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Topic: Modafinil



  
 Modafinil - Wikipedia, the free encyclopedia
Dosage varies and the drug is more effective on patients who are using modafinil for the first time.
In some cases modafinil produces side-effects such as headache (13% of users), nervousness (8%), nausea (5%), rashes, and intestinal problems.
The half-life in the human body is about 15 hours.
http://en.wikipedia.org/wiki/Modafinil   (1139 words)

  
 MODAFINIL
Modafinil is an mind and mood enhancing stimulant that is not addictive, has no side effects and does not affect sleep
Modafinil is an eugeroic drug, (which simply means ‘good arousal’).
Modafinil does not bring about the anxiety, agitation and insomnia associated with these more familiar stimulants.
http://www.antiaging-systems.com/a2z/modafinil.htm   (426 words)

  
 MedlinePlus Drug Information: Modafinil (Systemic)
Modafinil does not cure these conditions and will only work as long as you continue to take it.
Mothers who are taking modafinil and who wish to breast-feed should discuss this with their doctor.
It is important that you use another method of birth control to avoid pregnancy during and for 1 month after modafinil therapy.
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203466.html   (1650 words)

  
 SignOnSanDiego.com > Sports -- IAAF to go after coaches in modafinil cases
Gyulai stressed that modafinil should not be viewed in the same light as the designer steroid THG, which has turned up in the samples of several track and field athletes.
Some of the athletes have been coached by Ukrainian-born coach Remi Korchemny, who is based in Castro Valley, Calif. He did not return repeated messages left by the AP this week.
LONDON – Track and field's world governing body plans to punish any coaches directly connected to the spate of positive tests among U.S. athletes for the stimulant modafinil.
http://www.signonsandiego.com/sports/20031028-1340-run-iaaf-drugs.html   (600 words)

  
 modafinil (Provigil) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
Modafinil treatment should be carefully monitored if taken with any of these drugs.
Other drugs, such as ketoconazole (Nizoral) and itraconazole (Sporanox) may reduce the effectiveness of modafinil.
There are no adequate studies that assess effects of modafinil in pregnant women.
http://www.medicinenet.com/modafinil/article.htm   (707 words)

  
 CERTIFICATE OF MEDICAL NECESSITY ADDENDUM FOR PROVIGIL (MODAFINIL)
The pharmacologic actions of modafinil coupled with the positive findings from these published clinical studies suggest PROVIGIL may be a viable adjunct therapy to CPAP to improve wakefulness in patients with residual EDS associated with OSA/HS.
Adler et al evaluated the safety and efficacy of PROVIGIL as adjunctive therapy for the treatment of EDS associated with PD in a randomized, double-blind, placebo-controlled, cross-over study involving 21 patients.
in modafinil treated group independent of CPAP use.
http://www.mentalhealthandillness.com/forms/pbmFormsAddendum.html   (3514 words)

  
 The Great Awakening (washingtonpost.com)
His modafinil study is the one that kept awake the helicopter pilots -- "normals without any pathological conditions," as he so clinically puts it.
As with an increasing number of the so-called superhuman, posthuman or trans-human drugs or genetic manipulations rapidly entering our lives, modafinil thus calls into question some fundamental underpinnings of hundreds of thousands of years of thought regarding what are normal human capabilities.
Nobody knows exactly how modafinil works, but researchers marvel at the way it seems to target very specific regions of the brain believed to regulate normal wakefulness.
http://www.washingtonpost.com/ac2/wp-dyn?pagename=article&node=&contentId=A61282-2002Jun16¬Found=true   (3626 words)

  
 CBC Sports Online: Drugs and Sport: Frequently Asked Questions on modafinil
She has claimed that she used the drug to treat hereditary narcolepsy and didn't apply for a medical waiver or include it on her doping control form in Paris because it wasn't on the prohibited drug list.
WADA has classified it as a performance-enhancing drug because it is believed to increase an athlete's alertness.
"And modafinil seems to have become a fashionable stimulant among certain athletes as well.
http://www.cbc.ca/sports/indepth/drugs/stories/modafinil_faq.html   (725 words)

