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| | FDA/CFSAN Redbook 2000 IV.B.10 Contains non-binding recommendations |
 | | Among the various approaches that can be used for assessing neurotoxicity, behavioral testing in conjunction with neuropathological evaluation represent a practical means of obtaining a relatively comprehensive assessment of the functional development and integrity of the nervous system within the context of a standard toxicity study. | | | Leukroth, R.W. (1987) Predicting neurotoxicity and behavioral dysfunction from preclinical toxicologic data. | | | As appropriate, more sensitive and objective indices of neurotoxicity, such as tests of learning and memory, and quantitative measures of sensory function and motor behavior, could be included as part of the screen. |
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http://vm.cfsan.fda.gov/~redbook/redivc10.html
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| | Neurotoxicity associated with exposure to chemicals, principles and methods for the assessment of (EHC 60, 1986) |
| | It should be noted that Citovic (1930), a student of Pavlov, reported the use of conditioned reflexes to study the neurotoxic effects of gasoline and acetone. | | | Major outbreaks of neurotoxicity in human populations of various sizes have emphasized the importance of neurotoxicology as an independent discipline. | | | The purpose of this book is to provide an overview of the principles of neurobehavioural assessment and to identify methods that have been successfully applied to the study of neurotoxicity in the past. |
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http://www.inchem.org/documents/ehc/ehc/ehc060.htm
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| | NEUROTOXICITY RISK ASSESSMENT FOR HUMAN HEALTH: PRINCIPLES AND APPROACHES (EHC 223, 2001) |
| | Standardized test methods and the development of norms for evaluating neurotoxicity in infants and children are needed for use in cross-cultural studies of human developmental neurotoxicity. | | | The detection of neurotoxicity in human studies provides the most direct means of assessing health risk, but is often complicated by confounding factors and inadequate data. | | | Chapter 3 discusses basic principles of neurobiology and toxicology that could be useful for risk assessors seeking to understand the scientific basis for specific methods and procedures used in neurotoxicology and the relative vulnerability of specific structures and processes that are essential for normal functioning of the nervous system. |
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http://www.intox.org/databank/documents/supplem/supp/ehc223.htm
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| | MAPS - Volume 5 Number 3 Winter 1994-95 - neurochemical markers and mdma neurotoxicity |
| | First, it should probably be noted that there are some methodological concerns in the Neuropsychopharmacology study of human users.[15] One of those is that it is difficult to establish that psychological and biological factors do not predispose one to using MDMA (mixing up correlation and causality). | | | At this level, it would be of concern perhaps in the same way that the neurotoxicity of alcohol is of concern mostly to those who use to excess. | | | MDMA in non-human primates and found fairly good direct evidence of neurotoxicity using immunohistochemical techniques.[9,10] This strongly suggests that there is a level beyond which MDMA is neurotoxic. |
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http://www.maps.org/news-letters/v05n3/05310neu.html
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| | In Vitro Techniques for the Assessment of Neurotoxicity |
| | The approach used most often to discriminate between neurotoxicity and general toxicity is to examine specific end points unique to nervous system function and compare the exposure relationship between these end points and other nonspecific end points that would be ubiquitous to all eukaryotic cells. | | | If one is interested in investigating the effects on the central processing of a message received by receptor cells, storage of this information in short- and long-term memory, or behavioral and somatic responses resulting from some of the sensory perception, assessment of the whole animal is essential. | | | This advance has been seen in all levels of examination, from the integrative functioning of the nervous system as manifest by behavioral alterations, to morphological and biochemical alterations in the intact animal, to the molecular mechanisms associated with injury response or development, and to the intricate cellular changes examined by in vitro techniques. |
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http://www.herc.org/news/mcsarticles/harry.htm
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| | Neurotoxicity Testing: A Discussion of in Vitro Alternatives |
