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| | World Intellectual Property Organization |
 | | interfere with the analysis of morphinone, and none of these were quantitated using this method. | | | The method of claim 1, wherein the HPLC system comprises a first mobile phase adjusted to an apparent pH of about 6.5 to about 7.5. | | | 44 Percent of morphinone in the sample = 0.0005% Report the morphinone percent determined using the calculation above relating to percent morphinone Report as < LOQ (less than limit of quantitation) for result below the LOQ (0. |
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http://www.wipo.int/ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=05/16930.050224&ELEMENT_SET=DECL
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| | Alfentanil - Wikipedia, the free encyclopedia |
| | {Alfentanil} {Buprenorphine} {Carfentanil} {Codeine} {Codeinone} {Dextropropoxyphene} {Dihydrocodeine} {Endorphin} {Fentanyl} {Heroin} {Hydrocodone} {Hydromorphone} {Methadone} {Morphine} {Morphinone} {Oxycodone} {Oxymorphone} {Pethidine} {Remifentanil} {Sufentanil} {Thebaine} {Tramadol} | | | This page was last modified 13:32, 15 June 2005. |
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http://en.wikipedia.org/wiki/Alfentanil
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| | Biological Production of Semisynthetic Opiates Using Genetically Engineered Bacteria - Nature Biotechnology |
| | Here we describe the construction of recombinant strains of Escherichia coli that express morphine dehydrogenase and morphinone reductase. | | | French, C.E. and Bruce, N.C. Purification and characterisation of morphinone reductase from Pseudomonas putida M10. | | | French, C.E. and Bruce, N.C. Bacterial morphinone reductase is related to Old Yellow Enzyme and related eukaryotic proteins. |
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http://www.nature.com/nbt/journal/v13/n7/abs/nbt0795-674.html
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| | University of Leicester Biochemistry Department |
| | Morphinone reductase catalyses the saturation of the carbon-carbon double bond of the alkaloids morphinone and codeinone with oxidation of NADH on the pathway that converts morphine to hydromorphone. | | | (1997) Crystallisation and preliminary diffraction studies of morphinone reductase, a flavoprotein involved in the degradation of morphine alkaloids. | | | The closely related flavo-enzymes Morphinone reductase (from Psuedomonas putida M10) and PETN reductase (pentaerythritol tetranitrate reductase from Enterobacter cloacae PB2) have applications for both biotransformations and in sensors. |
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http://www.le.ac.uk/biochem/research/pcem1_r.html
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| | [No title] |
| | Morphinone (XI) is of interest, since it may be postulated that it is a biogenetic precursor of certain morphine alkaloids - e.g., morphine itself could be formed by reduction of (XI), codeine could be formed by reduction and methylation and thebaine would result by dehydrogenation and dimethylation (4). | | | Rapoport and his co-workers (5) have recently prepared this sensitive ketone (XI) by oxidation of morphine whose phenolic group was protected with a methoxymethyl group (IX), by means of silver carbonate in benzene. | | | Elution from the resin must be carried out under very-well-defined conditions in order to avoid the destruction of (XI) by alkali towards which it is extremely sensitive. |
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http://www.unodc.org/unodc/en/bulletin/bulletin_1959-01-01_3_page002.html?print=yes
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| | University of Leicester Depatment of Biochemistry |
| | [57] Crystallization and preliminary diffraction studies of morphinone reductase, a flavoprotein involved in the degradation of morphine alkaloids (1997). | | | [77] Structure and mechanism of an opiate-transforming enzyme: morphinone reductase. | | | [63] Reductive and oxidative half-reactions of morphinone reductase from Pseudomonas putida M10: a kinetic and thermodynamic analysis (1998). |
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http://www.le.ac.uk/biochem/staff/nss4/nss4_4.html
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| | ICPP98 Paper Number 1.6.5 |
| | putida, enzymatic activity was measured with morphinone, codeinone, neopinone and 2-cyclohexen-1-one as substrates [2]. | | | Temperature as an environmental signal plays an important role during the host-parasite interaction. | | | An approximately 40-kDa protein with an isoelectric point of 5.2 revealed significant sequence homology to morphinone reductase (MorB) of P. |
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http://www.bspp.org.uk/ICPP98/1.6/5.html
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| | PhD Project Details |
| | Projects available are of two general types, one is the determination of new structures, such as those of morphinone reductase and PETN reductase (flavoenzymes important for the biosynthesis of opiates and bioremediation of explosives), Nodl (involved in nitrogen fixation) and 'XAT' (involved in antibiotic resistance). | | | The other is the detailed examination of the interactions of interesting ligands with a protein for which the structure is already known, e.g.. | | | Collaborations exist with other members of the Department to study the structure and mechanisms of enzymes. |
