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| | txt001vka: Advances in the diagnosis and treatment of leprosy |
 | | Leprosy is a chronic infectious disease caused by Mycobacterium leprae that mainly affects the skin and peripheral nerves. | | | LEPRA is a UK-based medical development charity whose prime objective is to eradicate leprosy. | | | (1993) Combined multidrug and Mycobacterium w vaccine therapy in patients with multibacillary leprosy. |
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http://www-ermm.cbcu.cam.ac.uk/02004763h.htm
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| | Varalakshmi D. Vissa, Department of Microbiology, Immunology & Pathology |
| | leprae genome to develop reagents and techniques for application in a leprosy clinical setting. | | | As a member of the Leprosy research group at CSU, founded and headed by Dr. Patrick J. Brennan, there are several topics of research and clinical interest in our laboratory. | | | The approaches in our laboratory entail exploring and exploiting the M. |
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http://www.cvmbs.colostate.edu/mip/faculty/vissa.htm
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| | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND MYCOBACTERIUM LEPRAE CO-INFECTION: HIV-1 SUBTYPES AND CLINICAL, ... |
| | Detection of phenolic glycolipid I of Mycobacterium leprae in sera from leprosy patients before and after start of multidrug therapy. | | | Cellular immune response to Mycobacterium leprae infection in human immunodeficiency virus-infected individuals. | | | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND MYCOBACTERIUM LEPRAE CO-INFECTION: HIV-1 SUBTYPES AND CLINICAL, IMMUNOLOGIC, AND HISTOPATHOLOGIC PROFILES IN A BRAZILIAN COHORT -- PEREIRA et al. |
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http://www.ajtmh.org/cgi/content/full/71/5/679
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| | Mycobacterium leprae and Mycobacterium lepraemurium infections in domestic and wild animals |
| | Mycobacterium leprae, the aetiological agent of leprosy in humans, gives rise to a chronic granulomatous disease that affects primarily the skin and peripheral nerves, and secondarily some internal organs such as the testis and the eye; viscera are seldom involved. | | | The disease affects primarily viscera and the skin, and very rarely peripheral nerves. | | | Thus, in contrast to human leprosy, murine leprosy is not a zoonosis. |
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http://www.oie.int/eng/publicat/RT/2001/A_R2019.htm
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| | LEPRA - LEPROSY |
| | The centre is planned as a laboratory for providing services to patients, training to health workers and research in the areas of leprosy, TB and HIV/AIDS. | | | Action Programme for the Elimination of Leprosy, World Health Organization ``This homepage for the Action Programme (LEP) includes basic information on leprosy and its treatment. | | | The laboratory will assist the local district health authorities and private practitioners in the management of leprosy, TB and HIV/AIDS. |
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http://www.edae.gr/lepra.html
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| | Unité de Génétique Moléculaire Bactérienne |
| | Mycobacterium ulcerans is an emerging pathogen that causes Buruli ulcer, a chronic, necrotic skin lesion in humans, and has rapidly emerged as an important cause of morbidity around the world. | | | Parts of these studies were undertaken within the framework of the TB vaccine cluster | | | (86) describing in detail the clinical and pathological aspects of the Bairnsdale ulcer but also a new mycobacteria, Mycobacterium ulcerans, which they had identified as the causative agent of this disease. |
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http://www.pasteur.fr/recherche/unites/Lgmb/mycogenomics.html
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| | Active Skim View of: Appendix D-7: The Prospects for Immunizing Against Mycobacterium leprae |
| | The most significant social question will be whether the identification of an effective vaccine for leprosy and the development of suitable delivery systems can overcome the universal stigma associated with the disease. | | | This material may be derived from roughly machine-read images, and so is provided only to facilitate research. | | | Recent evidence suggests that some recombinant clones express antigens recognized by immune T-lymphocytes, and it will be important to develop means of introducing these potentially protective genes into a cultivable mycobacterium. |
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http://www.nap.edu/nap-cgi/skimit.cgi?isbn=0309036798&chap=241-250
