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| | eMedicine - 3-Beta-Hydroxysteroid Dehydrogenase Deficiency : Article by J Paul Frindik, MD |
 | | 3B HSD catalyzes the conversion of pregnenolone to progesterone (mineralocorticoid pathway), 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone (glucocorticoid pathway), and dehydroepiandrosterone to androstenedione (sex steroid pathway). | | | In this example, both the mineralocorticoid and glucocorticoid pathways are deficient. | | | Prognosis usually is good to excellent with adequate replacement glucocorticoid and mineralocorticoid (if needed) therapy and monitoring. |
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http://www.emedicine.com/ped/topic1051.htm
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| | Mineralocorticoids |
| | Another way to state this is that a small fraction of the mineralocorticoid response in the body is due to cortisol rather than aldosterone. | | | These phenomena are a direct result of loss of mineralocorticoid activity, and can largely be prevented by replacement of salts and mineralocorticoids. | | | Clearly mineralocorticoids are acutely critical for maintenance of life! |
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http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/adrenal/mineralo.html
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| | eMedicine - Hyperaldosteronism : Article by George P Chrousos, MD, FAAP, MACP, MACE |
| | Furthermore, bilateral adrenalectomy commits the patient to lifelong replacement therapy with glucocorticoids and mineralocorticoids. | | | Patients may need supplementation with mineralocorticoids for several months after successful surgery. | | | Secondary hyperaldosteronism can be distinguished clinically and biochemically from primary hyperaldosteronism. |
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http://www.emedicine.com/ped/topic1056.htm
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| | PERCORTEN®-V Product Information - Novartis Animal Health US, Inc. |
| | For use as replacement therapy for the mineralocorticoid deficit in dogs with primary adrenocortical insufficiency. | | | Results of two 75-day clinical studies in dogs with primary hypoadrenocorticism have demonstrated the clinical efficacy of PERCORTEN-V. Each dog received three doses of PERCORTEN-V (on days 0, 25 and 50). | | | Do not use this drug in pregnant dogs. |
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http://www.percorten.novartis.us/product_label/en/index.shtml
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| | Golestaneh, Mol Vis 2002; 8:221-225. |
| | Both the epithelial Na+ channel (ENaC) and the Na+/K+/ATPase pump were for instance found to be modulated by mineralocorticoids [4,5]. | | | Schafer JA, Hawk CT. Regulation of Na+ channels in the cortical collecting duct by AVP and mineralocorticoids. | | | Civan MM, Peterson-Yantorno K, Sanchez-Torres J, Coca-Prados M. Potential contribution of epithelial Na+ channel to net secretion of aqueous humor. |
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http://www.molvis.org/molvis/v8/a28
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| | Endotext.com - Adrenal Physiology And Diseases, Aldosterone Excess |
| | As a result of ineffective glucocorticoid synthesis, excess mineralocorticoids (such as 11-deoxycorticosterone) and androgens are produced as a result of shunting of precursors into blocked and unblocked pathways, respectively. | | | Mineralocorticoid-excess states (Table 2) comprise a group of disorders, logically separated into those mediated by the principle mineralocorticoid, aldosterone, and those caused by non-aldosterone etiologies. | | | BAH is best treated medically with the use of a mineralocorticoid receptor antagonist, eplerenone or spironolactone (46, 47). |
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http://www.endotext.org/adrenal/adrenal23/adrenal23.htm
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| | Congenital adrenal hyperplasia due to 11β-hydroxylase deficiency - Wikipedia, the free encyclopedia |
| | All of the issues related to virilization, neonatal assignment, advantages and disadvantages of genital surgery, childhood and adult virilization, gender identity and sexual orientation are similar to those of 21-hydroxylase CAH and elaborated in more detail in Congenital adrenal hyperplasia. | | | The mineralocorticoid effect differs: hypertension is usually the clinical clue that a patient has 11- rather than 21-hydroxylase CAH. | | | It also catalyzes the conversion of 11-deoxycorticosterone (DOC) to corticosterone in the mineralocorticoid pathway. |
