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| | Resistance to Therapy: p53 and Chemosensitivity in Gastric Cancer by James M Ford, MD |
 | | Again, there is a huge literature out there on measuring P53 status in various clinical samples and trying to correlate that with outcomes and drug sensitivity, but there is a whole series of caveats in interpreting those. | | | Resistance to Therapy: p53 and Chemosensitivity in Gastric Cancer | | | The second is to try to briefly try to summarize the role of P53 in chemosensitivity, which is a very complicated subject. |
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http://www.webtie.org/sots/Meetings/Gastrointestinal/March62001/lectures/FORD/transcripts/transcripts.htm
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| | Alcohol Impairs Tumor-Suppressing Gene in Smokers |
| | The researchers reported on the drinking and smoking habits of 105 patients who underwent surgery for lung cancer at The Johns Hopkins Medical Institutions. | | | Steven A. Ahrendt, MD, formerly an Assistant Professor of Hepatobiliary/Endocrine Surgery at the Medical College; David Sidransky, MD, from The Johns Hopkins School of Medicine, and their colleagues reported their findings in the journal Cancer Research. | | | MCW Health News presents up-to-date information on patient care and medical research by the physicians of the Medical College of Wisconsin. |
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http://healthlink.mcw.edu/article/964718193.html
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| | Baylor Health Care System: Cancer treatment involving the p53 gene |
| | Although this research is still in its infancy, the encouraging results provide the promise of new treatments in the future for cancers that have been considered untreatable. | | | The application of laboratory research technology to human cancer therapy is now in progress. | | | Our research program investigating p53 targeted approaches with Adp53, ONYX-015, and SCH-58500 has entered well over 100 patients into clinical trials—more than any other single site worldwide. |
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http://www.baylorhealth.edu/proceedings/12_2/12_2_nemunaitis.html
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| | p53 gene |
| | And in a number of cancers, p53 abnormalities are associated with a poor response to standard cancer therapies. | | | (SACRAMENTO, Calif.)--A new approach that examines prostate cancer for p53 genetic abnormalities is more sensitive than current screening methods and gives researchers a new tool to better understand the disease, say researchers at the UC Davis Cancer Center. | | | Mutations of p53, for example, have been shown to be critical in the development of colon cancer. |
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http://www.ucdmc.ucdavis.edu/news/medicalnews/p53.html
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| | First Adenoviral-p53 Gene Therapy Trial Shows Success In Lung Cancer |
| | Introgen Therapeutics, Inc. a leader in the development of gene-based cancer therapeutics, is a privately held company formed to commercialize anti-cancer technology developed at the University of Texas M.D. Anderson Cancer Center in Houston, Texas. | | | Introgen Therapeutics, Inc. an Austin-based company engaged in the development of cancer therapeutics, sponsors Dr. Roth along with 25 other clinicians and researchers at M.D. Anderson Cancer Center. | | | Introgen and RPR Gencell, the gene therapy division of Rhone-Poulenc Rorer, are collaborating to develop and commercialize gene therapy products based on the p53 pathway and k-ras oncogene inhibition. |
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http://www.pslgroup.com/dg/296ca.htm
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| | p53, "Molecule of the Year" |
| | The role of p21 in the pathway that is regulated by p53 is not yet clear, however. | | | Vogelstein's group has focused on the development of colorectal cancer. | | | Unlike most cancers, colorectal cancer can be studied through several well-defined stages, starting with small, benign polyps and progressing to malignant tumors. |
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http://www.hhmi.org/annual95/b140.html
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| | Gene P53ID88 |
| | Epidemiologic evidence suggests that exposure to ultraviolet (UV) radiation and the sensitivity of an individual's skin to UV radiation are risk factors for skin cancer including melanoma | | | For comments and suggestions or contributions, please contact us | | | P53 is mutated in 40-60% of skin cancers; hotspots at codons 196, 248, 278. |
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http://www.infobiogen.fr/services/chromcancer/Genes/P53ID88.html
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| | P53 - Wikipedia, the free encyclopedia |
| | Recent research has also linked the TP53 and RB tumour suppressor pathways, via the protein p14ARF, raising the possibility that the pathways may regulate each other (Bates et al, 1998). | | | McCormick F. Cancer gene therapy: fringe or cutting edge? | | | Restoring its function would be a major step in curing many cancers (Vogelstein et al 2000). |
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http://en.wikipedia.org/wiki/P53_gene
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| | The p53 Tumor Suppressor Gene and Apoptosis |
