-DTPA-labelled pegylated liposomes in a human tumour xenograft model: ... |
| | In-DTPA-labelled pegylated liposomes in tumour-bearing nude mice was studied to examine possible applications of pegylated liposome-targeted anti-cancer therapies. | | | The potential applications of pegylated liposomes in the arena of targeted therapy of solid cancers are discussed. | | | There was no indication of cumulative deposition of pegylated liposomes in the lung, central nervous system, musculoskeletal system, heart or adrenal glands. |
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http://www.nature.com/bjc/journal/v83/n2/abs/6691232a.html
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| | Hepatitis B Infection, pegylated interferon alpha offers the best treatment |
| | G-CSF During Chronic Hepatitis C Treatment With Pegylated Interferon-Ribavirin-Based Therapy? | | | Is the use of G-CSF recommended in patients who develop neutropenia and-or thrombocytopenia during chronic hepatitis C treatment with peginterferon-ribavirin-based therapy, despite dose reduction?... | | | Treatment with interferon-alfa has been shown to be effective in one-third of hepatitis B e antigen-positive chronic hepatitis B patients, but is clinically associated with relevant adverse events... |
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http://www.medical-buzz.com/hepatitis-b-infection-pegylated-interferon-alpha-offers-the-best-treatment,39327.html
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| | Pegylated interferon plus ribavirin more effective than standard HCV therapy |
| | Pegylated interferon plus ribavirin more effective than standard HCV therapy | | | Pegylated interferons are "the next generation of treatment" for HCV, Dr. Michael W. Fried, of the University of North Carolina at Chapel Hill, said in a statement issued by the American Association for the Study of Liver Diseases. | | | ATLANTA (Reuters Health) - Treatment with pegylated interferon in combination with ribavirin is more effective for hepatitis C virus (HCV) infection than treatment with interferon alfa-2b plus ribavirin, the current standard of care, according to several key presentations on Tuesday at the Digestive Disease Week annual meeting here in Atlanta. |
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http://www.aidsmeds.com/news/20010522clin003.html
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| | About Pegylated Alpha Interferons |
| | If you have any questions or concerns about your health, you should contact your health care provider. | | | Although standard interferon was dosed in a single amount for all patients, studies found that response rates were highest in patients who weighed the least. | | | REBETOL® should not be used in patients with creatinine clearance |
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http://www.all-about-hepatitisc.com/readytolearn/video/transcript.jsp?id=9
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| | Commercial Perspectives: Pegylated Interferons - Leading the Way in HCV Therapy? |
| | Commercial Perspectives: Pegylated Interferons - Leading the Way in HCV Therapy? | | | Alpha interferons have been the drug of choice for the treatment of hepatitis C since their discovery. | | | However, the launch of pegylated interferons, namely Roche's Pegasys and Schering-Plough's PEG-Intron, has begun to revolutionize hepatitis C therapy and the dynamics of this market. |
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http://www.marketresearch.com/researchindex/894693.html
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| | pegylated interferon 2b |
| | I appreciated hearing about your situation and I would like to make some comments. | | | Many hepatologists feel that the combination of pegylated interferon and ribavirin will be more effective against hepatitis C than regular combination therapy. | | | Based on your letter, I have to assume the drug may not been released in Italy. |
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http://www.medhelp.org/forums/hepatitis/messages/30381a.html
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| | Pharmacokinetics, Pharmacodynamics, and Safety of Administering Pegylated Recombinant Megakaryocyte Growth and ... |
| | of recombinant thrombopoietin or to pegylated recombinant human | | | PEG-rHuMGDF, pegylated recombinant human megakaryocyte growth and development factor | | | Basser RL, Rasko JEJ, Clarke K, Cebon J, Green MD, Hussein S, Alt C, Menchaca D, Tomita D, Marty J, Fox RM, Begley CG 1996 Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. |
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http://www.pedresearch.org/cgi/content/full/47/2/208
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| | Hepatitis Information Network - HepNet |