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http://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia_due_to_11_beta-hydroxylase_deficiency
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| | Bioreagents.com: Mineralocorticoid Receptor |
| | Due to the extremely low levels of MR expressed in native tissues, it is recommended that enhanced detection systems be used for Western blotting such as enhanced chemiluminescence. | | | MA1-620 has been successfully used in Western blot, immunocytochemistry and immunohistochemistry procedures. | | | These compounds exert their effect through their interaction with the mineralocorticoid receptor (MR) and that complex's subsequent association with DNA. |
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http://www.bioreagents.com/index.cfm/fuseaction/products.detail/CatNbr/MA1-620
(276 words)
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| | ASN: Post Renal Transplant Hyperkalaemia and Metabolic Acidosis after Giving Cyclosporine May Be Associated with ... |
| | Peter J. Heering, MD, and colleagues from the University of Cologne, in Solingen, Germany, compared the level of expression of mineralocorticoids in peripheral leukocytes of renal transplant patients taking cyclosporine and healthy controls. | | | The level of expression of mineralocorticoid receptor in renal transplant recipients did not differ significantly between both groups with 172 molecules/0.5 mg RNA in acidotic patients versus 137 molecules/0.5 mg RNA in nonacidotic patients. | | | The level of mineralocorticoid expression in peripheral leukocytes was measured using quantitative reverse-transcriptase polychromatography specific for the mineralocorticoid receptor. |
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http://www.pslgroup.com/dg/22203e.htm
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| | MedlinePlus Medical Encyclopedia: Addison’s disease |
| | However, these drugs must usually be continued for life. | | | Medication may need to be increased during times of stress, infection, or injury. | | | The glucocorticoid hormones (such as cortisol) maintain glucose (sugar) regulation, suppress the immune response, and help the body respond to stress. |
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http://www.nlm.nih.gov/medlineplus/ency/article/000378.htm
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| | Cecil Textbook of Medicine : /> |
| | Click here for important legal information about Cecil Textbook of Medicine. | | | In renin-angiotensin-dependent disease, the mineralocorticoid is produced in response to the renin-angiotensin trophic signal. | | | This trophic signal is commonly encountered in states of contracted arterial volume such as congestive heart failure or cirrhosis with ascites. |
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http://www.merckmedicus.com/ppdocs/us/common/cecils/chapters/240_006.htm
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| | The Adrenal Gland |
| | Mineralocorticoids promote Na reabsorption in exchange for K | | | The terms glucocorticoid and mineralocorticoid, in vivo, are based on biological effects of the steroid hormones of the adrenal cortex. | | | This is why we see such mixed steroid effects when persons either abuse steroids or when they have to chronically take steroids for pharmacological reasons. |
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http://faculty.etsu.edu/currie/adrenal.htm
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| | ARS Publication request: INVOLVEMENT OF MINERALOCORTICOID AND GLUCOCORTICOID RECEPTORS IN GLUCOCORTICOID REGULATION OF ... |
| | In contrast, CORT treatment does not stimulate GH secretion on e16-e20, suggesting that regulation of GH production changes during embryonic development. | | | Technical Abstract: Research in our lab focuses on the regulation and differentiation of GH-secreting somatotrophs within the anterior pituitary gland during chicken embryonic development. | | | CORT effects on somatotroph induction on e12 involve both glucocorticoid receptors (GR) and mineralocorticoid receptors (MR), however this novel involvement of MR has not been evaluated at other ages. |
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http://www.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=176072
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| | AccessMedicine - Harrison's Internal Medicine: Hypoaldosteronism |
| | The treatment is to replace the mineralocorticoid deficiency. | | | However, patients with hyporeninemic hypoaldosteronism may require higher doses of mineralocorticoid to correct hyperkalemia. | | | This need poses a potential risk in patients with hypertension, mild renal insufficiency, or congestive heart failure. |
