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Topic: Paclitaxel



  
 Biolyse Pharma Corporation - Paclitaxel for Injection
This discovery predates the marketing of any other paclitaxel and is of tremendous importance to the future availability of the drug at a bearable cost to the health care system.
Due to the scarcity of naturally occurring paclitaxel, extreme efforts were made to find alternative sources of the drug.
http://www.biolyse.ca/paclitaxel.asp   (792 words)

  
 MedlinePlus Drug Information: Paclitaxel (Systemic)
Paclitaxel is to be administered only by or under the immediate supervision of your doctor.
While you are being treated with paclitaxel, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval.
Before you begin treatment with paclitaxel, you and your doctor should talk about the good this medicine will do as well as the risks of using it.
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202682.html   (1589 words)

  
 paclitaxel news articles
Prolonged Paclitaxel therapy lengthens the recurrence-free interval, with increased neurotoxicity.
Weekly Chemotherapy with Paclitaxel May Be Effective in Epithelial...
Paclitaxel, one of the best antineoplastic drugs found from nature in the past decades, will be used as a prototype drug in this synergistic program due to its...
http://www.mongabay.com/drugs/drugs/paclitaxel.html   (9870 words)

  
 Timeline of Paclitaxel Disputes
Paclitaxel is to be made available to all women in England and Wales with ovarian cancer following the long awaited ruling by the National Institute for Clinical Excellence, which advises the NHS in England and Wales on the clinical and cost effectiveness of medicines.
Accordingly, we are not attempting to obtain approval of Paxene as a generic version of paclitaxel, but rather have undertaken extensive clinical studies and have submitted a full New Drug Application for Paxene.
Two of the studies were conducted in conjunction with the Netherlands Cancer Institute in Amsterdam, while the third was in conjunction with the Cancer Therapy and Research Center & Brooke Army Medical Center in San Antonio, Texas.
http://www.cptech.org/ip/health/taxol/taxol-timeline2001.html   (9338 words)

  
 Paclitaxel - Wikipedia, the free encyclopedia
There is also research to examine the possibility of extracting paclitaxel-like compounds from the Pacific yew's needles instead of its bark.
Arthur S. Barclay, one of those botanists, collected 15 lbs of twigs, needles, and bark from Pacific yew trees in a forest near Mount St. Helens.
Paclitaxel (Taxol®) is a drug used in the treatment of cancer.
http://en.wikipedia.org/wiki/Paclitaxel   (1035 words)

  
 Paclitaxel (Taxol®) : CancerBACUP
Aching or pain in joints and muscles may occur a few days after paclitaxel is given.
Tiredness and a general feeling of weakness It is important to allow yourself plenty of time to rest.
If you are given any of these tablets before treatment it is important to take them as directed and to tell your doctor or nurse if you forget.
http://www.cancerbacup.org.uk/Treatments/Chemotherapy/Individualdrugs/Paclitaxel   (1236 words)

  
 Lung Cancer, Non-Small Cell
Compartmental analysis of paclitaxel disposition was performed in these five patients and non-compartmental analysis was performed on data from all 21 patients.
For those 12 assessable patients receiving doxorubicin and paclitaxel as the second-line chemotherapy, no clinical response was seen, i.e.
The purpose of this study is to determine the response rate (RR) and toxicity associated with neoadjuvant therapy (NAT) using carboplatin (AUC 7) and paclitaxel (200 mg/M
http://www.rosoncoweb.ru/cure/taxol/thes22.htm   (11638 words)

  
 MedlinePlus Drug Information: Paclitaxel
Talk to your doctor about the possible risks of using this drug for your condition.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
tell your doctor and pharmacist if you are allergic to paclitaxel, cyclosporine (Neoral, Sandimmune), teniposide (Vumon), other drugs containing Cremophor EL (polyoxyethylated castor oil) or any other drugs.
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a698035.html   (502 words)

