|
| |
| | [No title] |
 | | DNA that encodes an oncogene which functions in a second biochemical pathway, wherein the first biochemical pathway and the second biochemical pathway are two distinct biochemical pathways. | | | that encodes an oncogene which functions in a second biochemical pathway, wherein the first biochemical pathway and the second biochemical pathway are two distinct biochemical pathways. | | | oncogene functions, downstream of that location/position or at the same location/position in the pathway. |
|
http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=00/73420.001207&ELEMENT_SET=DECL
(8509 words)
|
|
| |
| | Frequent Jumping Translocations of Chromosomal Segments Involving the ABL Oncogene Alone or in Combination With CD3-MLL ... |
| | We called this type of translocation "segmental jumping translocation (SJT)." SJT of the ABL oncogene was not detected in samples from 15 patients with de novo acute myelocytic leukemia (AML), 12 with myelodysplastic syndrome (MDS), or 20 with chronic myelocytic leukemia (CML) at the chronic phase. | | | Twenty patients with chronic myelocytic leukemia (CML) in the chronic phase, 12 with MDS, and 7 individuals without hematologic diseases, did not have an amplified ABL oncogene. | | | We studied bone marrow samples from these patients by fluorescence in situ hybridization (FISH). |
|
http://www.bloodjournal.org/cgi/content/full/89/2/596
(3117 words)
|
|
| |
| | Oncogene-induced transcriptional patterns in established cell lines as a model for in vitro analysis of tumor biology |
| | Both early and late changes may have significant biological or medical roles, either by participating in the tumorigenesis or by serving as tumor markers that can help classify tumors or sort them into prognostic groups (Jen et al., 1994; Telang et al., 1998; Isfort et al., 1999). | | | In our experiments, vector-attributed changes were not apparent at the 3-day time point, but they became obvious 10 days after transfection (Figures 1 and 2; pp2a and rig). | | | These so-called foci can be macroscopically visualized and scored, enabling the investigator to study signals that affect malignant transformation. |
|
http://www.funpecrp.com.br/gmr/year2004/vol3-3/gmr0098_full_text.htm
(3523 words)
|
|
| |
| | AEGiS-PRn: Oncogene Science and BioChem Therapeutic Expand Collaboration in Anti-Virals |
| | BioChem Therapeutic Inc. is a wholly-owned subsidiary of BioChem Pharma Inc. BioChem Pharma is an international company dedicated to the research, development and commercialization of innovative products for the prevention, detection and treatment of human diseases. | | | "BioChem Therapeutic is committed to the development of a broad portfolio of anti-viral drugs," stated Michael G. Grey, President, BioChem Therapeutic Inc. "Oncogene Science is an integral part of our strategy in this area and we are very pleased with the progress that has been made in the program to date." | | | In May 1996, Oncogene Science and BioChem Therapeutic Inc. entered into a collaborative research, development and commercialization agreement for the discovery and development of anti-viral drugs to treat hepatitis C (HCV) and human immunodeficiency virus (HIV). |
|
http://www.aegis.com/news/PR/1997/PR970241.html
(620 words)
|
|
| |
| | oncogene at MSN Shopping |
| | Oncogene and Transgenics Correlates of Cancer Risk Assessments: | | | 10 results for "oncogene" found in Business & Technical Books |
|
http://shopping.msn.com/results/shp?text=oncogene,userText=oncogenic,qc=1
(26 words)
|
|
| |
| | Rediscovering Biology - Online Textbook: Unit 8 Cell Biology & Cancer |
| | Mutations in MYC convert it into an oncogene associated with seventy percent of cancers. | | | However, a single oncogene is not usually sufficient to cause cancer, so inheritance of an oncogene does not necessarily result in cancer. | | | The result of any of these events is an altered form of the gene, which contributes to cancer. |
|
http://www.learner.org/channel/courses/biology/textbook/cancer/cancer_3.html
(1396 words)
|
|
| |
| | FASEB MEETING: Cancer Oncogene May Be Related To High Blood Pressure |
| | In addition, he and his colleagues have found that another oncogene, src kinase, is also responsible for regulating the actions of sodium channels in some individuals. | | | Eaton and his colleagues have found that one of those other proteins is the oncogene, p21 ras, which has been implicated in a variety of cancers. | | | FASEB MEETING: Cancer Oncogene May Be Related To High Blood Pressure |
