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Topic: Myometrium



  
 Expression of Connexin-43 and Connexin-26 in the Rat Myometrium during Pregnancy and Labor Is Differentially Regulated ...
Expression of Cx-43 mRNA in the myometrium of the nonpregnant rats.
Indirect immunofluorescence studies of Cx-43 in the myometrium of nonpregnant rats.
and labor-induced Cx-43 expression in rat myometrium ( 19).
http://endo.endojournals.org/cgi/content/full/138/12/5398

  
 EAGO Newsletter
Endometrial glands and stroma at the extreme end of the needle core may represent eutopic endometrium and such biopsies should be regarded as negative.
The controversy focuses on the microscopic criteria which define superficial adenomyosis, islets within the inner third of the myometrium, which can sometimes be indistinguishable from normal indentations of the basal endometrial layer.
This review summarises the merits and demerits of available diagnostic techniques.
http://www.obgyn.net/eago/art04.htm

  
 British Journal of Pharmacology - Enhanced contractile response to thrombin in the pregnant rat myometrium
We herein demonstrated that thrombin induced a contraction in the myometrium of the rat, and that this contractile response was greatly enhanced in the pregnant rat.
and tension in the rat myometrium, and this effect was greatly enhanced in the pregnant myometrium.
The contractile effects of thrombin on the rat myometrium.
http://www.nature.com/bjp/journal/v131/n8/full/0703729a.html

  
 Effect of NO donors on protein phosphorylation in intact vascular and nonvascular smooth muscles -- Hennan and Diamond ...
The rat myometrium can be classified as a "nonresponsive" smooth muscle, in that it does not relax in response to an elevation
rat myometrium and vas deferens, are not relaxed by sodium nitroprusside,
Thus the failure of the rat myometrium and rat vas deferens
http://ajpheart.physiology.org/cgi/content/full/280/4/H1565

  
 British Journal of Pharmacology - Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of ...
Furthermore, we observed that the contractile effect of phorbol ester in human myometrium is greater in the pregnant than in the nonpregnant state.
In contrast to the results in rat myometrium, others have suggested the importance of PKC in the agonist-induced contractions in human myometrium ( Morrison et al., 1996 ; Breuiller-Fouche et al., 1998 ; Eude et al., 2000).
As the results from the mechanical study using relatively specific PKC inhibitors suggested that conventional PKC might be involved in the increased contractility of the pregnant myometrium in response to phorbol ester, we examined the changes in mRNA of these isozymes using a semiquantitative RT−PCR method ( Figure 7).
http://www.nature.com/bjp/journal/v140/n7/full/0705552a.html

  
 Center for Uterine Fibroids: Leiomyoma-related bleeding
Subsequent studies utilizing light microscopy demonstrated ectasia of the venules in both the myometrium and the endometrium of uteri containing leiomyomas.
Among the evidence to support this theory of vascular dysregulation in leiomyoma-related bleeding is the classic descriptive study by Sampson (Sampson, 1912).
This progression of changes in the morphology of glands and stroma is parallelled by changes in the vascular structures.
http://www.fibroids.net/html/article1.html

  
 Complex Interactions Between Sex Steroids and Cytokines in the Human Pregnant Myometrium: Evidence for an Autocrine ...
system may be involved in an autocrine role in the human myometrium
Mershon JL, Mikala G, Schwartz A 1994 Changes in the expression of the L-type voltage-dependent calcium channel during pregnancy and parturition in the rat.
in the physiological processes preparing the myometrium for parturition
http://endo.endojournals.org/cgi/content/full/140/6/2533

  
 Progesterone Withdrawal and Estrogen Activation in Human Parturition Are Coordinated by Progesterone Receptor A ...
human myometrium in association with the onset of labor.
However, whether responsiveness of the human myometrium to progesterone
nonlaboring myometrium suggests that the process of human parturition
http://jcem.endojournals.org/cgi/content/full/87/6/2924

  
 Voltage-gated K+ currents in freshly isolated myocytes of the pregnant human myometrium -- Knock et al. 518 (3): 769 -- ...
Early studies in rat and guinea-pig myometrium suggested that K
This current has been previously described in primary culture of pregnant rat myometrium and non-pregnant human myometrium (Erulkar et al.
has not, to our knowledge, been previously described in the human myometrium.
http://jp.physoc.org/cgi/content/full/518/3/769

  
 Inhibition of Proliferation and Estrogen Receptor Signaling by Peroxisome Proliferator-activated Receptor {gamma} ...
Western analysis of PPAR expression in human leiomyoma and myometrium is shown.
Western analysis was performed using Eker rat myometrium, leiomyoma,
were expressed in the normal and neoplastic human myometrium
http://cancerres.aacrjournals.org/cgi/content/full/63/6/1221

