|
| |
| | Ototoxicity Identification Device |
 | | Thus, early identification and monitoring of ototoxicity are critical to facilitate responsible evidence-based practice by providing practitioners the critical information and opportunity to minimize or prevent the progression of hearing loss into the speech communication range. | | | We demonstrated that the most effective, reliable and sensitive method for detection of incipient ototoxicity could be achieved through serial evaluation of behavioral hearing thresholds at frequencies from 0.5-20kHz. | | | Advances of this nature are needed to make early detection of ototoxicity a standard level of health care for veterans and other individuals throughout the nation. |
|
http://www.va.gov/CRIISP/Projects/Ototoxicity.Identification.Device.htm
(593 words)
|
|
| |
| | eMedicine - Inner Ear, Ototoxicity : Article by James Kalkanis, MD |
| | Basic awareness of ototoxic medications and use of appropriate monitoring during treatment are important to preserve hearing. | | | Prevention of aminoglycoside ototoxicity involves careful monitoring of serum drug levels and renal function as well as hearing evaluations before, during, and after therapy. | | | Ototoxicity in this class of antibiotics has been well described; however, aminoglycosides are still used frequently because of their effectiveness. |
|
http://www.emedicine.com/ent/topic699.htm
(3888 words)
|
|
| |
| | OTOTOXICITY |
| | The authors found the incidence of ototoxicity to be 8.6% for gentamicin, 6.1% for tobramycin, 13.9% for amikacin, and 2.4% for netilmicin. | | | Figure 14-1 shows serial responses for the vestibular ocular reflex at baseline, when the patient was ototoxic, and during recovery. | | | Once ototoxicity is detected, unless there is a compelling reason to continue aminoglycoside therapy, it should be stopped. |
|
http://ivertigo.net/toxicity/tox1.html
(6111 words)
|
|
| |
| | Ototoxicity: Early Detection and Monitoring |
| | Most reports in patients receiving ototoxic drugs have focused on ABR or OAE test sensitivity, in which sensitivity was defined as a clinically significant change in the value of the objective measure. | | | Identifying patients for whom ototoxicity monitoring is an appropriate part of a therapeutic management plan requires a coordinated effort between the audiologist and members of the patient's health care team. | | | The goal of serial monitoring tests for detection of ototoxic hearing loss is typically to categorize patients into two groups: those who exhibit hearing change or those who do not based on a cutoff or hearing change criterion value. |
|
http://www.asha.org/about/publications/leader-online/archives/2005/050524/050524b.htm
(2475 words)
|
|
| |
| | Ototoxicity |
| | Comparative clinical studies of ototoxicity and nephrotoxicity of amikacin and gentamicin. | | | Cis-platinum ototoxicity: clinical experience and temporal bone histopathology. | | | Marot M, Uziel A, Romand R. Ototoxicity of kanamycin in developing rats: relationship with the onset of auditory function. |
|
http://www.bcm.edu/oto/grand/82092.html
(1293 words)
|
|
| |
| | Use of auditory brainstem responses for the early detection of ototoxicity from aminoglycosides or chemotherapeutic ... |
| | The high incidence of ototoxicity from aminoglycosides or chemotherapeutic drugs, and its potential impact on a patients' subsequent quality of life, justifies the investment required to establish clinically effective monitoring methods [2,3]. | | | These techniques can be used with unresponsive subjects, but the accuracy of the responses in relation to behavioral measures of auditory function is not known. | | | Techniques such as otoacoustic emissions, electrocochleography, and auditory brainstem responses have the potential for monitoring ototoxicity and have been used with various degrees of success [5-8]. |
|
http://www.vard.org/jour/04/41/3A/mitchell.html
(3854 words)
|
|
| |
| | PA-SHHH - Ototoxicity |
| | Finally, you should be aware of the common ototoxic medications, how they are prescribed, and for what conditions they are given. | | | These medications are ototoxic when given for treatment of cancer. | | | The following is a simplified list of ototoxic medications and represents the most common drugs. |
|
http://www.pa-shhh.org/resources/epstein.html
(903 words)
|
|
| |
| | Evaluation of insert earphones for high-frequency bedside ototoxicity monitoring |
