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| | eMedicine - Myxedema Coma or Crisis : Article by Elena Citkowitz, MD, PhD, FACP |
 | | The other skin condition, called myxedema, occurs in severe, long-standing hypothyroid states and is caused by the deposition of mucopolysaccharides within the dermis. | | | Medical Care: Myxedema crisis/coma is a life-threatening condition; therefore, patients with this condition must be stabilized in an intensive care unit. | | | Myxedema coma/crisis is a medical emergency and requires close monitoring and stabilization. |
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http://www.emedicine.com/med/topic1581.htm
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| | Pretibial Myxedema |
| | Topically applied corticosteroid therapy was used in 76 patients, and in this group 38% had sustained long-term partial remission, as opposed to 18% in the group receiving no corticosteroid therapy. | | | In comparison two patients with Graves' ophthalmopathy and pretibial myxedema treated with systemic corticosteroids did not present any improvement of the cutaneous ailment. | | | She received levothyroxine replacement and steroid pulse therapy followed by radiotherapy. |
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http://www.thedoctorsdoctor.com/diseases/pretibial_myxedema.htm
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| | Ch. 9 Part 4 |
| | Myxedema coma is a rare, life-threatening clinical condition in patients with long-standing severe untreated hypothyroidism in whom adaptive mechanisms fail to maintain homeostasis. | | | In view of the rarity of myxedema coma, it has been difficult to perform randomized studies to resolve the issue of whether T4 or T3 is the most appropriate treatment. | | | The patient may be entirely obtruded or may be roused by stimuli. |
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http://www.thyroidmanager.org/Chapter9/ch_9-4.htm
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| | Thyroid.org: Notes by Robert D. Utiger, M.D. July 2004 |
| | Among patients with myxedema coma, the level of consciousness and degree of impairment are the most important predictors of survival, and high-dose T4 therapy may be more effective. | | | This study described the clinical findings and evaluated the response to thyroxine (T4) therapy, given in two different ways, in patients with myxedema coma. | | | Patients with myxedema coma have impaired consciousness, and many have complicating illnesses. |
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http://www.thyroid.org/patients/notes/july04/04_07_28.html
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| | Mind-Sharpeners Directed Learning Modules |
| | Additonally, all of these conditions, may have contributed to the precipitation of the coma or are secondary consequences. | | | Also keep in mind that coma could be precipitated by an overwhelming systemic process in a patient with a milder clinical hypothyroidism who has few of these more dramatic signs of the disease. | | | generation may be reduced in myxedema coma as a consequence of an associated illness. |
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http://www.erworld.com/mindsharp/mindv_2.htm
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| | Hyperthyroidism and Graves' Disease |
| | It is less likely to develop in other locations, though cases have been reported that have presented with thickening of skin along the arms, hands, fingers, back, ears, and nose. | | | The word “pretibial” refers to the fact that this thickening usually involves the skin that covers the front of the tibia bone in the lower leg. | | | Pretibial myxedema is a skin condition that may develop in patients with Graves’ disease. |
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http://www.hopkinsmedicine.org/endocrine/graves/TopicAnswer.asp?QuestionID=61
(432 words)
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| | [No title] |
| | PRETIBIAL MYXEDEMA ---------------------------------------- I have a 50 y/o F pt who has classic clinical and biopsy changes of myxedema. | | | My questions are: Anyone know of any relationship between the degree of hypothyroidism and the degree of myxedema in the skin? | | | In hypothyroidism, generalized myxedema is reported, which is the case in my patient. |
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http://matrix.ucdavis.edu/rxderm-archives/pretibial-myxedema
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| | Graves' Disease: Skin rash / Pretibial Myxedema |
| | Posted by : Bobbi on 1/6/2004 at 5:32:59 PM If you are concerned that you might have pretibial myxedema (the skin condition about 1% of Graves' patients get on the lower legs) you should see a dermatologist. | | | Basically, the P.T. makes the skin look a bit like the rind of an orange: reddish perhaps in tone from the rest of the skin, thicker, clottier. | | | The difference is that this condition itches like mad. |
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http://www.ngdf.org/Messages/0604/82604.htm