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| | Malady of the Month Archives - Leprosy |
| | The disease mainly affects the skin, the peripheral nerves, mucosa of the upper respiratory tract and also the eyes, apart from some other structures. | | | Bacterial Leprosy is a chronic infectious disease caused by Mycobacterium leprae, an acid-fast, rod-shaped bacillus. |
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http://asylumeclectica.com/malady/archives/leprosy.htm
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| | Main Frame in Microbiology |
| | We therefore need drugs which will help the body to dispose of dead but still intact leprosy bacilli. | | | It is not unusual for solid-staining M. leprae to reappear for short periods in patients being successfully treated with drugs. | | | Two indices which depend on observation of M. leprae in smears from skin or nasal smears are useful in assessing the amount of infection, and the viability of the organisms and also the progress of the patient under treatment. |
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http://www.who.int/lep/disease/Microbiology/frmain.htm
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| | Detection of Mycobacterium leprae DNA by Polymerase Chain React |
| | Thirty eight patients with indeterminate leprosy (HI), at least 4 to 6 years after discharge from multibacillary (MB) or paucibacillary (PB) schemes of anti leprosy multidrug therapy (MDT), were submitted to traditional diagnostic procedures for leprosy and to polymerase chain reaction (PCR) analysis of different clinical samples for detection of Mycobacterium leprae DNA. | | | Key words: Mycobacterium leprae - PCR - diagnosis - therapy - post-treatment - paucibacillary leprosy | | | Overall, we feel that because of the high sensitivity of the assay, extreme care should be taken about association of PCR results, efficacy of treatment and disease status. |
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http://memorias.ioc.fiocruz.br/968/4285.html
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| | Discovery: The trisaccharide unit of the phenolic glycolipid-1 (PGL-1) (found in cell wall of Mycobaterium leprae) is ... |
| | With this new knowledge, techniques may be developed to better treat early neurological damage from leprosy. | | | In the paper, Role of the Cell Wall Phenolic Glycolipid-1 in the Peripheral Nerve Predilection of Mycobacterium leprae, Ng and his colleagues have discovered something new about the cell wall of this bacterium, which may result in developing better treatments for preventing its early damage to the nervous system. | | | The researchers concluded that PGL-1, the dominant glycolipid found in the cell wall of Mycobacterium leprae, is responsible for interacting with peripheral nerves and allowing bacterial invasion of Schwann cells. |
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http://www.owlnet.rice.edu/~ckchan/paper1.htm
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| | Specialty Laboratories ::: we help doctors help patients |
| | For test information, please call Specialty's Client Services at 800-421-4449. | | | DNA-PCR and RT-PCR for the 18kDa gene of Mycobacterium leprae to assess the efficacy of multi-drug therapy for leprosy. | | | Changes in the morphology of Mycobacterium leprae in patients under treatment. |
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http://www.specialtylabs.com/books/display.asp?id=395
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| | CRISP - Computer Retrieval of Information on Scientific Projects, Abstract Display |
| | These studies should provide important insights into the early molecular events of nerve damage in leprosy and other neurodegenerative diseases and will eventually lead to the development of novel therapeutics and diagnostics for peripheral neuropathies. | | | Abstract: DESCRIPTION (Adapted from the Applicant's Abstract): Mycobacterium leprae is unique among bacterial pathogens in its ability to invade the peripheral nervous system and to cause nerve damage, which accounts for the disabilities in leprosy patients. | | | The main theme of the application is to systematically identify the laminin-binding components of M. leprae that mediate the initial interaction with peripheral nerves and characterize their capacity to induce nerve damage. |
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http://crisp.cit.nih.gov/crisp/CRISP_LIB.getdoc?textkey=6532788&p_grant_num=5R01AI045816-04&p_query=&ticket=2988899&p_audit_session_id=14614905&p_keywords=
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| | Peripheral Neuropathy Pain Go Away |
