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| | Hospital Practice: Updating the Approach to Influenza |
 | | Since resistance appears not to be a clinical issue, neuraminidase inhibitors should be effective as therapy or prophylaxis--including outbreak control in nursing homes (although the drugs are only now being studied in that setting). | | | Some viewers were soon visiting their physicians with a sometimes vague idea that a novel flu therapy could be prescribed. | | | Antiviral drugs also have value as prophylaxis in unanticipated circumstances, such as surprise changes in the circulating virus or this year's problem, a delay in vaccine manufacture. |
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http://www.hosppract.com/issues/2000/12/monto.htm
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| | Flu Drugs, NIAID Fact Sheet |
| | In laboratory and in limited clinical studies, there have been no reported interactions of the neuraminidase inhibitors with other drugs. | | | For complete safety information about these drugs, talk with your pharmacist or health care provider. | | | These drugs have not been evaluated in pregnant women, and researchers do not know the effects these drugs could have on the unborn child. |
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http://www.niaid.nih.gov/factsheets/fludrugs.htm
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| | Worthington Neuraminidase |
| | Leach, S.: Release and Breakdown of Sialic Acid from Human Salivary Mucin and Its Role in the Formation of Dental Plaque, Nature 199, 486, 1963 | | | Chromatographic purification has been developed in this laboratory based on work of Cassidy et al. | | | Rosenberg, S., Plocinik, B., and Rogentine, G.: "Unmasking" of Human Lymphoid Cell Heteroantigens by Neuraminidase Treatment, J Natl Cancer Inst 48, 1271, 1972 |
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http://www.worthington-biochem.com/NEUP
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| | [No title] |
| | It will be appreciated by those skilled in the art that the neuraminidase inhibitors herein described may be derivatised at more than one position. | | | Surprisingly, we have found that neuraminidase inhibitors which are effective in the treatment of human influenza virus infections are also effective in the treatment of equine influenza virus infections. | | | Therefore, it is surprising and unexpected that neuraminidase inhibitors which are effective in the treatment of human influenza virus infections have now been found to be effective in the treatment of equine influenza virus infections. |
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http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=01/97792.011227&ELEMENT_SET=DECL
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| | Pereira Research |
| | However, the neuraminidase can potently promote survival of neuroglia and neurons subjected not only to T. | | | What's more, the neuraminidase and other parasitokines have the potential to become therapeutic agents to treat not only infectious diseases but also unrelated disorders. | | | In the case of the neuraminidase, we are testing its utility as a therapeutic gent for Parkinson's disease. |
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http://www.tufts.edu/sackler/immunology/miercio/research.html
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| | [No title] |
| | rat cytosolic neuraminidase (42); influenza A neuraminidase, strain A/NT/60/68, (A00885) influenza B neuraminidase, strain | | | A model of the tetramer was generated by superimposing the monomer models on the backbone of the influenza neuraminidase tetramer. | | | RPV has been suggested to be the archetype morbillivirus (46). |
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http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=99/02695.990121&ELEMENT_SET=DECL
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| | ARS Publication request: Manganese Activates Pasteurella Haemolytica Neuraminidase |
| | Activation by manganese was expressed as increased Vmax. | | | This study examined the effect of metal ions on the activity of the enzyme. | | | Technical Abstract: Neuraminidase is one of the secreted hydrolytic enzymes present in a 24-hour culture supernatant of Pasteurella hemolytica, the causative agent of acute bovine pneumonic pasteurellosis. |
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http://www.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=101782&pf=1
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| | eMedicine - Mucolipidosis Type I (Alpha-Neuraminidase Deficiency-Sialidosis) : Article by Grace Y Lee, MD |
