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| | Myelin Repair Foundation for Multiple Sclerosis |
 | | Myelin is the protective insulation surrounding nerve fibers of the central nervous system (the brain and spinal cord). | | | MS symptoms result when inflammation and breakdown affect myelin. | | | Scientists believe that overcoming this blockage and allowing the body to function as designed (remyelinate) is more straightforward than trying to induce an entirely foreign process or mechanism. |
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http://www.myelinrepair.org/faq.html
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| | The Myelin Project: June 2004 Progress Report |
| | Although these cells do not normally make myelin, they are able to do so when transplanted to areas of demyelination in the brain or spinal cord, as shown by Dr. Franklin’s previous work in rats. | | | As you know, The Myelin Project is based on a spirit of private initiative—most of our funds are contributed from families struck by one myelin disease or another. | | | Ian Duncan of the University of Wisconsin-Madison and his research associate Dr. Abdelmadjid Belkadi report further progress in their experiment involving transplantation of oligodendrocyte progenitor cells (OPCs) into the myelin-deficient (md) rat, a strain that is born without myelin, and serves as a model for both PMD and some aspects of MS. |
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http://www.myelin.org/06072004.htm
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| | FuturePundit: Stem Cell Therapy Replaces Missing Myelin In Mouse Brains |
| | Given that myelin, like everything else, deteriorates with age the ability to even partially repair it with a stem cell therapy would even offer some prospects for improving cognitive function in the aged. | | | When babies are born, many of their nerves lack mature myelin sheaths, so their movements are gross, jerky, and uncoordinated. | | | Is there no prventative or constructive medicine to improve my myelin within my body system. |
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http://www.futurepundit.com/archives/001901.html
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| | Adrenoleukodystrophy and Myelin: Where's the Connection? |
| | This excerpt from their mission statement sums up their goals concerning the task at hand and their methods for creating a solution: "Behind The Myelin Project is a multinational gathering of families struck by one demyelinating disease or another. | | | Because they have gathered such an extensive group of researchers who share similar ideas and beliefs concerning the practice both of medicine and research, they have been able to make progress at a very promising pace. | | | In the last decade there has been some amazing research done in conjunction with this disease and the few others who, like it, occur as a result from the breakdown or loss of myelin in the brain. |
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http://serendip.brynmawr.edu/bb/neuro/neuro99/web3/Kirbyglatkowski.html
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| | A Look at Myelin and Myelin-Related Disorders |
| | The characteristics and specific functions of myelin have not fully been explored by researchers, and as far as I can tell most current research efforts are initiated by groups that research myelin-related disorders, such as the Myelin Profect. | | | As we have seen, the production, make-up and functions of myelin are very complex, and they are interrupted in very specific ways in myelin-related disorders, some of which were described here. | | | These different ways of affecting the myelin lead to different symptoms in the patient, which explains the multitude of demyelinating disorders that have so far been identified These different disorders often have very fine distinctions. |
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http://serendip.brynmawr.edu/bb/neuro/neuro01/web1/Blumenfeld.html
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| | Serial MR Imaging of Experimental Autoimmune Encephalomyelitis Induced by Human White Matter or by Chimeric ... |
| | Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant. | | | Adoptive transfer of experimental allergic encephalomyelitis: recipient response to myelin basic protein-reactive lymphocytes. | | | Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease. |
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http://www.ajnr.org/cgi/content/full/20/6/965
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| | Myelin Project UK. Multiple Sclerosis, Leukodystrophy Research |
| | The Myelin Project directs research into therapies for all demyelinating diseases and every year, brings the top Researchers/Scientists/Specialists/Laypeople from around the world together in hopes of accelerating, promoting and networking research and myelin repair. | | | The Myelin Project: Researching therapies for demyelinating diseases, ( | | | The Myelin Project is an international charity founded by Augusto and Michaela Odone, who pioneered Lorenzo's Oil for the treatment of Adrenoleukodystrophy (ALD) after their son, Lorenzo Odone was stricken with the affects of ALD. |
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http://www.myelinproject.co.uk
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| | Myelin Repair Foundation for Multiple Sclerosis - Newsroom |
| | By working on a common research plan, sharing their findings in real time, and piggybacking experiments that might otherwise have taken years to accomplish, the scientists have been able to considerably accelerate their research. | | | When it comes to helping Americans lead healthier lives and get the care they need, the Foundation expects to make a difference in your lifetime. | | | September 21, 2005 – Saratoga, CA -- The Myelin Repair Foundation (MRF) announced today that it has been awarded a three-year, $1.2 million grant from the Robert Wood Johnson Foundation (RWJF) to further develop an innovative research model that may be able to speed the process of scientific discovery to medical treatment. |
