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| | Motor neurone disease - Wikipedia, the free encyclopedia |
 | | Skeletal muscles are innervated by a group of neurons (lower motor neurons) located on the ventral surface of the spinal cord which project to the muscle cells. | | | Around a third of all MND patients experiece labile affect, also known as emotional lability, pseudobulbar affect, or pathological laughter and crying. | | | Although previously described by other neurologists of the 19th century, it was Jean-Martin Charcot, a French neurologist, who suggested grouping together a number of disparate conditions all affecting the lateral horn of the spinal cord in 1869. |
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http://en.wikipedia.org/wiki/Motor_neurone_disease
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| | MOTOR NEURONE DISEASE-A Patient's Guide |
| | A common pattern of motor neurone disease is a loss of the spinal cord nerves causing stiffness and clumsiness of the legs and a loss of the nerves to the muscles in the arms causing weakness and shrinkage of the arm muscles. | | | Motor neurone disease refers to a group of conditions where the nerves that supply muscles degenerate. | | | While riluzole is not very effective for motor neurone disease, the fact that it works at all suggests that more powerful or effective medications will be developed in the future. |
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http://www.medic8.com/healthguide/articles/motorneuronedis.html
(1096 words)
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| | Motor neurone disease |
| | Motor neurone disease (MND) is a rare condition, which is caused by the breakdown of the nerve cells in the brain that control the muscles. | | | Unfortunately, there is currently no cure, and most people with MND die from it within a few years. | | | It affects the muscles used to move (voluntary muscles), but not the nerves dealing with sensation, so there is no numbness or pins and needles. |
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http://hcd2.bupa.co.uk/fact_sheets/html/motor_neurone_disease.html
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| | Motor Neurone Disease |
| | Generalised spasms and exaggerated reflexes indicate degeneration of the upper motor neurones. | | | Musculoskeletal and pressure pain associated with immobility and muscle cramp are the most common causes of pain. | | | These are nerves that lead from the spinal cord to the muscles of the body. |
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http://www.southerncross.co.nz/?6AA343B6-FAD0-48E4-8C9F-F4EA803A0FD7
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| | Motor Neurone Disease - Patient UK |
| | Most people with MND are cared for by a professional team which include neurologists, specialist nurses, physiotherapists, occupational therapists, dieticians, counsellors, etc. Each problem that arises needs to be assessed, and dealt with as far as possible by the relevant members of the team. | | | Motor nerves carry messages from the brain and spinal cord to muscles, and make the muscles contract. | | | This is the 'classical' MND, and symptoms tend to start in the hands and feet. |
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http://www.patient.co.uk/showdoc.asp?doc=23069193
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| | Amyotrophic lateral sclerosis - Wikipedia, the free encyclopedia |
| | Symptoms of upper motor neuron involvement include tight and stiff muscles (spasticity) and exaggerated reflexes (hyperreflexia) including an overactive gag reflex. | | | Health care professionals need to explain the course of the disease and describe available treatment options so that patients can make informed decisions in advance. | | | Now, scientists are trying to understand what mechanisms lead to a buildup of unneeded glutamate in the spinal fluid and how this imbalance could contribute to the development of ALS. |
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http://en.wikipedia.org/wiki/Amyotrophic_lateral_sclerosis
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| | mnd |
| | A number of other drugs are under development and the Kings College School of Medicine and Dentistry (KCSMD)/Institute of Psychiatry MND Care and Research Centre has taken a leading role in these. | | | In addition he will be applying new neurophysiological techniques to probe the balance between excitatory and inhibitory influences in the motor cortex. | | | The Tim Perkins MND Research Fund has also supported Dr Martin Turner (see picture above), a very able young clinical neurologist who is working with functional brain imaging. |
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http://www.iop.kcl.ac.uk/iop/prt/mnd.htm
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| | MOTOR NEURONE DISEASE |
| | Motor neurones are involved in nerve messages to muscles, which ‘make things happen’ such as, for example, moving your arm or leg or opening your mouth. | | | Certain things are thought to increase the risk of developing the condition. | | | Varying parts of the body may be affected. |
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http://www.mydr.com.au/?article=2287
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| | Motor Neurone Disease - Presentation |
| | It is also typical to find evidence of LMN and UMN features in the same limb, for example, leg muscle wasting and fasciculation in combination with increased muscle tone, exaggerated reflexes and an extensor plantar response. | | | Upper motor neurone (UMN) lesions in the motor cortex - resulting in degeneration in corticobulbar and corticospinal pathways: | | | Accordingly, clinical practice is guided by the opinions of experienced clinicians. |
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http://www.mndaust.asn.au/presentation.html
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| | eMJA: Motor neurone disease: a Pandora's box |
