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| Â | BBSRC - The science we support - Plant and microbial Metabolomics |
 | | Metabolomics will increase our understanding of biological systems and we wish to encourage the use of metabolomic technologies to address important biological questions. | | | Metabolomics is currently under-developed in the UK, but will be essential to the success of post-genomic research. |
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http://www.bbsrc.ac.uk/science/initiatives/metabolomics.html
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| Â | NIH Guide: METABOLOMICS: APPLICATION TO ENVIRONMENTAL HEALTH RESEARCH |
| | Metabolomics studies seek to define the levels, activities, regulation and interactions of all metabolites in a biological system and how these quantities or interactions change in response to external stimuli. | | | Ultimately, a metabolomic approach to studying biological systems should lead to (1) a better understanding of the mechanism(s) involved in the dysregulation of pathways by environmental agents, (2) the development of predictive biomarkers or surrogate endpoints of toxicity or clinical response and 3) a more rational approach for the development of disease intervention/prevention strategies. | | | Rather, applications should focus on using metabolomics approaches to enhance our understanding of a particular environmentally responsive pathway by defining metabolite changes or markers that can be correlated with perturbation or disease progression. |
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http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-04-008.html
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| Â | metabolomics |
| | Different physical methods can be used for the comprehensive analysis of metabolites within a biological sample. | | | NMR-techniques have been used in the past mainly to analyze metabolite changes in mammalian body fluids and tissues and this method may be extended by detecting other nuclei, for example | | | C are administered, metabolite analysis can even be taken onto a dynamic level by allowing the fluxes to be determined quantitatively. |
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http://www.nutrition.tum.de/nutriogenomics/seite5.htm
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| Â | Metabolon - Global Leaders in Metabolomics and the Discovery of Biomarkers |
| | Metabolon's patent-pending metabolomic technology is poised to dramatically impact drug discovery and development processes by accurately measuring the spectrum of biochemical changes and mapping these changes to metabolic pathways. | | | Contact Metabolon to find out how we can help you develop better drugs faster. | | | Metabolon is a leader in metabolic profiling or the application of metabolomics, a powerful, new scientific approach for drug discovery and development including early diagnosis of disease states. |
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http://www.metabolon.com
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| Â | The Sumner Group: Metabolomics |
| | These qualitative and quantitative analyses provide a holistic view of the biochemical status or biochemical phenotype of an organism. | | | Figure 1: An integrated functional genomic approach monitors quantitative and qualitative differences in the transcriptome, proteome, and metabolome as a means to study gene function and cellular responses to external stimuli. |
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http://www.noble.org/PlantBio/MS/metabolomics.html
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| Â | Metabolomics on the Norwich Research Park |
| | Our aims are to encourage cross-site, cross-disciplinary and collaborative activity and to communicate with the outside world in this important and rapidly expanding area of post-genomic research. | | | We welcome contact from any NRP scientists who would like to join our interest group and encourage contacts from those outside the NRP with an interest in metabolomics. | | | This website is a forum for Norwich Research Park based researchers with an interest in Metabolomics. |
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http://www.metabolomics-nrp.org.uk/
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| Â | ISAS Dortmund and Berlin: Metabolomics |
| | The processes under investigation are correlated to proteomics directly. | | | Metabolomic studies also offer opportunities to study regulation processes and signaling between cells and inside organisms under the control of small molecules. | | | Such correlations of biochemical information with molecular data will allow much better insight into the functions of unknown gene, cell systems or organisms, especially with respect to the response to external stimuli. |
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http://www.isas-dortmund.info/isas_cms/index.php?id=13&type=1
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| Â | Nutrigenomics and metabolomics |
| | He will also discuss the role of "metabolomics" in defining biochemical markers and the effective construction of the data into useful formats through infomatics. | | | This revolution has lead to significant new understandings of the role of food and nutrition in human health, and with the Human Genome Project, a new ability to understand the role of genetics in metabolism and health. | | | This combination of various disciplines is called "Nutrigenomics," and provides a potential for early identification of those at high risk to metabolic stress and to understand the molecular basis of physiological defects. |
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http://www.scienceblog.com/community/older/2002/G/2002020.html
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| Â | Genego: Systems Biology for Drug Discovery About ... |