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http://www.myelinrepair.org/newsroom.html
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| | National MS Society Sourcebook: Myelin |
| | Scientists have discovered that the body heals some lesions naturally, by stimulating oligodendrocytes in the area, or recruiting young oligodendrocytes from further away, to begin making new myelin at the damaged site. | | | The CNS (the brain, spinal cord and optic nerves) is made up of several different components: | | | Eventually, therapies may be developed to stop these components of myelin from inhibiting the repair process. |
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http://www.nationalmssociety.org/Sourcebook-Myelin.asp
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| | Myelin - Wikipedia, the free encyclopedia |
| | The immune system may play a role in demyelination associated with such diseases. | | | Demyelination is a loss of myelin and is the root cause of symptoms experienced by patients with diseases such as multiple sclerosis and transverse myelitis. | | | These techniques include surgically implanting oligodendrocytes in the central nervous system and inducing myelin repair with certain antibodies. |
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http://en.wikipedia.org/wiki/Myelin
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| | Medical Glossary - Multiple Sclerosis Society of Auckland, New Zealand |
| | Destruction of myelin, resulting in disruption in the flow of messages between the brain, spinal cord and other parts of the body. | | | The core nerve fiber extending from a cell body which is protected by the myelin sheath. | | | Research is currently under way to find a way to speed the healing process. |
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http://www.msakl.org.nz/glossary.htm
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| | Myelin and Brain Development Section |
| | Our Section does research on glycoproteins and glycolipids related to myelination and disorders of myelin. | | | MAG is important for a signaling pathway from Schwann cells to axons in the PNS that is essential for the normal maintenance of myelinated axons. | | | The overall goal is to determine the molecular mechanisms by which MAG mediates glia-axon interactions. |
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http://intra.ninds.nih.gov/Lab.asp?Org_ID=28
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| | The Myelin Project: What does the future have in store for MS patients |
| | This problem only applies to persons who have had MS for a long period of time and have no surviving axons. | | | The completion of the Myelin Project will be beneficial to all persons possessing demyelinating diseases such as multiple sclerosis. | | | The Myelin Project looks promising for the future of MS patients and others suffering with demyelinating diseases. |
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http://www.texarkanacollege.edu/~mstorey/piazza.html
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| | Myelin components |
| | Associated with clustering of voltage-gated Na channels at nodal axolemma | | | Carbohydrate epitope may be involved in homophilic cell-cell interactions | | | Stabilizes contacts between myelinating axons and glial processes |
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http://www.neuro.wustl.edu/neuromuscular/lab/schcell.html
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| | Myelin Research News |
| | Within two months, these rats began to show significant improvements in walking ability in comparison to injured rats who received no treatment. | | | Regards, Seung Kim, MD posted by CMRI at 10:54 AM | | | In the study, the researchers took cells called special cells called glial-restricted precursors from the spinal cords of embryonic rats. |
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http://www.myelinresearch.com
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| | Myelin |
| | To find more information on specific conditions, please visit our partner sites: | | | The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. | | | Myelin is an insulating layer that forms around nerves. |
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http://www.healthscout.com/ency/1/002261.html
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| | External Components of a Neuron - Myelin Sheath |
| | The symptoms are determined by the functions normally contributed by the affected neurons. | | | Disruption of muscle control, speech, and visual disturbances are common. | | | The glial cells forming myelin sheaths are called oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system. |
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http://psych.athabascau.ca/html/Psych402/Biotutorials/2/myelin.shtml
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| | myelin -- Encyclopædia Britannica |
| | Gliomas may form in the retina of the eye, in the brain, in the heart, in the myelin sheaths of nerves (neurilemmoma), and occasionally in the sinus, where the tumour has been derived from the olfactory bulb of the brain. | | | Information on this genetic disease characterized by a loss of myelin surrounding nerve cells in the brain and progressive adrenal gland dysfunction. | | | The myelin sheath is deposited by Schwann cells in layers surrounding the nerve fibres of the central and peripheral nervous systems of many organisms. |
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http://www.britannica.com/eb/article-9054530
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| | British Trust for the Myelin Project - Objectives - introduction. |
