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| | GiantVirus.org |
 | | The authors insist that their results should be interpreted with caution, and that the formal demonstration that Acanthamoeba polyphaga mimivirus is a bona fide human pathogen -that would make it the virus with the broadest host range - is not in yet. | | | The AAAATTGA motif may correspond to an ancestral promoter structure predating the radiation of the eukaryotic kingdoms. | | | Is Acanthamoeba polyphaga mimivirus also a human pathogen ? |
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http://www.giantvirus.org/news.html
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| | Gallileus - Biomedcentral Open Access Articles |
| | Lateral transfer (homing) might be responsible for the phylogenetic incongruence between inteins and exteins, and the same intein locations within homologues of distantly related organisms such as Mimivirus and archaea. | | | N4 motif is occasionally absent in the previously characterized active inteins [14]. | | | Accordingly the Mimivirus intein is a canonical "asparagine-type" intein, of which the close homologues have previously been observed only in archaea species. |
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http://www.gallileus.info/search/bmc_detail?id=1743-422X-2-8
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| | A MOMENT OF CLARITY - On Science |
| | I was recently referred to the March 2006 issue of Discover Magazine and the article "Unintelligent Design" by Charles Siebert, which explores the developing body of research on viruses and its influence on views of origins and evolution. | | | This theme is later reinforced using subtle, but leading terminology and dogmatic assertions. | | | Abstract: A review of the structure, function, and role of viruses in ecology is presented. |
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http://goldseth.blogspot.com
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| | Huge New Virus Defies Classification |
| | Although it will likely take time to generate any consensus for it, the researchers advocate a fourth branch of life for mimivirus, and any other giant viruses that may turn up. | | | Navigation: use the links below to view more comments. | | | Mimivirus is, however, like other viruses in that it is not able to convert energy or replicate on its own. |
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http://www.freerepublic.com/focus/f-news/1536753/posts
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| | Unintelligent Design and The Origin of Species - Asylum Forums |
| | But simple does not always mean less evolved. | | | While there is some evidence to suggest that it may have once caused a type of pneumonia in humans, Mimivirus now seems to infect only amoebas. | | | Asked why Mimivirus hadn't been discovered sooner, he says it may come down to the simple fact that we just haven't been looking. |
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http://www.asylumnation.com/asylum/_r/showthread/threadid_44482
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| | MedicalPost.com: ICAAC: Bacterial mimic now considered a human pathogen |
| | "These preliminary data are in favour of a possible role of mimivirus as a human pathogen," Dr. Raoult said. | | | The first characterization of mimivirus by Dr. Raoult and his colleagues in Marseille appeared in Science in 2003. | | | A French study showed similar results from patients with nosocomial pneumonia—that more patients (five of 26) seroconverted or had a fourfold rise in titre compared with controls (zero of 50). |
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http://www.medicalpost.com/mpcontent/article.jsp?content=20060220_172900_2324
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| | Virology Journal Full text Mimivirus relatives in the Sargasso sea |
| | To further assess the viral nature of these unknown microbes, we studied the phylogenetic relationships between the corresponding Mimivirus proteins, their Sargasso Sea homologues, and the closest homologues in other NCLDVs (see Materials and Methods). | | | To focus our study on environmental organisms most likely to be viruses, we limited further analyses to Mimivirus homologues member of the NCLDV core gene sets [2,6]. | | | Phylogenetic analyses also suggested that the Mimivirus lineage could have emerged prior to the individualization of cellular organisms from the three established domains, triggering a debate that can only be resolved by generating and analyzing more data. |
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http://www.virologyj.com/content/2/1/62
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| | Karsten Suhre homepage |
| | Mimivirus TyrRS: preliminary structural and functional characterisation of the first amino-acyl tRNA synthetase found in a virus. | | | Mimivirus phylogenomic profiling (part of PhD thesis work by Francois Enault). | | | Suhre K, Making molrep models EMBO practical course on automated macromolecular structure solution, Amsterdam, Netherlands, Mai 25-28, 2004 [invited talk]. |
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http://archimede.cnrs-mrs.fr/~suhre
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| | Futurismic: A Virus Made You |
