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Topic: Neutrophil granulocyte


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 Phase I/II trial of neutrophil transfusions from donors stimulated with G-CSF and dexamethasone for treatment of ...
Filtration leukapheresis for granulocyte transfusion therapy: clinical and laboratory studies.
Randomized trial of granulocyte transfusions versus intravenous immune globulin therapy for neonatal neutropenia and sepsis.
An important concern for the development of granulocyte transfusion therapy is the long-term safety of the practice of treating
http://www.bloodjournal.org/cgi/content/full/95/11/3302   (5265 words)

  
 THE MERCK MANUAL, Sec. 11, Ch. 135, Leukopenia And Lymphocytopenia
It usually corresponds to a period of acute viremia and is related to virus-induced redistribution of neutrophils from the circulating to the marginal pool.
This improvement can often be maintained with alternate-day therapy.
Long-term G-CSF has also been used to prevent neutropenia in other circumstances, including myelodysplasia, HIV and AIDS, and autoimmune disorders.
http://www.merck.com/mrkshared/mmanual/section11/chapter135/135a.jsp   (2424 words)

  
 Induction of Neutrophil Apoptosis by the Pseudomonas aeruginosa Exotoxin Pyocyanin: A Potential Mechanism of Persistent ...
The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants
Proinflammatory interactions of pyocyanin and 1-hydroxyphenazine with human neutrophils in vitro.
neutrophil apoptosis may be a clinically important mechanism
http://www.jimmunol.org/cgi/content/full/168/4/1861   (5802 words)

  
 Oxidized Low-Density Lipoprotein Activates Migration and Degranulation of Human Granulocytes -- Sedgwick et al. 29 (6): ...
In contrast, granulocyte migration in response to PAF (5.4 ±
neutrophils and eosinophils were isolated and their response
did not stimulate neutrophil or eosinophil migration through
http://ajrcmb.atsjournals.org/cgi/content/full/29/6/702   (4129 words)

  
 Human neutrophil lipocalin is a unique marker of neutrophil inflammation in ulcerative colitis and proctitis -- Carlson ...
Purification and characterization of a human neutrophil liopcalin (HNL) from secondary granules of human neutrophils.
The development of an assay for human neutrophil lipocalin (HNL)—to be used as a specific marker of neutrophil activity in vivo and vitro.
that NGAL is mainly expressed in neutrophil precursors in bone
http://gut.bmjjournals.com/cgi/content/full/50/4/501   (3999 words)

  
 Horst Ibelgaufts'COPE: Cytokines Online Pathfinder Encyclopaedia
Journal of Immunology 131: 2983-8 (1983); Kitagawa S et al Recombinant human granulocyte colony-stimulating factor enhances superoxide release in human granulocytes stimulated by the chemotactic peptide.
Hematology 62: 22-4 (1991); Gabrilove JL Clinical applications of granulocyte colony stimulating factor (G-CSF).
11: 198-208 (1992); Glaspy JA et al Therapy for neutropenia in hairy cell leukemia with recombinant human granulocyte colony-stimulating factor.
http://www.copewithcytokines.de/cope.cgi?003985   (3267 words)

  
 Attenuation of the Bacterial Load in Blood by Pretreatment with Granulocyte-Colony-Stimulating Factor Protects Rats ...
peripheral neutrophil count affected the outcome of the meningitis.
increase in both the number of peripheral neutrophils and their
Efficacy of recombinant human granulocyte colony-stimulating factor in a murine model of pneumococcal pneumonia: effects of lung inflammation and timing of treatment.
http://iai.asm.org/cgi/content/full/72/8/4647   (4409 words)

  
 Filgrastim in Patients with Chemotherapy-induced Febrile Neutropenia: A Double-Blind, Placebo-Controlled Trial -- Maher ...
drugs were withdrawn before study completion if the blood neutrophil
Objective: To determine if filgrastim (recombinant human methionyl
Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer.
http://www.annals.org/cgi/content/full/121/7/492   (5010 words)

  
 Granulocyte - Wikipedia, the free encyclopedia
This condition reduces the body's resistance to many infections.
In common parlance, the term polymorphonuclear leukocyte often refers specifically to neutrophil granulocytes, the most abundant of the granulocytes.
Their names are derived from their staining characteristics; for example, the most abundant granulocyte is the neutrophil granulocyte, which has neutrally-staining cytoplasmic granules.
http://en.wikipedia.org/wiki/Granulocyte   (237 words)