| | Backed by the families and friends of people battling the many myelin diseases, we focus public and scientific attention on the single problem common to all these diseases. | | | Myelin, the white matter insulating the nerves, allows the conduction of impulses from one part of the body to another. | | | It can be destroyed by acquired diseases such as Multiple Sclerosis and in hereditary metabolic disorders such as Leukodystrophies. |
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http://www.myelinprobritish.demon.co.uk/geninfo/objectives.htm
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| | MS is AUTOIMMUNE so why isn't ALD? Does Ahlzeimer's Have Similar Concerns? |
| | Myelin allows for the smooth, high-speed transmission of electrochemical messages between the brain, the spinal cord, and the rest of the body. | | | This is followed by destruction of myelin, the fatty covering that insulates nerve cell fibers in the brain and spinal cord. | | | Myelin is the layer that forms around nerves. |
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http://home.gci.net/~blessing/pages/myelin.htm
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| | The Myelin Project: Home |
| | Myelin is produced by specialized cells: oligodendrocytes in the central nervous system, and Schwann cells in the peripheral nervous system. | | | Hope for Multiple Sclerosis, the Leukodystrophies, and other Myelin Disorders | | | ...an international grassroots organization whose mission is to accelerate medical research on myelin repair. |
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http://www.myelin.org
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| | Myelin-Associated Glycoprotein Demonstrated Immunocytochemically in Myelin and Myelin-Forming Cells of Developing Rat ... |
| | The unlabeled peroxidase-antiperoxidase method has been used with antiserum against ``myelin-associated glycoprotein'' to establish the presence of the glycoprotein in myelin and myelin-forming cells of the developing rat nervous system. | | | Myelin-Associated Glycoprotein Demonstrated Immunocytochemically in Myelin and Myelin-Forming Cells of Developing Rat | | | Myelin-Associated Glycoprotein Demonstrated Immunocytochemically in Myelin and Myelin-Forming Cells of Developing Rat -- Sternberger et al. |
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http://www.pnas.org/cgi/content/abstract/76/3/1510
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| | myelin - multiple sclerosis encyclopaedia |
| | It seems likely from animal models of multiple sclerosis (experimental autoimmune encephalomyelitis) that initial relapsing-remitting phases of the disease centre on one antigen component, perhaps of myelin basic protein, but that, as the disease progresses, antigens from other proteins become involved. | | | Myelin occurs in both the Central Nervous System (CNS) and the Peripheral Nervous System (PNS) but the cells that produce the myelin differ. | | | This means that the sodium and potassium ions that contribute to the resting potential do not have far to move when the action potential occurs. |
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http://www.mult-sclerosis.org/myelin.html
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| | Canavan Research Foundation |
| | We spearheaded the world's first trial of gene therapy in the brain in 1996 and demonstrated the first ever regrowth of myelin in a deteriorating disease. | | | Our mission is to found and support research to cure Canavan Disease and other genetic brain diseases. | | | We have been on "Sixty Minutes" and the "CBS Morning Show," have been featured in The New York Times and TIME Magazine, and have published research results in numerous scientific journals. |
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http://www.canavan.org
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| | Pfam 18.0 : Myelin_MBP |
| | Myelin basic protein (MBP) MEDLINE:1710177, MEDLINE:1710279 is a hydrophilic protein that may function to maintain the correct structure of myelin, interacting with the lipids in the myelin membrane by electrostatic and hydrophobic interactions. | | | In mammals various forms of MBP exist which are produced by the alternative splicing of a single gene; these forms differ by the presence or the absence of short (10 to 20 residues) peptides in various internal locations in the sequence. | | | The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction MEDLINE:2435734. |
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http://pfam.wustl.edu/cgi-bin/getdesc?acc=PF01669
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| | Intraoperative values of S-100 protein, myelin basic protein, lactate, and albumin in the CSF and serum of ... |
| | Intraoperative values of S-100 protein, myelin basic protein, lactate, and albumin in the CSF and serum of neurosurgical patients | | | Intraoperative values of S-100 protein, myelin basic protein, lactate, and albumin in the CSF and serum of neurosurgical patients -- de Vries et al. | | | To assess the concentrations of S-100 protein, myelin basic protein (MBP), and lactate, and the (CSF)/serum albumin ratio |
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http://jnnp.bmjjournals.com/cgi/content/abstract/71/5/671
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| | World of MS - MS - The Disease - Demyelination |
| | Demyelination is the term used for a loss of myelin, a substance in the white matter that insulates nerve endings. | | | Myelin helps the nerves receive and interpret messages from the brain at maximum speed. | | | When nerve endings lose this substance they can not function properly, leading to patches of scarring, or ‘sclerosis’, occurring where nerve endings have lost myelin. |
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http://www.msif.org/en/ms_the_disease/demyelination.html