| | There's a fascinating article at Discover about the Mimivirus, and what it suggests about the origin of life. | | | Evidence suggests that the Mimivirus, or similar as yet undiscovered viruses, are actually the precursors to all other forms of life. | | | The Mimivirus is a virus with a gene sequence orders of magnitude longer than other viruses. |
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http://www.futurismic.com/2006/02/a_virus_made_you.html
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| | Mimivirus in Pneumonia Patients CDC EID |
| | Serologic evidence of infection was observed in 5 (19.2%) of 26 ICU patients. | | | Mimivirus was found in bronchoalveolar lavage specimens from 1 of 32 patients with ICU-acquired pneumonia and none in specimens from 21 intubated control patients in ICU who did not have pneumonia (5). | | | DNA of Mimivirus was also found in the bronchoalveolar lavage specimens of patients with hospital-acquired pneumonia. |
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http://www.cdc.gov/NCIDOD/EID/vol11no03/04-0538.htm
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| | Journal Club - Spring 2005 |
| | What’s the relationship between Mimivirus and the three domains of life? | | | What’s the relationship between Mimivirus and other nucleocytoplasmic large DNA viruses(NCLDVs)? | | | How does Mimivirus distinguish itself from other dsDNA viruses? |
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http://statgen.ncsu.edu/journal_club/Spring_2005/post.php?topic=48&response_to=63
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| | Mimivirus: discovery of a giant virus |
| | Preliminary data suggest that it could be linked to pneumonia in humans. | | | Finally, some preliminary serological evidence (antibody levels) shows that Mimivirus could be linked to pneumonia. | | | This research was published in the magazine Science on March 28, 2003. |
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http://www.cnrs.fr/cw/en/pres/compress/mimivirus.htm
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| | GiantVirus.org |
| | 2)Yet, an analysis of the most similar homologs of mimivirus genes, as well as its pattern of loss of facultative NCLDV "core genes" does not suggest an affinity with one of the established NCLDV families. | | | The detailed analysis of mimivirus genome analysis brings about three different lines of evidence [3]. | | | The enzymatic activity of mimivirus tyrRS has been experimentally verified. |
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http://www.giantvirus.org/intro.html
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| | BBC NEWS Health 'World's largest virus' found |
| | The researchers who examined Mimivirus, from the National Centre for Scientific Research in Paris, France, said that blood samples from people with pneumonia had revealed antibodies for this virus, suggesting that their immune systems had come into contact with it at some point. | | | Although it has been linked to pneumonia in humans, it is in no way related to the SARS virus currently sweeping the Far East. | | | Amoebas, large single-celled organisms, are commonly found in air-conditioning systems in large buildings, and often harbour various bacteria and viruses inside them, which can go on to infect people working in those buildings. |
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http://news.bbc.co.uk/2/hi/health/2895165.stm
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| | New Scientist Breaking News - Massive virus discovered in water tower |
| | Intriguingly, Raoult says that preliminary results have revealed antibodies to the virus in human patients - suggesting that Mimivirus infects humans as well. | | | But when the researchers tried to detect bacterial-specific genes, they could not. | | | So far, however, the researchers have little idea what these extra genes do. |
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http://www.newscientist.com/article.ns?id=dn3559
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| | Genome Encyclopedia of Microbes |
| | The pair's new analysis of the Mimivirus genome reveals even more surprises. | | | After comparing the sequence to those of a variety of other organisms, the researchers concluded that the Mimivirus lineage dates back some 3.3 billion years to the separation of early life into three major divisions: archaea, bacteria, and the more complex eukaryotes. | | | The Mimivirus genome may also help explain how complex life emerged. |
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http://www.gem.re.kr/htm/information_03_load.php?No=245&pagenum=1
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| | More... |
| | Mimivirus, which has no domain, may be a link between the pre- and post-Darwinian worlds. | | | Mimivirus, however, “brings home the point that a fundamental revision of the tree of life to include viruses is certainly in order,” explained Lynn Enquist, molecular biology department chair at Princeton University and editor-in-chief of the Journal of Virology. | | | A soft plush toy can often be found snugly clutched under the arm of a small child, but a growing number of elders are beginning to cling tightly to soothing dolls as well. |
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http://www.science-spirit.org/archive_cm_detail.php?new_id=558
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| | CBC News:Giant virus discovered in water tower |