  
 Endocrine and Paracrine Regulation of Birth at Term and Preterm -- Challis et al. 21 (5): 514 -- Endocrine Reviews
prostacyclin was observed on human myometrium ( 56), and it is
myometrium can then undergo "stimulation" in response to endogenous
of decidua and myometrium in species such as rat before parturition
http://edrv.endojournals.org/cgi/content/full/21/5/514

  
 Reproductive Biology and Endocrinology Full text Nitric oxide synthase activity in human trophoblast, term placenta ...
From our recent studies showing important differences between NOS activity in human and rat or rabbit myometrium, it was concluded that placental and fetal NOS could be of considerable importance in maintaining quiescence of the myometrium in human pregnancy [ 21 ].
In view of the marginal activity of NOS in the myometrium, NO produced by the trophoblast and placenta could play a significant role in maintaining uterine quiescence by paracrine effect.
In view of the marginal activity of NOS in the pregnant myometrium, NO produced by the trophoblast and placenta could play a significant role in maintaining uterine quiescence by paracrine effect.
http://www.rbej.com/content/1/1/51

  
 Female reproductive system
This pattern of early junctional zone enhancement occurs prominently in the proliferative phase of the premenopausal and postmenopausal uterus (Yamashita et al., 1993, 1992).
The cervical stroma enhances at a slower rate on dynamic imaging than the myometrium.
The uterine corpus is divided into three tissue layers: the serosa which consists of the peritoneum; the myometrium which is largely made up of involuntary smooth muscle; and the endometrium composed of the mucosal stratum functionalis (responsive to hormonal stimuli) and the stratum basale (responsible for growth and regeneration of the endometrium).
http://mripractice.tripod.com/mrpractice/id67.html

  
 ERK1/2-mediated phosphorylation of myometrial caldesmon during pregnancy and labor -- Li et al. 284 (1): 192 -- AJP - ...
Izumi, H. Changes in the mechanical properties of the longitudinal and circular muscle tissues of the rat myometrium during gestation.
Although myometrial quiescence in vivo is a clinical hallmark of normal pregnancy, it has not been clear whether this change
been previously reported for rat myometrium ( 14), the amplitude
http://ajpregu.physiology.org/cgi/content/full/284/1/R192

  
 Hemoxygenase and Nitric Oxide Synthase Do Not Maintain Human Uterine Quiescence during Pregnancy -- Barber et al. 155 ...
Buhimschi I, Yallampalli C, Dong Y-L, Garfield RE: Involvement of a nitric oxide-cyclic guanosine monophosphate pathway in control of human uterine contractility during pregnancy.
for relaxation of myometrium during pregnancy and as a modulator
Howe DH, Sangha R, Kilby MD, Whittle MJ, Ahmed A: Identification and expression of nitric oxide synthase isoforms in human myometrium before and after the onset of labour.
http://ajp.amjpathol.org/cgi/content/full/155/3/831

  
 Apparent up-regulation of stimulatory G-protein {alpha} subunits in the pregnant human myometrium is mimicked by ...
instance, in rat and human myometrium, stimulation of
-adrenergic receptor-coupled adenylyl cyclase system in rat myometrium during pregnancy.
data have been reported from rat myometrium (7)
http://www.fasebj.org/cgi/content/full/14/1/17

  
 Adenomyosis: US Features with Histologic Correlation in an in Vitro Study -- Atri et al. 215 (3): 783 -- Radiology
(b) Corresponding low-power microscopic section demonstrates replacement of the whole normal myometrium by multiple endometrial islands separated by whorls of muscle hypertrophy (arrowheads), the explanation for the edge shadows.
(a) In vitro US image demonstrates extensive heterogeneous adenomyosis of the inner two-thirds of the myometrium.
http://radiology.rsnajnls.org/cgi/content/full/215/3/783

  
 e-uterus.com: information, uterus, cervix, menstrual cycle, dysmenorrhea, amenorrhea, cervical cancer, infections
The hypogastric and ovarian nerve plexuses supply sympathetic and parasympathetic fibers as well as carry uterine afferent sensory fibers on their way to the spinal cord (T11 and 12).
Hormone therapy that prevents ovulation may be helpful.
Endometrial cancer spreads first to the cervix and myometrium followed by the vagina, pelvis and lungs.
http://www.e-uterus.com