| | Despite these potential problems, in vitro systems are extremely relevant from the point of view of mechanistic neurotoxicology, and their use is expected to increase. | | | Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news on the impact of the environment on human health. | | | The same caution as for any in vitro test system, particularly when the results are extrapolated to an in vivo situation, also applies to mechanistic studies. |
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http://www.ehponline.org/members/1998/Suppl-2/505-510costa/costa.html
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| | MAPS - Volume 6 Number 1 Autumn 1995 - MDMA Neurotoxicity: New Data, New Risk Analysis |
| | Nevertheless, it is crucial that MDMA neurotoxicity research continue, and also research into the beneficial therapeutic uses of MDMA, so that the risks and benefits of MDMA can be accurately balanced. | | | McCann and Ricaurte that is the most comprehensive and controlled research project to date investigating the long-term effects of MDMA on experienced MDMA users.(7) The study showed that a group of MDMA users (average exposure of 95 times) had roughly 32% less serotonin metabolite in their spinal fluid on average than a group of controls. | | | The best indirect evidence for MDMA neurotoxicity comes from a study by Drs. |
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http://www.maps.org/news-letters/v06n1/06108neu.html
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| | Developmental Neurotoxicity Induced by Therapeutic and Illicit Drugs |
| | Sixth, only a small fraction of the drugs currently in use have ever been examined for developmental neurotoxicity; hence, the full scope of the problem cannot even be accurately estimated based on current information. | | | The purpose of this paper, as the title implies, is to review evidence that there are established examples of both therapeutic and illicit drugs that induce prenatal neurotoxicity. |
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http://www.ehponline.org/members/1994/Suppl-2/vorhees-full.html
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| | TheDEA.org: Neurotoxicity |
| | There's just no reason to believe that it is at a sane dosage/under normal circumstances, and your odds can be greatly improved with a little common sense: Don't mix drugs, be aware of overheating dangers, and take some antioxidants. | | | In one of the earlier experiments with MDMA neurotoxicity, MDMA was directly injected into a small part of some rat's brains. | | | A more radical approach is the use of the MAOI L-Deprenyl (Selegiline), which has proven to be extremely effective in preventing MDMA neurotoxicity in lab animals and does not interfere with MDMA's desired activity. |
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http://thedea.org/neurotoxicity.html
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| | Mold Neurotoxicity: Validity, Reliability and Baloney |
| | This article was adapted from Lees-Haley, P. Mold neurotoxicity: validity, reliability and baloney, presented at the conference "Mold Medicine and Mold Science: Its Practical Applications for Patient Care, Remediation and Claims," hosted by the International Center for Toxicology and Medicine and the Georgetown University Department of Pharmacology. | | | The so-called "study" most often cited as evidence of neuropsychological impairment due to mold neurotoxicity is not actually a scientific study and was not peer reviewed in any conventional sense. | | | The mold neurotoxicity debate is not simply about health care and science -- a focus on money and litigation is pervasive in the communications of the toxic mold promoters. |
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http://www.quackwatch.org/01QuackeryRelatedTopics/toxicmold.html
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| | [No title] |
| | Improve the outcome of treating patients with Neurotoxicity. | | | Apply the concepts of this conference to your practice using nutrition and environmental manipulation for the treatment of Neurotoxicity. | | | Use the information presented to enhance the effectiveness, cost-efficiency, and competitiveness of your practice in relation to Neurotoxicity. |
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http://www.aehf.com/articles/2001symp.htm
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| | Fluoride's Neurological Effects |
| | is neurotoxic when chronically administered in the drinking water of rats. | | | This study examined the neurotoxic consequences of the chronic ingestion of AlF | | | But in the light of the human research in China and now the animal research in the United States, these clinical observations by Dr Waldbott on the neurotoxicity of fluoride in drinking water clearly deserve greater attention and credence. |
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http://www.fluoridation.com/brain.htm
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| | Neurotoxicity |
| | To date, it is still the dominant theory of how MDMA causes axon damage in laboratory animals, and would most likely apply to humans as well, should neurotoxic damage in humans be proven conclusively. | | | Below are some rather techincal explanations of how they came up with this theory. | | | To further support the theory, in 1995 they discovered that MAO-B inhibitors (L-deprenyl or MDL-72974) reduce neurotoxic damage in rats given 40mg/kg of MDMA. |