| | Efforts to find therapies that will stimulate apoptosis despite p53 malfunction are underway. | | | Clin Cancer Res 1998 Apr;4(4):835-46 Adenovirus-mediated p53 gene therapy and paclitaxel have synergistic efficacy in models of human head and neck, ovarian, prostate, and breast cancer. | | | Cancer 1999 Mar 15;85(6):1293-9 p53 protein overexpression is associated with increased cell proliferation in patients with locally recurrent prostate carcinoma after radiation therapy. |
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http://www.psa-rising.com/medsci/p53.htm
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| | The p53 tumor suppressor protein |
| | Help with unraveling the molecular mechanisms of cancerous growth has come from the use of mice as models for human cancer, in which powerful 'gene knockout' techniques can be used. | | | The amount of information that exists on all aspects of p53 normal function and mutant expression in human cancers is now vast, reflecting its key role in the pathogenesis of human cancers. | | | This condition is rare, and is known as Li-Fraumeni syndrome. |
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http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.107
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| | P53 Gene |
| | For this reason p53 gene is a prime target for the development of novel anti cancer therapies such as "gene therapy". | | | This process is called APOPTOSIS and it consists in disintegration of the entire cell into membrane bound vesicles (apoptotic bodies), these can be phagocytosed by macrophages (they are specific cells whose function is to digest these vesicles) | | | This consists of injecting the "normal p53 gene" (it is called p53 wild type) into the ill human body. |
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http://www.york.ac.uk/inst/ltc/efl/courses/Found_n/2001/p53gene.htm
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| | Novel p53 gene-based therapy boosts immune system and reduces tumor size |
| | The therapy, known as Advexin, also showed evidence that the p53 protein it was delivering was actually being replaced in the targeted tumors, and that the treatment produced beneficial and possibly sustained local immune responses in the patients tested. | | | "We have nice evidence of a double-acting mechanism of gene therapy, something that has not been seen before in patients treated with only chemotherapy," says Massimo Cristofanilli, M.D., an associate professor in the Department of Breast Medical Oncology. | | | About half of patients with locally advanced breast cancer have mutations in their p53 gene, which plays a critical role in suppressing cancer development. |
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http://www.eurekalert.org/pub_releases/2004-12/plos-npg120304.php
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| | Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations |
| | These studies support clinical trials using p53 gene transfer to potentially improve the efficacy of radiation therapy in human malignancies. | | | Results: Cells expressing the p53 gene product were more sensitive to radiation than control cells expressing the luciferase gene in in vitro clonogenic survival assays. | | | Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link. |
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http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=20420889
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| | eMedicine - Li-Fraumeni Syndrome : Article Excerpt by: Gary R Jones, MD |
| | Specifics of the inherited TP53 mutation may have a significant effect on the cancer phenotype in the affected family. | | | Somatic (ie, nongermline) TP53 tumor suppressor gene mutations are very common human cancers, suggesting that TP53 alterations play an important role in the development of cancer. | | | Since LFS was first characterized in 1969, more than 100 LFS kindreds have been described. |
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http://www.emedicine.com/ped/byname/li-fraumeni-syndrome.htm
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| | NEJM -- Clinical Implications of the p53 Tumor-Suppressor Gene |
| | Prevalence of p53 mutations in patients with squamous cell carcinoma of the esophagus. | | | In vitro p53 and/or Rb antisense oligonucleotide treatment in association with growth factors induces the proliferation of peripheral hematopoietic progenitors. | | | Other tumor-suppressor genes important in human cancers, such |
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http://content.nejm.org/cgi/content/short/329/18/1318
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| | CHEST: An atypical carcinoid tumor of the lung with mutations in the p53 gene and the retinoblastoma gene |
| | Although D'Amico et al[4] reported that the p53 gene mutation in SCLC was not associated with tumor response to therapy or to patient survival, the incidence of the p53 gene mutations in established lung cancer cell lines is higher than in nonimmortalized lung neoplasms. | | | The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern. | | | In the carcinogenesis and progression of lung cancer, I various genes have been reported to be involved. |
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http://www.findarticles.com/p/articles/mi_m0984/is_n5_v104/ai_14636683
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| | IARC TP53 DATABASE - Welcome |