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| | Myxedema and pericardial effusion with cardiac tamponade (a case report). Retnam VJ, Chichgar JA, Patkar LA, ... |
| | Kern et al[5] described pericardial effusion as a "constant, early and major factor in myxedema heart." Its presentation is similar to that of congestive cardiac failure. | | | The rarity of cardiac tamponade[2], [8], [9] in myxedema patients with pericardial effusion is attributed to the slow accumulation of fluid and the remarkable distensibility of the pericardium. | | | The pathophysiologic derangements responsible for the collection of fluid in the serous cavities of myxedema patients are probably increased systemic capillary permeability[6] and disturbances in electrolyte metabolism. |
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http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1983;volume=29;issue=3;spage=188;epage=190B;aulast=Retnam
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| | Medicine: Dermopathy of Graves disease (pretibial myxedema): review of 150 cases.@ HighBeam Research |
| | Pretibial myxedema or, more appropriately, thyroid dermopathy is a condition in which there is localized thickening of the skin, usually in the pretibial area. | | | Search for more information on HighBeam Research for. | | | The condition is a known manifestation of Graves disease, and it is commonly associated with infiltrative ophthalmopathy [5,28]. |
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http://www.highbeam.com/library/doc0.asp?DOCID=1G1:14863420&refid=ip_encyclopedia_hf
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| | Emergency Medicine |
| | Hallmark signs of hypothyroidism will be present—dry, coarse, scaly skin; sparse or coarse hair; nonpitting edema of the periorbital regions, hands, and feet; macroglossia; hoarseness; and delayed deep tendon reflexes. | | | Unfortunately, the patient with myxedema coma typically is more vulnerable to such infections because of hypoventilation and obtundation. | | | Gastrointestinal tract involvement in myxedema coma may result in decreased intestinal motility, paralytic ileus, or megacolon, causing patients to present with abdominal pain, constipation, and nausea. |
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http://www.emedmag.com/html/pre/cov/covers/021503.asp
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| | Hyperthyroidism and Graves' Disease |
| | Some patients who develop moderate pretibial myxedema may need to be treated if they develop problems with pain, disfigurement, or impaired motion of the feet or ankles. | | | Most patients who develop mild pretibial myxedema do not require any specific treatment. | | | In rare cases of severe myxedema, surgery with skin grafting may be considered to remove enlarging lesions that do not respond to applications of glucocorticoids. |
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http://www.hopkinsmedicine.org/endocrine/graves/TopicAnswer.asp?QuestionID=62
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| | Hypothyroidism MEDSTUDENTS-ENDOCRINOLOGY |
| | Levothyroxine has a sufficiently long half-life so that if the patient is unable to take medication by mouth for a few days, omitting T4 therapy will not be detrimental. | | | Patients with myxedema and coronary artery disease can be treated surgically first, and more rapid thyroxin replacement therapy will then be tolerated. | | | Myxedema coma is an acute medical emergency and should be treated in the intensive care unit. |
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http://www.medstudents.com.br/endoc/endoc4.htm
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| | Skin Changes in Graves' Disease |
| | One recent study describes a patient developing localized myxedema on the thigh at the site of a donor skin graft. | | | The dermatological conditions or skin disorders associated with GD include pretibial myxedema (PTM), and rarely acropachy. | | | This was the initial presentation or earliest symptoms of Graves’ disease for this patient. |
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http://www.suite101.com/article.cfm/graves_disease/56432
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| | Hypothyroidism - Wikipedia, the free encyclopedia |
| | Dry puffy skin, especially on the face, and hair loss, especially thinning of the outer 1/3 of the eyebrows | | | Others have moderate symptoms that can be mistaken for other diseases and states. | | | Advanced hypothyroidism may cause severe complications, the most serious one of which is myxedema. |
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http://en.wikipedia.org/wiki/Myxedema
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| | Pretibial Myxedema: Long-Term Treatment Outcome |
| | While PTM can develop at any time, most patients first develop Graves’ hyperthyroidism, followed by GO and then PTM. | | | Pretibial myxedema (PTM) is a dermatological condition that occurs in a small number of patients with Graves’ disease, almost always in individuals who also have Graves’ ophthalmopathy (GO). | | | Graves' Disease - Pretibial Myxedema: Long-Term Treatment Outcome - http://www.suite101.com/article.cfm/graves_disease/90137 |