|
http://www.pslgroup.com/dg/6D7BA.htm
(540 words)
|
|
| |
| | Method of detecting ras oncogene related malignancies (US5068175) |
| | M. McCoy et al., "Characterization of a human colon/lung carcinoma oncogene," Nature 302:79-81 (1983). | | | circulating serum protein(s) from cancer patients interacting specifically with a region(s) of the ras oncogene promoter DNA). | | | Bands migrating at a slower rate than the uncomplexed DNA are indicative of a protein-DNA interaction (i.e. |
|
http://www.delphion.com/details?&pn=US05068175__
(704 words)
|
|
| |
| | UNSW Embryology- DNA Tumor Suppressor and Oncogene |
| | spleen focus forming virus (SFFV) proviral integration oncogene spi1 | | | v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog | | | This page not yet completed Links will not work. |
|
http://embryology.med.unsw.edu.au/DNA/DNA10.htm
(672 words)
|
|
| |
| | MYCN (myc myelocytomatosis viral related oncogene, neuroblastoma derived) |
| | For comments and suggestions or contributions, please contact us | | | MYCN oncogene amplification in neuroblastoma is associated with worse prognosis, except in stage 4s: the Italian experience with 295 children. | | | MYCN amplification is found in 15% of neuroblastoma, is an adverse prognostic feature per se, and is often associated with other adverse features (older age, abdominal tumor, advanced disease, and high lactate dehydrogenase, ferritin, and neuron-specific enolase serum levels) |
|
http://www.infobiogen.fr/services/chromcancer/Genes/NMYC112.html
(354 words)
|
|
| |
| | Oncogene - Wikipedia, the free encyclopedia |
| | Src was in fact first discovered as an oncogene in a chicken retrovirus. | | | Some oncogenes, usually involved in early stages of cancer development, increase the chance that a normal cell develops into a tumor cell, possibly resulting in cancer. | | | A mutation within a proto-oncogene can cause a change in the protein structure, caused by |
|
http://en.wikipedia.org/wiki/Oncogene
(627 words)
|
|
| |
| | [No title] |
| | The abl oncogene is found to be activated in leukemia (CML) patients. | | | The Cancer Information Service provides a nationwide telephone service for cancer patients, and their families, the public, and health care professionals. | | | This showed the association between cancer and an overproduced oncogene product. |
|
http://rex.nci.nih.gov/massmedia/CANCER_RESRCH_WEBSITE/GENE_ALTERS.html
(1260 words)
|
|
| |
| | Potential ovarian cancer oncogene offers possibility of predictive test and a novel therapy |
| | Potential ovarian cancer oncogene offers possibility of predictive test and a novel therapy | | | They further report PKCi is over-expressed in serous ovarian cancer, which makes up the remaining 60 percent of ovarian cancer cases. | | | The study was supported by grants from the National Cancer Institute and the Department of Energy. |
|
http://www.eurekalert.org/pub_releases/2005-08/uotm-poc081705.php
(773 words)
|
|
| |
| | Closing In On Cancer |
| | Oncogenes—the hypothesized cancer-causing genes—could actually be identified, and George Todaro and Robert Huebner's oncogene theory expanded to accomodate new theories. | | | The next step—confirming the existence of human oncogenes—was complicated and involved the work of several research groups. | | | Since that time, several human oncogenes have been identified. |
|
http://rex.nci.nih.gov/behindthenews/cioc/tech/tech.htm
(872 words)
|
|
| |
| | Harvey Ras oncogene |
| | To help unravel the intricate network of events that lead to cancer, mice are being used to model the human disease, which will further our understanding and help to identify possible targets for new drugs and therapies. | | | Usually, a single oncogene is not enough to turn a normal cell into a cancer cell, and many mutations in a number of different genes may be required to make a cell cancerous. | | | Ras is one such oncogene product that is found on chromosome 11. |
|
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.111
(253 words)
|
|
| |
| | Oncogene |
