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| | Molecular Mechanisms Involved in Muscarinic Acetylcholine Receptor-mediated G Protein Activation Studied by Insertion ... |
 | | The resulting increases in intracellular inositol monophosphate levels were determined as described under ``Experimental Procedures.'' The data are expressed as means ± S.E. and are representative of a single experiment carried out in triplicate; three to five additional experiments gave similar results. | | | The data are given as means ± S.E. of triplicate determinations in a single experiment; a separate experiment gave similar results. | | | The inositol monophosphate fraction was then isolated by anion exchange chromatography as described (Berridge et al. |
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http://www.jbc.org/cgi/content/full/271/11/6172
(6718 words)
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| | Single Nucleotide Polymorphisms of the Human M1 Muscarinic Acetylcholine Receptor Gene |
| | Many GPCRs have been found to contain single nucleotide polymorphisms (SNPs) that are involved in disease susceptibility or drug response (for a review, see reference | | | Although the muscarinic receptors are thought to contribute to certain neurological and psychiatric disorders, no sequence variations or alleles have been found that affect susceptibility to these diseases or response to muscarinic agonists. | | | Indeed, for the past 20 years, the cholinergic hypothesis has proposed that loss of cholinergic function is responsible for the cognitive symptoms of Alzheimer's. |
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http://www.aapspharmsci.org/view.asp?art=ps030431
(2027 words)
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| | OriGene - Antibodies - Muscarinic Acetylcholine Receptor M4 |
| | Muscarinic acetylcholine receptor M4 has been reported to be expressed in many regions of the rat brain, particu | | | The clinical relevance of this receptor is unknown. | | | However, mouse studies have linked it to adenylyl cyclase inhibition. |
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http://www.origene.com/antibody/TA200234.aspx
(182 words)
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| | Bioreagents.com: Muscarinic 2 Acetylcholine Receptor |
| | There are 5 subtypes (m1-m5) of the receptor that have a tissue specific pattern of expression. | | | The m2 receptor is localized primarily in cardiac tissue and is also expressed at low levels in the hippocampus, cortex, striatum, thalamus, basal forebrain, brainstem, lung, vas deferens and uterus. | | | The non-channel linked AChR that medicates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine. |
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http://www.bioreagents.com/index.cfm/fuseaction/products.print/Product/ma3-044
(226 words)
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| | Muscarinic Toxins (MT1, MT3, MT7) Available from Peptides International |
| | here are 5 subtypes (M1-M5) of muscarinic acetylcholine receptor belonging to the G protein-coupled receptor family that are expressed in mammalian brain. | | | MT1 has also been implicated as a tool for further investigation of Alzheimer’s research. | | | Muscarinic Toxin 7 (MTx7, MT7) is reported to be an M1 specific ligand. |
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http://www.pepnet.com/muscarinic.html
(331 words)
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| | Muscarinic acetylcholine |
| | ACM1_RAT : Chrm1 -- Muscarinic acetylcholine receptor M1. | | | ACM2_RAT : Chrm2 -- Muscarinic acetylcholine receptor M2. | | | ACM3_RAT : Chrm3 -- Muscarinic acetylcholine receptor M3. |
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http://www.gpcr.org/7tm/seq/001_001_001/001_001_001.SEQ.html
(304 words)
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| | Paxil Side Effects, Interactions and Information - Paxil on ThePills.info |
| | In receptor binding studies, paroxetine did not exhibit significant affinity for the adrenergic (alpha(1), alpha(2), beta), dopaminergic, serotonergic (5HT(1), 5HT(2)), or histaminergic receptors of rat brain membrane. | | | A weak affinity for the muscarinic acetylcholine receptor was evident. |
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http://paxil.thepills.info
(5786 words)
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