| | Uncertainty about the aetiology often creates added concern in MND patients with regard to heritability, as highlighted by the Personal Perspective article in this issue of the Journal (page 344). | | | Acknowledgements: Research support from the Motor Neurone Disease Research Institute of Australia is gratefully acknowledged. | | | Neurotrophic and immunomodulatory treatments likewise have shown little clinical benefit, while preliminary studies focusing on neuroprotective approaches (eg, with minocycline12) suggest promise. |
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http://www.mja.com.au/public/issues/178_07_070403/kie10067_fm.html
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| | The Health Report: 8 November 2004 - Motor Neurone Disease |
| | But whatever the name, there are about 1400 people in Australia with the condition, mostly in the age range 50 to 70. | | | Rod MacKenzie: We look for atrophy, or loss of muscle bulk, and then when we test the reflexes, we find that the reflexes are brisk. | | | There’s a few other drugs, Monocillin, which is an antibiotic which is also said to help. |
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http://www.abc.net.au/rn/talks/8.30/helthrpt/stories/s1139597.htm
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| | Motor Neurone Disease - Patient UK |
| | Their mission is to ensure that every single person affected by MND can secure the care and support they need and to promote research that will lead to effective treatments and a cure for MND | | | Dr Oliver spells out what the disease is, what the doctors will do, how to cope with the difficulties, what the future holds, and the role of carers and support agencies. | | | For sites and information on Evidence Based Medicine. |
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http://www.patient.co.uk/showdoc/438
(283 words)
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| | Motor neurone disease explained |
| | Increasing pressure on carers as the physical needs of the person with MND change. | | | For more information see Better Health Channel quality assurance page. | | | Disability Online home > Health Information > Health conditions > Bones muscles and joints > Muscles > Motor neurone disease explained |
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http://www.disability.vic.gov.au/dsonline/dsarticles.nsf/(Pages)/Motor_neurone_disease_explained?OpenDocument
(466 words)
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| | MND - Scottish Motor Neurone Disease Association |
| | Caters for the information needs of people with MND, families, carers and health and social care professionals. | | | We provide specialist care, information and fund research to ultimately improve the quality of life of people affected by MND. | | | We hope you find this site useful, if you have any outstanding questions or concerns please |
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http://www.scotmnd.org.uk
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| | Motor neurone disease awareness campaign launched |
| | "This important campaign delivers a message of hope and reinforces to the 1400 Australians with MND, their families and carers that they are not alone when it comes to dealing with this disease. | | | So, too, the Association's own constant efforts and this new awareness campaign will bear a great harvest of hope and practical help to all those who are directly affected by Motor Neurone Disease," Dr Wooldridge said. | | | Booklets on Motor Neurone Disease are now regularly given to people when they are first diagnosed with the disease and clinical guidelines have been the development that help ensure the better treatment and care of people with MND. |
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http://www.health.gov.au/internet/wcms/Publishing.nsf/Content/health-mediarel-yr1999-mw-mw99030.htm
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| | PDSG |
| | The lack of understanding and concern for his condition by those involved was very hurtful. | | | He was intelligent, ambitious and worked hard, but was also a very practical man and much-loved and admired by our families. | | | Unfortunately, it remains typical for those suffering with mental illness and brain disease. |
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http://www.pdsg.org.uk/caregiver_stories/motor_neurone_disease
(2078 words)
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| | Justgiving - The Great Chopper Adventure |
| | Established in 1979, the MND Association provides care and support for people with MND and their families; and funds vital research into causes, treatments and a cure for MND. | | | They strive to ensure that all those affected by MND can secure the care and support they need, whilst promoting research into causes and treatments. | | | The MND Association provides care and support to people with Motor Neurone Disease and to those who care for them. |
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http://www.justgiving.com/choppertour
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| | Motor neurone disease |
| | Neurones are cells that transmit data from the brain to the muscles, allowing us to move our limbs and breathe etc. MND is a disorder where these neurones degenerate to the point where the muscles weaken and movement is impaired. | | | Certain drug treatments may be available that can slow the progress of the disease, for example anti-glutamate drugs. | | | Some patients also find that their symptoms may be partially assuaged by alternative therapies such as acupuncture. |
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http://health.ninemsn.com.au/article.aspx?id=19149
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| | Amazon.com: Motor Neurone Disease (Experience of Illness): Books: IAN ROBINSON |
| | However in recent years a number of organizations have set up to support sufferers and their families and consequently, the public profile of the condition has changed dramatically. | | | Comprehensive Site Details Natural Health Options for Halting MND. | | | Motor Neurone Disease, also known as Lou Gehrig's disease, is one of the most difficult conditions to manage medically and socially. |