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http://www.accessmedicine.com/content.aspx?aID=98729
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| | Search Results for mineralocorticoid - Encyclopædia Britannica |
| | While cholesterol can be synthesized in many body tissues, further... | | | The biologic effect of aldosterone, the principal mineralocorticoid produced by the zona glomerulosa, is to set in motion a set of reactions at the cell surface of all body tissues in order to... | | | The anti-inflammatory and glucocorticoid activities of cortisol are enhanced, in some cases with relative reduction of its mineralocorticoid activity, by various structural modifications (). |
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http://www.britannica.com/search?query=mineralocorticoid&submit=Find&source=MWTAB
(299 words)
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| | Distribution of Glucocorticoid and Mineralocorticoid Receptors and 11{beta}-Hydroxysteroid Dehydrogenases in Human and ... |
| | Distribution of Glucocorticoid and Mineralocorticoid Receptors and 11ß-Hydroxysteroid Dehydrogenases in Human and Rat Ocular Tissues | | | Distribution of Glucocorticoid and Mineralocorticoid Receptors and 11{beta}-Hydroxysteroid Dehydrogenases in Human and Rat Ocular Tissues -- Stokes et al. | | | Arriza, JL, Simerly, RB, Swanson, LW, Evans, RM (1988) The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response Neuron 1,887-900 |
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http://www.iovs.org/cgi/content/full/41/7/1629
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| | Mineralocorticoid - Wikipedia, the free encyclopedia |
| | Mineralocorticoids is a class of steroids characterised by their similarity to aldosterone and their influence on salt and water metabolism. | | | If deficient in mineralocorticoids and glucocorticoids, Addison's disease occurs. | | | The only endogenous mineralocorticoid is aldosterone, although a number of hormones (mainly progesterone) have mineralocorticoid function. |
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http://en.wikipedia.org/wiki/Mineralocorticoids
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| | Gene mutation linked to hypertension during pregnancy |
| | It is especially puzzling since pregnancy typically lowers—not raises—blood pressure, yet six percent of childbearing women in the United States suffer the debilitating and sometimes fatal condition. | | | Researchers, who reported their findings in a recent issue of Science, suspected a mutation in the mineralocorticoid receptor might influence the way blood pressure builds, much like a spigot stuck in the "on" position too long. | | | Ultimately, researchers hope their findings about steroid receptors will provide insight into more common forms of high blood pressure as well as diabetes, thyroid disease, and prostrate and breast cancer. |
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http://www.genomenewsnetwork.org/articles/07_00/mutation_hypertension.shtml
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| | Reference.com/Encyclopedia/Adrenal gland |
| | Situated along the perimeter of the adrenal gland, the adrenal cortex mediates the stress response through the production of mineralocorticoids and glucocorticoids, including aldosterone and cortisol. | | | Notable effects of epinephrine and norepinephrine include increased heart rate, blood vessel constriction, bronchiole dilation, and increased metabolism, all of which are characteristic of the fight-or-flight response. | | | In response to increased potassium levels or decreased blood flow to the kidneys, cells of the zona glomerulosa secrete the mineralocorticoid aldosterone into the blood as part of the renin-angiotensin system. |
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http://www.reference.com/browse/wiki/Adrenal_gland
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| | IngentaConnect Effects of Aldosterone and Mineralocorticoid Receptor Blockade on... |
| | In an integrated view, mineralocorticoids seem to mainly effect intracellular electrolytes genomically to induce transepithelial transport, and induce nongenomically mediated alterations of cell function (e.g. | | | The present article summarizes both traditional and rapid effects of mineralocorticoid hormones on intracellular electrolytes, e.g. | | | Latter effects are almost immediate, reach a plateau after only 3 to 5 minutes and are characterized by high specificity for mineralocorticoids versus glucocorticoids. |
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http://www.ingentaconnect.com/content/klu/hrev/2005/00000010/00000001/00002347
(364 words)
