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| | Osteosarcoma |
 | | This is the type of radiation therapy that has been tried as a treatment for osteosarcoma. | | | When children with retinoblastoma are treated with radiation therapy, it increases their risk of osteosarcoma in the bones of the skull. | | | Most cases of osteosarcoma are treated with chemotherapy given as an adjuvant (addition) to surgery. |
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http://www.btinternet.com/~webpageit/ostesarcoma.htm
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| | Common Cancers - Osteosarcoma |
| | Because of this, systemic chemotherapy is recommended as follow-up therapy for dogs with appendicular osteosarcoma. | | | There is currently limited information regarding the effect of adjuvant radiation therapy in dogs with axial osteosarcomas. | | | The average survival in dogs with osteosarcoma treated with surgery and chemotherapy is approximately 1 year. |
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http://www.caninecancerawareness.org/CommonCancers-Osteosarcoma.html
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| | Sarcomas |
| | Osteogenic sarcoma, or osteosarcoma, is the most common form of bone cancer, accounts for six percent of all instances of the disease, and for about five percent of all cancers that occur in children. | | | Osteosarcomas, which grow very rapidly, can develop in any bone but most often occur along the edge or on the end of one of the fast-growing long bones that support the arms and legs. | | | Since the 1960s, when amputation was the only treatment for bone cancer, new chemotherapy drugs and innovative surgical techniques have improved survival with intact limbs. |
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http://www.chclibrary.org/micromed/00064340.html
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| | [No title] |
| | Osteosarcomas can also be defined by position within the bone. | | | High-grade lesions should be treated with surgical excision as well as chemotherapy. | | | Palliative radiation therapy may be offered to patients who are not surgical candidates. |
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http://www.iupui.edu/~sarcoma/sopt5.html
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| | Osteosarcoma |
| | Osteosarcoma Online - Indiana University Cancer Centre (USA) This is the Web site of the Osteosarcoma Clinical Care and Research Program at Indiana University Cancer Centre. | | | Most are high grade intramedullary osteosarcomas, about 5% are low grade lesions, some are secondary osteosarcomas (for example those caused by radiation therapy). |
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http://www.cancerindex.org/ccw/guide2o.htm
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| | WHO's Discussion of NTP Fluoride Bioassay |
| | Moreover, the level of fluoride in the bones of the high-dose group of male rats in the NTP carcinogenicity bioassay, in which a non-significant increase in osteosarcomas was observed, is similar to that measured in humans with a preclinical phase of skeletal fluorosis. | | | It was concluded (NTP, 1990) that the osteosarcoma finding was Òequivocal evidence of carcinogenic activityÓ in male rats, and that there was Òno evidence of carcinogenic activityÓ in the female rats exposed to fluoride under these conditions. | | | In male F344/N rats receiving 0.2, 0.8, 2.5 or 4.1 mg fluoride/kg body weight per day, the incidence of osteosarcomas (three tumours in the vertebra and one in the humerus) was 0/80, 0/51, 1/50 and 3/80, respectively (NTP, 1990). |
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http://www.slweb.org/WHO-cancer.html
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| | [No title] |
| | Although osteosarcoma of the appendicular skeleton arises in the medullary cavity of the metaphyseal region, in many instances the cortex and surrounding soft tissue are invaded prior to clinical presentation or surgical intervention. | | | In the dog the clinical course of parosteal osteosarcoma is considerably longer than that of osteosarcoma arising in the medullary cavity of long bones. | | | Parosteal osteosarcoma, because it is rare in the dog, requires further investigation to provide better clinical pathologic information. |
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http://cal.vet.upenn.edu/saortho/chapter_74/74mast.htm
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| | Fluoride & Osteosarcoma (Bone Cancer) |
| | The incidence of bone osteosarcomas of 3/80 and the incidence of all osteosarcomas of 4/80 in the high-dose male rats are both significantly greater than the rate of 0.6% for osteosarcomas and osteomas at all sites in control male rats in the historical database... | | | Osteosarcomas (in bone or extraskeletal) are not commonly observed in control male rats in NTP studies. | | | As acknowledged by the U.S. National Toxicology Program there is a "biological plausibility" of a link between fluoride exposure and osteosarcoma. |
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http://fluorideaction.net/health/cancer/osteosarcoma.html
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| | NIH Consensus Statements: 46. Limb-Sparing Treatment of Adult Soft-Tissue Sarcomas and Osteosarcomas |
| | Disease-free survival and overall survival data for patients with osteosarcoma treated by limb-sparing surgery combined with adjuvant chemotherapy (and radiation in some instances) are similar to those of patients treated with amputation and adjuvant chemotherapy. | | | Limb-sparing surgery for osteosarcoma is contraindicated when the extent of a tumor is such that a clear surgical margin cannot be achieved and still allow a functional limb; in such situations, amputation is indicated. | | | The incidence of these complications may be reduced with refined surgical and radiation therapy techniques and appropriate rehabilitation. |
