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| | * Neural tube defects - (Pregnancy & Parenting): Definition |
 | | The most common neural tube defect is spina bifida, in which the baby's spine does not develop properly... | | | The most common neural tube defects are spina bifida (an incomplete closure of the spinal cord and spinal column), anencephaly (severe underdevelopment of the brain),... | | | neural tube defects - the neural tube is a structure that forms in the first few weeks of pregnancy and eventually becomes the child's spine and spinal cord... |
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http://www.bestknows.com/pregnancy/neural_tube_defects.html
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| | Neural Tube Defects |
| | However, MOD says 90 to 95 percent of babies with NTDs are born to parents with no family history of these disorders. | | | This serious condition can usually be treated with surgery to place a special tube called a shunt in the body. | | | The shunt runs under the skin, redirecting the fluid and passing it harmlessly into the chest or abdomen, where it is reabsorbed by the body. |
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http://www.stayinginshape.com/3osfcorp/libv/k36.shtml
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| | [Clinical Preventive Services] Screening for Neural Tube Defects -- Including Folic Acid/Folate Prophylaxis |
| | Identification and abortion of pregnancies affected by neural tube defects raises important ethical concerns, a full discussion of which is beyond the scope of this chapter. | | | The offering of screening for neural tube defects by maternal serum a-fetoprotein (MSAFP) measurement is recommended for all pregnant women who are seen for prenatal care in locations that have adequate counseling and follow-up services available (see Clinical Intervention). | | | In a third study, screening was performed in 72% of clinic patients and detected 59% of all affected pregnancies, 94% of which were aborted.36 Offering screening therefore prevented the births of 55% of affected fetuses. |
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http://cpmcnet.columbia.edu/texts/gcps/gcps0052.html
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| | Case Based Pediatrics Chapter |
| | Myelodysplasia refers to defects of spinal cord development, which commonly occurs with spina bifida; however not necessarily associated with failure of fusion of the arches of the vertebral spine, so this could include entities such as syringomyelia and diastematomyelia. | | | Spina bifida, the most common NTD, means "split spine" in Latin and is a result of failure of the neural tube to close during the 3rd-5th week of pregnancy. | | | Spina bifida is often not only an isolated birth defect of the spinal cord and spine, but there commonly are associated congenital malformations of the brain. |
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http://www.hawaii.edu/medicine/pediatrics/pedtext/s18c10.html
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| | Neural Tube Defects |
| | The neural tube is the very primitive structure which develops into the brain and spinal cord. | | | Closure of this tube to create the spinal column begins at several sites and proceeds in both directions, much like a zip. | | | This exposes the meningeal and nervous tissue of the spinal canal as well as the spinal cord. |
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http://www.btinternet.com/~tetheredcordresources/ntds.htm
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| | Large Women and Neural Tube Defects |
| | They noted several differences in their study population---this group was much more likely than those in other studies to have some college education, for example, which might affect things like dietary habits or use of vitamins---but they note that this would not affect the validity of comparisons within this study itself. | | | The authors note that pregnancy after gastric bypass surgery has been noted to be associated at times with increased NTD risk, and observe that women were not asked whether they had ever had a gastric bypass. | | | This study examined 499 mothers whose offspring had NTDs and compared them with 337 mothers of offspring with other major birth defects, and also with 534 mothers of offspring without birth defects. |
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http://www.plus-size-pregnancy.org/neuraltubedefects.htm
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| | Neural Tube Defects |
| | Tethered cord syndrome: lubosacral defects with variable combinations of thickening of the filum terminale, low or dilated conus medullaris, spinal lipoma, dermoid cyst, split cord, hydromyelia, and sacral agenesis. | | | Spina bifida occulta: Least severe NTD, with defects in spinal cord and skeletal, anorectal, and urogenital systems. | | | Skin covering is atrophic and lacks rete pegs and skin appendages. |
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http://webhome.idirect.com/~brainology/brainology/devpath_1_neuraltube.html
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| | Prevention of Neural Tube Defects |