  
 Clinical Evidence for Topotecan-Paclitaxel Non-Cross-Resistance in Ovarian Cancer -- Gore et al. 19 (7): 1893 -- ...
A total of 226 patients received second-line therapy with topotecan
multicenter study of paclitaxel, in which responses were confirmed
drug as third-line therapy: 61 patients crossed over from paclitaxel
http://www.jco.org/cgi/content/full/19/7/1893   (4352 words)

  
 A beta -Tubulin Leucine Cluster Involved in Microtubule Assembly and Paclitaxel Resistance -- Gonzalez-Garay et al. 274 ...
of paclitaxel in early clinical studies of patients who were pretreated
leads to greater heterogenity in their response to paclitaxel.
Our own studies have described a resistance mechanism mediated by tubulin alterations that affect microtubule assembly (reviewed
http://www.jbc.org/cgi/content/full/274/34/23875   (6117 words)

  
 Preoperative Twice-Weekly Paclitaxel With Concurrent Radiation Therapy Followed by Surgery and Postoperative ...
Preoperative Twice-Weekly Paclitaxel With Concurrent Radiation Therapy Followed by Surgery and Postoperative Doxorubicin-Based Chemotherapy in Locally Advanced Breast Cancer: A Phase I/II Trial -- Formenti et al.
Bellon JR, Lindsley KL, Ellis GK, et al: Concurrent radiation therapy and paclitaxel or docetaxel chemotherapy in high-risk breast cancer.
Preoperative Twice-Weekly Paclitaxel With Concurrent Radiation Therapy Followed by Surgery and Postoperative Doxorubicin-Based Chemotherapy in Locally Advanced Breast Cancer: A Phase I/II Trial
http://www.jco.org/cgi/content/full/21/5/864   (4221 words)

  
 Vascular Endothelial Growth Factor Immunoneutralization Plus Paclitaxel Markedly Reduces Tumor Burden and Ascites in ...
The third group was treated with paclitaxel alone.
the drug resistance that develops with paclitaxel alone.
The second group was treated with VEGF mAb alone.
http://ajp.amjpathol.org/cgi/content/full/161/5/1917   (4631 words)

  
 Paclitaxel Injection quality control, 21CEC
The adverse event profile in the Phase 3 study was consistent with that seen for a pooled analysis performed on 812 patients treated in ten clinical studies (See ADVERSE REACTIONS Section).
The initial rapid decline represents distribution to the peripheral compartment and elimination of the drug.
All patients should be pretreated with corticosteroids, diphenhydramine, and H
http://www.21cecpharm.com/px/pxinj.htm   (1845 words)

  
 Synergistic Interaction of Lovastatin and Paclitaxel in Human Cancer Cells -- Holstein and Hohl 1 (2): 141 -- Molecular ...
no evidence to suggest that paclitaxel either affects isoprenylation
These results provide in vitro support for the novel therapeutic
Table 1 Quantification of Annexin V apoptosis experiment
http://mct.aacrjournals.org/cgi/content/full/1/2/141   (4666 words)

  
 ZD1839 Modulates Paclitaxel Response in Renal Cancer by Blocking Paclitaxel-Induced Activation of the Epidermal Growth ...
drugs such as paclitaxel has been well documented by many groups
Department of Urology, National Defense Medical College, Tokorozawa, Saitama, Japan
Experimental Design: Eight human RCC lines and the surgical
http://clincancerres.aacrjournals.org/cgi/content/full/10/2/794   (4051 words)

  
 New designed paclitaxel analog kills more cancer cells than natural product
The conformation of microtubule-bound drug has been the subject of intense study, and various suggestions have been made.
"The issue has been, what is the shape or orientation of the side chain when paclitaxel is sitting on the microtubule?
Paclitaxel, a natural compound from yew trees, is the world's best-selling anticancer drug.
http://www.eurekalert.org/pub_releases/2004-06/vt-ndp062104.php   (739 words)

  
 Disputes involving Paclitaxel, a cancer drug sold under different brand names, including Taxol.
May 13, 2000, The Pharmaceutical Journal, Paclitaxel should be standard therapy for ovarian cancer, says NICE
December 3, 1996, Doctor's Guide, & Other Medical News, Agreement With NCI for Extended Collaborative Research of Taxol
Disputes involving Paclitaxel, a cancer drug sold under different brand names, including Taxol.
http://www.cptech.org/ip/health/taxol   (989 words)