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| | Adrenoleukodystrophy; "Lorenzo's Oil" and Teaching |
| | Without a myelin sheath, nerve cells do not conduct action potentials; in essence, the neurons stop telling muscles to contract and the patient cannot move. | | | If you could isolate them, put them into the patient and cause them to make myelin, then this would restore patients to normal function. | | | However, the solubilizing effect of VLCSFAs may not be how they act (or it may not be all of the answer). |
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http://carbon.cudenver.edu/~bstith/loren.htm
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| | A gene therapy approach for treating T-cell-mediated autoimmune diseases -- Chen et al. 97 (4): 886 -- Blood |
| | Kerlero de Rosbo N, Mendel I, Ben-Nun A. Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)derived peptide: preliminary analysis of MOG T cell epitopes. | | | Myelin proteolipid protein-induced experimental allergic encephalomyelitis: variations of disease expression in different strains of mice. | | | Tolerance induction and autoimmune encephalomyelitis amelioration after administration of myelin basic protein-derived peptide. |
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http://www.bloodjournal.org/cgi/content/full/97/4/886
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| | WOMEN ON THE MOVE 1999 |
| | The beautiful seven-year-old girl was born without myelin in her brain, the white matter that insulates nerve cells and allows signals from the brain to be transmitted to parts of the body. | | | With Wayne by her side, Simmons started the Canadian Myelin Research Initiative (formerly the Myelin Project of Canada) to fund research to help Emmy and those with other forms of myelin disease like Lou Gehrig's disease and multiple sclerosis. | | | You can also contribute through your place of employment. |
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http://www.canoe.ca/LifewiseWorkWomen/simmons.html
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| | All About Multiple Sclerosis : MS news and information on diagnosis, symptoms & treatments |
| | It includes symptoms like optic neuritis, L'Hermittes sign, spasticity, fatigue etc., diagnostic procedures like the new diagnostic criteria, MRI, VEP, Babinsky's sign, etc., neurological things such as EDSS, lesion, myelin, neuron, brainstem, etc., acquired immunity, endothelium, EAE, etc., treatments such as Rebif, Copaxone, Betaseron/Betaferon, Avonex, Antegren, Campath-1H, 4-aminopyridine, Amantadine, etc. |
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http://www.mult-sclerosis.org
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| | Myelin Sheath Support - Nerve Tissue Support - Thread |
| | Myelin Sheath Support - Nerve Tissue Support - Thread | | | Subject: Myelin Sheath Support - Nerve Tissue Support | | | A comprehensive botanical preparation designed to support the fat-like insulating sheath (myelin) that surrounds certain nerve tissues. |
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http://vitanetonline.com/forums/3/Thread/482
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| | Autopathogenic T Helper Cell Type 1 (Th1) and Protective Th2 Clones Differ in Their Recognition of the Autoantigenic ... |
| | Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. | | | Myelin basic protein- specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from disease. | | | Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. |
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http://www.jem.org/cgi/content/full/186/6/867
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| | 2000 GRC on Myelin |
| | Hugo Moser (Baltimore) Human genetic disorders of myelin: Adrenoleukodystrophies. | | | Bob Skoff (Detroit) Myelin genes PLP and MBP are expressed in many tissues. | | | Marie Filbin (New York) Overcoming Inhibitors of Regeneration; Clues from Development. |
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http://www.grc.uri.edu/programs/2000/myelin.htm
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| | Pathology of a mouse mutation in peripheral myelin protein P0 is characteristic of a severe and early onset form of ... |
| | Pathology of a mouse mutation in peripheral myelin protein P0 is characteristic of a severe and early onset form of human Charcot-Marie-Tooth type 1B disorder -- Rünker et al. | | | Pathology of a mouse mutation in peripheral myelin protein P0 is characteristic of a severe and early onset form of human Charcot-Marie-Tooth type 1B disorder | | | Key Words: myelin P0 protein; myelin; peripheral neuropathies; tomacula; dominant-negative effects |
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http://www.jcb.org/cgi/content/abstract/165/4/565
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| | Myelin Disorders / Family Village |
| | It provides a communication network among families (and professionals that work with them) who affected by hypomyelination and myelin deficient disorders. | | | It also aims to increase awareness, find causes and treatments, and fund research. | | | A service for families, friends and professionals dealing with children's myelin related disabilities. |
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http://www.familyvillage.wisc.edu/lib_myel.htm
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| | Demyelinating Neuropathies |
| | Segmentally thickened or folded myelin sheath ± Tomaculous change | | | Thick myelin sheath relative to axon caliber: CMT 1A with PMP-22 duplication: Early stages of disease | | | Uncompacted myelin: Cytoplasmic aspects of Schwann cell membrane not apposed |
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http://www.neuro.wustl.edu/neuromuscular/nother/myelin.html
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