| | Medicine is a constantly changing science and not all therapies are clearly established. | | | Preliminary studies indicate that both of these properties have positively correlated with the clinical subtype of ML I. However, the wide variability of clinical presentation in these patients cannot be fully explained by alpha-N-acetyl neuraminidase mutations. | | | Because of the neuraminidase deficiency, ML I is now categorized with the sialidoses, a group of clinically distinct disease entities due to either an isolated neuramidase deficiency or a combined deficiency of neuraminidase and beta-galactosidase. |
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http://www.emedicine.com/ped/topic2093.htm
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| | ☞ Bird - Bird Picture |
| | Avian Influenza (" Bird Flu "): Study of Combination Therapy Utilizing Biologic TNF Inhibitors and Neuraminidase Inhibitors May be Warranted | | | The award winning short story and short screenplay is put in motion. |
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http://www.allbirdinfo.com/birdpicture
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| | ISMRD - Sialidosis |
| | It is the lysosomal neuraminidase (N-acetyl-a-neuraminidase) that is lacking in sialidosis patients. | | | However, sialidosis patients and individuals with combined deficiencies of neuraminidase and b-galactosidase suffer from two distinct and separate genetic disorders. | | | About 25 mutations have been identified in the neuraminidase gene of unrelated patients with sialidosis. |
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http://www.mannosidosis.org/sialidosisOverview.htm
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| | American Family Physician: Neuraminidase Inhibitors in the Treatment of Influenza |
| | American Family Physician: Neuraminidase Inhibitors in the Treatment of Influenza | | | As with zanamivir, oseltamivir also was associated with a decrease in the rate of respiratory complications that required antibiotic therapy. | | | Neither drug interferes with the antibody response to influenza vaccine. |
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http://www.findarticles.com/p/articles/mi_m3225/is_4_61/ai_59481018
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| | Illini PorkNet: Paper Display: Purification of Haemophilus... |
| | Immunologic and genetic analysis of the neuraminidase of Pasteurella multocida. | | | Neuraminidase was not expressed in a functional form in screened plaques. | | | To do so, we devised a method to renature the activity of the neuraminidase. |
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http://www.traill.uiuc.edu/porknet/paperDisplay.cfm?ContentID=127
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| | Neuraminidase - Wikipedia, the free encyclopedia |
| | Administration of chemical inhibitors of neuraminidase is a treatment that limits the severity and spread of viral infections. | | | Neuraminidase is also a virulence factor for the bacteria Bacteroides fragilis. | | | Nine neuraminidase subtypes are known, many occur only in various species of duck and chicken. |
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http://en.wikipedia.org/wiki/Neuraminidase
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| | Neuraminidase, Exoglycosidases, New England Biolabs |
| | Q6: What is a good positive control for neuraminidase? | | | Q3: What is the difference between Neuraminidase and α2-3 Neuraminidase? | | | As with the above question we've observed excellent Neuraminidase activity at higher and lower pH's, and we've also found it to work very well on a protein that has been denatured. |
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http://www.neb.com/nebecomm/products/faqproductP0720.asp
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| | [No title] |
| | What I would like to mention is that the viruses that we are seeing with the 155/156 change are also clustering in terms of their neuraminidase. | | | We had been sequencing neuraminidase for a number of years, but we've also been looking at the antigenic properties of neuraminidase. | | | There hasn't been very much variation in the N1 neuraminidase genes since 1999, when the vaccine strain was chosen. |
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http://www.fda.gov/ohrms/dockets/ac/03/transcripts/3922t1.htm
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| | Neuraminidase Inhibitors |
| | Clinical trials have shown that both these drugs are effective when taken within 48 hours of the onset of the symptoms of influenza, shaving off up to two days off flu's typical run of six days or more. | | | Tamiflu, a neuraminidase inhibitor in pill form, is effective against the A strain, but has minimal activity against the B strain (US approval covered both A and B strains). | | | During an interview with IMS HEALTH in September 1999, Dr James Niedel, executive director science and technology Glaxo Wellcome said, "If Tamiflu is equally effective to Relenza, the battle will be on side effects — Relenza is 100% free of side effects, but we know that Tamiflu is associated with some nausea and vomiting." |