  
 Paclitaxel (Taxol), Best quality, Large quantity, Lowest price in the world, 21CEC
Today, Paclitaxel is the No. 1 Anti-cancer Drug in the battle of we humans against cancer.
These figures reflect the urgent needs of effective anti-cancer drugs.
No matter you are the patient or your family member / friend need help; or you are the professionals, the merchant, the scientist, you can find some information useful or interesting here.
http://www.21cecpharm.com/px   (486 words)

  
 Paclitaxel (Taxol) mechanism of action, 21CEC
The synthesis of new taxoids with improved biological activity is still an important research area today.
Some results suggest that Docetaxel may be superior to Paclitaxel in the treatment of certain cancers like metastatic breast cancer.
Among these, Paclitaxel emerged as one of the most popular anti-cancer drugs.
http://www.21cecpharm.com/px/action.htm   (747 words)

  
 Paclitaxel
Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
It is used as a chemotherapy drug to treat people with a wide variety of
Paclitaxel is a natural (though quite toxic) substance derived from the yew tree by taking a naturally present substance from the tree and chemically altering it to form the drug.
http://www.gianteagle.com/healthnotes/Drug/Paclitaxel.htm   (2987 words)

  
 Cyberbotanica: Paclitaxel (Taxol) & Docetaxel (Taxotere)
Docetaxel has been trademarked as Taxotere by Rhone-Poulenc Rorer as an investigational drug.
Paclitaxel is given intravenously (it irritates skin and mucous membranes on contact), and is most effective against ovarian carcinomas and advanced breast carcinomas.
Slightly less than half of the patients receiving paclitaxel during clinical trials developed an allergic reaction to it, which resulted in problems ranging from rashes or a mild drop in blood pressure to major breathing problems, hives and/or fluid buildup around the heart.
http://biotech.icmb.utexas.edu/botany/tax.html   (347 words)

  
 Product Label
FDA Oncology Tools Approval Summary for paclitaxel for second line therapy for AIDS related Kaposi's sarcoma.
Study Details (Click on NDA or Supplement Number to view details)
http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=126   (80 words)

  
 Estrogen Inhibits Paclitaxel-Induced Apoptosis via the Phosphorylation of Apoptosis Signal-Regulating Kinase 1 in Human ...
the induction of apoptosis by paclitaxel is mediated by the
The majority of patients with ovarian cancer require treatment
apoptosis and antiapoptosis in cells treated with paclitaxel.
http://endo.endojournals.org/cgi/content/full/145/1/49   (5615 words)

  
 National Cancer Institute - Dictionary of Cancer Terms
A form of the anticancer drug paclitaxel that may have fewer side effects and work better than paclitaxel.
http://www.cancer.gov/dictionary/db_alpha.aspx?expand=p   (5795 words)

  
 (Taxol) Paclitaxel
The treatment plan for paclitaxel depends on which cancer you are being treated for.
This page tells you about a drug called paclitaxel.
The side effects associated with Taxol (paclitaxel) are below.
http://www.cancerhelp.org.uk/help?page=4016   (1212 words)

  
 paclitaxel - OneLook Dictionary Search
paclitaxel : The On-line Medical Dictionary [home, info]
paclitaxel : Dictionary of Cancer Terms [home, info]
paclitaxel : Dorland's Illustrated Medical Dictionary [home, info]
http://www.onelook.com/?w=paclitaxel&ls=a   (166 words)

  
 Molecule of the Month: TAXOL
N.Y. A normal version which does not use the Chime plug-in is also available here, and a Chime enhanced version is available here.
"Taxol" is used in these pages to refer to the drug that now has the generic name "paclitaxel", and the registered tradename "Taxol ®" (Bristol-Myers Squibb Company, New York.
To find out more, try searching for taxol using any of the available search engines.
http://www.bris.ac.uk/Depts/Chemistry/MOTM/taxol/taxol2.htm   (800 words)

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