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| | mineralocorticoid - OneLook Dictionary Search |
| | Mineralocorticoid, mineralocorticoid : Technical and Popular Medical Terms [home, info] | | | mineralocorticoid : The On-line Medical Dictionary [home, info] | | | mineralocorticoid : Dorland's Illustrated Medical Dictionary [home, info] |
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http://www.onelook.com/?w=mineralocorticoid&ls=a
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| | Decreased mineralocorticoid receptor expression in blood cells of kidney transplant recipients undergoing ... |
| | Median values are indicated for each group, and were significantly lower in patients undergoing immunosuppressive treatment, when investigated by cRT-PCR. | | | that cyclosporine A and FK 506 are able to induce mineralocorticoid | | | Figure 3 Distribution of patients and healthy volunteers by the expression level of mineralocorticoid receptor (hMR) in their blood cells detected either by (A) quantitative reverse transcription polymerase chain reaction (cRT-PCR) or (B) conventional receptor binding studies. |
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http://jcp.bmjjournals.com/cgi/content/full/57/1/33
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| | [No title] |
| | Binds to mineralocorticoid response elements (MRE) and CC transactivates target genes. | | | There are 2 forms of PHA1: CC the autosomal dominant form that is mild, and the recessive form CC which is more severe and due to defects in any of the epithelial CC sodium channel subunits. | | | CC -!- FUNCTION: Receptor for both mineralocorticoids (MC) such as CC aldosterone and glucocorticoids (GC) such as corticosterone or CC cortisol. |
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http://receptors.ucsf.edu/NR/seq/sw/MCR_HUMAN.SW
(1538 words)
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| | Mineralocorticoid Receptors and Hormones: Fishing for Answers -- Gilmour 146 (1): 44 -- Endocrinology |
| | in fact possible, what is the compound with selective mineralocorticoid | | | Bern HA, Madsen SS 1992 A selective survey of the endocrine system of the rainbow trout (Oncorhynchus mykiss) with emphasis on the hormonal regulation of ion balance. | | | A commercially available goat polyclonal antibody raised against the N-terminal region of the human MR together with an antigoat fluorescein isothiocyanate-conjugated secondary antibody were used to label trout gill sections (A). |
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http://endo.endojournals.org/cgi/content/full/146/1/44
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| | naturopathy |
| | Ulick S, Wang JZ, Blumenfeld JD, et al: Cortisol inactivation overload: a mechanism of mineralocorticoid hypertension in the ectopic adrenocorticotropin syndrome. | | | Williams GH: Guardian of the gate: receptors, enzymes, and mineralocorticoid function (editorial). |
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http://www.anma.com/monref53.html
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| | BLAST Search Results |
| | 417 e-114 gbM16801.1HUMMCR Human mineralocorticoid receptor mRNA (h... | | | 421 e-115 gbM36074.1RATMCR Rat mineralocorticoid receptor (MR) mRNA... |
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http://www.chickest.udel.edu/orthohuman/h50.html
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| | Professional Links |
| | Trune, D. Kempton, J. B., and Kessi, M. Aldosterone (mineralocorticoid) equivalent to prednisolone (glucocorticoid) in reversing hearing loss in autoimmune mice. |
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http://www.ncrar.org/publications.htm
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| | Mineralocorticoid receptor |
| | Please send any questions or comments about the Human Protein Reference Database to help | | | You are at: Home » Proteins » Mineralocorticoid receptor |
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http://www.hprd.org/protein/02991
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| | Signal Transduction - BioChemWeb.org |
| | The Nuclear Receptor Resource - A collection of individual databases on members of the steroid and thyroid hormone receptor superfamily (such as glucocorticoid, androgen, thyroid hormone and mineralocorticoid receptors). | | | The Olfactory Receptor Database (ORDB) - Database that "aims to house all of the known olfactory receptor and chemoreceptor sequences in both nucleotide and amino acid form." (Yale University) |
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http://www.biochemweb.org/signaling.shtml
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