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http://www.amazon.com/exec/obidos/tg/detail/-/0415097118?v=glance
(670 words)
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| | Motor Neuron Disease |
| | Motor Neuron Diseases may affect the upper motor neurons, nerves that lead from the brain to the medulla (a part of the brain stem) or to the spinal cord, or the lower motor neurons, nerves that lead from the spinal cord to the muscles of the body, or both. | | | Motor Neuron Disease comprises a group of severe disorders of the nervous system characterized by progressive degeneration of motor neurons (neurons are the basic nerve cells that combine to form nerves). | | | This disease entry is based upon medical information available through the date at the end of the topic. |
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http://www.webmd.com/hw/health_guide_atoz/nord656.asp
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| | [No title] |
| | It aims to support parents, to bring about more public awareness of mucopolysaccharide diseases, and to promote and support research. | | | Provides counselling and funding for patients and their families. | | | The umbrella term embraces a broad spectrum of disorders due to deficiencies of one of a group of enzymes which degrade particular mucopolysaccharides and includes Hurler's Syndrome, Scheie's Syndrome, Hunter's Syndrome, Sanfilippo's Mucopolysaccharidoses, Morquio's Syndrome, Maroteaux Lamy's Disorders as well as other diseases. |
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http://www.imd.ie/g14x.htm
(796 words)
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| | Action Medical Research - Motor neurone disease |
| | Motor neurone death occurs in a variety of conditions including spinal muscular atrophy and Motor Neurone Disease (MND). | | | MND patients suffer a progressive muscle paralysis, the disease is invariably fatal and, so far, there is no way of preventing the process of nerve cell death. | | | This research should help in the future design of suitable forms of treatment for diseases such as MND. |
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http://www.action.org.uk/research_projects/grant/58
(121 words)
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| | BBC NEWS Health Medical notes Motor neurone disease |
| | Sometimes a muscle biopsy will be carried out so that a small sample of muscle can be examined under a microscope. | | | Motor neurone disease is a progressive fatal condition that causes muscle wastage. | | | The rate of progression of the disease, however, varies enormously from patient to patient. |
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http://news.bbc.co.uk/2/hi/health/medical_notes/1500231.stm
(405 words)
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| | MOTOR NEURONE DISEASE |
| | The weakness may start in the hand or leg, or may affect the muscles of the palate and throat (bulbar muscles). | | | Motor neurone disease is a disease of the nerve cells and fibres that control the muscles of the body. | | | Important emotional support can be provided for the sufferers and the family through a counsellor. |
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http://www.surgerydoor.co.uk/medical_conditions/Indices/M/motor_neurone_disease.htm
(640 words)
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| | Motor Neurone Disease |
| | One drug, riluzole, can improve life expectancy, with an increase in the survival at 18 months of around 35%. | | | Motor Neurone Disease (MND) is the third most common neurological degenerative disease in adults after Alzheimer's and Parkinson's Disease and has an incidence of 1 or 2:100,000. | | | Initial symptoms can be mild and transient with muscle twitching, cramps or stiffness without sensory symptoms. |
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http://www.listermedicalcentre.com/mnd.htm
(213 words)
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| | Motor Neurone Disease Association - Merseyside Branch |
| | We also liaise with health and social care professionals such as speech therapists, occupational therapists and the medical profession. | | | MND is an incurable condition that paralyses the muscles leaving people unable to do everyday things the rest of us take for granted. | | | This includes people with MND, their carers, family and friends. |
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http://www.mnda-merseyside.org.uk
(179 words)
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| | MND Association - Homepage |
| | Share the experience of living with MND and socialise with friends at our Spring Conferences. | | | Walk to D'Feet MND is a World Cup Winner | | | Read about Association Visitors - befriending people with MND |
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http://www.mndassociation.org
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| | Motor Neurone Disease Association |
| | SCIENTIFIC AREAS: Relevant research covers all basic, clinical and healthcare research of relevance to ALS and other neurodegenerative diseases which principally involve the destruction of motor neurons (such as Spinal Muscular Atrophy and X-linked Spinal and Bulbar Atrophy). | | | Other CNS or neuromuscular disorders will not be considered, unless relevance can be demonstrated. |
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http://www.weizmann.ac.il/RGP_open/postdoc/MNDA.html
(91 words)
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| | Motor Neurone Disease Association |
| | Your support will help us make a difference to the lives of those living with MND, their families and carers. | | | MND is a rapidly progressive, fatal illness that has no known cure. | | | The MND Association co-ordinates support, guidance and advice for people affected by MND, while promoting research into causes, treatments and a cure. |