| | Molecular pathology of cancer, to understand the clinical significance of mutations identified in cancer patients; | | | Basic research, to study the structural and functional aspects of the p53 protein; | | | The IARC TP53 Mutation Database compiles all TP53 gene mutations identified in human cancers and cell lines that have been reported in the peer-reviewed literature since 1989. |
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http://www-p53.iarc.fr/index.html
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| | THE 1993 WALTER-HUBERT-LECTURE - THE ROLE OF THE P53 TUMOR-SUPPRESSOR GENE IN TUMORIGENESIS |
| | Loss of p53 function accelerates the process of tumorigenesis and alters the response of cells to agents that damage DNA, indicating that successful strategies for radiation therapy may well need to take into account the tissue of origin and the status of p53 in the tumour. | | | It is thought that the growth-suppressive effects of p53 are mediated through the transcriptional transactivation activity of the protein. | | | Thus, the role of p53 in suppressing tumorigenesis may be to rescue the cell or organism from the mutagenic effects of DNA damage. |
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http://www.carelife.com/cancer/med_onc/p53a.html
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| | An Infrequent Point Mutation of the p53 Gene in Human Nasopharyngeal Carcinoma -- Sun et al. 89 (14): 6516 -- ... |
| | This result contrasts with the relatively high frequency of p53 mutations associated with several other human carcinomas and suggests the importance of other genes in NPC genesis. | | | We conclude from this study that mutational or other alterations of the p53 gene are not common in nasopharyngeal carcinogenesis and that a codon-280 mutation of p53 may be involved in <10% of NPC cases. | | | Point mutations in the p53 gene have been detected in a variety of human cancers; the mutations are clustered in four "hot-spots" located in the coding region of exons 5, 7, and 8, which coincide with the four most highly conserved regions of the gene. |
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http://www.pnas.org/cgi/lookup?vol=89&fp=6516&view=abstract
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| | LHC p53 Resources Page |
| | The development of human cancer often involves inactivation of this suppressor function through various mechanisms, including gene deletions and point mutations. | | | Since the identification of tumor-specific, missense p53 mutations in 1989, there has been a widespread interest in the possibility that the localization and the characteristics of these mutations may reveal clues about the etiology and the molecular pathogenesis of human cancer (Greenblatt et al., 1994. | | | Good resources on p53 structure, function, Expression, Metabolism, and other information. |
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http://www3.cancer.gov/intra/LHC/p53ref.htm
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| | Reisman Lab p53 Home Page |
| | The major goals of our research are to define the role that mutant p53 plays in transformation and to determine the mechanisms that lead to de-regulated expression of the p53 gene in tumor cells. | | | Unlike other tumor suppressors where loss of function is sufficient to promote tumorigenesis, greater than 75% of the observed mutations in p53 are missense mutations that, in some cases, may confer some selective advantage to cells expressing them. | | | The wild type p53 gene is a tumor suppressor gene which encodes a protein that regulates a cell cycle checkpoint and the induction of programmed cell death (apoptosis) in response to DNA damage, cell stress or the aberrant expression of some oncogenes. |
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http://www.biol.sc.edu/~reisman
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| | Study of Hypoxia and New Gene Reveals Early-Stage Action of p53 Tumor Suppressor Gene |
| | Under conditions of stress to the cell – such as radiation or chemotherapy and hypoxia – p53 normally eliminates tumors. | | | Understanding how cells die after they are starved for oxygen is important for fighting cancer as well as other diseases. | | | A team led by Wafik El-Deiry, MD, PhD, Associate Professor, Departments of Medicine, Genetics, and Pharmacology with the Abramson Cancer Center of the University of Pennsylvania, discovered a gene related to p53 called Bnip3L that can also cause cell death. |
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http://www.uphs.upenn.edu/news/News_Releases/jan05/p53gene.htm
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| | p53 description |
| | Database and software for the analysis of mutations in the human p53 gene. | | | Database and software for the analysis of mutations at the human p53 gene. | | | The p53 database contains information on nearly 5,867 mutations found in the human p53 gene. |
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http://www.ibiblio.org/dnam/des_p53.htm
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| | Neal's DNA Mutation Site |
| | Databases and software for the analysis of mutations at the human hprt, human p53, transgenic - bacterial lacI and transgenic lacZ genes | | | A program for entering mutation data into a relational database | | | A program for statistical comparison of mutational spectra |
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http://www.ibiblio.org/dnam/mainpage.html
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