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http://www.suite101.com/article.cfm/graves_disease/90137
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| | Best Practice Medicine-Professional Reference - Hypothyroidism |
| | Treat the precipitating illness in patients with myxedema coma [4] [5]. | | | The presentation of myxedema coma may be similar to that of myocardial infarction or sepsis [5]. | | | Since some patients with myxedema coma may also suffer from adrenal insufficiency, a cortisol level or a cosyntropin stimulation test should be done. |
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http://merck.micromedex.com/index.asp?page=bpm_report&article_id=BPM01EN10§ion=report&ss=3
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| | MedlinePlus Medical Encyclopedia: Hypothyroidism |
| | Calling your health care provider Return to top | | | Call your health care provider if chest pain or rapid heart beat occur, infection occurs, symptoms worsen or do not improve with treatment, or new symptoms develop. | | | It may be caused by an infection, illness, exposure to cold, or certain medications in an individual with untreated hypothyroidism. |
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http://www.nlm.nih.gov/medlineplus/ency/article/000353.htm
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| | Question_set 119 |
| | If such a patient develops myocardial ischemia, why should beta-blockers be avoided? | | | Is hypertension or hypotension more often seen in patients with myxedema? | | | Pubic hair in patients with secondary myxedema may be absent, while usually present in those with primary myxedema. |
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http://www.ncemi.org/cgi-ncemi/qad.pl?cmd=showquestion&rf=/usr/www/htdocs/ncemi/qad/119.hypothyroidism_and_my.qad&rfj=94
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| | Infantile myxedema definition - Medical Dictionary definitions of popular medical terms |
| | Another name, now little used, for the condition is Brissaud's infantilism, after the French physician Edouard Brissaud (1852-1909). | | | Infantile myxedema definition - Medical Dictionary definitions of popular medical terms | | | Please consult your healthcare provider before beginning any course of supplementation or treatment. |
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http://www.medterms.com/script/main/art.asp?articlekey=6456
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| | Introduction: Myxedema - CureResearch.com |
| | Treatments for Myxedema: Various information is available about treatments available for Myxedema, or research treatments for other diseases. | | | Researching symptoms of Myxedema: Further information about the symptoms of Myxedema is available including a list of symptoms of Myxedema, or alternatively return to research other symptoms in the symptom center. | | | Myxedema: Skin and tissue disorder usually due to hypothyroidism |
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http://www.cureresearch.com/m/myxedema/intro.htm
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| | UpToDate Myxedema coma |
| | Important clues to the possible presence of myxedema coma in a poorly responsive patient are the presence of a thyroidectomy scar or a history of I-131 therapy or hypothyroidism. | | | The possibility of a precipitating infection or other acute illness should always be considered; it is important to appreciate, however, that the patient may not have a febrile response to infection (show table 1). | | | Myxedema coma can occur as the culmination of severe, long-standing hypothyroidism or be precipitated by an acute event such as infection, myocardial infarction, cold exposure, or the administration of sedative drugs, especially opiates. |
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http://patients.uptodate.com/topic.asp?file=thyroid/11535
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| | HASHIMOTO’S THYROIDITIS ASSOCIATION WITH OPTHALMOPATHY AND PRETIBIAL MYXEDEMA |
| | The patient had infiltrative ophthalmopathy and elephantiatic form of pretibial myxedema. | | | Dermopathy of Graves' Disease (Pretibial Myxedema): Long-Term Outcome. | | | At that time, he had thyroid opthalmopathy (grade 3) and pretibial myxedema (nonpitting edema accompanied by typical color changes and plaque of the skin, Figure 1), but he was clinically euthyroid. |
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http://www.istanbul.edu.tr/istanbultip/mecmua/fakmecmua/sayi2-04/06.htm
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| | Hypothyroidism |
| | A number of conditions can cause this disorder, and it is usually progressive and irreversible. | | | Patients with myxedema complain of fatigue, lethargy, sleepiness, poor tolerance to cold, mental sluggishness, a tendency to gain weight, and generalized aches and pains. | | | It was first diagnosed in the late nineteenth century when physicians observed that after surgically removing the thyroid gland, a patient developed swelling of the hands, face, feet, and tissues around the eye. |
