|
| |
| | Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors : Nature |
 | | Nicotine Therapy in Adulthood Reverses the Synaptic and Behavioral Deficits Elicited by Prenatal Exposure to Phenobarbital | | | We thus demonstrate the sufficient role of the VTA in both nicotine reinforcement and endogenous cholinergic regulation of cognitive functions. | | | The ventral tegmental area (VTA) of the midbrain is thought to mediate the reinforcement properties of many drugs of abuse. |
|
http://www.nature.com/nature/journal/v436/n7047/abs/nature03694.html
(409 words)
|
|
| |
| | ABC News: Nicotine Addiction Gene Identified |
| | But the complex nature of the nicotinic acetylcholine system makes that pathway anything but smooth, Lester said. | | | Developing a mouse that lives only for nicotine will accelerate the development of a cure for human addiction, he said. | | | The path ahead for a treatment to stop nicotine addiction would seem to be clear: simply find a molecule that blocks the alpha4 subunit. |
|
http://abcnews.go.com/Health/Healthology/story?id=227939
(559 words)
|
|
| |
| | Robin Lester CV |
| | Ceballos, R.M., Ransom, C.B. and Lester, R.A.J., Sensitivity of neurons in medial habenula slices to nicotinic agonists, Soc. | | | Lester, R.A.J., McIntosh, J.M. and Quick, M.W. Relationship between nicotinic acetylcholine receptor subunit mRNA levels and channel function in central neurons. | | | Lester, R.A.J. and Dani, J.A. Time-dependent changes in central nicotinic acetylcholine channel kinetics in outside-out patches. |
|
http://www.neurobiology.uab.edu/Faculty/lester/CV.htm
(1010 words)
|
|
| |
| | Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, ... |
| | This longest component of the burst length distribution is the most important for physiological purposes as it carries the majority of the charge in the steady state record, and because there should be a similar long time constant in the macroscopic response to a short pulse of agonist (Wyllie et al. | | | This should not be allowed to obscure the main conclusion, that the things that matter from the point of view of physiology can be estimated with good precision by the methods described here. | | | However the prediction of the plot of conditional mean apparent open time against adjacent shut time tended to be rather worse than when the extra shut state was omitted (compare Fig. |
|
http://jp.physoc.org/cgi/content/full/547/3/729
(14136 words)
|
|
| |
| | Nicotine - Wikipedia, the free encyclopedia |
| | The primary therapeutic use of nicotine is in treating nicotine dependence. | | | Nicotine Therapy for ADNFLE: "Nicotine as an antiepileptic agent in ADNFLE: An n-of-one study" | | | Nicotine and its metabolites are being researched for the treatment of a number of disorders, including ADHD, Parkinson's Disease and Alzheimer's Disease. |
|
http://en.wikipedia.org/wiki/Nicotine
(1215 words)
|
|
| |
| | Cognetix |
| | Receptor subtypes mediating depressor responses to microinjections of nicotine into medial NTS of the rat. | | | Methyllycaconitine is a potent antagonist of alpha-conotoxin-MII-sensitive presynaptic nicotinic acetylcholine receptors in rat striatum. | | | Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum. |
|
http://www.cognetix.com/news_publications.asp
(4884 words)
|
|
| |
| | acetylcholine on Encyclopedia.com |
| | A sensitive ESI-MS HILIC method for the analysis of acetylcholine and choline.(General)(Advertisement) | | | Some nerve gases operate by preventing the breakdown of acetylcholine causing continual stimulation of the receptor cells, which leads to intense spasms of the muscles, including the heart. | | | Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in [M.sub.3] muscarinic acetylcholine receptor--deficient mice.(Islet Studies) |
|
http://www.encyclopedia.com/html/a1/acetylch.asp
(440 words)
|
|
| |
| | Graham's work |
| | This channel, which is the present focus of my work, is the best-understood member of its family, the ligand-gated ion channels. | | | A more up-to-date report on recent work I have been doing to use simulation to measure the diffusion coefficients of ions in models of the nicotinic receptor and other channels, including the fungal peptide alamethicin and an artificial Leucine-Serine peptide (They turn out to be quite substantially reduced). | | | The figure above is a semi-schematic representation of the Nicotinic Acetylcholine Receptor (nAChR), a cation-selective ion channel found in the nerve-muscle synapse and in neurons. |
|
http://indigo1.biop.ox.ac.uk/graham/work.html
(414 words)
|
|
| |
| | nicotinic Acetylcholine Receptor antibody [88B] (ab2804) datasheet |
| | Immunohistochemical staining of nAChR in rat skeletal muscle results in strong staining of the motor endplate. | | | Customer reviews (feedback) regarding nicotinic Acetylcholine Receptor antibody [88B] | | | The non-channel linked AChR that medicates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine. |