| | The medical profession has been aware that if a woman system has a shortage of the B vitamin Folic Acid during her pregnancy, the result may be an infant with brain and spine defects. | | | There is a major difference between the Chinese approach to supplementation and the American approach which is worth examining. | | | Researchers in China reported that after studying 250,000 females of pregnancy-age, they had found that women who regularly took folic acid supplements had 89 percent fewer babies with brain and spine defects. |
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http://www.prevention-news.com/1999/novdec99/neural.htm
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| | Neural tube defects |
| | Isolated laminar defects are seen on about 5% of lumbar spine x-rays | | | Only clinical sign is often a tuft of hairs of skin dimple at the site of the defect | | | Result from failure of the posterior vertebral arch to fuse |
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http://www.surgical-tutor.org.uk/system/hnep/neural_tube.htm
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| | Neural tube birth defects |
| | Neural tube defects are malformations of the brain, spinal cord, or both that occur in a developing infant two to eight weeks after conception (embryonic stage of development). | | | The two main types of neural tube defects are spina bifida and anencephaly (which basically means being born with most or all of the brain missing). |
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http://www.solae.com/cn/glossary/neuraltubebirthdefects.htm
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| | Neural Tube Defects, NTDs |
| | The neural tube later becomes the baby’s spinal cord, spine, brain, and skull. | | | Thus, the spinal cord and back bones do not develop properly. | | | Anencephaly is a fatal condition in which the upper end of the neural tube fails to close. |
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http://www.habibintl.com/ntds.htm
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| | Combatting neural tube defects |
| | Statistics show 2 percent to 3 percent of babies born have some sort of congenital anomaly, the majority of which aren't preventable. | | | It's sad but true that you can do everything right and still have something go wrong. | | | It is a failure for the earliest component of the neurologic system to develop properly, resulting in spine and brain abnormalities such as spina bifida or meningomylocele. |
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http://www.suntimes.com/output/streicher/cst-ftr-obgyn12.html
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| | Neural Tube Defects |
| | NTDs include several disorders ranging from spina bifida (incomplete closure of the bones around the spinal cord that can lead to paralysis) to a lack of a cranium (the bones of the head) and its contents, called anencephaly. | | | NTDs result when the neural tube (which includes the spinal cord and brain) fails to close during the first month of embryonic development. | | | A healthcare practitioner should review all over-the-counter and prescription medications, as well as any nutritional or herbal supplements. |
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http://stress-medicine.org/health-dictionary/neural_tube_defects_592_prd1.php
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| | CTF Summary Table: Neural Tube Defects |
| | Maternal serum alpha-fetoprotein (MSAFP) measurement at 16-18 weeks should be offered to those who may wish to consider interruption of pregnancy with an affected child; elevated levels followed by ultrasonography and amniocentesis if necessary. | | | Prepared by Marie-Dominique Beaulieu, MD, MSc, FCFP, Department of Family Medicine, University of Montreal, and Brenda L. Beagan, MA, Research Associate, Canadian Task Force on Preventive Health Care | | | However, there is some risk of terminating unaffected pregnancies. |
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http://www.ctfphc.org/Tables/Ch07tab.htm
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| | Neural Tube Defects |
| | All medical information needs to be carefully reviewed with your health care provider. | | | DISCLAIMER: NOAH is an information guide only and cannot answer personal health-related or research questions. | | | NOAH > Genetic Diseases > Specific Conditions > Neural Tube Defects |
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http://www.noah-health.org/en/genetic/conditions/neuraltube
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| | Folic Acid & Neural Tube Defects |
| | Diet also seems to play a significant role, as folic acid supplementation beginning at conception reduces the incidence in women at high risk (Czeizel and Dudás, 1992; Wald et al., 1991). | | | - Mothers with prior history of pregnancies with this defect or a positive family history, abusers of alcohol, cigarettes, and drugs, and patients with malabsorbtion syndromes. | | | The best known condition associated with a deficiency of this vitamin is one of the Megaloblastic Anemias. |
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http://www.theberries.ns.ca/Archives/neural.html
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| | MedlinePlus: Neural Tube Defects |
