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| | BBC NEWS Health Medical notes Pancreatic Cancer |
 | | There are two types of pancreatic cancer - carcinoma of the pancreas, and, far more rarely, cancer of the cells which make insulin. | | | Pancreatic cancer patients may also be given radiotherapy or chemotherapy. | | | Professor John Neoptolemos, an expert in pancreatic cancer who undertakes research work supported by the Cancer Research UK, said: "Cancer of the pancreas is common in the UK. |
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http://news.bbc.co.uk/1/hi/health/medical_notes/3244445.stm
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| | Hepatocellular carcinoma |
| | Hepatitis - Cirrhosis - NASH - PBC - PSC - Budd-Chiari syndrome - Hepatocellular carcinoma - Pancreatitis - Pancreatic cancer- Gallstones - Cholecystitis | | | '''Hepatocellular carcinoma''' (HCC, also called hepatoma) is a primary malignancy (cancer) of the liver. | | | In the western world, hepatocellular carcinoma (HCC) most commonly appears in a patient with chronic viral hepatitis (hepatitis B or hepatitis C) or with cirrhosis. |
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http://hepatocellular-carcinoma.ask.dyndns.dk
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| | Genatlas sheet |
| | rarely in epithelian ovarian cancer, pancreatic and biliary cancers and in thyroid carcinoma,renal clear cell carcinoma | | | prevalently mutated in squamous cell carcinoma of head and neck,pancreatic adenocarcinoma,hepatocellular carcinoma,sporadic gastric cancer and rarely in epithelian ovarian cancer |
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http://www.dsi.univ-paris5.fr/genatlas/fiche.php?symbol=TGFBR2
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| | KRAS2 |
| | Finkelstein SD, Przygodzki R, Pricolo VE, Sayegh R, Bakker A, Swalsky PA, Keller G. Detection of this point mutation in K-ras might be useful for distinguishing pancreatic ductal cell carcinoma from those of other origins in the pancreatic head region. | | | The two oncogenes that were found to be associated with pancreatic adenocarcinoma were K-ras and c-erbB-2. | | | Tateishi K, Tada M, Yamagata M, Isayama H, Komatsu Y, Kawabe T, Shiratori Y, Omata M. Diagnosis of pancreatic cancer by cytology and measurement of oncogene and tumor markers in pure pancreatic juice aspirated by endoscopy. |
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http://www.cist-pancreaticcancer.com/database/KRAS2.htm
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| | Ralph Moss on Cancer--Expert Guidance for Crucial Decisions |
| | Tumors of Vater's ampulla arise from the epithelium where the whole bile and pancreatic juice system enters the small intestines. | | | These include carcinoma in situ; adenocarcinoma; papillary adenocarcinoma; adenocarcinoma, intestinal type; mucinous adenocarcinoma; clear cell adenocarcinoma; signet-ring cell carcinoma; adenosquamous carcinoma; squamous cell carcinoma; small cell (oat cell) carcinoma; and undifferentiated carcinoma. | | | This one happens to be on cancer of the Ampulla of Vater, a rare kind of cancer that occurs in the small intestine. |
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http://www.ralphmoss.com/html/ampulla-vater.shtml
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| | World Journal of Surgical Oncology Full text Pancreatic metastasis from gastric carcinoma: a case report |
| | Whereas renal cell carcinoma appears to be the most common primary tumor to cause secondary pancreatic tumors, a variety of other cancers may spread to the pancreas, such as colon cancer, non-small cell lung cancer, and sarcomas [3]. | | | Despite this, in large autopsy series the prevalence of pancreatic metastasis has been described to be as high as 6% to 11% [2]. | | | For differential diagnosis, a primary carcinoma of the pancreas and a metastasis of the gastric carcinoma were considered. |
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http://www.wjso.com/content/2/1/43
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| | eMedicine - Pleural Effusion : Article by Fredrick M Abrahamian, DO, FACEP |
| | Determination of the amylase isoenzyme level is useful in distinguishing effusions caused by pancreatic disease (pancreatic isoamylase) from effusions caused by esophageal rupture or nonpancreatic carcinoma (salivary isoamylase). | | | Pleural effusions associated with breast carcinoma typically are ipsilateral to the primary breast cancer (58-70%); however, 20-26% develop effusions contralateral to the primary lesion, and 10-16% develop bilateral effusion. | | | Isolated left-sided effusions occur with esophageal rupture, pancreatic disease, subphrenic or splenic abscess, splenic infarction, diaphragmatic hernia, pericardial disease, or coronary artery bypass surgery. |