| | Because subjects in our study were not receiving ototoxic drugs, this percentage was taken as a "false positive rate" for ototoxic hearing change. | | | Because many veterans receive ototoxic medications, a great need exists and much emphasis is placed on providing the most effective ototoxicity detection and monitoring methods at the Department of Veterans Affairs (VA) Medical Centers. | | | This study set out to determine whether insert earphones were reliable for ototoxicity monitoring of patients' hearing at bedside. |
|
http://www.vard.org/jour/05/42/3/gordon.html
(4457 words)
|
|
| |
| | U.S. Pharmacist |
| | Additional aminoglycoside risk factors include therapy that exceeds two weeks in duration, extremes of age, family history of ototoxicity, and peak and trough levels that are elevated beyond those required for a therapeutic response. | | | For this reason, it is preferable to consider the use of therapeutic heat wraps as a safer alternative for knee or back pain or for pains in the shoulder-to-arm area, particularly in patients with risk factors that would predispose them to ototoxicity. | | | This precaution is vital, as the typical patient does not notice that hearing is affected until the loss has progressed to influence perception of speech. |
|
http://www.uspharmacist.com/index.asp?show=article&page=8_1588.htm
(1634 words)
|
|
| |
| | Ear, Nose & Throat Journal: Topical antibiotics: strategies for avoiding ototoxicity |
| | An important point to keep in mind is that these patients already had an existing vestibular deficit secondary to Meniere's disease, and they did not have evidence of chronic ear disease. | | | Most patients experienced ototoxicity by day 12, and half of them exhibited no response to ice-water calorics. | | | Still, for many years otolaryngologists were net completely aware of the true clinical incidence of ototoxicity from topical aminoglycosides. |
|
http://www.findarticles.com/p/articles/mi_m0BUM/is_1_83/ai_113337445
(1376 words)
|
|
| |
| | 1999; Salicylate attenuates cisplatin-induced ototoxicity in the rat |
| | This view is supported by the partial success of antioxidant therapy in attenuating cisplatin-induced ototoxicity in animal models. | | | 1999; Salicylate attenuates cisplatin-induced ototoxicity in the rat | | | We have successfully employed antioxidant therapy to reduce aminoglycoside-induced ototoxicity in animals. |
|
http://www.aro.org/archives/1999/616.html
(271 words)
|
|
| |
| | Ototoxic Drugs: The Drugs |
| | There is evidence [1] that under some situations azithromycin use is associated with hearing loss, but so far no cause-effect relationship has been established. | | | However, based on how they work and act in the body, it is unlikely that they are ototoxic. | | | Here are some key points about the main groups of drugs known to be ototoxic in one way or another, and those that might (or might not) be “guilty by association.” |
|
http://www-personal.umich.edu/~mshlafer/ototox2.html
(4832 words)
|
|
| |
| | Deafness From Chemotherapy More Common Than We Think |
| | Johnson, now 33, has suffered since 1986 from the effects of ototoxicity, a condition in which platinum-based chemotherapy drugs, such as carboplatin and the more common cisplatin, damage the tiny hair cells in the inner ear that vibrate in response to sound waves. | | | Scientists want to boost awareness of ototoxicity because it may soon be preventable. | | | According to the study, hearing loss was found in 61 percent of patients, with average onset beginning 135 days after chemotherapy. |
|
http://www.medicalnewstoday.com/medicalnews.php?newsid=34885
(1294 words)
|
|
| |
| | NEOMYCIN (addendum)(JECFA Food Additives Series 51) |
| | The ADIs that could be derived from studies in bacteria in vitro, from studies of human flora-associated animals in vivo and from studies in humans were evaluated. | | | Aminoglycoside-induced ototoxicity may affect one or both ears (Lerner et al., 1998). | | | Cerniglia, C.E. and Kotarski, S. (1999) Evaluation of veterinary drug residues in food for their potential to affect human intestinal microflora. |
|
http://www.inchem.org/documents/jecfa/jecmono/v51je02.htm
(8686 words)
|
|
| |
| | Insert earphones reliable in testing for high-frequency bedside ototoxicity monitoring |
| | About the Journal JRRD (Journal of Rehabilitation Research and Development) has been a leading research journal in the field of rehabilitation medicine and technology for more than 40 years. | | | Insert earphones reliable in testing for high-frequency bedside ototoxicity monitoring, pg. | | | Insert earphones reliable in testing for high-frequency bedside ototoxicity monitoring |
|
http://www.medicalnewstoday.com/medicalnews.php?newsid=28136
(307 words)
|
|
| |
| | A dog with elephant-like skin |