| | Systems biology, networks pathways, interactions, tissue-specific pathways, metabonomic, metabolomic, proteomic expression, mapping, visualization, integration, references, literature | | | A unique feature of the MetaCore™ Platform is its ability to allow the researcher to integrate and visualize data from many different biological levels and types of experiments within the same system, and in the context of the existing knowledge in the literature and the extensive systems biology databases provided with the platform. | | | Customers can choose to add optional data parsers for proteomics, metabolomics, or other levels of biological data, which are custom-built to work with the specific type of data being generated. |
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http://www.genego.com/about/about.shtml
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| Â | Phenomenome Discoveries: Comprehensive Metabolomics and Biomarker Discovery |
| | To explore developing a relationship or strategic partnership with Phenomenome Discoveries email us, or see our contact information ; we welcome your communications. | | | Metabolites affected by these factors are identified, their biological | | | At Phenomenome Discoveries, we use our proprietary metabolomics technology to study the global effects of genetic |
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http://www.phenomenome.com/
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| Â | NIH Guide: PROTEOMICS AND METABOLOMICS IN TYPE 1 DIABETES AND ITS COMPLICATIONS |
| | Proteomic approaches have been successfully used for studying complex biological problems and for the identification of disease markers. | | | Proteomics and metabolomics could be used for the analysis of biofluids of patients or animal models for identifying biomarkers of complications, including cardiovascular diseases, retinopathy, neuropathy and nephropathy. | | | Proteomic technologies have been successfully used for the identification of cancer biomarkers, for the identification of novel drug targets and for studying several biological processes relevant to human health. |
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http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-03-024.html
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| Â | The Scientist :: Metabolomics: Small-Molecule 'Omics, Apr. 21, 2003 |
| | Thermo Finnigan recently introduced a new time-of-flight (TOF) mass spectrometer that analyzes samples in about six minutes. | | | Metabolomics can also highlight groups of people who respond poorly to a given drug. | | | Metabonomics is the study of how the metabolic profile of a complex biological system changes in response to stresses like disease, toxic exposure, or dietary change. |
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http://www.the-scientist.com/yr2003/apr/lcprofile_030421.html
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| Â | The National Centre for Plant and Microbial Metabolomics |
| | Access to the service is open to all research groups seeking metabolomic analysis or training in the plant and microbial areas. | | | Rothamsted Research is one of eight institutes sponsored by the biotechnology and biological sciences research council | | | Advanced machine learning and other computational techniques, will be applied, by MeT-RO staff at Aberystwyth and UMIST, to further mine the datasets and relate profiles to the functioning of the biochemical network. |
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http://www.metabolomics.bbsrc.ac.uk/MeT-RO.htm
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| Â | Metabolomics |
| | Whilst there is much current interest in the genome-wide analysis of cells at the level of transcription (to define the 'transcriptome') and translation (to define the 'proteome'), the third level of analysis, that of the 'metabolome', has been curiously unexplored to date. | | | As proven in the summation theorem of Metabolic Control Analysis (MCA), changes in the concentrations of individual enzymes tend to have little effect on particular metabolic fluxes (nor, indeed, on the phenotype under most laboratory conditions). | | | It is likely that measurement of the metabolome in different physiological states will in fact be much more discriminating for the purposes of functional genomics. |
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http://dbk.ch.umist.ac.uk/metabol.htm
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| Â | metabolomics |
| | general aim of metabolomics is to identify, measure and interpret the complex time-related concentration, activity and flux of endogenous metabolites in cells, tissues, and other biosamples such as blood, urine, and saliva; here metabolites include small molecules that are the products and intermediates of metabolism, as well as carbohydrates, peptides, and lipids. |
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http://www.crisp.cit.nih.gov/Thesaurus/00012860.htm
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| Â | [No title] |
| | For the Norwich Research Park metabolomics group, click here. | | | Metabolomics is therefore the study of all the low molecular weight chemicals in a plant. |
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http://www.jic.bbsrc.ac.uk/corporate/Facilities/metabolomics.html
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| Â | WWW.EHGONLINE.NET |
| | The eventual goal must however be the integration of transcriptomics, proteomics and metabolomics (the complete identification of cellular metabolic pathways), into a new discipline: structural biology at the molecular and cellular level. | | | Ultimately, the genome, transcriptome, proteome and metabolome combine to determine an individual's "phenome" (the observable characteristics of the cells, tissues and organs of an individual) which in turn interacts with their environment, broadly defined. | | | It should also permit the large-scale determination of protein structure and function, and facilitate the construction of protein interaction maps. |
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http://www.ehgonline.net/preface.asp
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| Â | Metabolomics Technology Development - FAQ |
| | However, the complete elucidation of cellular pathways and networks will require powerful new analytical methods that could, for example, measure metabolite concentrations at specific subcellular locations, or metabolites that are present at very low concentrations. | | | ‘Metabolomics’; is the study of these low-molecular weight molecules. |