| | May 19, 2000: Paul Glue, Director, Clinical Pharmacology, Schering-Plough Research Institute, presents ''Clinical Pharmacology of Pegylated Interferon alfa-2b'' at the EASL 2000 conference. | | | May 28, 2000: From the DDW 2000 Conference: On the Horizon: Future Therapies for Treatment of HCV Infection by Bruce R. Bacon, MD. | | | May 28, 2000: From the DDW 2000 Conference:Management of Hepatitis C in the Patient with Normal ALT by Ira M. Jacobson, MD. |
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http://www.hepnet.com
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| | Hepatitis C Experimental Treatments / Monotherapy and Combination |
| | Low-dose Interleukin-2, Pegylated Interferon Alfa-2b and Ribavirin for the Treatment of HCV in HIV Patients: A Pilot Study | | | Combination Therapy of Low Dose Ribavirin and Pegylated Interferon for Patients with HCV and End-Stage Renal Disease on Dialysis | | | Long-term Interleukin 10 (IL-10) Therapy in HCV Patients Has a Proviral and Anti-inflammatory Effect |
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http://www.hivandhepatitis.com/hep_c/hepc_news_alter.html
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| | Aidsmap Hepatitis C and HIV: genotype 1 is not a lost cause, report Spanish doctors |
| | Depression was diagnosed in 43% of patients (37% pegylated interferon versus 51% interferon), and nine patients developed mitochondrial toxicity, one experiencing symptoms of weight loss, abdominal pain, nausea and vomiting. | | | “In our study pegylated interferon and ribavirin was significantly more effective than interferon and ribavirin for the treatment of chronic hepatitis C in HIV coinfected patients,” comment the investigators. | | | A total of 27% of patients developed anaemia (31% pegylated interferon versus 23% interferon), the most common haematogical side-effect. |
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http://www.aidsmap.com/en/news/48DAD871-F308-40C5-B0EE-326672AB1830.asp
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| | Use of pegylated interferons is associated with an increased incidence |
| | None of the non-respiratory infections was observed in patients with neutropenia. | | | To this end, we studied 255 patients treated with standard (103) or pegylated (152) interferon, in combination with ribavirin, for hepatitis C. | | | Use of pegylated interferons is associated with an increased incidence of infections during combination treatment of chronic hepatitis C: a side effect of pegylation? |
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http://archive.mail-list.com/hbv_research/msg07213.html
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| | Pegylated Interferon |
| | Combination therapy with peginterferon and ribavirin is the most effective treatment for patients with chronic hepatitis C. Long-term response rates appear to be similar for the two combinations of pegylated interferon and ribavirin. | | | Approximately 24 percent of treatment-naive people who take either form of pegylated interferon for a period of 48 weeks demonstrate sustained virological response- that is, their HCVRNA is nondetectable (less than 50 IU/mL) six months after completion of therapy. | | | Response rates, dosage of ribavirin and length of therapy vary with HCV genotype as follows: |
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http://liverdisease.com/pegylatedinterferon.html
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| | Review of Satellite Symposium on Pegylated Interferons Held During Conference... |
| | Update on Clinical Trials with the Pegylated Interferons to Treat Chronic HCV | | | Rationale for the Development of the Pegylated Interferons to Treat Chronic Hepatitis C | | | Four distinguished liver specialists gave presentations on various aspects of the two pegylated interferons now in Phase III testing and under review by the US Food and Drug Administration (FDA). |
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http://www.hivandhepatitis.com/hep_c/news/120100.html
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| | Hepatitis C - pegylated interferons, ribavarin and alfa interferon (No. 75) |
| | Health Technology Assessment: Interferon alpha (pegylated and non-pegylated) and ribavirin in the treatment of chronic hepatitis C | | | TA075 - Interferon alfa (pegylated and non-pegylated) and ribavarin for the treatment of chronic hepatitis C - Quick reference guide | | | TA075 - Interferon alfa (pegylated and non-pegylated) and ribavarin for the treatment of chronic hepatitis C - Guidance |
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http://www.nice.org.uk/cat.asp?c%3D101627
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