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| | Nevirapine - Wikipedia, the free encyclopedia |
 | | Nevirapine is a key component of HAART (highly active anti-retroviral therapy) used clinically to treat AIDS patients in the U.S. and elsewhere. | | | As a solo medication, nevirapine has been shown to prevent the transmission of HIV from an infected mother to her child during childbirth. | | | Since the virus that causes AIDS (HIV) evolves so rapidly, it has the propensity to become resistant to medications used to combat it. |
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http://en.wikipedia.org/wiki/Nevirapine
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| | The Body: Sex Differences in Nevirapine Rash and Hepatitis |
| | If nevirapine is slower to clear from women's bodies, whether pregnant or not, then the increased incidence of rash and liver problems among women on daily-dosing regimens may be due to a gradual accumulation of the drug to toxic levels. | | | Nevirapine for prevention of mother-to-child HIV transmission was effective, it was practical and it was relatively affordable. | | | Although the key clinical trials that led to the approval of nevirapine uncovered a risk of having skin reactions when starting the drug, none of those studies examined the differential risk between men and women. |
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http://www.thebody.com/gmhc/issues/jan01/viramune.html
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| | Pharmacokinetics of Nevirapine and Lamivudine in Patients with HIV-1 Infection |
| | Disposition and biotransformation of the antiretroviral drug nevirapine in humans. | | | However, with the possibility of using these 2 drugs as part of a long-term combination therapy, the question of a pharmacokinetic interaction between lamivudine and nevirapine or lamivudine and one of nevirapine's urinary metabolites became a question of clinical importance. | | | Overall, this study showed that a pharmacokinetic drug interaction did not exist between nevirapine, an inducer of P450 metabolism, and lamivudine when the 2 drugs were administered concurrently as part of triple-combination therapy that included 5a nucleoside. |
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http://www.aapspharmsci.org/view.asp?art=ps020101
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| | The Body: Nevirapine (Viramune) |
| | Nevirapine is a drug used for antiretroviral therapy (ART). | | | Although AZT (another anti-HIV drug) prevents more infections, nevirapine costs less and works better where women breast-feed their babies. | | | This approach could be very beneficial in developing countries. |
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http://www.thebody.com/nmai/nevirapine.html
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| | MedlinePlus Drug Information: Nevirapine |
| | Nevirapine does not cure HIV and may not prevent you from developing HIV-related illnesses.Nevirapine does not prevent the spread of HIV to other people. | | | Nevirapine is also sometimes used to prevent unborn babies whose mothers have HIV or AIDS from becoming infected with HIV during birth. | | | Do not stop taking nevirapine or any of the other medications that you are taking to treat HIV or AIDS without talking to your doctor.Your doctor will probably tell you to stop taking your medications in a certain order. |
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http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a600035.html
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| | Nevirapine Misinformation: Will It Kill? |
| | Because of the resistance problem, single-dose nevirapine is not the first choice -- but sometimes it is the only choice possible. | | | Summary: In mid December 2004 three Associated Press stories created widespread doubts about nevirapine, a well-known, critically important drug that can prevent HIV in many of the 1,800 babies now infected every day by their mothers in childbirth. | | | No new information about nevirapine was released; doctors know that it still has the same risks and benefits after the newspaper stories as before. |
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http://www.aidsnews.org/2004/12/nevirapine-ap.html
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| | CNN - Affordable drug reduces mother-to-child HIV transmission, study says - July 14, 1999 |
| | With nevirapine, that risk drops to a 13 percent chance of transmitting the virus, according to researchers. | | | The Uganda-U.S. study was funded in part by the National Institute of Allergy and Infectious Diseases at the National Institutes of Health. | | | Without any HIV medications, a pregnant woman has a 25 percent to 35 percent risk of transmitting HIV to her child during delivery. |
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http://www.cnn.com/HEALTH/AIDS/9907/14/preventing.baby.hiv
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| | Boehringer Ingelheim provides key background on nevirapine |
| | Research supporting nevirapine has helped evolve clinical management standards and has defined the current role of this drug both in chronic combination therapy and in the prevention of mother to child transmission (pMTCT) during childbirth in resource-limited settings. | | | Treatment with nevirapine as part of combination therapy needs to be managed differently than the single-dose regimen administered in the developing world for pMTCT. | | | The first drug in its class (non-nucleoside reverse transcriptase inhibitor), nevirapine has been an important component in the effort to improve HIV drug therapy. |
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http://www.medicalnewstoday.com/medicalnews.php?newsid=17982