| | Leprosy is caused by the bacterium Mycobacterium leprae, which attacks the peripheral nerves of affected people. | | | Other bacterial illness may set the stage for an immune-mediated attack on the nerves. | | | Leprosy is caused by the bacteria M. leprae, which directly attack sensory nerves. |
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http://www.neprinolenzyme.com/peripheral-neuropathy.htm
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| | Mycobacterium leprae |
| | leprae stains with carbol-fuchsin rather than with the traditional Gram staining method. | | | The bacterium was discovered in 1873 by a Norwegian physician named Gerhard Armauer Hansen. | | | In size and shape, it closes resembles M. |
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http://microbes.historique.net/leprae.html
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| | eMedicine - Leprosy : Article by Richard H Snyder, MD |
| | In response to increased incidence of dapsone resistance, the World Health Organization (WHO) introduced a multidrug regimen in 1982 that includes rifampicin, dapsone, and clofazimine. | | | Background: Leprosy, an infection caused by Mycobacterium leprae, primarily affects superficial tissues, especially the skin and peripheral nerves. | | | Cell-mediated immunity to M leprae is absent (anergic skin test) in the lepromatous form of disease but present in the tuberculoid form of disease. |
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http://www.emedicine.com/med/topic1281.htm
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| | Mycobacterium leprae |
| | This may cause loss of sensation, subcutaneous nodules and skin lesions. | | | The milder of the two forms, tuberculiod leprosy, causes loss of sensation of the skin and atrophy of the muscles, which often contracts the hand into a claw. | | | “
M. leprae may use linkage between the extracellular matrix and cytoskeleton through laminin-2 and Alpha-DG for its interaction with Schwann cells” (Rambukkana 1). |
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http://ctl.unbc.ca/outloud/docs/marko
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| | Mycobacterium leprae* |
| | M. leprae is not cytotoxic to the cells it infects, and establishes colonies in the peripheral nerves and skin (primarily). | | | Lepromatous leprosy is severe due to the almost complete absence of a cell mediated immune response and bacteria are found not only in skin and nerves, but are widely disseminated and found in almost every organ of the body. | | | While humans were long considered the only reservoir for the disease the finding that the organism can grow in the armadillo has led to speculation that there may be armadillo to human transmission in some parts of the world. |
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http://medinfo.ufl.edu/year2/mmid/bms5300/bugs/myclepr.html
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| | Infolep |
| | Mycobacterium leprae was discovered in 1873 when Gerhard Henrik Armauer Hansen demonstrated that rod-shaped bodies were directly related to the nodules of leprosy patients. | | | However, further scientific research on the mycobacterium has been hampered by the fact that, up to now, it has not been possible to culture the bacterium on an artificial medium. | | | Most of these organisms are inhabitants of soil, with the exception of two of the major pathogens: Mycobacterium leprae and Mycobacterium tuberculosis. |
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http://www.leprastichting.nl/infolep/pagina.asp?pagkey=35227
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| | Association of Mycobacterium leprae with Human Endothelial Cells In Vitro |
| | leprae may play an important role in the selective localization of this organism to peripheral nerve. | | | leprae with HUVEC are much slower than has previously been observed with macrophages, possibly due to differences in the binding of M. | | | Association of Mycobacterium leprae with Human Endothelial Cells In Vitro |
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http://info.med.yale.edu/labinvest/abstracts/00months/0005May/0005_663.html
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| | Leprosy, Hansen's Disease, Division of Microbiology and Infectious Diseases |
| | Leprosy (Hansen’s Disease), is a chronic infectious disease that primarily affects the peripheral nerves, skin, upper respiratory tract, eyes, and nasal mucosa. | | | Changes in immunity of the host and therapy can shift the clinical disease across the spectrum. | | | leprae are the superficial sites of the skin and peripheral nerves because of preference to survive at low temperatures. |
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http://www.niaid.nih.gov/dmid/leprosy