  
 MedlinePlus Drug Information: Modafinil
Also tell your doctor if you have ever had chest pain, an irregular heartbeat, or other heart problems after taking a stimulant, and if you have or have ever had high blood pressure, a heart attack, angina (chest pain), mental illness, or heart, liver, or kidney disease.
It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.
Talk to your child's doctor about the risks of giving modafinil to your child.
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a602016.html   (1150 words)

  
 Hypothalamic Arousal Regions Are Activated during Modafinil-Induced Wakefulness -- Scammell et al. 20 (22): 8620 -- ...
Modafinil is an increasingly popular wake-promoting drug used for the treatment of narcolepsy, but its precise mechanism of
Modafinil produces clear increases in waking, whereas rats treated with vehicle have no increase in waking.
The purpose of our experiments was to define the pattern of neuronal activation induced by modafinil in rats.
http://www.jneurosci.org/cgi/content/full/20/22/8620   (6193 words)

  
 Wake Up, Little Susie - Can we sleep less? By David Plotz
The seduction of modafinil is that you can feel as peppy after six hours sleep as you would after nine.
What is clear is that modafinil differs from most other pick-me-ups, which tend to be indiscriminate in their function.
The drug is approved only for treating narcolepsy, and doctors are not going to prescribe it like aspirin anytime soon.
http://www.slate.com/id/2079113   (1605 words)

  
 Modafinil - Drugs & Vitamins - Drug Library - DrugDigest
Doses of your other medications may need to be adjusted or you may have to be monitored more closely.
Contact your pediatrician or health care professional regarding the use of this medicine in children.
You should never share or give your modafinil prescription to anyone else.
http://www.drugdigest.org/DD/DVH/Uses/0,3915,550410Modafinil,00.html   (946 words)

  
 Provigil (Modafinil Tablets) : Buy Provigil (Modafinil Tablets) at ABC Online Pharmacy
Provigil may also be used for other conditions as determined by your doctor.
Your doctor may need to change the doses of your medications or monitor you carefully for Provigil Modafinil Tablets (Alertec) side effects.
Call your doctor immediately if you have: chest pains, fast, pounding, or irregular heartbeat, shortness of breath, rash or hives, fever, sore throat, chills, and other signs of infection.
http://www.abconlinepharmacy.com/ns/customer/product2382-c-p1   (1200 words)

  
 Clinical Trial: Effects of Modafinil on Brain Function in Patients with Schizophrenia
During Week 3, medications will be crossed over in all participants (those given placebo in week 1 will receive modafinil, and vice versa).
Drug-induced changes in the catecholaminergic system can enhance some aspects of cognitive functions.
Catechol O-methyltransferase pharmacogenetics: photoaffinity labelling and western blot analysis of human liver samples.
http://www.clinicaltrials.gov/ct/show/NCT00057707?order=1   (831 words)

  
 Provigil 200mg -- stimulant / Prescription included with order
In Europe modafinil is most times prescribed instead of Ritalin because of its effectiveness.
Buy Vicodin Online, Modafinil, dihydrocodeine, or oxycodone (such as Tylox, Tylenol with Codeine, Vicodin), contact your doctor or pharmacist BEFORE TAKING THIS MEDICINE.
Buy medicines online like vicodin, hydrocodone, lorazepam, oxycodone.
http://www.pmbsc.org/provigil_stimulant   (187 words)

  
 Modafinil in Fibromyalgia Treatment
These mishaps represent naturalistic "on-off" experiments, supporting the immediate efficacy of modafinil.
We excluded 2 patients for comorbid secondary major depression (MD) until they went into full remission on their antidepressants, confirmed by two MD research scales, to remove the variable of modafinil antidepressant augmentation.7,8
Cochran JW: Effect of modafinil on fatigue associated with neurological illnesses.
http://www.fibromyalgiasupport.com/library/showarticle.cfm/id/3260   (760 words)