| | The primary NIH organization for research on Neural Tube Defects is the National Institute of Neurological Disorders and Stroke | | | U.S., Irish Researchers Identify Important Clue to Genetic Basis for Neural Tube Defects (05/21/2004, National Institute of Child Health and Human Development) | | | You may also be interested in these MedlinePlus related pages: |
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http://www.nlm.nih.gov/medlineplus/neuraltubedefects.html
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| | NEURAL TUBE DEFECTS |
| | "In producing an animal model that closely parallels the clinical experience of humans, we hope to better understand how folic acid works to prevent NTD," said university neurologist Elizabeth Ross, who directed the research. | | | NTD occurs when the neural tube, containing cells that eventually form the brain and spinal cord, fails to seal during fetal development, causing nerve tissue to spill out from either the skull area, a condition called anencephaly, or the backbone, a condition called spina bifida. | | | The mice closely mimic humans in the appearance of NTD as well as in their response to folic acid, which is known to reduce the incidence of NTD. |
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http://www1.umn.edu/urelate/datebook/1999/99_11neural.html
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| | Nitrates and Neural Tube Defects |
| | Further research must focus on other factors—for example, consideration of other contaminants or the toxicological interactions within drinking water. | | | Nitrates—a commonly occurring group of substances found in foods, medications, drinking water and cigarette smoke—have been implicated in cancer and other health outcomes. | | | A number of medications were identified which are metabolized to nitrate-like compounds in the body. |
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http://www.ca-nv-awwa.org/Bulletins/nitrates.htm
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| | Neural Tube Defects Spina Bifida |
| | Always seek the advice of your local health care provider. | | | We at IBIS urge you to support our mission to ameliorate and prevent birth defects and genetic disorders by making a contribution to our cause. | | | Birth Defects are the major cause of infant mortality and a leading cause of disability. |
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http://www.ibis-birthdefects.org/start/ntdfact.htm
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| | Neural Tube defects |
| | This condition occurs when there is failure of formation of the fetal cranial vault. | | | This is a slight variation of a neural tube defect known as iniencephaly in which there is lack of proper formation of occipital bones with a short neck and defect of the upper cord. | | | A severe rachischisis is shown here in a fetus that also has iniencephaly. |
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http://medgen.genetics.utah.edu/photographs/pages/neural_tube_defects.htm
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| | Neural tube -- Facts, Info, and Encyclopedia article |
| | Formation of the neural tube is the result of an invagination of the (The outer germ layer that develops into skin and nervous tissue) ectoderm following (The process in which a gastrula develops from a blastula by the inward migration of cells) gastrulation. | | | Among the most common tube defects are (A defect in brain development resulting in small or missing brain hemispheres) anencephaly, encephalocele, and (A not uncommon congenital defect in which a vertebra is malformed; unless several vertebrae are affected or there is myelomeningocele there are few symptoms; can be diagnosed by amniocentesis) spina bifida. | | | This process is induced by signaling molecules produced in the (A flexible rodlike structure that forms the supporting axis of the body in the lowest chordates and lowest vertebrates and in embryos of higher vertebrates) notochord and basal plate. |
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http://www.absoluteastronomy.com/encyclopedia/n/ne/neural_tube.htm
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| | Neural Tube Defects |
| | Many birth defects are multifactoral, that is, things may be several predisposing factors influencing their development. | | | Birth defects in the fetus such as kidney and heart problems may produce high AFP levels as well. | | | Factors such as genetics and environmental exposures contribute to the risk. |
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http://www.birthsource.com/scripts/article.asp?articleid=106
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| | Neural Tube Defects - Patient UK |
| | Neural Tube Defects - Patient UK PatientPlus articles are written for doctors and so the language can be technical. | | | This causes the medulla to be kinked and the cerebellar vermis to be indented, fourth ventrical elongated and midbrain distorted. | | | Can occur as part of a number of different syndromes and chromosomal disorders. |
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http://www.patient.co.uk/showdoc/40000439
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| | Neural Tube Defects |