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| | Mycobacterium leprae - definition of Mycobacterium leprae in Encyclopedia |
| | It was discovered in 1873 by the Norwegian physician Gerhard Henrik Armauer Hansen, who was searching for the bacteria in the skin nodules of patients with leprosy. | | | Mycobacterium leprae, also known as Hansen& bacillus, is the bacterium that causes leprosy (now called Hansen's disease). | | | It has not been possible to culture Mycobacterium leprae on artificial culture media, but it can be cultivated transiently in the mouse footpad. |
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http://encyclopedia.laborlawtalk.com/Mycobacterium_leprae
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| | Title page for ETD etd-1109101-145509 |
| | Therefore, the neuropathy observed in leprosy is most likely due to an aggressive immune response to infection within the nerve and not direct effects of M. leprae upon the Schwann cell. | | | Globally, millions of leprosy patients suffer irreversible peripheral nerve damage resulting in blindness or other disabilities as a consequence of Mycobacterium leprae infection. | | | The mechanisms of nerve damage have not been fully elucidated but appear to be the direct result of M. leprae within Schwann cells or a combined effect with an aggressive immune response to M. leprae within the nerves. |
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http://etd.lsu.edu/docs/available/etd-1109101-145509
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| | mycobacterium |
| | leprae are hardly typical of the genus, and are consequently called 'wayward sons of honorable parents.' In recent years, with the ushering in of the antibiotic age, when penicillin is used to treat everything, new, drug-resistant forms of these pathogens have begun to emerge allowing both diseases to become serious threats to humanity once again. | | | With the emergence of antibiotic resistant strains of tuberculosis, research into mycobacteria has become all the more important in combatting these modern mutants of ancient pathogens. | | | A man with nodules on his face as the result of lepromatous leprosy. |
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http://biology.kenyon.edu/Microbial_Biorealm/bacteria/gram-positive/mycobacteria/mycobacteria.htm
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| | Pfam 19.0 : Myco_19_kDa |
| | Homologs of Mycobacterium leprae 18-kilodalton and Mycobacterium tuberculosis 19-kilodalton antigens in other mycobacteria. | | | Most of the antigens of Mycobacterium leprae and Mycobacterium tuberculosis that have been identified are members of stress protein families, which are highly conserved throughout many diverse species. | | | Most of the antigens of Mycobacterium leprae and M. tuberculosis that have been identified are members of stress protein families, which are highly conserved throughout many diverse species. |
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http://pfam.wustl.edu/cgi-bin/getdesc?name=Myco_19_kDa
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| | Leprosy (Hansen's disease). DermNet NZ |
| | Leprosy is a chronic bacterial infection with Mycobacterium leprae. | | | It primarily affects the skin, mucous membranes (e.g. | | | Home For patients For doctors Find a dermatologist About Store Contact Site map |
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http://www.dermnetnz.org/bacterial/leprosy.html
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| | Did the loss of two-component systems initiate pseudogene accumulation in Mycobacterium leprae? -- Tyagi and Saini 150 ... |
| | Mayuri Bagchi, G., Das, T. and Tyagi, J. Molecular analysis of the dormancy response in Mycobacterium smegmatis: expression analysis of genes encoding the DevR-DevS two-component system, Rv3134c and chaperone alpha-crystallin homologues. | | | Did the loss of two-component systems initiate pseudogene accumulation in Mycobacterium leprae? | | | Boon, C. and Dick, T. Mycobacterium bovis BCG response regulator essential for hypoxic dormancy. |
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http://mic.sgmjournals.org/cgi/content/full/150/1/4
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| | Mycobacterium leprae genome project |
| | The Sanger Institute sequenced Mycobacterium leprae in collaboration with the laboratory of Stewart Cole at the Unit de Genetique Moleculaire Bacterienne, Institut Pasteur. | | | leprae genome, combined with our own cosmid sequences. | | | Sequencing was funded by the Heiser Program for Research in Leprosy and Tuberculosis of The New York Community Trust, |
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http://www.sanger.ac.uk/Projects/M_leprae
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