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http://aihc1998.tripod.com/thyroid.html
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| | Symptoms of Myxedema - WrongDiagnosis.com |
| | Furthermore, signs and symptoms of Myxedema may vary on an individual basis for each patient. | | | This signs and symptom information for Myxedema has been gathered from various sources, may not be fully accurate, and may not be the full list of Myxedema signs or Myxedema symptoms. | | | Medical articles on symptoms: These general reference articles may be of interest in relation to medical signs and symptoms of disease in general: |
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http://www.wrongdiagnosis.com/m/myxedema/symptoms_printer.htm
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| | myxedema |
| | Pretibial myxedema, ophthalmopathy and acropachy in a male patient with Graves' disease.(Letter To Editor)(Letter to the Editor) (Indian Journal of Dermatology, Venereology and Leprology) | | | myxedema, condition associated with severe hypothyroidism and lack of thyroid hormone in the adult. | | | Symptoms include a dry swelling of the skin, slowed speech and mental awareness, deepened voice, intolerance to cold, fatigue and weakness, and nonspecific degeneration of the heart. |
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http://www.infoplease.com/ce6/sci/A0834668.html
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| | Myxedema coma |
| | Myxedema coma occurs as an extreme manifestation of severe hypothyroidism, seen in patients with long standing hypothyroidism that is untreated. | | | Steroid treatment -Inj Hydrocortisone 100mg, 8 hourly parennterally during initial 7 -10 days then tapered off. |
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http://www.geocities.com/jainthyroid/new_page_10.htm
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| | THE MERCK MANUAL, Sec. 2, Ch. 8, Thyroid Disorders |
| | Myxedema coma is treated with a large initial dose of T | | | (L-thyroxine) are preferred; the average maintenance dosage is 75 to 125 µg/day po, but initial doses must be much lower, especially in the elderly, those with heart disease, and those with long-standing or severe hypothyroidism (except for myxedema coma). | | | Myxedema coma is a life-threatening complication of hypothyroidism. |
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http://www.merck.com/pubs/mmanual/section2/chapter8/8e.htm
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| | HON Mother & Child Glossary, Thyroid Gland Disorders: Hypothyroidism |
| | Severe hypothyroidism can lead to a condition called myxedema, characterised by dry, thickened skin and course facial features. | | | The most common cause of hypothyroidism is the body's autoimmune reaction to itself, producing antibodies against the thyroid gland. |
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http://www.hon.ch/Dossier/MotherChild/child_hormones/hypothyroidism.html
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| | DermAtlas: Online Dermatology Image Library dermatology image,acropachy, thyroid,myxedema, pretibial,Grave ... |
| | She also had nontender subcutaneous nodules on her upper legs, hands, and arms, diffuse thickening of the soft tissue of the hands and fingers and thickening of the soft tissue of the orbits with bilateral proptosis. | | | This 52-year-old woman with a 5 year history of goiter and Grave disease developed progressive nontender thickening with exuberant folding of the skin on the shins and tops of the feet. | | | Alcian blue demonstrates increased interstitial mucin within the deep dermis. |
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http://dermatlas.med.jhmi.edu/derm/result.cfm?Diagnosis=1466585723
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| | Search Results for myxedema - Encyclopædia Britannica |
| | Simple goitres that are not associated with a change in the amount of thyroid hormone in the mother's blood do not affect pregnancy, nor does pregnancy affect the thyroid in such a case. | | | He was one of the first to use extractions of animal thyroid to relieve myxedema (severe hypothyroidism) in humans. | | | Expand your search on myxedema with these databases: |
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http://www.britannica.com/search?query=myxedema&submit=Find&source=MWTEXT
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| | FindArticles search for "Myxedema" |
| | Myxedema coma, the extreme manifestation of hypothyroidism, is an uncommon but potentially lethal condition. | | | At eBay you can find practically anything, even myxedema. | | | FindArticles > All Publications > Results for "Myxedema" |
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http://www.findarticles.com/p/search?tb=art&qt=Myxedema
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| | MSN Encarta - Dictionary - myxedema |
| | Click here to search all of MSN Encarta | | | Search for "myxedema" in all of MSN Encarta |
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http://encarta.msn.com/dictionary_1861632247/myxedema.html
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