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http://www.onrunning.com/runners_services/charity_description.asp?id=62
(123 words)
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| | THE MERCK MANUAL, Sec. 14, Ch. 183, Disorders Of The Peripheral Nervous System |
| | Each spinal nerve (in 31 pairs) emerges from a segment of the spinal cord as an anterior (ventral) motor root and a posterior (dorsal) sensory root. | | | In some disorders, the upper motor neurons from the motor cortex to the brain stem (corticobulbar tracts) or spinal cord (corticospinal tracts) are also involved; in others (bulbar palsies), cranial nerve motor nuclei in the brain stem (bulbar nuclei) are selectively affected. | | | When metabolic injury to the cell body alters axoplasmic nutrients, the most distal part of the nerve process is affected first, and axonal degeneration ascends proximally, producing the distal-to-proximal pattern of symptoms characteristic of metabolic neuropathies. |
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http://www.merck.com/mrkshared/mmanual/section14/chapter183/183a.jsp
(647 words)
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| | MND Welcome |
| | If you do have MND there is a lot of information on the web already and most of it is far more medically orientated than our site. | | | But put them all together and you have a disease that effectively makes the body waste away but usually leaves the intellect just fine. | | | So, someone with MND will still be able to cry from laughter at something really funny, but they may not be able to wipe away the tears. |
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http://www.mndanz.org.nz
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| | Brain & Spine Foundation - Motor neurone disease |
| | Brain and Spine Foundation - Motor neurone disease | | | Other organisations that may be able to help |
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http://www.brainandspine.org.uk/information/publications/brain_and_spine_booklets/motor_neurone_disease
(16 words)
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| | Motor Neurone Disease Research |
| | My simple advice is always to be positive and look to explore alternative medicines if it can provide some form of hope or opportunity in the face of this terrible disease. | | | This is not always easy to do or say, especially as MND progresses in a person, but the mind set and being mentally positive is I feel essential. | | | This work has been completed in a variety of ways. |
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http://www.mndresearch.com
(389 words)
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| | Motor Neurone Disease - Introduction |
| | (e) To encourage the interchange and dissemination of ideas, operational methods and research data, the arousing of interest and the development of awareness and an informed public opinion to promote the welfare of people living with MND and their carers. | | | The third publication is the clinical guide for health and medical professionals who | | | The Motor Neurone Disease Association of Australia (MNDAA) is the peak body for MND Associations in |
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http://www.mndaust.asn.au
(356 words)
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| | World Federation of Neurology Amyotrophic Lateral Sclerosis |
| | This web site is sponsored by the World Federation of Neurology Research Group on Motor Neuron Diseases to link researchers and clinicians worldwide with the goal of finding effective treatment and a cure for ALS. | | | The Alzheimer Research Forum's editorial staff researches and reports on the most recent advances of relevance to neurodegenerative disease research, and they are generously sharing this information on the WFN ALS website because of our common research interests. | | | Information is available about the WFN Research Group on Motor Neuron Diseases including membership and the journal. |
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http://www.wfnals.org
(221 words)
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| | Motor Neurone Disease Association |
| | It provides care and support for people with MND and their families, and funds vital research into causes, treatments and a cure for MND | | | The MND Association produces a wide variety of publications for anyone interested in MND. | | | The Association has around 100 staff, including 25 regional staff working with volunteers and families affected by MND out in the community. |
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http://www.netdoctor.co.uk/support_groups/006165.htm
(186 words)
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| | MND Victoria Home Page |
| | Treatment offers better quality of life for people with MND | | | Information is also available about Kennedy's Disease, a slower progressing form of motor neurone disease. | | | Motor Neurone Disease Association of Victoria No liability or responsibility is taken by the Association for any information or services that may appear on any linked web sites. |
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http://www.mnd.asn.au
(561 words)
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| | ALS MND Alliance - Home Page |
| | New research shows treatment offers better quality of life and longer survival for people with MND | | | ALS and MND are abbreviations for Amyotrophic Lateral Sclerosis and Motor Neurone Disease respectively. | | | ALS/MND is a neurological disease that affects over 350,000 of the world’s population, and kills over 100,000 every year. |
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http://www.alsmndalliance.org
(630 words)
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| | Motor Neurone Disease: Equipment |
