|
| |
| | Osteopetrosis and osteoporosis:two sides of the same coin -- Lazner et al. 8 (10): 1839 -- Human Molecular Genetics |
 | | Osteoclastic resorption of bone is a two-phase process. | | | The key to understanding the basis of each of these bone diseases is to determine whether the primary defect resides in the osteoblast or osteoclast lineage or indeed whether the skeletal phenotype arises as a consequence of other immunological and/or endocrinological defects. | | | This possibility suggests that cathepsin K may be the (or at least a) mediator by which the post-menopausal loss of oestrogen results in bone loss. |
|
http://hmg.oupjournals.org/cgi/content/full/8/10/1839
|
|
| |
| | SVI - New targets to reduce bone disease |
| | These inhibitors affect osteoclast formation and activity and we are determining their mechanism of action. | | | Imbalances between the bone resorption and bone formation, in which the former is in excess or the latter is reduced, results in bone loss that is frequently associated with several disorders. | | | These patients are at risk for development of a generalized form of bone loss. |
|
http://www.svimr.unimelb.edu.au/reducebone.htm
|
|
| |
| | The National Association for the Relief of Paget's Disease - Research Update |
| | Our studies have focused on the way in which osteoclasts are formed in Paget's disease. | | | The National Association for the Relief of Paget's Disease - Research Update | | | Increased levels of M-CSF are likely to play a role in osteoclast formation in Paget's disease as are other as yet unidentified factors which are present in the serum of patients with Paget's disease. |
|
http://www.paget.org.uk/res_athan.htm
|
|
| |
| | G. David Roodman, M.D., Ph.D. |
| | Our laboratory has been interested for many years in the identification and characterization of the mechanism of action of cytokines on osteoclast formation in human and murine systems. | | | Choi SJ, Devlin RD, Reddy SV, Chung H, Boyce BF, Roodman GD: Identification of human asparaginyl endopeptidase (legumain) as an autocrine inhibitor of osteoclast formation and bone resorption. | | | We have developed marrow culture systems in which osteoclast-like cells form and have also developed techniques for purifying osteoclasts from giant cell tumors of bone. |
|
http://www.uthscsa.edu/faculty/roodman.html
|
|
| |
| | Osteoclast Library Construction and MRNA Phenotyping |
| | It is therefore important to understand osteoclast ontogeny and function in order to more fully comprehend mechanisms associated with bone loss in periodontal disease and to design successful strategies for intervention. | | | In so doing, our objective is to identify and characterize molecular probes which are specific to cells of the osteoclast lineage, as well as those which reflect the efferent and afferent mechanisms which regulate and define its function as the cell responsible for the bone loss associated with periodontal disease. | | | Clones for osteoclast genes which are functionally regulated will be studied using gene-specific antisense oligodeoxynucleotides to determine whether inhibition of their translation effects the ability of osteoclasts to function in in vitro assays of resorption and attachment. |
|
http://www.usc.edu/hsc/dental/Info/Research/24.html
|
|
| |
| | Profile |
| | Our laboratory is at the forefront of examining the hypothesis that bacterially-derived endotoxin is one of the factors that contribute to aseptic loosening. | | | Bi Y,Collier TO,Goldberg VM,Anderson JM,Greenfield EM,Adherent endotoxin mediates biological responses of titanium particles without stimulating their phagocytosis. | | | Our research focuses on cell-cell interactions between osteoblasts (the bone-forming cells) and osteoclasts (the cells that resorb bone). |
|
http://myprofile.cos.com/greenfie44
|
|
| |
| | osteoclast: Definition and Much More From Answers.com |
| | Meaning #1 : cell that functions in the breakdown and resorption of bone tissue | | | Osteoclasts arise from haemopoietic cells of the monocyte / macrophage lineage, specifically CFU-GM. | | | This last hormone, IL-6, is one of the factors in the disease osteoporosis, which is an imbalance between bone resorption and bone formation. |
|
http://www.answers.com/topic/osteoclast
|
|
| |
| | Osteoclast |
| | The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. | | | An osteoclast is one of the two types of cells that are needed to repair bone. |
|
http://www.healthcentral.com/ency/408/ImagePages/1481.html
|
|
| |
| | Osteoclast |
| | An osteoclast is a large cell in growing bone that dissolves and removes bony tissue. |
|
http://solae.com/cn/glossary/osteoclast.htm
|
|
| |
| | Osteoclast Precursors - Cambrex |
| | Osteoclasts are large, multinucleated cells that play an active role in bone resorption. | | | Poietics Osteoclast precursors yield up to 20-30 percent conversion to Osteoclasts when differentiated using Poietics media systems. | | | Other customers please refer to the Contact Us section of our web site for the local distributor in your area. |
|
http://www.cambrex.com/catnav.oid.860.prodoid.OCP
|
|
| |
| | swf001mhu: An osteoclast in three dimensions |
| | This animation of two human osteoclasts, which were cultured on dentine, was derived from the isosurface image shown in Figure 4c ( fig004mhu). | | | The same colours have been used in both Figure 4 and the animation; thus, green represents the vitronectin receptor, red represents F-actin and blue represents the dentine surface. |
|
http://www-ermm.cbcu.cam.ac.uk/00001678h.htm
|
|
| |
| | Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim -- Akiyama et al. ... |
| | Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim | | | Akt1/Akt2 and Mammalian Target of Rapamycin/Bim Play Critical Roles in Osteoclast Differentiation and Survival, Respectively, Whereas Akt Is Dispensable for Cell Survival in Isolated Osteoclast Precursors | | | Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim -- Akiyama et al. |
|
http://embojournal.npgjournals.com/cgi/content/abstract/22/24/6653
|
|
|