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http://www.emedicine.com/emerg/topic462.htm
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| | Clinical Significance of Aminopeptidase N/CD13 Expression in Human Pancreatic Carcinoma -- Ikeda et al. 9 (4): 1503 -- Clinical Cancer Research |
| | Ikeda N., Nakajima Y., Sho M., Adachi M., Huang C., Iki K., Kanehiro H., Hisanaga M., Nakano H., Miyake M. The association of K-ras gene mutation and vascular endothelial growth factor gene expression in pancreatic carcinoma. | | | We examined 50 patients with pancreatic carcinoma who underwent | | | Ikeda N., Adachi M., Taki T., Huang C., Hashida H., Takabayashi A., Sho M., Nakajima Y., Kanehiro H., Hisanaga M., Nakano H., Miyake M. Prognostic significance of angiogenesis in human pancreatic cancer. |
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http://clincancerres.aacrjournals.org/cgi/content/full/9/4/1503
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| | Choriocarcinoma involving the pancreas as first manifestation of a metastatic regressing mixed testicular germ cell tumor |
| | The distinction of choriocarcinoma from undifferentiated pancreatic carcinoma may be impossible by cytomorphology alone. | | | However, the differential diagnosis of choriocarcinoma from a poorly differentiated pancreatic carcinoma, particularly undifferentiated (anaplastic) carcinoma may be very challenging, even more so if the typical biphasic pattern of syncytiotrophoblast and cytotrophoblast cells of choriocarcinoma is absent or unappreciated, as was the case in this patient. | | | One pure choriocarcinoma of the bladder has been reported to have the i(12p) by FISH analysis, but no details of the probes used for such analysis were provided by the authors. |
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http://www.nature.com/modpathol/journal/v17/n12/full/3800226a.html
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| | National Cancer Institute - Cáncer del páncreas (PDQ®) |
| | Thomas CR Jr, Weiden PL, Traverso LW, et al.: Concomitant intraarterial cisplatin, intravenous 5-flourouracil, and split-course radiation therapy for locally advanced unresectable pancreatic adenocarcinoma: a phase II study of the Puget Sound Oncology Consortium (PSOC-703). | | | Berlin JD, Catalano P, Thomas JP, et al.: Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. | | | Storniolo AM, Enas NH, Brown CA, et al.: An investigational new drug treatment program for patients with gemcitabine: results for over 3000 patients with pancreatic carcinoma. |
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http://www.cancer.gov/espanol/pdq/tratamiento/pancreas/healthprofessional/allpages/print
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| | Capecitabine |
| | Capecitabine for the treatment of other conditions or diseases including, but not limited to, pancreatic, ovarian or renal carcinoma is considered investigational. | | | Capecitabine for the treatment of metastatic colorectal carcinoma is considered medically appropriate as a first-line treatment when treatment with fluoropyrimidine therapy alone is preferred. | | | Capecitabine for the treatment of metastatic breast carcinoma and metastatic colorectal carcinoma is considered medically necessary if the medical appropriateness criteria are met. |
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http://www.bcbst.com/MPManual/Capecitabine.htm
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| | Pancreatic Cancer |
| | Despite the low overall incidence of resectability and postoperative cure rate for pancreatic carcinoma, exploration for potential curative resection should not necessarily be withheld for healthy, selected patients who are older than 70 years. | | | For the surgical treatment of pancreatic head cancer, the classical Whipple operation is still the standard procedure but during the last two decades, pylorus-preserving duodenopancreatectomy has been evolved as a more conservative procedure in order to omit the consequences of partial gastrectomy. | | | However, due to the resistance of pancreatic cancers against chemoradiation, curative resection represents the only therapy with a potential for cure. |
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http://www.foxhall.com/panc_ca.htm
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| | List of Papers Published in 2002 |
| | Yachida S, Fukushima N, Kanai Y, Nimura S, Shimada K, Yamamoto J, Sakamoto M. Pancreatic metastasis from renal cell carcinoma extending into the main pancreatic duct: a case report. | | | Takei H, Asamura H, Maeshima A, Suzuki K, Kondo H, Niki T, Yamada T, Tsuchiya R, Matsuno Y. Large cell neuroendocrine carcinoma of the lung: a clinicopathologic study of eighty-seven cases. | | | Fukushima S, Wanibuchi H, Morimura K, Wei M, Nakae D, Konishi Y, Tsuda H, Uehara N, Imaida K, Shirai T, Tatematsu M, Tsukamoto T, Hirose M, Furukawa F, Wakabayashi K, Totsuka Y. Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5- f ]quinoxaline or N -nitrosodiethylamine. |