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http://www.findaphd.com/search/showproject.asp?projectid=1488
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| | Codeinone - pillscatalog.net |
| | Codeinone can described as the methylether of morphinone: 3-Methyl-morphinone. | | | Codeinone can be also described as the Ketone of Codeine: Codein-6-on |
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http://www.pillscatalog.net/Codeinone.html
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| | Ps. putida |
| | Sequence analysis and structural characteristics indicated that morphinone reductase is related to the flavoprotein alpha/beta-barrel oxidoreductases, and is particularly similar to Old Yellow Enzyme of Saccharomyces spp. | | | Morphinone reductase was overexpressed in Escherichia coli, and has potential applications for the industrial preparation of semisynthetic opiates. | | | Expressed sequence tags from several plant species show high homology to these enzymes, suggesting the presence of a family of enzymes conserved in plants and fungi. |
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http://www.bionewsonline.com/m/1/pseudomonas_putida_c.htm
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| | Untitled |
| | ethyl) at the 14-position of morphinone greatly increases its agonist potency. | | | During the continuing study on potent and selective opioid receptor ligands, we have synthesized 14-(3'-phenylpropyl)-dihydrocodeinone, dihydromorphinone, their N-cyclopropylmethyl analogs and the corresponding indole derivatives by using a thebaine Diels-Alder reaction with phenyl vinyl ketone. | | | It has been found that the introduction of a simple alkyl group (i.e. |
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http://www.cpdd.vcu.edu/98abs/tian.html
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| | Opiates |
| | Other modifications include: pholcodeine a cough surpresant, morphinone a painkiller with 10* the potency of morphine, dextromehorphan the d-isomer of morphine which has no alalgesic properties but still retains cough suppressant properties and apomorphine which is a potent emetic. | | | Contempary herbal remedies have become a lot safer. |
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http://sis.bris.ac.uk/~rh9939/chem.html
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| | PHA 4220 - Neurology Pharmacotherapeutics |
| | Oxidation of the 6-OH to a ketone reduces activity when the 7,8-double bond is present (morphinone = 37% of morphine). | | | However, as shown below, when the 7,8-double bond is saturated, a 6-keto will increase activity. | | | Conversion of the 6-OH to a 6-OCH3, yielding heterocodeine, results in a six-fold increase in activity. |
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http://wiz2.pharm.wayne.edu/module/opioid.html
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| | Antinociceptive properties of two alkylating derivatives of morphinone: 14 beta-(thioglycolamido)-7,8-dihydromorphinone ... |
| | Antinociceptive properties of two alkylating derivatives of morphinone: 14 beta-(thioglycolamido)-7,8-dihydromorphinone (TAMO) and 14 beta- (bromoacetamido)-7,8-dihydromorphinone (H2BAMO) -- Jiang et al. | | | Articles by Jiang, Q. Articles by Bidlack, J. Antinociceptive properties of two alkylating derivatives of morphinone: 14 beta-(thioglycolamido)-7,8-dihydromorphinone (TAMO) and 14 beta- (bromoacetamido)-7,8-dihydromorphinone (H2BAMO) |
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http://jpet.aspetjournals.org/cgi/content/abstract/262/2/526
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| | Molecules To Go (Formerly known as Molecules R Us) |
| | First 100 lines from the PDB structure record... | | | HEADER OXIDOREDUCTASE 18-MAR-02 1GWJ TITLE MORPHINONE REDUCTASE COMPND MOL_ID: 1; COMPND 2 MOLECULE: MORPHINONE REDUCTASE; COMPND 3 CHAIN: A; |
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http://molbio.info.nih.gov/cgi-bin/moldraw?1GWJ
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| | [No title] |
| | Morphinone + NADH R03592 Morphine:NAD(P)+ 6-oxidoreductase; Morphine + NADP+ | | | Morphinone + NADPH R00734 L-Tyrosine:2-oxoglutarate aminotransferase; L-Tyrosine + 2-Oxoglutarate |
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http://www.infobiogen.fr/db/kegg/pathway/cgl/cgl00950.rn
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| | BLAST LBI |
| | 133 5e-30 gi2120681pirS64687 morphinone reductase (EC 1.-.-.-) - Pseu... |
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http://cancer.lbi.ic.unicamp.br/xanthomonas/campestris/2001-04-16/BLASTP_NF/20035.1.blastp.html
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| | BLAST Search at FIMO: 7004 |
| | 4fbe5fe6706976e5 of: pirP1;S64687 morphinone reductase (EC 1.-.-.-) - Pseudomonas putida tremblQ51990 MORPHINONE REDUCTASE. |
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http://www.tigem.it/RET/ret9/blastx/RET9H8.html
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