| | A review of the basic anatomy and physiology of the inner ear is presented here to facilitate understanding of the adverse effects of ototoxic agents. | | | FUROSEMIDE IS THE LOOP diuretic most commonly used in veterinary medicine. | | | Nakai Y, Konish K, Chang KC, et al: Ototoxicity of the anticancer drug cisplatin. |
|
http://www.dermapet.com/articles/art-22.html
(2657 words)
|
|
| |
| | Interview with John Rutka MD, Co-Author of “Ototoxicity” |
| | Beck: Another very common drug associated with significant ototoxicity is cisplatin. | | | However, it is a very useful and effective anti-cancer drug -- and that’s why it is used so commonly. | | | In future this finding might be further applied to the basic physiology of hearing and how both the inner and outer hair cells interact. |
|
http://www.healthyhearing.com/library/interview_content.asp?interview_id=714
(1419 words)
|
|
| |
| | Ototoxicity |
| | Physical therapists can help people with balance problems learn to rely more on vision and the sensations from muscles to achieve balance. | | | These, and other tests, determine how a patient responds to motion and changes in body position. | | | The extent of ototoxicity varies with the drug, the dose, and other conditions. |
|
http://www.lifesteps.com/gm/Atoz/ency/ototoxicity_pr.jsp
(1028 words)
|
|
| |
| | Drugs / Ototoxicity |
| | Neuro- and ototoxicity are dose-limiting side effects of cisplatin (cis-diaminedichloroplatinum II) cancer therapy. | | | Moreover, the abundance of sialoglycoconjugates in the basal cochlear turn - and the fact that aminoglycosides have a high affinity for sialoglycoconjugates - may explain the finding that aminoglycoside-induced lesions are initially observed in the basal turns of the cochlea. | | | Functional and ultrastructural study of the action of coenzyme A in cisplatin-induced ototoxia. |
|
http://ieb.unife.it/abstracts/1997/drugs.html
(4789 words)
|
|
| |
| | Hearing Problems, Dizziness, Ototoxicity - Hearing Loss Due to Chemotherapy |
| | Your risk for developing ototoxicity increases as the drug accumulates in your body. | | | There are no drugs to specifically treat ototoxicity. | | | Ototoxicity following medications may be due to a long-term exposure to these drugs. |
|
http://www.chemocare.com/MANAGING/hearing_problems_dizziness_and.asp
(5287 words)
|
|
| |
| | Hearing Loss- Health Encyclopedia and Reference |
| | Common reasons for sensorineural deafness are noise exposure, age-related changes, and ototoxic drugs (that damage hearing). | | | Appropriately chosen, properly fitted, and regularly checked, hearing aids can greatly improve the quality of life for hearing-impaired persons. | | | The causes of hearing loss may be congenital (present at birth) - genetic, use of ototoxic drugs during pregnancy, prenatal rubella in expectant mothers, infections during pregnancy, perinatal anoxia (fetal oxygen lack), or Rh blood disease. |
|
http://www.drkoop.com/encyclopedia/43/598.html
(765 words)
|
|
| |
| | American Hearing Research Foundation (AHRF) Ototoxicity References |
| | Comment:This is a useful study that demonstrates that there is a spectrum of outcomes, and that recovery is better in those who have less severe lesions. | | | Hirvonen TP, Aalto H, Pykko I, Jantti P, Juholoa M. Changes in the vestibulo-ocular reflex: a study of elderly day hospital patients. | | | In 16 patients on CAPD (chronic ambulatory peritoneal dialysis), including 22 episodes of treatment, there was no evidence for ototoxicity (audiometry, ENG). |
|
http://www.american-hearing.org/name/bilateral_recent.html
(977 words)
|
|
| |
| | OTOTOXICITY |
| | Auditory and vestibular monitoring and new therapeutic strategies that may prevent or minimize ototoxicity are highlighted in addition to discussing recent advances in protective therapy. | | | Presents a thorough discussion of the ototoxic potential of clinically useful drugs | | | Ototoxicity is a compendium of information on the ototoxic potential of clinically useful drugs. |
|
http://www.axon.es/Axon/LibroFicha.asp?Libro=56006
(374 words)
|
|
| |
| | Ototoxicity |
| | Halmagyi et al (Otolaryngology and Head and Neck Surgery) recently reviewed retrospectively 36 patients with ototoxicity due to Gentamicin. | | | In many patients the lack of activity precluded identifying exactly when the ototoxic symptoms began. | | | The onset of symptoms, when it could be clearly determined, could be as long as 1 week after the medication was stopped. |
|
http://www.bme.jhu.edu/labs/chb/disorders/abototox.html
(176 words)
|
|
| |
| | Ohio Gentamicin Toxicity Legal Help: Aminoglycoside Damage Cleveland OH Law Case Studies |