|
http://www.abcam.com/?datasheet=2804
(623 words)
|
|
| |
| | ipedia.com: Acetylcholine receptor Article |
| | Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine. | | | Nicotinic receptors are the main mediator of nicotine and tobacco addiction. | | | Like other transmembrane receptors, acetylcholine receptors are classified according to their "pharmacology", or according to their relative affinities and sensitivities to different molecules. |
|
http://www.ipedia.com/acetylcholine_receptor.html
(306 words)
|
|
| |
| | Mechanism of block of nicotinic acetylcholine receptor channels by purified IgG from seropositive patients with ... |
| | Mechanism of block of nicotinic acetylcholine receptor channels by purified IgG from seropositive patients with myasthenia gravis | | | Mechanism of block of nicotinic acetylcholine receptor channels by purified IgG from seropositive patients with myasthenia gravis -- Jahn et al. | | | Pharmacokinetic/Pharmacodynamic Modeling of Rocuronium in Myasthenic Patients Is Improved by Taking into Account the Number of Unbound Acetylcholine Receptors |
|
http://www.neurology.org/cgi/content/abstract/54/2/474
(305 words)
|
|
| |
| | Image Of The Week - Nicotinic Acetylcholine Receptor |
| | Some members of this family of receptors in the brain bind nicotine and are targets for the addictive activity of this drug. | | | The electrostatic isopotential surface--a surface representing constant electric potential--for a model of the nicotinic acetylcholine receptor. | | | The model was developed by Igor Tsigelny, Naoya Sugiyama, and Palmer Taylor at the Departments of Pharmacology and Chemistry/Biochemistry at the University of California, San Diego, in collaboration with Steven M. Sine at the Mayo Foundation in Rochester, Minnesota. |
|
http://www.sdsc.edu/IOTW/week19.96/iotw.html
(240 words)
|
|
| |
| | Antidepressants Noncompetitively Inhibit Nicotinic Acetylcholine Receptor Function - J Neurochem, Vol 72, Issue 3, pp. ... |
| | The present study establishes for the first time the acute functional effects of sertraline (Zoloft), paroxetine (Paxil), nefazodone (Serzone), and venlafaxine (Effexor) on two human and one chick nAChR subtype. | | | Abstract : Nicotinic acetylcholine receptors (nAChRs) are diverse members of the neurotransmitter-gated ion channel superfamily and play critical roles in chemical signaling throughout the nervous system. | | | Antidepressants Noncompetitively Inhibit Nicotinic Acetylcholine Receptor Function - J Neurochem, Vol 72, Issue 3, pp. |
|
http://www.antidepressantsfacts.com/SSRIs-inhibit-nicot-acetylch-receptor.htm
(282 words)
|
|
| |
| | Nicotinic Acetylcholine Receptor |
| | The nicotinic acetylcholine receptor (nAChR) is the best understood member of a family of ligand-gated ion channels that are responsible for synaptic neurotransmission. | | | Cryoelectron microscopy and a wide range of mutagenesis and labelling studies have established that the transmembrane (TM) pore lies in the centre of the molecule and is lined by five M2 -helices. | | | Previous: Glutamate Receptors, Next: Channel Gating Mechanisms, Up: Ion Channels, Return to: Contents. |
|
http://biop.ox.ac.uk/www/lj2000/sansom/sansom_03.html
(315 words)
|
|
| |
| | eMedicine - Rabies : Article by Mark Merlin, DO, FACEP |
| | Since 1980, most patients with human rabies in the United States have not had definite exposure through a bite wound, making total understanding of the mechanism of transmission somewhat elusive. | | | After inoculation, viral glycoprotein attaches to the nicotinic acetylcholine receptor of skeletal muscle. |
|
http://www.emedicine.com/emerg/topic493.htm
(4089 words)
|
|
| |
| | Faculty Publications |
| | Evedence for sexual dimorphism of estrogen receptors in hypothalamus and thymus of neonatal and immature Wistar rats. | | | Dependence of Nicotinic Acetylcholine Receptor Recovery from Desensitization on the Duration of Agonist Exposure. | | | Effects of AT1 receptor blockade after myocardial infarct on myocardial fibrosis, stiffness, and contractility. |
|
http://www.medicine.arizona.edu/faculty/facpubs-1999-2000/g.html
(5241 words)
|
|
| |
| | Novel Putative Nicotinic Acetylcholine Receptor Subunit Genes, D{alpha}5, D{alpha}6 and D{alpha}7, in Drosophila ... |
| | Conservation within the RIC-3 Gene Family: EFFECTORS OF MAMMALIAN NICOTINIC ACETYLCHOLINE RECEPTOR EXPRESSION | | | Novel Putative Nicotinic Acetylcholine Receptor Subunit Genes, D{alpha}5, D{alpha}6 and D{alpha}7, in Drosophila melanogaster Identify a New and Highly Conserved Target of Adenosine Deaminase Acting on RNA-Mediated A-to-I Pre-mRNA Editing -- Grauso et al. | | | The Drosophila Acetylcholine Receptor Subunit D{alpha}5 Is Part of an {alpha}-Bungarotoxin Binding Acetylcholine Receptor |
|
http://www.genetics.org/cgi/content/abstract/160/4/1519
(532 words)
|
|
|