  
 Discovery Health :: Modafinil: The Ultimate Wake-up Pill?
Before modafinil, the heavy-hitter stimulants of choice for those combating the urge to snooze have been amphetamines such as Dexedrine.
They were given modafinil in one session and a placebo in the other.
In 1998, the Food and Drug Administration approved the prescription drug modafinil for the treatment of excessive daytime sleepiness in narcoleptics.
http://health.discovery.com/centers/sleepdreams/basics/wakeuppill.html   (464 words)

  
 Part III: Bright-Eyed and Bushy-Tailed - Modafinil, A Better Stimulant
The only way to be certain is through more research.
Modafinil has already been found useful in the treatment of narcolepsy.
It may also be helpful in treating other conditions such as Alzheimer's disease, because the neurons affected by it seem to be related to GABA.
http://www.cem.msu.edu/~cem181h/projects/98/sleep/part3.html   (392 words)

  
 APA: Provigil (Modafinil) Reduced Attention Deficit/Hyperactivity Disorder Symptoms
Taylor indicated that he and his colleagues initiated the study because some of their patients wanted an alternative therapy.
In addition, some patients do not respond to currently available therapies.
Results of the study demonstrated that an average daily dose of approximately 200 mg of modafinil produced a statistically and clinically significant reduction (30 percent or more) in the symptoms of ADHD as measured by the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) ADHD Behavior Checklist for Adults, compared to placebo.
http://www.docguide.com/dg.nsf/PrintPrint/65463A047727962B852568E30067C15D   (634 words)

  
 AAN: Modafinil (Provigil) Helps Sleepy Parkinson’s Disease Patients Stay Awake
The patient-rated Clinical Global Impression of Change (CGI-C), a secondary outcome measure, improved by 0.75 with modafinil treatment compared with 0.15 for placebo.
Adler said that the improvement in mean ESS score in Parkinson’s disease patients during modafinil treatment is similar to that which has been reported in narcolepsy patients.
Overall, seven (35 percent) patients reported definite improvement during modafinil treatment compared with one (five percent) patient during placebo treatment and two (10 percent) patients on both modafinil and placebo.
http://www.pslgroup.com/dg/1FA886.htm   (362 words)

  
 National MS Society Provigil (Modafinil)
or, any of the following drugs whose action or effectiveness might be affected by the modafinil:
Causes and types of MS-related fatigue, therapies, personal stories, and more.
There are no reports at the present time of the side effects associated with the use of this drug in the treatment of MS-related fatigue.
http://www.nationalmssociety.org/Meds-modafinil.asp   (793 words)

  
 Modafinil - the Scary Time-Shifting Drug @ Alice Hill’s Real Tech News - Independent Tech
However, as was mentioned above, modafinil is not a miracle and tolerance develops so that it becomes less effective after a while.
I have used modafinil and Ritalin to counter these sedative effects in several patients sucessfully.
“Marketed as Provigil ‘, ‘Aletec’ and ‘Vigicer’, Modafinil is a psychostimulant approved by the US Federal Drug Administration for improving wakefulness in patients with excessive sleepiness associated with shift work sleep disorder, obstructive sleep apnea / hypopnea syndrome and narcolepsy.
http://realtechnews.com/posts/1525   (1625 words)

  
 Modafinil receives expanded indication
As explained in a NewsRx.com wire story on the FDA action, “A tentative approval reflects FDA’s preliminary determination that a generic product satisfies the substantive requirements for approval, subject to the expiration of all statutorily improved non-approval periods.
Modafinil (Provigil—Cephalon) has received an expanded indication for improving wakefulness in patients with excessive sleepiness associated with obstructive sleep apnea (OSA) and shift work sleep disorder (SWSD).
Also, coadministration of modafinil and drugs that are substrates, inhibitors, or inducers of the cytochrome P450 isoenzymes may lead to reductions in plasma concentrations of modafinil.
http://www.medicalnewstoday.com/index.php?newsid=5644   (352 words)

  
 Erowid Modafinil (Provigil) Vault : Interactions & Contraindications
Support accessible drug information by Becoming an Erowid Member.
Because modafinil up-regulates CYP1A2, CYP2B6, and CYP3A4/5, the action of methadone may be substantially shortened.
Substances which are not listed below may still have significant and/or dangerous interactions with Modafinil.
http://www.erowid.org/smarts/modafinil/modafinil_interactions.shtml   (465 words)