| | Amoebae, large single-celled organisms, are commonly found in air conditioning systems and temperate waters. | | | The team compared its genes to other viruses and found it is related to other large viruses, such as smallpox. | | | The virus has been classified as the first of a completely new virus family, the Mimiviridae. |
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http://www.cbc.ca/stories/print/2003/03/28/virus_giant030328
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| | [No title] |
| | In addition, correspondence in Science suggests that other genes used in this analysis may be most similar to those of the ameoba that acts as its host, a contention that the virus's discoverers dismiss as spurious. | | | The first option is supported by an analysis of several of its genes, which shows that they collectively place Mimivirus sequences distant from all other viruses, as well as from all three branches of cellular life. | | | This suggests that it is derived from a virus that was around near the time of life's origins. |
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http://arstechnica.com/journals/science.ars/2006/3/3/3044
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| | Henry's Webiocosm Blog: Mimivirus / Giant Virus Update |
| | This is a paragraph of text that could go in the sidebar. | | | Back in March I blogged about the Mimivirus, after someone had mentioned it in the comments of a post at The Loom. | | | He also points to an article titled "The Mimivirus and the emerging Concept of the Giant Virus" in which the authors bring us up to date on the most recent information and ideas about Giant viruses. |
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http://webiocosm.blogspot.com/2005/08/mimivirus-giant-virus-update.html
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| | Telegraph News |
| | After much debate among his team, "for the first time we have enough genetic information to conclude that there is a fourth domain of life", he said. | | | However, Dr Dave Roberts, head of microbiology at the Natural History Museum, London, was "deeply sceptical" that the Mimivirus deserves to be placed in its own domain, though he agreed that it did mark a new family. | | | Two research teams in the Marseille School of Medicine, led by Prof Didier Raoult and Prof Jean-Michel Claverie, have "read" the genetic code of the organism and found a number of genes previously thought to belong only to more complex life forms. |
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http://www.telegraph.co.uk/news/main.jhtml?xml=/news/2004/10/15/nbug15.xml
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| | Lab Manual Exercise # 1 |
| | A primitive nucleus (protonucleus) may have evolved from an intracellular virus; however, one weakness of this hypothesis is that viruses generally lack some of the key genes found in eukaryotes. | | | Whether mimivirus should be placed in an existing domain (superkingdom), or in its own domain, remains to be seen. | | | Mimivirus was found inside an amoeba within a cooling tower in Bradford, UK. |
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http://waynesword.palomar.edu/lmexer1.htm
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| | News in Science - Bizarre giant virus rewrites the record books - 31/03/2003 |
| | Although Mimivirus is not known to cause any human disease, initial tests suggest it might be capable of causing a type of pneumonia. | | | Scientists discovered the Mimivirus living inside the common single-celled amoebae Acanthamoeba polyphaga, during an environmental study of water in a British cooling tower. | | | Gibbs said that with such an extensive genome derived from an unknown array of sources, the Mimivirus may be a 'treasure trove' of new genes for potential use in biotechnology. |
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http://www.abc.net.au/science/news/stories/s818289.htm
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| | Hyperion Court: Mimivirus redux |
| | One researcher makes an analogy between cars and viruses, saying that the mimivirus is a luxury car. | | | I think a better analogy would be to say that viruses are like bicycles and bacteria are like cars. | | | There is DNA, RNA and plenty of proteins," says Didier Raoult, a lead member of the team from the Mediterranean University in Marseilles, France, who reports the work in this week's Science. |
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http://www.pushby.com/friends/jesse/archives/007795.html
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| | Microbe Magazine |
| | Our hypothesis is that Mimivirus has evolved through reductive evolution from a predecessor of the present unicellular protists. | | | Mimivirus may constitute the missing link between the families of large DNA viruses and the tree of life. | | | Furthermore, “Mimivirus hosts an overly large proportion of genes compared with bacteria and eukaryotes that have no homologues in the other three domains of life,” says Suhre. |
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http://www.asm.org/news/index.asp?bid=40075
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| | Mimivirus |
| | Mimivirus particles also have a unique protruding vertex similar to that observed in tailed bacteriophages. | | | The complexity and magnitude of the Mimivirus genome, combined with the large size of the virus, calls into question some of the established divisions between viruses and single-celled organisms, as well as raising questions about their evolution. | | | The 1.2 Mbp genome provides sufficient information to allow the virus to perform most of the functions of living cells. |