  
 Blood Components Reference Manual Administration Guidelines - Granulocytes (Neutrophils)
Once assured the patient is tolerating the transfusion, increase flow to the desired rate.
Patients with a history of non-hemolytic febrile transfusion reactions may be at greater risk of reaction to granulocyte (neutrophil) concentrates.
Checking vital signs and observing the patient is important to detect reactions early.
http://www.psbc.org/bcrm/02_granulocytes_admin.htm   (681 words)

  
 Neonatal Alloimmune Neutropenia in Premature Monozygous Twins -- Felix and Calhoun 106 (2): 340 -- Pediatrics
Thorsby E HLA antigens on human granulocytes studies with cytotoxic iso-antisera obtained by skin grafting.
Human granulocyte colony-stimulating factor may improve outcome attributable to neonatal sepsis complicated by neutropenia.
Madyastha P, Blassman A, Levine D Incidence of neutrophil antigens on human cord neutrophils.
http://pediatrics.aappublications.org/cgi/content/full/106/2/340   (1727 words)

  
 Neutropenia
Sequestration and margination are processes in which neutrophils are removed from the general blood circulation and redistributed within the body.
Neutropenia has no specific symptoms except the severity of the patient's current infection.
Neutrophils are the most common type of granulocyte.
http://www.healthatoz.com/healthatoz/Atoz/ency/neutropenia.jsp   (757 words)

  
 Liles, W. Conrad, MD, Ph.D.
The ultimate goal of these studies is the development of novel therapeutic strategies for clinical diseases associated with inflammation.
Current status of granulocyte (neutrophil) transfusion therapy for infectious diseases.
Current studies are examining the molecular events involved in the processing of Fas ligand by human neutrophils and monocytes/ macrophages.
http://depts.washington.edu/daid/faculty/liles.htm   (374 words)

  
 American Red Cross -- North Central Blood Services
Able to communicate effectively with medical staff of other institutions, imparting necessary and useful information concerning neutrophil testing, platelet testing and shipment of patient specimens.
Demonstrates knowledge and understanding of the basic principles of neutrophil and platelet serology.
Performs appropriate quality control procedure to insure the accuracy of results.
http://www.yourbloodcenter.org/Employment/MedTech.htm   (328 words)

  
 Granulocyte colony-stimulating factor (G-CSF)
Inflammatory response following abdominal surgery and its modulation by recombinant human granulocyte colony-stimulating factor (rhG-CSF, filgrastim)
In two recent studies on the prophylactic use of rhG-SF in surgery (neck dissection and esophagectomy for cancer), neutrophil funtions were enhanced in rhG-CSF-treated patients (Schäfer
Among the indirect effects of G-CSF on neutrophil function are enhanced antibody-dependent cell-mediated cytotoxicity (Inoue
http://herkules.oulu.fi/isbn9514268474/html/x496.html   (2097 words)

  
 ASCO - General Information - Onsite Details
While not cancer Chemotherapy agents, this class of drugs may be used as an adjuvant in some instances.
Filgrastim acts only on mature progenitor cells that are already committed to one pathway, the granulocyte pathway, and therefore increases only neutrophil concentrations.
http://www.asco.org/ac/1,1003,_12-002179-00_18-0015748,00.asp   (1632 words)

  
 ELASTASE
Neutrophil elastase is responsible for the blistering in bullous pemphigoid, a skin condition, in the presence of antibodies.
There appear to be two forms of neutrophil elastase, termed IIa and IIb.
The rare disease cyclic hematopoeiesis is an autosomal dominant genetic disorder characterised by fluctuating neutrophil granulocyte counts over 21-day periods.
http://www.yotor.org/wiki/en/el/Elastase.htm   (262 words)

  
 Neutrophil Granulocyte FcR and CR Receptor Expression
The material under examination consisted of a group of 52 patients with AP.
The aim of the study was to assess the FcR and CR receptor expression in neutrophil granulocytes from peripheral blood in individuals with adult periodontitis (AP).
Neutrophil Granulocyte FcR and CR Receptor Expression in Patients with Adult Periodontitis (AP)
http://www.torf.com/clinical09.html   (139 words)