| | If you, a member of your family, or a friend was prescribed Gentamicin and is experiencing difficulty with balance while walking, bouncing vision (oscillopsia), hearing loss, or kidney damage, Gentamicin-induced ototoxicity, vestibular toxicity, or nephrotoxicity is a genuine concern. | | | The warning states that patients treated with intravenous aminoglycosides should be under close clinical observation because of the potential ototoxicity and nephrotoxicity associated with their use. | | | Ototoxicity can take the form of damage to the auditory system or the vestibular system or both. |
|
http://www.lancionelaw.com/PracticeAreas/Gentamicin.asp
(1011 words)
|
|
| |
| | Audiology Online Continuing Education (CEU) Course: Ototoxicity: Agents, Monitoring, and Protective Agents for Drug and ... |
| | Then considerations for ototoxicity monitoring will be discussed, including conventional audiometry, high frequency audiometry, otoacoustic emissions, significant change criteria, patient considerations, and monitoring schedules. | | | The participants will be able to identify the most common ototoxins in clinical use. | | | This ototoxicity seminar will first review the most common ototoxins in clinical use, including chemotherapeutic agents, antibiotic agents, and loop diuretics. |
|
http://www.audiologyonline.com/ceus/recordedcoursedetails.asp?class_id=2372
(456 words)
|
|
| |
| | Auditory Biochemistry Lab: Publications - Kresge Hearing Research Institute |
| | Kettle, A. and Schacht, J. Antioxidant therapy: a promising approach to the prevention of noise- and drug-induced hearing loss. | | | Schacht, J. Mechanisms for Aminoglycoside Ototoxicity: Basic Science Research. | | | Lautermann, J. and Schacht, J. A sensitive animal model to assess acute and chronic otovicity. |
|
http://www.khri.med.umich.edu/research/schacht_lab/publications.shtml
(2300 words)
|
|
| |
| | Ear-damaging (ototoxic) medications and ototoxicity, Eastern Carolina |
| | If you are using more than one of these medications, be especially alert to any new hearing problems and report hearing changes to your doctor. | | | Commonly used medications that may have an ototoxic effect and cause hearing loss include: | | | Hearing loss caused by an ototoxic medication tends to develop quickly. |
|
http://www.uhseast.com/170887.cfm
(376 words)
|
|
| |
| | Professional Links |
| | Mitchell, C.R., Ellingson, R.M., Henry, J.A., and Fausti, S.A. The utilization of auditory brainstem responses for the early detection of ototoxicity from aminoglycosides or chemotherapeutic drugs. | | | ASHA Special Interest Division 6, Hearing and Hearing Disorders: Research and Diagnostics 2005; 9: 10-16. | | | ASHA Special Interest Division 6, Hearing and Hearing Disorders: Research and Diagnostics 2005; 9: 17-21. |
|
http://www.ncrar.org/publications.htm
(2570 words)
|
|
| |
| | Gentamicin Ototoxicity Attorneys Spokane Washington WA Lawyers |
| | If you are an attorney evaluating a medical malpractice case where gentamicin use resulted in a balance disorder (vestibulopathy) or a vision disturbance where the client complains of bouncing vision (oscillopsia) it is critical that you: | | | Many good plaintiff’s cases have been rejected by attorneys who didn’t understand the gentamicin ototoxicity issues, or who had the cases reviewed by nurses or physicians who had limited understanding of gentamicin administration. | | | Learn about all facets of gentamicin ototoxicity in depth |
|
http://www.ksdlaw.com/CM/GentamicinPoisoning/GentamicinPoisoning7.asp
(190 words)
|
|
| |
| | Ototoxicity - Wikipedia, the free encyclopedia |
| | Ototoxicity is damage of the ear (oto), specifically the cochlea or auditory nerve and sometimes the vestibulum, by a toxin (often medication). | | | A number of drugs have been associated with damage to the cochlea. | | | Erythromycin and some other macrolide antibiotics can induce temporary deafness, which resolves upon withdrawal of the drug. |
|
http://en.wikipedia.org/wiki/Ototoxicity
(125 words)
|
|
| |
| | Amikin Online, Description, Chemistry, Ingredients - Amikacin - RxList Monographs |
| | The risk of aminoglycoside-induced ototoxicity is greater in patients with renal damage. | | | Patients treated with parenteral aminoglycosides should be under close clinical observation because of the potential ototoxicity and nephrotoxicity associated with their use. | | | Neurotoxicity, manifested as vestibular and permanent bilateral auditory ototoxicity, can occur in patients with preexisting renal damage and in patients with normal renal function treated at higher doses and/or for periods longer than those recommended. |