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http://www.dancesafe.org/slideshow/slide19.html
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| | ClinicalTrials.gov - Information on Clinical Trials and Human Research Studies: Trial List |
| | Conditions: Long-Term Effects Secondary to Cancer Therapy in Children; Neurotoxicity; Psychosocial Effects/Treatment;... | | | Conditions: Neurotoxicity; Long-Term Effects Secondary to Cancer Therapy in Children | | | A Pilot Study of Dextromethorphan for the Prevention and Treatment of Methotrexate Neurotoxicity |
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http://clinicaltrials.gov/search/term=Neurotoxicity
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| | NTC: The Neurotoxicity Testing Center |
| | Our proprietary high throughput methods are as much as 40X more efficient than traditional methods, enabling cost and time efficiencies applied to our clients' choice of scientific methods to employ. | | | The science behind our scientific testing approach reduces the number of animals required for testing by as much as 75% and enables our clients to work "smarter" not "harder". | | | The NTC Leverages proprietary high throughput technology and relies on contemporary scientific principles of neurotoxicity to deliver assessments faster, more cost effectively and more accurately than otherwise possible. |
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http://www.thentc.com
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| | Salon Books Professor Neurotoxicity |
| | Suggesting that toxins can affect the brain and, therefore, behavior is one thing, but it would seem to be a stretch to apply the thesis to an assault so calculated and specific and one so statistically rare. | | | But Masters, who has an unusually avid appetite for conjecture, cites neurological data and little-known facts about southwest suburban Denver to speculate that Harris and Klebold were affected by long-term neurotoxicity. |
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http://www.salon.com/books/it/1999/06/18/littleton
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| | Fluorine |
| | William Marcus, believes that a study conducted by Battelle for the National Toxicology Program on the toxicology of fluoride shows that there were dose-related increases in bone cancer in male rats. | | | This condition, though worrisome, may not be the key concern, at least according to some researchers. | | | Phyllis Mullenix believes, based on her research, that fluoride acts in a way that lowers the I.Q. of children ("Neurotoxicity of Sodium Fluoride in Rats", Mullenix, P. Neurotoxicology and Teratology, 17 (2), 1995). |
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http://www.ithyroid.com/fluorine.htm
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| | TestSmart Developmental Neurotoxicity |
| | Such damage can range from subtle to severe, and it may impose substantial burdens on affected individuals, their families, and society. | | | Developmental neurotoxicity (DNT) is a major issue in children’s health worldwide. | | | The developing human nervous system is susceptible to many toxicants, and chemical exposure during development may cause lasting neurological deficits. |
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http://caat.jhsph.edu/dnt
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| | Statement from Dr. Phyllis Mullenix on the Neurotoxicity of Fluoride |
| | Statement from Dr. Phyllis Mullenix on the Neurotoxicity of Fluoride | | | The new technology enabled us to study the clinically recognized neurotoxicity associated with the treatment for childhood leukemia. | | | My studies focused on detection procedures for neurotoxicity, and they typically considered a variety of environmental and therapeutic agents, i.e., radiation, lead, amphetamine, phenytoin, nitrous oxide. |
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http://www.fluoridealert.org/pmullenix.htm
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| | Neurotoxicity and cytokines |
| | Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons. | | | The cytokine IL-6 enhances neurotoxicity involving NMDA receptors in developing central nervous system neurons. | | | Chronic interleukin-6 alters NMDA receptor mediated membrane responses and enhances neurotoxicity in developing CNS neurons. |
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http://www.math.ubc.ca/~ais/website/status/neurotox.htm
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| | Manganese Neurotoxicity - Manganese Medical Links: Neurologic effects of Manganese in humans. |
| | "Neurologic effects of Manganese in humans: a review." A discussion of Manganese neurotoxicity by Levy BS, Nassetta WJ. | | | Manganese Neurotoxicity - Manganese Medical Links: Neurologic effects of Manganese in humans. | | | Manganese neurotoxicity analysis by Takeda A. Brain Res Brain Res Rev. 2003 Jan;41(1):79-87. |