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| | Nevirapine news articles |
| | The antiretroviral drug nevirapine -- a low-cost medication that is used as a standard method of reducing mother-to-child HIV transmission in the developing... | | | Efavirenz cannot be used after the failure of the nevirapine (the core drug used in combination therapy in resource-limited settings), due to cross-resistance... | | | In the mid-1990s, for instance, the National Institutes of Health performed a study of the AIDS drug nevirapine in Uganda that later was shown to have violated... |
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http://www.mongabay.com/drugs/drugs/Nevirapine.html
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| | "Dokumentation(4): the trouble with nevirapine" |
| | Guay concluded the report of her drug trial with some self-promoting sales-spin: “Single-dose nevirapine given to the mother and the baby is likely to be one of the few deliverable and sustainable strategies for prevention of perinatal HIV-1 transmission in resource-poor settings. | | | In Mother to child transmission of HIV and its prevention with AZT and nevirapine: a critical analysis of the evidence,published as a monograph on 1 October 2001, Papadopulos-Eleopulos and her colleagues point out another basic problem with giving nevirapine to women entering labour. | | | Many more are detailed in the Powerpoint presentation — itself a summary, with an expanded focus on nevirapine, of Mother to child transmission of HIV and its prevention by AZT and nevirapine: A critical analysis of the evidence, published as a stand-alone monograph on 1 September 2001. |
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http://www.aidsinfobbs.org/nevirap-4.htm
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| | MedlinePlus Drug Information: Nevirapine (Systemic) |
| | Nevirapine will not keep you from spreading HIV to other people. | | | Warfarin— Your doctor will want to monitor your blood levels when you are taking this medicine at the same time as nevirapine. | | | You and your doctor should discuss nevirapine when you start taking your medicine and at regular checkups. |
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http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203527.html
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| | The HIVNET 012 Study and the Safety and Effectiveness of Nevirapine in Preventing Mother-to-Infant Transmission of HIV |
| | The simple and cost-effective nevirapine regimen has been used in developing countries to prevent HIV infection in thousands of infants; it represents a major public health advance and is one of the true success stories in HIV prevention. | | | The researchers found that this intervention reduced the risk of mother-to-infant HIV transmission by approximately 50 percent. The results of this landmark study were published in The Lancet in 1999. | | | The reduction of perinatal HIV transmission by the use of the readily accessible, inexpensive nevirapine regimen studied by the HIVNET 012 investigators represents a major public health advance for developing countries. |
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http://www2.niaid.nih.gov/newsroom/Releases/HIVNET012.htm
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| | Exclusive: The Truth about Nevirapine |
| | The exclusion of a placebo group is a near-standard protocol in AIDS research trials, where doctors claim that it would be unethical not to offer patients at least one drug. | | | Before entering the study, she was healthy and pregnant, but was convinced to go on the drug because of her HIV test result. | | | This summer in the U.S. the same drug was being used in an NIH sponsored trial of U.S. patients. |
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http://www.gnn.tv/articles/article.php?id=1011
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| | Nevirapine Approved by FDA, September 1996 |
| | In combination with nucleoside analogs, nevirapine could be used as a first-line therapy or as an alternative treatment for patients who either show no improvement with other drugs or experience adverse reactions to them, says Steven M. Schnittman, M.D., assistant director for clinical research in NIAID's Division of AIDS. | | | "For those patients, it may turn out that a regimen of two nucleosides combined with nevirapine provides anti-HIV activity reasonably close to that seen with protease inhibitors." Dr. Schnittman adds that the additional combination therapy regimens made possible by nevirapine could help physicians devise better strategies for avoiding drug resistance. | | | "Although HIV quickly develops resistance to nevirapine when it is administered alone, that should not be a concern in perinatal settings, where the drug will only be given for a day or two." |
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http://www.niaid.nih.gov/publications/agenda/0996/page9.htm
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| | Viramune (nevirapine) - Complete Drug Summary |
| | Nevirapine- vs Efavirenz-based Therapy in Treatment-naive Indian patients: Comparision of Effectiveness | | | First-line Therapy with Efavirenz or Nevirapine is Effective in Patients with Advanced HIV Infection, and the Incidence of Rash in the Nevirapine Group Is Significantly Higher in Women with Higher CD4 Counts | | | Efficacy and Safety of Once-daily Combination Therapy with Didanosine, Lamivudine and Nevirapine in Treatment-naive HIV Patients |
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http://www.hivandhepatitis.com/hiv_and_aids/viramune_1.html
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| | Exaggerated Concerns About Anti-AIDS Drug Nevirapine - US Department of State |