  
 Technorati Tag: modafinil
MedlinePlus Drug Information: Modafinil: "Contents of this page: * Why is this medication prescribed?
A tag is like a subject or category.
Modafinil & Adrafinil - Research and Sources: "Modafinil and Adrafinil are the first of an entirely new class of pharmaceutical - the Eugeroics...
http://technorati.com/tag/modafinil   (434 words)

  
 NEJM -- Modafinil for Excessive Sleepiness Associated with Shift-Work Sleep Disorder
modafinil for treating sleepiness in patients with this disorder.
Modafinil for Excessive Sleepiness Associated with Shift-Work Sleep Disorder
Conclusions Treatment with 200 mg of modafinil reduced the extreme
http://content.nejm.org/cgi/content/abstract/353/5/476   (479 words)

  
 Anti Aging - Anti Aging Treatments ☼
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Articles on vinpocetine, milnacipran, deprenyl, ADD, piracetam, carnosine, NADH, pyritinol, tryptophan, Hydergine, metformin, nootropics, growth hormone, androstenedione, modafinil, GH3,
http://www.anti-aging-secrets.info/antiagingtreatments   (2417 words)

  
 CliniCareRx - Modafinil
Modafinil, like other stimulants, has the potential for abuse.
Modafinil is a stimulant used to prevent the excessive daytime sleepiness for people suffering with narcolepsy.
Note that discontinuation of Modafinil does not produce physical withdrawal symptoms.
http://www.clinicarerx.com/modafinil.asp   (135 words)

  
 Erowid Modafinil Vault (Provigil, Modavigil)
Modafinil is a mild central nervous system stimulant used in the treatment of fatigue and sleepiness.
It is approved in the U.S. for the treatment of narcolepsy.
http://www.erowid.org/smarts/modafinil/modafinil.shtml   (93 words)

  
 Modafinil Improves Recovery After General Anesthesia -- Larijani et al. 98 (4): 976 -- Anesthesia & Analgesia
by 71% of the patients receiving modafinil versus 18% of those
Modafinil Improves Recovery After General Anesthesia -- Larijani et al.
Copyright © 2004 by the International Anesthesia Research Society.
http://www.anesthesia-analgesia.org/cgi/content/abstract/98/4/976   (306 words)

  
 Ambient Irony: Ticky Tacky Sleep Compilers
You wake up feeling rested, you find it easy to concentrate, you feel like doing work.
It's not a stimulant; there's no high with modafinil.
As a sufferer of the dread 28-hour sleep cycle† I'm more than a little interested; as a cowardly chicken who ain't gonna take no nasty pills‡ I'm inclined to wait and see.
http://ambientirony.mu.nu/archives/2005/05/sleep_compilers.php   (603 words)

  
 Narcolepsy Internet Jumpstation
Minnasota Public Radio's September 1997 coverage of Narcolepsy, some of the research that Dr. Mignot is doing and some people who have to live with it.
A very brief review of narcolepsy and the effects of it on a persons daily life.
Describes at an extreamly simple level how Modafinil works.
http://www.narcolepsy.org/narc.links.html   (1907 words)

  
 Modafinil in the UK Ask MetaFilter
Two main differences: potency (100mg for M vs. 600mg for A) and Adrafinil has been associated with elevation of some liver enzymes if in some people, if you use it daily for some months.
It seems to do the same job as modafinil, although I haven't sampled modafinil.
You can order Adrafinil instead, which is the metabolic precursor of Modafinil.
http://ask.metafilter.com/mefi/19374   (238 words)

  
 Provigil Online, Description, Chemistry, Ingredients - Modafinil - RxList Monographs
Modafinil is a white to off-white, crystalline powder that is practically insoluble in water and cyclohexane.
For information on ordering Provigil Online, please click the "online pharmacy" link on the blue horizontal navigation bar at the top of every page.
Provigil Online, Description, Chemistry, Ingredients - Modafinil - RxList Monographs
http://www.rxlist.com/cgi/generic2/modafinil.htm   (103 words)

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