| | Oncogene is one of the world's leading cancer research journals. | | | It is published weekly and covers all aspects of the structure and function of Oncogenes. | | | Oncogene also publishes 8 Reviews issues a year, on a broad range of topics. |
|
http://www.nature.com/onc/index.html
(178 words)
|
|
| |
| | Sarkar et al. |
| | For an example, erb B2 was initially isolated from rat neuroglioblastomas (18), but now it has been implicated in both human breast cancer and ovarian cancer (19,20). | | | In view of the notion that a number of oncogenes, are involved in human mammary tumorigenesis, we determined whether or not human breast tumors express jun.. | | | In addition, a number of other oncogenes, such as erb B2 (also known as c-neu or HER -2), and p53, have also been implicated in human breast carcinogenesis (10-16). |
|
http://www.epress.com/w3jbio/vol1/sarkar/sarkar.html
(4712 words)
|
|
| |
| | Papers Link Oncogene Activity And Oxidative Stress |
| | C-Myc is one such oncogene, and in fact it appears to be unusually powerful in terms of its ability to induce the cellular changes associated with cancer. | | | Understanding the mechanisms that regulate cell growth and survival is vital for identifying potential targets for future cancer therapeutics. | | | Together, these papers provide an illustration of how a single oncogene, in this case c-Myc, can affect a number of different cellular pathways to promote cancer progression. |
|
http://unisci.com/stories/20022/0524022.htm
(537 words)
|
|
| |
| | Oncogene definition - Cancer information on MedicineNet.com |
| | Oncogene is a journal for researchers interested in the molecular biology of malignant change including molecular biologists, cell biologists, oncologists, geneticists and biotechnologists. | | | Please consult your healthcare provider before beginning any course of supplementation or treatment. | | | MedicineNet Home > MedTerms medical dictionary A-Z List > Cancer Home Page > Oncogene |
|
http://www.medterms.com/script/main/art.asp?articlekey=4636
(227 words)
|
|
| |
| | oncogene |
| | More than one oncogene may be necessary to transform a cell in this way. | | | In 1989 US scientists J Michael Bishop and Harold Varmus were jointly awarded the Nobel Prize for Physiology or Medicine for their concept of oncogenes, although credit for the discovery was claimed by a French cancer specialist, Dominique Stehelin. | | | Oncogenes arise from mutations in genes (proto-oncogenes) found in all normal cells. |
|
http://www.tiscali.co.uk/reference/encyclopaedia/hutchinson/m0026164.html
(273 words)
|
|
| |
| | Proto-Oncogenes and Cancer |
| | Proto-oncogenes can be classified into many different groups based upon their normal function within cells or based upon sequence homology to other known proteins. | | | Tumor cells also can arise by non-genetic means through the actions of specific tumor viruses. | | | The process of activation of proto-oncogenes to oncogenes can include retroviral transduction or retroviral integration (see below), point mutations, insertion mutations, gene amplification, chromosomal translocation and/or protein-protein interactions. |
|
http://web.indstate.edu/thcme/mwking/oncogene.html
(1490 words)
|
|
| |
| | Oncogene Blockers |
| | A very important category of cancer-causing mutations do their mischief at the very beginning of the cell division process. | | | It has been clear for several years that one way to attack cancer would be to somehow mute the overly-loud “divide” signal being sent to the cell nucleus by oncogenes. | | | These cancer-causing genes, called “oncogenes,” trick the cell into deciding that it is time to divide, when in fact it is not. |
|
http://www.txtwriter.com/Onscience/Articles/oncogenes.html
(752 words)
|
|
| |
| | NEJM -- Correction: Location of bcl-2 Oncogene |
| | oncogene has been characterized at the t(11;14) (q13;q32) breakpoint | | | The chromosomal location of this oncogene is incorrectly identified. | | | This oncogene was cloned at the site of the t(14;18) (q32;q21) |
|
http://content.nejm.org/cgi/content/extract/328/2/141
(132 words)
|
|
| |
| | Potential New Oncogene May Be Missing Link in Cancer-Causing Chain |
| | “Because no one has ever connected LRP6 to proliferation in tumors, we believe we may have identified a new oncogene,” says Guojun Bu, Ph.D., associate professor of pediatrics and of cell biology and physiology. | | | Louis, Nov. 1, 2004 — High levels of a protein called LRP6 can make cancer cells more aggressive, according to Washington University researchers affiliated with the Siteman Cancer Center. | | | Potential New Oncogene May Be Missing Link in Cancer-Causing Chain |
