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| | Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice |
 | | To elucidate the role of cardiac myosin-binding protein-C (MyBP-C) in myocardial structure and function, we have produced mice expressing altered forms of this sarcomere protein. | | | Homozygous mice bearing mutated MyBP-C alleles are viable but exhibit neonatal onset of a progressive dilated cardiomyopathy with prominent histopathology of myocyte hypertrophy, myofibrillar disarray, fibrosis, and dystrophic calcification. | | | Echocardiography of homozygous mutant mice showed left ventricular dilation and reduced contractile function at birth; myocardial hypertrophy increased as the animals matured. |
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http://cardiogenomics.med.harvard.edu/publication-detail?publication_id=373
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| | Cardiac Proteomics & Signaling Laboratory - Guang-Wu Wang, M.D., Ph. D. |
| | Wang GW, Baines CP, Gu Y, Prabhu SD, Bhatnagar A, Ping P. Chronic exposure induces myocardial dynsfunction, myofibril disarray, and cardiomyocyte apoptosis in the mouse. | | | Wang GW, Kang DR, Yang Q, Wang F. Changes of NADH-methemoglobin reductase activity in erythrocytes of rats fed on grains from Keshan Disease area and the influence of selenium and vitamin E, B1. | | | Wang GW, Zhao YZ, Wang F. Effect of selenium on cumene hydroperoxide-induced DNA damage in cultured cardiomyocytes. |
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http://www.signalingmodules.org/people/wang.html
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