| | You will find that many of the sites listed elsewhere in this document point to similar pages including information from drug companies, medical centres and the like. | | | Please let me know of any new and useful sites you discover by e-mailing me. | | | And, please, if you know of useful tools for those with MND, e-mail me now! |
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http://easyweb.easynet.co.uk/~paulgriffith/MND/mnd04.htm
(89 words)
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| | [No title] |
| | Motor Neurone Disease (MND) is the name given to a group of relatively rare disorders that affects the motor neurones in the brain and spinal cord. | | | Motor neurones are the nerves cells that control muscles. | | | Motor neurone disease is a disease of adulthood and it is most common among people aged 50 to 70 and is slightly more common in men than women. |
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http://www.nhsdirect.nhs.uk/he.asp?articleID=251
(142 words)
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| | ALS (motor neurone disease) |
| | Neurological dysfunction is a known complication of coeliac disease (gluten sensitivity). | | | 30 of 53 patients with neurological disease (ataxia, peripheral neuropathy, nononeuritis multiplex, myopathy, motor neuropathy) of unknown cause were found to have antibodies to the substance gliaden found in gluten. | | | This suggests that gluten sensitivity may be a significant causative factor in neurological diseases of unknown cause. |
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http://www.health-diets.net/research/ALS.htm
(283 words)
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| | Motor Neurone Disease |
| | in patients with motor neurone disease (ALS) because of clumping and condensation of chromatin in the dying anterior horn cells in ALS patients. | | | (A copy of the vitamin assays in 20 ALS patients and autoimmune disease in 16 ALS patients is available on request). | | | Motor Neurone Disease and the Life of Motor Neurones. |
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http://www.acnem.org/journal/16-1_december_1997/motor_neurone_disease.htm
(842 words)
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| | Transcript - Motor neurone disease |
| | Motor neurone disease inevitably kills but you may recall from the last story that American scientists are experimenting with a genetic manipulation technique that could arrest the disease. | | | It's a race between her disease on the one hand and the progress in the laboratory on the other. | | | Well, there has been a development — not a cure, but at least a glimmer of hope. |
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http://sixtyminutes.ninemsn.com.au/sixtyminutes/stories/2005_05_29/story_1398.asp
(657 words)
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| | Motor neurone disease - riluzole (No. 20) |
| | Routine supervision of therapy may be managed by general practitioners, but this should be under an agreement known as a shared care arrangement with the specialist. | | | Want to read our guidance on an illness or condition? | | | NICE has recommended that riluzole should be available for the treatment of individuals with MND in accordance with its licensed indications. |
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http://www.nice.org.uk/Cat.asp?c=14401
(194 words)
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| | [No title] |
| | One idea about disease mechanisms in MND is that too much glutamic acid is present in spinal cord and brain and that this may cause motor neurones to malfunction and eventually degenerate. | | | Batten Disease / Pediatric Storage Disorders laboratory (PSDL) | | | Motor Neurone Disease (MND) / Amyotrophic Lateral Sclerosis (ALS) |
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http://www.iop.kcl.ac.uk/iopweb/departments/home/default.aspx?locator=305
(141 words)
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| | Norhteast ALS Consortium--Links |
| | Forum for clinicians and researchers of motor neuron disease. | | | Researches genetic factors of ALS and creates disease models to aid treatment. | | | An organizing body for groups supporting the treatment of ALS. |
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http://hedwig.mgh.harvard.edu/alsconsortium/links.html
(111 words)
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| | Motor Neurone Disease Association of New South Wales |
| | To provide and promote the best possible support for people living with motor neurone disease, their families and carers, to advance research, and to raise awareness. | | | The blue cornflower has been adopted in most countries as the symbol of hope for the future for people living with Motor Neurone Disease – the hope that a treatment and cure will soon be found. | | | Motor Neurone Disease Association of New South Wales |
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http://www.mndnsw.asn.au
(78 words)
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| | MNDAWA - Motor Neurone Disease Association of WA |
| | MNDAWA - Motor Neurone Disease Association of WA • Home | | | It is a member of the Motor Neurone Disease Association of Australia. | | | The Motor Neurone Disease Association of Western Australia is a registered charity and support organisation. |
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http://www.mndawa.iinet.net.au
(123 words)
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| | Kent and Medway NHS > Motor neurone disease |
| | Offers information on the causes, symptoms and treatments of motor neurone disease, with links to organisations dedicated to the condition. | | | District nurses are responsible for assessing any nursing care you require at home and can be contacted through your GP. | | | The only national organisation in England, Wales and Northern Ireland dedicated to the support of people with MND and those who care for them. |
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http://www.kentandmedway.nhs.uk/disability/physical_disabilities/motor_neurone_disease.asp
(136 words)
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