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http://consensus.nih.gov/cons/046/046_statement.htm
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| | NEW EVIDENCE ON FLUORIDATION |
| | The report’s profluoridation bias was further demonstrated by its failure to cite any of the studies presenting the evidence against fluoridation published in refereed journals. | | | Thus, there is a consistent pattern of evidence — hip fractures, skeletal fluorosis, the effect of fluoride on bone structure, fluoride levels in bones, and osteosarcomas — pointing to the existence of causal mechanisms by which fluoride damages bones. | | | But there is already a strong basis for concern, because the human data are supported by an animal experiment: the US National Toxicology Program has recorded a statistically significant, dose-related increase in the incidence of osteosarcoma in male rats ingesting fluoride. |
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http://www.fluoride-journal.com/97-30-3/303-179.htm
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| | Case#20 |
| | In elderly, osteosarcoma is usually seen in association with a pre-existing bone disease, such as Paget's, radiation osteitis, or bone infarct. | | | Based on the location within the bone, osteosarcomas are subdivided into intarmedullary, intracortical and surface osteosarcomas. | | | Recent studies have shown frequent over-expression of Her2/neu by osteosarcoma and its correlation with a significantly worse histologic response to pre-operative chemotherapy and shorter event-free survival. |
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http://www.umdnj.edu/tutorweb/case20.htm
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| | Combined Modality Treatment for Osteosarcoma Occurring as a Second Malignant Disease -- Bielack et al. 17 (4): 1164 -- ... |
| | Saeter G, Alvegard TA, Elomaa I, et al: Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single-agent high-dose methotrexate: A Scandinavian Sarcoma Group study. | | | Bielack S, Wulff B, Delling G, et al: Osteosarcoma of the trunk treated by multimodal therapy: Experience of the cooperative osteosarcoma study group COSS. | | | Definitive surgery was performed for 28 of 30 secondary osteosarcomas. |
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http://www.jco.org/cgi/content/full/17/4/1164
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| | Final Diagnosis -- Case 10 |
| | Whatever the morphologic variant and site of origin, all osteosarcomas are aggressive lesions that metastasize widely through the bloodstream, usually first to the lungs, but also to other parenchymal organs and other osseous sites. | | | The origins of osteosarcomas are as mysterious as those of all other forms of cancer. | | | The vascularization may be subtle or take the form of large, cavernous telangiectatic channels, distributed throughout the tumor-telangiectatic osteosarcomas. |
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http://path.upmc.edu/cases/case10/discussion.html
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| | FDG PET predicts outcome in osteosarcomas |
| | "The prognosis for a patient with osteosarcoma is always dependent on the therapy they undergo," said Dr. Franzius. | | | The authors noted that this finding could change the course of therapy offered and that the individualized assessment provided by PET may improve chances of event-free survival among children with the disease. | | | Christiane Franzius and colleagues from the Department of Nuclear Medicine at the University of Münster, Germany, used PET to evaluate the prognostic significance of 18F-fluorodeoxyglucose (FDG) uptake in primary osteosarcomas. |
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http://www.eurekalert.org/pub_releases/2002-06/sonm-fpp060802.php
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| | [No title] |
| | The two approaches used to determine whether there is an association between exposure to fluoridated water and cancer are: a) carcinogenicity studies of rodents and b) epidemiologic analyses to compare cancer incidence and mortality rates in communities with fluoridated water and in those with negligible levels of fluoride in drinking water. | | | Similarly, there was no apparent relation between introduction and duration of fluoridation and the incidence of cancer, including bone and joint cancer and the subset of osteosarcomas. | | | Conduct analytical epidemiologic studies of osteosarcoma to determine the risk factors associated with its development. |
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http://www.cda.org/public/pubhsrvc.html
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| | eMedicine - Osteosarcoma, Variants : Article by Geoff Hide, MBBS, MRCP, FRCR |
| | Approximately 75% of all osteosarcomas are of the classic or conventional type, and the remaining 25% comprise the osteosarcoma variants, which are the subject of this article. | | | The variants are a heterogeneous group of osteosarcomas with a range of different imaging and behavioral features. | | | Findings: MRI is the optimum technique for local staging of osteosarcomas. |
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http://www.emedicine.com/radio/topic505.htm
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| | Skeletal System |
| | Osteosarcoma, as a general rule, presents with severe, local pain, although, in some cases, protracted, slowly developing, slight-to-moderate pain and tenderness may be observed. | | | In contrast, secondary osteosarcomas occur in older patients with Paget's disease of bone or with a history of remote fracture or radiation therapy. | | | Which organ is the preferential site for metastases in patients with osteosarcoma? |
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http://pathcuric1.swmed.edu/PathDemo/sklqs/sklqs.htm
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| | Prognostic value of DNA ploidy response to chemotherapy in human osteosarcomas |