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http://www.monheit.com/manganism/Manganism_medical.shtml
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| | A Study in Suppression of Information -- References |
| | Nemeroff, C.B. Monosodium glutamate-induced neurotoxicity: review of the literature and call for further research. | | | Toxicological studies of monosodium L-glutamate in rodents: relationship between routes of administration and neurotoxicity. | | | Garattini, S. Evaluation of the neurotoxic effects of glutamic acid. |
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http://www.truthinlabeling.com/L-ref.html
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| | Neurotoxicity - Wikipedia, the free encyclopedia |
| | Individuals with certain disorders may be especially vulnerable to neurotoxicants. | | | The term neurotoxic is used to describe a substance, condition or state that damages the nervous system and / or brain, usually by killing neurons. | | | Neurotoxicity can result from exposure to substances used in chemotherapy, radiation treatment, drug therapies and organ transplants, as well as exposure to heavy metals such as lead and mercury, certain foods and food additives, pesticides, industrial and/or cleaning solvents, cosmetics, and some naturally occurring substances. |
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http://en.wikipedia.org/wiki/Neurotoxicity
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| | Home |
| | A person may or may not be aware of neurotoxic damage when it occurs. | | | Legal difficulties may result from mental health problems stemming from neurotoxicity, including irrational, unusual, criminal or violent behavior. | | | Chemicals that we have studied that can cause neurotoxic illness include: |
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http://www.neurotox.com
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| | NEUROTOXICITY FROM CHEMOTHERAPY |
| | Although both drugs are neurotoxic, neurotoxicity is the dose-limiting toxicity for VCR. | | | Paresthesias of the extremities and painful myopathies have also been reported. | | | Another common manifestation of VCR neurotoxicity, seen in about 50% of patients, is CONSTIPATION. |
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http://www.uic.edu/classes/pmpr/pmpr652/Final/bressler/neurochemo.html
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| | Holistic Health Encyclopedia - D |
| | It has been used to treat decreased immune function, neurotoxicity, hormonal dysfunction, allergies, arthritis, psychological disturbances and even cancer. |
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http://www.myholistic.com/glossary/D.php3
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| | Environmental Neurotoxicity |
| | Symptoms of neurotoxicity include muscle weakness, loss of sensation and motor control, tremors, cognitive alterations and autonomic nervous system dysfunction. |
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http://www.trufax.org/general/envirotox.html
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| | Fluorouracil-induced neurotoxicity -- Pirzada et al. 34 (1): 35 -- The Annals of Pharmacotherapy |
| | Delayed neurotoxicity has been reported when fluorouracil was given in combination with levamisole; this form of subacute multifocal leukoencephalopathy is immune mediated and responds to treatment with corticosteroids. | | | CONCLUSIONS: Clinicians should be aware of the adverse neurologic effects of fluorouracil and should include them in the differential diagnosis when patients receiving the drug present with neurologic problems. | | | Various mechanisms for such toxicity have been postulated, and treatment with thiamine has been recommended. |
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http://www.theannals.com/cgi/content/abstract/34/1/35
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| | The Ibogaine Dossier. Ibogaine Neurotoxicity |
| | subsequently report that ibogaine induced neurotoxicity is dose-dependent, not causing pathological changes at therapeutic doses in the rat. | | | While O'Hearn and Molliver describe that ibogaine and harmaline have selective neurotoxic effects, leading to degeneration of Purkinje cells in the cerebellar vermis, (O'Hearn 1993a, 1993b) Molinari et al. | | | However, an intra-peritoneal dose of 40 mg/kg for 12 days, or 10 mg/kg for 30 days caused no significant pathologic findings in rat heart, liver, kidneys, and brain. |
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http://www.ibogaine.org/neurotoxicity.html
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| | EPA NCEA - Guidelines for Neurotoxicity Risk Assessment |
| | EPA NCEA - Guidelines for Neurotoxicity Risk Assessment | | | A link between human exposure to some chemical substances and neurotoxicity has been firmly established. | | | The Guidelines help develop a sound scientific basis for neurotoxicity risk assessment and promote consistency in the Agency's assessment of nervous system effects. |
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http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=12479