|
http://mednewsarchive.wustl.edu/medadmin/panews.nsf/0/613EB5EF0A841DBC86256F34007876FA
(564 words)
|
|
| |
| | Genome Glossary |
| | A gene, one or more forms of which is associated with cancer. | | | Many oncogenes are involved, directly or indirectly, in controlling the rate of cell growth. | | | The sequence of DNA or RNA located between the start-code sequence (initiation codon) and the stop-code sequence (termination codon). |
|
http://www.ornl.gov/TechResources/Human_Genome/glossary/glossary_o.html
(166 words)
|
|
| |
| | RET - RET proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung ... |
| | Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. | | | High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation. | | | Characterization of the promoter region and oligomerization domain of H4 (D10S170), a gene frequently rearranged with the ret proto-oncogene. |
|
http://www.cancerindex.org/geneweb/RET.htm
(1150 words)
|
|
| |
| | Linking Tumor-Suppressor Loss and Oncogene Activation |
| | the team focused on the repressed tags; to their surprise one of the most highly down-regulated tags corresponded to c-MYC, one of the first oncogenes to be identified. | | | couple of citation superstars are at it again, with a paper that built a bridge between two well studied, but hitherto unlinked, genes and demonstrated the first connection between the loss of a tumor suppressor gene and the activation of an oncogene. |
|
http://www.sciencewatch.com/march-april2000/sw_march-april2000_page8.htm
(761 words)
|
|
| |
| | oncogene : Definition |
| | Oncogenes are found in the oncogenically activated state in retroviruses and transformed cells and in their normal non-oncogenically activated state in non-transformed cells in which they are called proto-oncogenes. | | | Oncogenes are generally mutated forms of normal cellular genes (proto-oncogenes). | | | Search for oncogene in these other databases too |
|
http://www.everythingbio.com/glos/definition.php?ID=1986
(157 words)
|
|
| |
| | RET Proto-Oncogene in the Development of Human Cancer -- Eng 17 (1): 380 -- Journal of Clinical Oncology |
| | Santoro M, Dathan NA, Berlingieri MT, et al: Molecular characterisation of RET/PTC3, a novel rearranged verson of the RET proto-oncogene in a human thyroid papillary carcinoma. | | | Inducible Dimerization of RET Reveals a Specific AKT Deregulation in Oncogenic Signaling | | | Pasini A, Geneste O, Legrand P, et al: Oncogenic activation of RET by two distinct FMTC mutations affecting the tyrosine kinase domain. |
|
http://www.jco.org/cgi/content/full/17/1/380
(8421 words)
|
|
| |
| | Regulation of the c-met Proto-oncogene Promoter by p53 -- Seol et al. 274 (6): 3565 -- Journal of Biological Chemistry |
| | described as an activated oncogene in a chemically treated human | | | Naldini, L., Vigna, E., Narshiman, R. Gaudino, G., Zarnegar, R., Michalopoulos, G., and Comoglio, P. Oncogene 6, 501-504 | | | Moghul, A., Lin, L., Beedle, A., Kanbour-Shakir, A., DeFrances, M. Liu, Y., and Zarnegar, R. Oncogene 9, 2045-2052 |
|
http://www.jbc.org/cgi/content/full/274/6/3565
(4683 words)
|
|
| |
| | Current Research Focusing on Euchromatin Within the Cell Nucleus. |
| | Frenster JH, "Oncogenes as Molecular Targets within Active Chromatin". | | | Frenster JH, "Model of Single-Stranded Integration of Oncogenic Viral Genomes", | | | Dunham I, Hunt AR, Collins JE, et al, "The DNA Sequence of Human Chromosome 22". |
|
http://www.euchromatin.net/current1.html
(10576 words)
|
|
| |
| | SEARCH FOR AN ONCOGENE |
| | to find information about an oncogene Mark Whidby |
|
http://www.bioscience.org/urllists/oncogene.htm
(18 words)
|
|
| |
| | PHOSITA® : EUROPEAN UNION RESTRICTS ONCOGENE MOUSE PATENT |
| | That patent had already been restricted in 2001 to only rodents. | | | The EPO on July 6 limited the patent to mice; the original European patent, covered all mammalian species with a transgenic oncogene. | | | The European Patent Office (EPO) approved a restricted patent on the Harvard OncoMouse. |
|
http://www.okpatents.com/phosita/archives/2004/07/european_union_1.html
(344 words)
|
|
|