  
 A Decline in Myometrial Nitric Oxide Synthase Expression Is Associated with Labor and Delivery -- Bansal et al. 99 ...
Natriuretic Peptide-Induced Relaxation of Myometrium from the Pregnant Guinea Pig Is Not Mediated by Guanylate Cyclase Activation
oxide synthase within human myometrium at midgestation, a time
Expression of nitric oxide synthase isoforms in pregnant human myometrium
http://www.jci.org/cgi/content/abstract/99/10/2502

  
 Adenomyosis - New Treatments, January 22, 2005
The most popular theory of the histogenesis of adenomyosis is that the basoendometrium invades the myometrium to give rise to foci of adenomyosis.
Uterine trauma at the time of delivery, increased uterine pressure, or chronic endometritis may contribute to this invasion.
Adenomyosis is characterized by the presence of endometrial glands and stroma in the myometrium and is often associated with local myometrial hypertrophy.
http://www.ccspublishing.com/journals2a/Adenomyosis.htm

  
 Decreased Expression of Early Growth Response-1 and Its Role in Uterine Leiomyoma Growth -- Shozu et al. 64 (13): 4677 ...
C-fos and c-jun expression in human endometrium and myometrium.
Gene expression profile of leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy.
(normal myometrium or leiomyoma), and culture method (38, 51, 52)
http://cancerres.aacrjournals.org/cgi/content/full/64/13/4677

  
 Adenomyosis - Medical Dictionary definitions of popular medical terms
Adenomyosis is made up of adeno (gland) + myo (muscle) + osis (a condition of) = a condition of glandular tissue (referring to the endometrium) in the muscle (the myometrium).
Adenomyosis: Pronounced a-den-o- mi-o-sis, this is a common benign condition of the uterus in which the endometrium (the mucous membrane lining the inside of the uterus) grows into the myometrium (the uterine musculature located just outside the endometrium).
Adenomyosis goes by several other names including endometriosis interna, endometriosis uterina, adenomyosis uteri and adenomyometritis.
http://www.medterms.com/script/main/art.asp?articlekey=6848

  
 Center for Endometriosis Care Newsletter - Adenomyosis
Much work is ongoing to get more information as to the diagnostic accuracy of this technique.
by Robert B. Albee, MD Adenomyosis ( add-en-o-my-OH-sis) is defined as ‘the presence of endometrial tissue within the myometrium.’; (The myometrium is the medical term for the muscular portion of the uterine wall.) In the past, adenomyosis was referred to as ‘endometriosis interna’ in the medical world, and sometimes as ‘inside-out endometriosis’ in lay terms.
For diagnosis and treatment advice you should consult your healthcare practitioner.
http://www.centerforendo.com/news/adenomyosis/adenomyosis.htm

  
 eMedicine - Uterus, Adenomyosis : Article by Karen L Reuter, MD, FACR
Specific details of this observation have been analyzed.
Furthermore, most focal adenomas are in the posterior myometrium.
The bright foci seen in the myometrium on T2-weighted images in 50% of patients (see Image 3) are islands of heterotopic endometrial tissue or cystic dilation of heterotopic glands or hemorrhage.
http://www.emedicine.com/radio/topic737.htm

  
 Characterization and Functional Analysis of cAMP Response Element Modulator Protein and Activating Transcription Factor ...
Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A 1993 Identification and expression of G-proteins in human myometrium: up-regulation of G
phosphorylation that occurs in the myometrium and not in the
s in human myometrium in term and preterm labour: a mechansim for parturition.
http://jcem.endojournals.org/cgi/content/full/87/4/1717

  
 Diffusely Enlarged Uterus: Evaluation with MR Imaging -- Kido et al. 23 (6): 1423 -- RadioGraphics
The uterine position has changed from retroflexion to anteflexion.
into the myometrium with reactive overgrowth of the musculature.
Fine hyperintense striations (arrows) extend into the myometrium; this appearance is an extreme example of pseudowidening of the endometrium.
http://radiographics.rsnajnls.org/cgi/content/full/23/6/1423

  
 Uterine Adenomyosis: Endovaginal US and MR Imaging Features with Histopathologic Correlation -- Reinhold et al. 19 ...
(a) Sagittal oblique endovaginal US scan of a patient receiving tamoxifen therapy shows that the inner myometrium is hypoechoic and heterogeneous.
http://radiographics.rsnajnls.org/cgi/content/full/19/suppl_1/S147

  
 Myometrium
The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cells.
Down-regulation of the alpha- and beta-subunits of the calcium-activated potassium channel in human myometrium with parturition.
A comparative analysis of structure and spatial distribution of decorin in human leiomyoma and normal myometrium.
http://www.find-health-articles.com/Cate-Myometrium.htm