| | The results showed that 12 diploid and nine non-diploid osteosarcomas did not change their ploidy pattern, but nine non-diploid tumors changed to a diploid pattern with the disappearance of the aneuploid cells. | | | Prognostic value of DNA ploidy response to chemotherapy in human osteosarcomas. | | | We analyzed the DNA ploidy alterations after preoperative chemotherapy in 30 patients with non-metastatic osteosarcomas of the extremities. |
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http://www.meb.uni-bonn.de/cgi-bin/mycite?ExtRef=ICDB/99382056
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| | PRIMARY BONE TUMORS OF CATS |
| | This disease is included in the discussion of primary bone tumors because of its aggressive natural behavior. | | | Although the prognosis for humans with parosteal osteosarcoma is much better than for patients with central osteosarcoma, data are insufficient to conclude that the prognosis for cats with parosteal osteosarcoma differs from that of central osteosarcoma. | | | There may be a considerable amount of cartilage present, and osteoid may be scant. |
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http://maxshouse.com/Oncology/primary_bone_tumors_of_cats.htm
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| | Sloan-Kettering - Primary Bone Tumors |
| | We treat more patients with primary bone cancer than any other institution in the world. | | | The most common kinds of bone tumors are osteosarcoma and Ewing's sarcoma. | | | Symptoms often include pain or a mass arising from the bones where the tumor is located. |
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http://www.mskcc.org/mskcc/html/9904.cfm
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| | Expression of Platelet-Derived Growth Factor-AA is Associated with Tumor Progression in Osteosarcoma |
| | Ozaki T, Flege S, Liljenqvist U, Hillmann A, Delling G, Salzer-Kuntschik M. et al Osteosarcoma of the spine: experience of the cooperative osteosarcoma study group. | | | Disease-free survival of osteosarcoma patients relative to PDGF-AA expression. | | | The patients underwent treatment between 1992 and 1999 at the Department of Orthopedics at the Vienna General Hospital. |
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http://www.nature.com/modpathol/journal/v16/n1/full/3880711a.html
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| | MIR Teaching file case bs061 |
| | Additional views of the neck with chin up. | | | Metastases to other internal organs by craniofacial osteosarcomas were rare. | | | There is also a focus of increased uptake in the left neck in the soft tissues. |
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http://gamma.wustl.edu/bs061te143.html
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| | Michele Carbone, M.D., and Maurizio Bocchetta, Ph.D. - Loyola University's Department of Pathology |
| | During the past 8 years we have had the exciting experience of seeing our research move from tissue culture, to animal models, to humans, and, soon, to clinical trials. | | | We demonstrated that SV40 inhibited p53 (Nature Medicine 1997) and Rb (Nature Medicine 1997) in human mesothelioma, and that the same strains of SV40 found in mesothelioma were present in the poliovaccines used in the 50s (Cancer Res. | | | These results prompted experiments in which we demonstrated the presence of SV40 in human mesotheliomas (Oncogene 1994) and osteosarcomas (Oncogene 1996). |
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http://www.luhs.org/depts/path/physicians/carbocc.htm
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| | EID V3 N2: News & Notes - Simian Virus 40 (SV40), a Possible Human Polyomavirus (Workshop Held at NIH) |
| | These discussions emphasized the need for caution in interpreting PCR data and the need for standardized, quantitative PCR assay procedures. | | | The surveys compared tumor incidence data in persons who could have been exposed to SV40 in polio vaccines with those who, because of their date of birth, could not have been exposed directly; no discernible relationship between exposure to SV40 and development of tumors was found. | | | During the past 4 years, polymerase chain reaction (PCR) assays have detected DNA sequences related to SV40 (an oncogenic simian polyomavirus) in a variety of human tissues, especially choroid plexus tumors, ependymomas, mesotheliomas, and osteosarcomas (1-7). |
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http://www.cdc.gov/ncidod/EID/vol3no2/news245.htm
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| | OMIM Entry 259500 |
| | Approximately 1% of Paget patients develop osteosarcoma, which represents an increase in risk that is several thousand-fold over that of the general population. | | | Osteosarcoma in Paget patients is the underlying basis for a substantial fraction of osteosarcomas occurring after age 60 years. | | | provided evidence that some human osteosarcomas arise subsequent to the development of homozygosity at loci on the long arm of chromosome 13. |
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http://www.hgmp.mrc.ac.uk/cgi-bin/wrapomim?259500
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| | FreeOrtho Oncology |
| | Osteosarcoma and Ewing's sarcoma are the most common mesenchymal bone tumours occurring during childhood and adolescence. | | | Above the age of 40, metastatic bone tumours are the most common tumours. | | | Periosteal osteosarcoma is high grade lesion in contrast to parosteal osteosarcoma. |
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http://freeortho.com/Revision/Oncology.html
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| | FDG PET predicts outcome in osteosarcomas |
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http://www.eurekalert.org/emailrelease.php?file=sonm-fpp060802.php
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