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http://www.ncc.go.jp/en/nccri/annrep/2002/list2002.html
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| | Cancer Spectrum: Kawakami et al., pp. 1805-1811. |
| | Ueki, T., Toyota, M., Skinner, H., Walter, K. M., Yeo, C. J., Issa, J.-P. J., Hruban, R. H., Goggins, M. Identification and Characterization of Differentially Methylated CpG Islands in Pancreatic Carcinoma. | | | Matsubayashi, H., Sato, N., Fukushima, N., Yeo, C. J., Walter, K. M., Brune, K., Sahin, F., Hruban, R. H., Goggins, M. Methylation of Cyclin D2 Is Observed Frequently in Pancreatic Cancer but Is Also an Age-related Phenomenon in Gastrointestinal Tissues. | | | Mandelker, D. L., Yamashita, K., Tokumaru, Y., Mimori, K., Howard, D. L., Tanaka, Y., Carvalho, A. L., Jiang, W.-W., Park, H. L., Kim, M. S., Osada, M., Mori, M., Sidransky, D. PGP9.5 Promoter Methylation Is an Independent Prognostic Factor for Esophageal Squamous Cell Carcinoma. |
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http://jncicancerspectrum.oxfordjournals.org/cgi/content/abstract/jnci;92/22/1805
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| | artikkel |
| | £1@-U cher,-.otherai)eutic agent capable of providing long-terrp- remission or cure for patients with pancreatic carcinoma. | | | Also advocated is the discovery of new chemotherapeutical agents and combinations, capable of systemic effects on pancreatic carcinoma and its distal spread. | | | Interestingly, the 5-fluorourcil seems to act as a radiation sensitizer that enhances the local effect of radiation therapy, rather than as a systemie agent. |
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http://www.hib.no/AHS/radiograf/master/artikkel.html
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| | MUSC Digestive Disease Center - Case Studies |
| | Duodenal obstruction caused by pancreatic head carcinoma: palliation with self-expandable endoprostheses. | | | Another group presented two patients with symptomatic duodenal obstruction from carcinoma of the pancreas who failed endoscopic therapy, but were palliated subsequently by duodenal Wallstents inserted perorally under fluoroscopic guidance. | | | Duodenal obstruction develops in approximately 5-15% of pancreatic cancer patients treated by endoscopic biliary decompression. |
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http://www.ddc.musc.edu/ddc_pro/pro_development/case_studies/case010.htm
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| | The Singapore Urological Association |
| | Both AFP and HCG are not tumour specific as AFP are raised in NSGCT and hepatocellular carcinoma, but also in gastric, colon, biliary, pancreatic and lung cancers while HCG levels may be increased in pancreatic adenocarcinoma and islet cell tumours, tumours of the small and large bowel, hepatoma, stomach, ovarian, breast and renal cancer. | | | The presence of yolk sac tumour elements is associated with raised serum alpha-foetoprotein (29), while embryonal carcinoma is regarded as more aggressive (30). | | | There is also the reported negative correlation between the histological finding of yolk sac tumour elements and occult metastases in clinical stage I patients (31). |
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http://www.sua.org.sg/whatsnew/whatsnew_testis.htm
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| | Ampulla of Vater Carcinoma |
| | Ampulla of Vater and pancreas adenocarcinomas have similar CK immunophenotypes that cannot assist in distinguishing ampullary from pancreatic neoplasms on endoscopically procured tissue. | | | This retrospective study details 94 patients after surgical resection of carcinoma of the ampulla of Vater to determine prognostic factors. | | | Carcinoma of the ampulla of Vater associated with other organ malignancies. |
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http://www.thedoctorsdoctor.com/diseases/ampulla_of_vater_ca.htm
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| | Department of Surgery : Research : Massachusetts General Hospital |
| | Despite the ductal phenotype of most human pancreatic carcinomas, there is still considerable debate regarding the cell origin of pancreatic adenocarcinoma, and it remains a critical unanswered question. | | | To determine whether inhibition of this pathway using small molecule antagonists will have any significant impact on the biologic behavior of pancreatic cancer. | | | Importance of histone hyperacetylation and the p21 gene in butyrate-induced growth arrest of colon carcinoma cells. |
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http://www.mgh.harvard.edu/surgery/research/gensurg.htm
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