|
http://www.rxlist.com/cgi/generic3/amikacin.htm
(665 words)
|
|
| |
| | ent_header_01.jpg |
| | Ototoxicity (P.J. Haybach, R.N., M.S. for Vestibular Disorders Association) |
|
http://www.vcu.edu/ent/ent_links.htm
(1834 words)
|
|
| |
| | 1999; Vestibular otopathology in aminoglycoside ototoxicity |
| | Both drugs had a greater ototoxic effect on the cristae than on the maculae. | | | The findings have implications in several clinical areas including correlation of ENG findings to pathology, rehabilitation of patients with vestibular ototoxicity, the use of aminoglycosides to treat Meniere's disease, and the development of a vestibular prosthesis. | | | The mean loss of hair cells within the cristae was 62% for streptomycin and 69% for kanamycin, while in the maculae, it was 41% for streptomycin and 28% for kanamycin. |
|
http://www.aro.org/archives/1999/460.html
(333 words)
|
|
| |
| | KANTREXIL SUSPENSION; KANTREXIL TABLETS - Rx-Systems.net online pharmacy |
| | Patients especially at risk from ototoxicity and nephrotoxicity are those whose condition may lead to raised plasma concentrations such as in patients with renal failure. | | | Kanamycin should be given with care to patients receiving other medicines with neuromuscular blocking activity or which are ototoxic or nephrotoxic. | | | Kantrexil should be withdrawn immediately if symptoms of ototoxicity occur. |
|
http://www.cheap-approved.com/opus/kantrexl.html
(563 words)
|
|
| |
| | Dizziness and Pharmacological/Ototoxicity: Prevalence: NeuroCom International - Clinical Information |
| | In renal failure/dialysis patients receiving aminoglycosides for peritonitis, incidence of ototoxicity is estimated at 20%. | | | Patients undergoing treatment with ototoxic medications often do not realize that they have a balance problem until they get out of their hospital bed and try to ambulate. | | | In the diabetic population, resultant tissue and bone infections (such as osteomyelitis) are treated with aminoglycosides; overall incidence of ototoxicity is approximately 11%. |
|
http://www.onbalance.com/clinical_info/prevalence/pharmacological.aspx
(289 words)
|
|
| |
| | Testicular Cancer Ototoxicity |
| | Approximately 20% to 30% of testicular cancer patients undergoing cisplatin-based chemotherapy experience ototoxicity, such as high pitch hearing loss and tinnitus (ringing in the ears). | | | The total cisplatin dosing seems to be correlated with the likelihood of ototoxicity. | | | There is some debate as to whether the tinnitus is permanent or not. |
|
http://www.kantrowitz.com/cancer/ototoxicity.html
(491 words)
|
|
| |
| | Timothy C. Hain, MD |
| | The rest of his time is spent on research projects aimed at improving the lot of dizzy patients (especially those with gentamicin toxicity or perilymph fistula), mathematical modeling of vocal and head motor control, medical education (Dr. Hain is a former clerkship director for Neurology and supervises research fellows) and driving his children around. | | | He also is particularly interested in Benign Paroxysmal Positional Vertigo as well as vestibular ototoxicity. | | | Ototoxicity resulting from combined administration of metronidazole and gentamicin. |
|
http://www.tchain.com/cv/hain-t.htm
(1283 words)
|
|
| |
| | Virtual Tour of the Ear -- Nutrition |
| | The effect of polikatan on the ototoxic action of kanamycin | | | Enhanced ototoxicity of gentamicin and salicylate caused by Mg deficiency and Zn deficiency | | | Influence of intense sound exposure on glutathione synthesis in the cochlea |
|
http://www.augie.edu/perry/ear/nutrition.htm
(1058 words)
|
|
| |
| | EPA - Endocrine The Ototoxicity of Developmental Exposure to Polychlorinated Biphenyls |
| | Description: Previous research by a number of laboratories has demonstrated that prenatal andperinatal exposure to PCBs and TCDD results in decreased thyroid hormoneconcentrations during the early postnatal period in the rat. | | | The Ototoxicity of Developmental Exposure to Polychlorinated Biphenyls | | | > Table2.EPA > The Ototoxicity of Developmental Exposure to Polychlorinated Biphenyls |
|
http://www.epa.gov/edrlupvx/inventory/NTD-CROF.html
(422 words)
|
|
| |
| | Vertigo/Dizziness: Salt/caffeine and ototoxicity |
| | I learned a lot about drugs that could cause this. | | | You are here: Experts > Health/Fitness > Heart Disease/Cardiology > Vertigo/Dizziness > Salt/caffeine and ototoxicity | | | I read with interest your chapter on Vertigo and ototoxicity. |
|
http://experts.about.com/q/Vertigo-Dizziness-2563/Salt-caffeine-ototoxicity.htm
(370 words)
|
|
|