  
 Zalavary, Stefan, Adenosine regulation of neutrophil function
The neutrophil granulocyte is an essential component of the human immune system.
The aim of the present work was to characterize the effects of adenosine on neutrophil functions, particularly phagocytosis and the production of reactive oxygen species (ROS).
Expanded ADA activity associated with IgG-stimulation counteracted the inhibitory effects of adenosine accumulated during neutrophil-platelet interaction.
http://www.bibl.liu.se/liupubl/disp/disp97/med535s.htm   (344 words)

  
 Neutrophil Granulocyte-committed Cells Can Be Driven to Acquire Dendritic Cell Characteristics -- Oehler et al. 187 ...
Phenotypic and functional change of cytokine-activated neutrophils: inflammatory neutrophils are heterogeneous and enhance adaptive immune responses
of end-stage neutrophilic PMN (PMNp) can be reverted in their
Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factor
http://www.jem.org/cgi/content/abstract/187/7/1019   (1064 words)

  
 Joint Meeting Immunology Duesseldorf 2000 - Abstract H.14
The process may be either CD18-dependent or CD18-independent.
These results may be a demonstration of PECAM-1 induced adhesion, which upregulates neutrophil migration in the murine lung.
In the lung an alternative mechanism of neutrophil extravasation was found.
http://www.uni-duesseldorf.de/dgfi2000/abstract/h14.htm   (306 words)

  
 The Influence of Conservative Treatment on Neutrophil Granulocyte Activity
Impaired phagocytic function of neutrophil granulocytes was found in the group with AP.
The mean value for tests for phagocytic activity of PMN increased after treatment.
The Influence of Conservative Treatment on Neutrophil Granulocyte Activity in Peripheral Blood in Individuals with Gingival Inflammation
http://www.torf.com/clinical10.html   (87 words)

  
 Loss of C/EBP{alpha} cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil ...
in vivo development of the neutrophil granulocyte and adipose
This article has been cited by other articles:
Loss of C/EBP{alpha} cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage -- Porse et al.
http://www.jem.org/cgi/content/abstract/202/1/85   (322 words)

  
 Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding ...
Mature neutrophils and eosinophils are not observed in the blood
Aberrant expression of neutrophil and macrophage-related genes in a murine model for human neutrophil-specific granule deficiency
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha -deficient mice -- Zhang et al.
http://www.pnas.org/cgi/content/abstract/94/2/569   (2961 words)

  
 cancer care ontario - action cancer ontario
Readers are advised to consult the specific regimens monograph, or the Cancer Care Ontario Practice Guidelines Initiative Guideline Use of Granulocyte Colony-Stimulating Factor (G-CSF) in Patients Receiving myelosuppressive Chemotherapy for the Treatment of Cancer Guidelines.
Note that these recommendations do not address the potential usage of G-CSF or GM-CSF for specific regimens.
Dose modifications for myelosuppression on the planned day of treatment:
http://www.cancercare.on.ca/print/index_drugFormularyappendix6.htm   (226 words)

  
 Phagy - Art History Online Reference and Guide
Phagocytes include the macrophage and the neutrophil granulocyte.
Phagocytes are cells that can perform phagocytosis of inorganic or organic (including other cells and pathogens) material.
http://www.arthistoryclub.com/art_history/Phagy   (100 words)

  
 Chemotherapy
The latter two, when they occur, are improved with blood transfusion.
Neutropenia (a decrease of the neutrophil granulocyte count below 0.5 x 10
http://www.sciencedaily.com/encyclopedia/chemotherapy   (1437 words)

  
 Cutting Edge: Neutrophil Granulocyte Serves as a Vector for Leishmania Entry into Macrophages -- van Zandbergen et al. ...
Cutting Edge: Neutrophil Granulocyte Serves as a Vector for Leishmania Entry into Macrophages -- van Zandbergen et al.
Cutting Edge: Neutrophil Granulocyte Serves as a Vector for Leishmania Entry into Macrophages
http://www.jimmunol.org/cgi/content/full/173/11/6521/DC1   (249 words)

  
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Antineutrophil Antibodies, Neutrophil (Granulocyte) Antibody (View in report form.)
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http://www.rush.edu/webapps/rml/RMLTestEntryDtl.jsp?id=3897   (51 words)

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