| | While Nevirapine is not the first treatment of choice when combination antiretroviral therapy is available, it is clearly better than doing nothing. | | | Health professionals have expressed concern that misinformation about Nevirapine may prevent its use in saving the lives of some of the 1,900 infants born every day infected with HIV. | | | • The use of single-dose Nevirapine, alone or in combination with other antiretroviral drugs, is recommended by all international health agencies and national governments conducting prevention of mother-to-child transmission (PMTCP) programs. |
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http://usinfo.state.gov/media/Archive/2005/Jan/14-954432.html
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| | Simple Facts Sheets: nevirapine (Viramune) |
| | The drug prednisone should not to be used to prevent nevirapine-associated rash, as a clinical trial found that this made the problem worse. | | | For updated information on drug interactions, there is a medical information contact at the manufacturer that can be reached by calling (800) 542-6257. | | | Nevirapine is processed in the body by the liver, as are many other drugs. |
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http://www.atdn.org/simple/nevi.html
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| | Nevirapine Versus Efavirenz: The 2NN Study |
| | Finally, given the substantial price differential in favor of nevirapine, it is anticipated that third party payers and HIV treatment programs around the world would welcome these results as an opportunity to help to deal with the sustainability of antiretroviral therapy, a problem that currently affects not only the developing but also the developed world. | | | Lipid changes in a randomized comparative trial of first-line antiretroviral therapy with regimens containing either nevirapine alone, efavirenz alone or both drugs combined, together with stavudine and lamivudine (2NN study). | | | Results of the 2NN study: a randomized comparative trial of first-line antiretroviral therapy with regimens containing either nevirapine alone, efavirenz alone or both drugs combined, together with stavudine and lamivudine. |
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http://www.hivandhepatitis.com/recent/nnrtis/022403a.html
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| | Case 2: Discussion - Nevirapine-Induced Hepatotoxicity - Antiretroviral Rx: Adverse Effects |
| | Patients starting nevirapine should have transaminase levels monitored very closely in the first 18 weeks of therapy and these tests should continue to be followed in persons who remain on nevirapine. | | | The incidence of clinically symptomatic hepatitis among persons taking nevirapine is approximately 1% [3, 5]. | | | All patients who are prescribed nevirapine should be instructed to seek immediate medical attention if signs and symptoms of hepatitis develop. |
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http://depts.washington.edu/hivaids/arvae/case2/discussion.html
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| | nevirapine - HIV: health and medical information about HIV and AIDS |
| | DRUG INTERACTIONS: Rifampin (Rifadin), rifabutin (Mycobutin), ketoconazole (Nizoral) and St. John's Wort decrease blood concentrations of nevirapine by increasing its breakdown. | | | nevirapine - HIV: health and medical information about HIV and AIDS | | | PREGNANCY: There are no adequate studies of nevirapine in pregnant women. |
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http://www.medicinenet.com/nevirapine/article.htm
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| | NEVIRAPINE Faq |
| | Nevirapine does not cure HIV nor does it prevent HIV transmission. | | | It is important that your physician or pharmacist knows about other drugs you are taking, even medications you can buy without a prescription. | | | Nevirapine works differently than other drugs such as AZT, 3TC or ddI. |
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http://www.tthhivclinic.com/nev.htm
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| | NEVIRAPINE |
| | It is extremely important that you take nevirapine and your other antiretroviral medications exactly as directed. | | | This interaction could make nevirapine less effective and increase the chances of developing a resistant virus. | | | Some drugs taken together may have interactions that cause illness or impair the effectiveness of the drugs. |
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http://depts.washington.edu/actu/drugs/nevirapine.htm
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| | Nevirapine |
| | This medicine should always be used with other medicines in the treatment of HIV disease. | | | If you have an allergy to nevirapine or any other part of the medicine. | | | If you have a severe skin reaction, an allergy, or any signs or symptoms of hepatitis then never take nevirapine again |
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http://www.umm.edu/altmed/ConsDrugs/Nevirapinecd.html
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| | Side effects – liver toxicity, rash and nevirapine |
| | Your doctor will recommend whether you need to stop all your treatments or just switch the nevirapine to another drug. | | | Close monitoring (every two weeks) in the first two months of therapy is important for anyone who starts a nevirapine-based combination. | | | They do not relate to pregnant women who are using a single dose of nevirapine as part of a one-week course of treatment to reduce the risk of transmitting HIV to their baby. |
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http://www.i-base.org.uk/guides/side/liver.html
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| | Global Challenges AIDS Groups Worried About Backlash Against Nevirapine Use in Pregnant Women, Say Drug Only Way To ... |