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| | Lung Cancer Online: Symptoms, Side Effects and Complications: Neurotoxicity |
| | Abstract of a study published in the March 1, 2003 issue of the Journal of Clinical Oncology to evaluate the neuroprotective effect of antioxidant supplementation with Vitamin E in patients treated with cisplatin chemotherapy. | | | Concludes that Vitamin E supplementation of patients receiving cisplatin chemotherapy decreases the incidence and severity of peripheral neurotoxicity. | | | Provides basic information on cancer-related cognitive problems, which may include memory loss, distractibility, difficulty in performing multiple tasks, and trouble with arithmetic and language skills. |
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http://www.lungcanceronline.org/effects/neurotoxicity.html
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| | Purchase All Natural Phentermine No Prescription Required |
| | A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease. | | | Brooks JO 3rd, Yesavage JA, Carta A, Bravi D. Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. | | | Scorziello A, Meucci O, Calvani M, Schettini G. Acetyl-L-carnitine arginine amide prevents beta 25-35-induced neurotoxicity in cerebellar granule cells. |
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http://www.herbalphentermine.co.uk/howdoesitwork.html
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| | Smell and Taste Treatment and Research Foundation, ltd. |
| | Hirsch, A.R. “Chronic Neurotoxicity of Acute Hydrogen Sulfide Exposure Without Loss of Consciousness,” Abstracts of Scientific Presentations, American College of Occupational and Environmental Medicine. | | | “Chronic Neurotoxicity of Acute Hydrogen Sulfide Exposure without Loss of Consciousness.” The American Occupational Health Conference. | | | Hirsch, A.R. “Neurotoxicity as a Result of Acute Nitrogen Tetroxide Exposure.” International Congress on Hazardous Waste: Impact on Human and Ecological Health, U.S. Department of Health and Human Services, Public Health Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, 1995, p. |
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http://www.scienceofsmell.com/scienceofsmell/index.cfm?action=about
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| | Erowid MDMA Vault : MDMA (Ecstasy) Neurotoxicity |
| | The (Pseudo-) Science of the War on Drugs | | | Quotes & Notes on the Mechanism of MDMA Neurotoxicity | | | The issue of MDMA's neurotoxicity is very complex, including debate about what constitutes 'neurotoxicity', but |
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http://www.erowid.org/chemicals/mdma/mdma_neurotoxicity.shtml
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| | Development of Alternatives to Animal Use for Safety Testing and Hazard Assessment |
| | Other tests to assess carcinogenicity (ability to cause cancer), genotoxicity (ability to damage genetic material), reproductive toxicity (ability to harm the developing fetus or organs of reproduction), neurotoxicity (effect on the brain and nervous system), and other adverse effects swiftly followed. | | | Some of the first tests to be developed and required by regulatory agencies in the U.S. and throughout the world included the Draize tests for eye and skin irritation and the LD50 test for acute toxicity. | | | By 1975, a broad range of tests requiring large numbers of animals were recommended by the Organization for Economic Cooperation and Development (OECD), whose 29 member countries produce two-thirds of the world’s good and services, to establish the safety of products. |
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http://www.solutions-site.org/artman/publish/article_67.shtml
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| | Neurotoxicity |
| | How 5-HTP supplementation prevents a small amount of the neurotoxic damage in rats. | | | What is the best way to use Prozac for its neuroprotective effect? | | | How exactly does MDMA cause the release of serotonin once it is uptaken into the axon? |
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http://www.dancesafe.org/slideshow/slide24.html
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| | Publications |
| | Isopropanol Ninety-Day Vapor Inhalation Neurotoxicity Study in Female F-344 Rats, Gill, M., Burleigh-Flayer, H., Bevan, C., Gardiner, T., Kapp, R., Tyler, T. and Wright, G. Abstract in The Toxicologist 14:97 (1994). |
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http://biotox.net/_wsn/page4.html
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| | NeuroScience Associates: Premier Neurohistology Services and Products |
| | ) capable of decreasing processing time by 40X, a variety of unique, specialized neurohistology stains, a packaged neurotoxicity testing service and neurohistology products and reference materials. | | | Request a free customized quote to incorporate NSA's services into your budget or grant proposal. |
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http://www.neuroscienceassociates.com
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