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http://www-micro.msb.le.ac.uk/3035/Mimivirus.html
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| | VIROLOGY: ON VIRUS DIVERSITY |
| | However, analysis of the evolutionary affinities and predicted functions of those genes that do have well-characterized homologs clearly shows that mimivirus did not originate from Mars, but has a lot in common with other viruses. | | | Most striking, mimivirus crosses the boundary between viruses and cells that was considered more or less self-evident: viruses are assumed to be tiny and to have (much) smaller genomes than cellular life forms. | | | Of course, in virology, which by definition deals with tiny intracellular parasites, the era of descriptive discoveries was delayed until the 20th century, and reports of new, sometimes unusual families of viruses continued into the new millennium [1]. |
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http://scienceweek.com/2005/sw050729-5.htm
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| | New Scientist Archive - News - Megavirus breaks all the rules |
| | Mimivirus was discovered last year in amoebas in a cooling tower in the UK by a research team from France | | | But the mimivirus might just be alive: its genome suggests it carries out functions never before seen in viruses, such as making its own RNA and proteins, repairing its DNA and producing various chemicals. | | | It has the characteristic coat of a virus but, at 400 nanometres across, the organism is larger than some bacteria. |
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http://www.newscientist.com/article/mg18424702.600.html
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| | Sploid: And on the first day God created the virus |
| | Incredibly complex, the Mimivirus appears to be as old as the basic building blocks of life on Earth. | | | Scientists once believed viruses were a latecomer in evolution, a mutant that developed specifically to hijack living things. | | | Biologists in France have identified an awful thing called Mimivirus, named for its sinister ability to mimic bacteria. |
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http://www.sploid.com/news/2006/02/on_the_first_da.php
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| | Evolution Group: 11.2005 |
| | I'd like to generally discuss the virus and see what people think about its possible evolutionary origins. | | | Mimivirus and the emerging concept of a giant virus (you can download the PDF here), or | | | On Nov. 9, 1230, at the Grad House we will discuss our ideas on the evolution of the giant virus (or girus) called Mimivirus. |
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http://evogroup.blogspot.com/2005_11_01_evogroup_archive.html
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| | Mimivirus phylogenetic profiling |
| | Enter a sequence and find the most similar ones in Mimivirus |
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http://igs-server.cnrs-mrs.fr/phydbac/Mimi/indexvirus.html
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| | Mimivirus: Encyclopedia topic |
| | It has 800,000 bases (bases: Installation from which a military force initiates operations) and 900 gene (gene: (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity) s. | | | The updated page can be found at: mimivirus |
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http://www.absoluteastronomy.com/reference/mimivirus
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| | The Esoteric Science Resource Center - Mimivirus |
| | After spending most of my life being repeatedly informed that viruses are too small to be observed directly with any method other than electron microscopy, reading about Mimivirus, one of the only virii visible with a standard light microscope, suddenly makes me feel very old. | | | Prime Books (the folks putting out the books) | | | It's a shame they resorted to the stereotype of a scientist in a lab coat (photo first page), but that's the *only* flaw I can find. |
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http://sclerotic-rings.livejournal.com/1318825.html
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| | NodeWorks - Encyclopedia: Mimivirus |
| | It was first discovered in 1992 in an industrial cooling tower in Bradford in England and identified in 2003 by researchers at the Université de la Méditerranée in Marseille in France. | | | Press Release: Mimivirus: discovery of a giant virus, Paris, March 28, 2003. | | | The mimivirus is a giant virus with mature particles of 400 nm in diameter (icosahedral capsid). |
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http://pedia.nodeworks.com/M/MI/MIM/Mimivirus
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| | [No title] |
| | HEADER TRANSFERASE 10-OCT-05 2B8Q TITLE X-RAY STRUCTURE OF ACANTHAMOEBA PLOYPHAGA MIMIVIRUS TITLE 2 NUCLEOSIDE DIPHOSPHATE KINASE COMPLEXED WITH TDP COMPND MOL_ID: 1; COMPND 2 MOLECULE: PROBABLE NUCLEOSIDE DIPHOSPHATE KINASE; COMPND 3 CHAIN: A, B, C, D, E, F; ATOM 1205 CD1 LEU B 17 82.972 57.339 57.169 1.00 24.10 |
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http://www.cmpharm.ucsf.edu/~walther/webmol/pdb/b8/pdb2b8q.ent
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