| | The problem of drug resistance has partly been as a result of violations in prescription rules. | | | However, to date, there is no evidence of negative clinical outcomes as a result of subsequent antiretroviral therapy," the statement said (Nyakairu, | | | Although the World Health Organization recommends a six-week course of nevirapine and zidovudine combination therapy when possible because of recent studies indicating that even single doses of nevirapine can result in drug resistance, this combination regimen costs about $40. |
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http://www.kaisernetwork.org/daily_reports/rep_index.cfm?DR_ID=27338
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| | FDA APPROVES NEVIRAPINE TO TREAT HIV |
| | These studies also showed that the virus rapidly becomes resistant when nevirapine is used alone. | | | While safety and effectiveness of nevirapine have not been established for pediatric patients, the drug manufacturer is currently conducting Phase II studies in pediatric HIV patients. | | | The following can be used to answer questions: Reviewed in 119 days, nevirapine was approved for use in combination with nucleoside analogues to treat adults with HIV infection who have experienced clinical and/or immunological deterioration. |
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http://www.fda.gov/bbs/topics/ANSWERS/ANS00742.html
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| | [No title] |
| | Can you take other medication while taking Nevirapine? | | | Additional side effects are possible; report any unusual reactions to your pharmacist or doctor since Nevirapine may interact with many other medications. | | | For questions about Nevirapine, please contact the clinic pharmacist at 234-2388. |
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http://www.crha-health.ab.ca/clin/sac/nevirapi.htm
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| | HIV & AIDS - Nevirapine, Viramune® |
| | , 'Mother to Child Transmission of HIV and its Prevention with AZT and Nevirapine' | | | Roberto Giraldo, 'Scientific Data Against the Use of Nevirapine' | | | Manfred Haehl, Letter from Boehringer Ingelheim/Roxane Laboratories Inc. |
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http://www.virusmyth.net/aids/index/nevirapine.htm
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| | 2NN: compares nevirapine & efavirenz |
| | The study results from 2NN are for 48 weeks of following patients. | | | Grade 3/4 hepatoxicity was more common in the nevirapine patients with 2.1% of patients receiving NVP twice daily and 1.4% of those receiving NVP once daily experiencing at least 1 grade 3/4 event compared to 0.3% in patients receiving efavirenz. | | | Regarding side effects and toxicities this study demonstrated worse hepatitis and skin related events for patients receiving nevirapine, and worse CNS/psychiatric related events for patients receiving efavirenz. |
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http://www.natap.org/2003/Retro/day5.htm
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| | nevirapine - definition of nevirapine by the Free Online Dictionary, Thesaurus and Encyclopedia. |
| | A non-nucleoside analogue that is used as an antiviral drug in the treatment of HIV infection. | | | This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. | | | NNRTI, non-nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; binds directly to reverse transcriptase and prevents RNA conversion to DNA; often used in combination with other drugs |
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http://www.thefreedictionary.com/nevirapine
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| | Research Flawed on Key AIDS Medicine (washingtonpost.com) |
| | NIH's nevirapine research in Uganda was so riddled with sloppy record-keeping that NIH investigators could not be sure from patient records which mothers got the drug. | | | One lesson derived from a closer review of the Uganda research is that even single doses of nevirapine can create instant resistance, meaning patients may not be able to use the drug or others in its class again when their AIDS worsens, Lane said. | | | The documents show that Tramont and other NIH officials dismissed problems with the nevirapine research in Uganda as overblown and were slow to report concerns to the Food and Drug Administration. |
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http://www.washingtonpost.com/wp-dyn/articles/A62360-2004Dec13.html
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| | NEVIRAPINE (Viramune®) a Commonly Used Medication |
| | Nevirapine may decrease levels of protease inhibitors, and should not be used with them. | | | Oral contraceptives or other hormonal birth control methods, and the usual protease inhibitor dosages should not be used with nevirapine due to potential decreases in their levels (indinavir dose can be increased to 1000 mg po q8h to compensate.) Macrolides and cimetidine may somewhat increase nevirapine levels. | | | Saquinavir and indinavir levels are decreased by 27-28%. |
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http://www.hivdent.org/drugs/NEVIRAPINE.htm
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| | nevirapine - definition of nevirapine in Encyclopedia |
| | There are new found concerns that nevirapine may cause long-term resistance in patients to further AIDS treatments and potentially lethal side effects like liver damage when taken in multiple doses over time. | | | Embed a dictionary search in your own web page | | | It is sold under the trade name of Viramune. |
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http://encyclopedia.laborlawtalk.com/nevirapine
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