| | Fetal and young child nervous system : the story of the development and maldevelopment of the brain | | | There is also information on contraindication, precautions and side effects and a list of references. | | | This paper focuses on periconceptional folic acid and food fortification in the prevention of neural tube defects (NTDs) and briefly describes what evidence there is to support the view that folate supplementation prevents NTDs. |
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http://omni.ac.uk/browse/mesh/D009436.html
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| | Neural Tube Defects Publications |
| | Genetic and embryological approaches to studies of neural tube defects: A critical review. | | | Recurrence risks for neural tube defects in siblings of patients with lipomyelomeningocele. | | | SNPs in the neural cell adhesion molecule 1 gene (NCAM1) may be associated with human neural tube defects. |
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http://www.chg.duke.edu/research/ntd_papers.html
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| | Neural Tube Defects Decrease With Folic Acid Fortification |
| | Recent data in Chile have suggested that the incidence of the neural tube defects spina bifida and anencephaly (a fatal condition that results in malformation of the brain) have significantly declined since January 2000, when wheat flour began to be fortified with folic acid. | | | While the prevalence rates of neural tube defects did not significantly change between the two pre-fortified periods, the rate of spina bifida decreased by 51 percent and the rate of anencephaly decreased by 46 percent in the 2001-2002 period. | | | Because different hospitals might experience different rates in neural tube defects at different times, the study examined only those hospitals with data for two consecutive periods. |
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http://www.sciencedaily.com/releases/2005/05/050513230056.htm
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| | BDMP - Neural Tube Defects |
| | NTDs are a group of birth defects that include spina bifida, anencephaly, and certain other central nervous system malformations. | | | These data will be used to help develop and evaluate folic acid promotion activities in the state. | | | The Centers for Disease Control recommends that all women of childbearing age take 0.4 mg of folic acid daily, in order to reduce their risk of having a child with a neural tube defect. |
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http://www.schs.state.nc.us/SCHS/bdmp/ntd.html
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| | NEURAL TUBE DEFECTS |
| | All characterized by abnormalities involving both neural tissue and overlying bone or soft tissues | | | Most common type of CNS malformation, wide geographic and ethnic variation in frequency, recurrence rate: 4-5% | | | Neural tube defects are due to failure of a portion of the neural tube to close or reopening of a region after successful closure |
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http://www.uic.edu/depts/mcpt/curriculum/ppt/neuro_72/sld039.htm
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| | Neural Tube Defects(Bibliography) |
| | Weitkamp,LR; Tackels,DC; Hunter,AGW; Holmes,LB; Schwartz,CE (1998): Heterozygote advantage of the MTHFR gene in patients with neural-tube defect and their relatives. | | | Wheeler,T (1920): Variability in the spinal column as regards defective neural arches (rudimentary spina bifida). | | | Gruenwald,P (1941): Tissue anomalies of probable neural crest origin in a twenty millimeter human embryo with myeloschisis. |
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http://ibis-birthdefects.org/start/ntdbib.htm
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| | UNSW Embryo- Abnormal Development - Folic Acid and Neural Tube Defects |
| | A randomised controlled trial conducted by the Medical Research Council of the United Kingdom demonstrated a 72% reduction in risk of recurrence by periconceptional (ie before and after conception) folic acid supplementation (4mg daily). | | | Other epidemiological research, including work done in Australia, suggests that primary occurrences of neural tube defects may also be prevented by folic acid either as a supplement or in the diet. | | | Abnormalities in human development can be due to many different factors, this page gives a few starting points to look at the topic of folate and its role in preventing neural tube defects. |
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http://embryology.med.unsw.edu.au/Defect/page5e.htm
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| | Folic Acid, NCBDDD, CDC |
| | It is used in our bodies to make new cells. | | | If a woman has enough folic acid in her body before she is pregnant, it can help prevent major birth defects of her baby’s brain and spine. | | | Please talk with your doctor for questions about yourself. |
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http://www.cdc.gov/node.do?id=0900f3ec80010af9
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| | Neural tube defects |
| | Overall incidence of neural tube defects is 2.6 per 1000 total single births world-wide. | | | Neural tube defects are malformations of the neural tube during embryogenesis. |
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http://www.cartage.org.lb/en/themes/Reference/dictionary/Biologie/N/54.html
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