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http://www.ims-global.com/insight/news_story/news_story_991103c.htm
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| | [No title] |
| | The RNA genome has enormous capacity to change and thus influenza escapes from vaccines or antiviral drugs. | | | Air, G.M., Laver, W.G. and Webster, R.G. 1990: Mechanism of antigenic variation in an individual epitope on influenza virus N9 neuraminidase. | | | Laver, W.G., Colman, P.N., Webster, R.G., Hinshaw, V.S. and Air, G.M. 1984: Influenza virus neuraminidase with hemagglutinin activity. |
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http://w3.ouhsc.edu/biochem/ocmg/Air.htm
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| | Modeling of Protein- Neuraminidase Complexed with Zanamivir |
| | As with the NDV HN, the active site of the HN of parainfluenza viruses is structurally flexible, suggesting that it may be able to switch between a receptor-binding state and a catalytic state. | | | Furthermore, as demonstrated by the diagram, the neuraminidase structure is mostly made up of beta pleated sheets and one alpha helix, an observation which is supported by looking back at the initial image of neuraminidase (Figure 1). | | | Figure 10 shows the ligand interactions with respect to the entire A protein chain of neuraminidase (indicated by a grey line ribbon), while still focusing in on the specific ligand interactions indicated by the LIGPLOT. |
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http://mason.gmu.edu/~dniessen/chem350/project/protein/final.htm
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| | TAMIFLU How TAMIFLU Works |
| | These inhibitors treat the cause of influenza infection by inhibiting the critical neuraminidase protein on the surface of the virus. | | | The relationship between the invitro anti-viral activity in cell culture and the inhibition of influenza virus replication in humans has not been established. | | | TAMIFLU works to stop the spread of flu virus in the body. |
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http://www.tamiflu.com/consumer_howitworks.asp
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| | Hemagglutinin-Neuraminidase |
| | In almost all mutants there is a decreased level of both HA and NA activities (8). | | | Having a structure similar to the influenza neuraminidase, it contains a barrel motif composed of b-propellers. | | | The structure of the globular head of HN in Newcastle virus has been determined using hexagonal crystal and orthorhombic crystal forms (4). |
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http://www.arches.uga.edu/~tye/bcmb8010
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| | TAMIFLU Neuraminidase Information |
| | Use and access of this site is subject to the terms and conditions as set out in our Legal Statement and PRIVACY Statement. | | | Inhibition of viral neuraminidase prevents newly formed influenza virus from escaping infected cells, therefore interrupting the spread of infection between cells | | | Neuraminidase is a critical protein on the surface membrane of the influenza virus |
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http://www.tamiflu.com/hcp/neuramin/neura_index.asp
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| | NYSL: Reference: Databases (Arranged Alphabetically) |
| | Gale Encyclopedia of Medicine Articles on diseases or disorders typically cover definition; description; causes and symptoms; diagnosis; treatments; prevention; and more. | | | Disorders covered include Down Syndrome, trisomy, hemophilia and Tourette Syndrome, and rarely seen diseases such as Meckel Syndrome, neuraminidase deficiency and phenylketonuria. |
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http://www.nysl.nysed.gov/reference/dbers.htm
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| | ISD: PDB information page |
| | The Protein Data Bank (PDB) includes structural information about the hemagglutinin, neuraminidase and matrix proteins of influenza. | | | NEURAMINIDASE N9 (E.C.3.2.1.18) (SIALIDASE) (MUTANT WITH LYS 432 REPLACED | | | For convenience, we provide a list of these proteins. |
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http://www.flu.lanl.gov/tools/pdb_info.html
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| | Publications |
| | Shibazaki, M., Tanaka, K., Nagai, K., Watanabe, M., Fujita, S., Suzuki, K., Okada, G., and Yamamoto, T. YM-92447 (spinosulfate A), a neuraminidase inhibitor produced by an unidentified pycnidial fungus. |
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http://www.jcm.riken.jp/JCM/publish.html
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