  
 Regulation of the Ca2+-sensitive Domains of the Maxi-K Channel in the Mouse Myometrium during Gestation -- Benkusky et ...
from non-pregnant rat and human myometrium are stimulated by protein
the myometrium is by expressing multiple maxi-K channel isoforms
The Maxi-K Channel Is Alternatively Spliced in the Mouse Myometrium-- The expression of the diverse maxi-K channel variants is thought to have tissue-specific effects on cellular excitability,
http://www.jbc.org/cgi/content/full/275/36/27712

  
 Uterus - Wikipedia, the free encyclopedia
The uterus mostly consists of muscle, known as myometrium.
adenomyosis - ectopic growth of endometrial tissue within the myometrium
The innermost layer of myometrium is known as the junctional zone, which becomes thickened in adenomyosis.
http://en.wikipedia.org/wiki/Uterus

  
 Home Page for Enrico Stefani, Ph.D. M.D.
This new information is analyzed to define protein changes and discover new genes involved in myometrium functional and pathological changes during pregnancy.
The molecular mechanisms of ion channel regulation by sex hormones and their functional consequences in myometrium and 2.
We are using as model systems myometrium and heart at different stages of pregnancy.
http://www.anes.ucla.edu/~estefani

  
 RU486 suppresses prolactin production
Conclusions: Prolactin production is suppressed in both leiomyomas and myometrium after treatment with RU486 in vitro, and this suppression may serve as a marker for the clinical effectiveness of agents used in the treatment of leiomyomas.
M. Immunohistochemistry results suggest that the A form of the PR is the dominant form in both leiomyomas and myometrium.
Design: Explant cultures using tissue from nine premenopausal women undergoing hysterectomy in the proliferative phase of the menstrual cycle; immunohistochemical staining of tissue sections from five patients for P receptor (PR) subtype.
http://www.fibroids.net/html/article9.html

  
 Molecularlabor
Analysis of the dicidua and the myometrium showed no change in the progesterone receptor concentration (Mashoumeh, 1997).
This led researchers to look for a change in steroid hormone receptor concentrations as the mechanism for the uncoupling of progesterone's activity in the myometrium.
Estrogen is also found to stimulate and increase in prostaglandin production and an increase in oxytocin receptors in the myometrium to estrogen.
http://molecularlabor.blogspot.com

  
 Multiple Trp Isoforms Implicated in Capacitative Calcium Entry Are Expressed in Human Pregnant Myometrium and ...
hTrp6 from human myometrium all exhibited 100% identity to the
65 kDa in human myometrium and 66 kDa in PHM1 cells, similar
Multiple Trp Isoforms Implicated in Capacitative Calcium Entry Are Expressed in Human Pregnant Myometrium and Myometrial Cells -- Yang et al.
http://www.biolreprod.org/cgi/content/full/67/3/988

  
 The Activin-Follistatin System in the Neonatal Ovine Uterus -- Hayashi et al. 69 (3): 843 -- Biology of Reproduction
Collectively, the results of the present study support our working
had increased in the periglandular stroma and myometrium.
endometrial stroma and myometrium between PND 21 and PND 56.
http://www.biolreprod.org/cgi/content/full/69/3/843

  
 Endometrial Carcinoma
Residual non-neoplastic endometrium (absent, unremarkable, atrophy, simple hyperplasia with or without atypia, complex hyperplasia with or without atypia, polyp, radiation changes):
If the tumor is a sarcoma or a MMMT, report the number of mitoses per 10 high power fields and the total number of fields counted.
Lower uterine segment invasion (no invasion, mucosal invasion only, stromal invasion only, both mucosa and stroma involved):
http://www.peacefulpackers.com/informatics/m01_54.htm

  
 Placental Pathology
This is placenta accreta, which will result in lack of normal separation at delivery, leading to marked hemorrhage necessitating emergency hysterectomy.
The classification of placental invasion into myometrium is as follows:
Microscopically, the placental villi interdigitate directly with uterine myometrium, without an intervening decidual plate.
http://www-medlib.med.utah.edu/WebPath/PLACHTML/PLAC070.html

  
 UMIC: News & Announcements
Geimonen, E., Boylston, E., Royek, A., Anderson, J. Elevated Connexin-43 Expression in Term Human Myometrium Correlates with Elevated c-Jun Expression and Is Independent of Myometrial Estrogen Receptors.
http://www.umic.sunysb.edu/news.htm

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