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http://nihroadmap.nih.gov/grants/faq-metabolomics.asp
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| Â | Metabolomics |
| | The high levels of variability in the metabolome and the need to undertake sophisticated analysis of the data based on meaningful comparisons mean that relatively large amounts of metadata must be stored with the basic results of metabolome estimation. | | | In the context of our Computational Biology Group and the Aberystwyth quantitative biology and analytical biotechnology group I have an interest in data handling in metabolomics. | | | Metabolomics involves the systematic estimation of metabolomes from a range of organisms, followed by statistical analyses and other investigations of that large quantity of data. |
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http://users.aber.ac.uk/nwh/metabolomics.html
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| Â | The National Centre for Plant and Microbial Metabolomics |
| | Rothamsted Research is one if eight institutes sponsored by the biotechnology and biological sciences research council | | | Max Planck Institute of Molecular Plant Physiology Department of Molecular Physiology Metabolomic Analysis. | | | WIT WIT is a www-based system to support the curation of function assignments made to genes and the development of metabolic models. |
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http://www.metabolomics.bbsrc.ac.uk/links.htm
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| Â | TNO Pharma - Metabolomics: applications in microbiology |
| | Metabolomics is the comparative, non-targeted analysis of the complete set of metabolites (small organic molecules) in a cell. | | | Ultimately, the application of metabolomics will result in a reduction of both research and development costs and time-tomarket, as no time nor financial resources are wasted on irrelevant targets. | | | The key issue in metabolomics is the translation of differences in the metabolomes into phenotypic differences. |
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http://www.pharma.tno.nl/Product.cfm?PShID=705&DivID=27
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| Â | Metabolomics |
| | It is the study of the entire metabolome within a system, allowing for a more comprehensive look at how that system functions and reacts. | | | Metabolomics is a diverse field encompassing a wide range of specialists from plant biologists to chemists. | | | Metabolomics at UCDavis has flourished thanks to the active and supportive environment fostered. |
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http://metabolomics.ucdavis.edu/
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| Â | Tof mass spec for proteomics and metabolomics - Bruker Daltonics |
| | It can be applied to expression proteomics, biomarker discovery or small molecule analysis in metabolomics or natural products research with superior performance. | | | Tof mass spec for proteomics and metabolomics - Bruker Daltonics | | | The Ultrotof-Q system can be an integral module of Bruker's Proteineer solution for high-success expression proteomics. |
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http://www.laboratorytalk.com/news/bru/bru124.html
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| Â | Welcome to www.metabolomics.dk |
| | These pages are under construction and will be updated with the latest information about the Metabolomics research activities in Denmark. |
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http://www.metabolomics.dtu.dk/introduction.htm
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| Â | Mass spectrometry glossary |
| | Analysis of the mass of an object through means of determining the wave length(s) at which electromagnetic energy is absorbed by that object. | | | The exquisite selectivity, sensitivity, and specificity of mass spectrometry make it an unrivalled technology for detection and identification of biopolymers and metabolites derived from complex body tissue and fluids. | | | Within the " -omics " revolution, mass spectrometry has emerged as the premier platform of choice in metabolomic and proteomic analyses. |
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http://www.genomicglossaries.com/content/mass_spectrometry.asp
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| Â | 2nd International Conference on Plant Metabolomics |
| | The conference will feature two and a half days of seminars and workshops on the field of metabolomics, with special emphasis being placed on the themes of methodology, bioinformatics and applications (functional genomics, plant biochemistry, and substantial equivalence). | | | The conference is organized by the Max Planck Institute of Molecular Plant Physiology in Golm, Germany. | | | Following on from the inaugral meeting held in April 2002 in Wageningen, The Netherlands, the next Plant Metabolomics Conference will be held in Potsdam, Germany, in April, 2003. |
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http://metabolomics-2003.mpg.de/
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| Â | Research - Metabolomics |
| | Metabolomics represents the final step in understanding the function of genes and their proteins. | | | While metabolites can include proteins and nucleic acids, traditionally, they are thought of as small molecules. |
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http://masspec.scripps.edu/research/hnp
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| Â | Cornell, nutrition, biochemistry, molecular, biology, genetics, mammalian, genomics, metabolomics, epigenetics, fetal ... |
| | Cornell, nutrition, biochemistry, molecular, biology, genetics, mammalian, genomics, metabolomics, epigenetics, fetal development, nutritional sciences |
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http://www.nutrition.cornell.edu/grad/mhnhome.html
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| Â | In the News, 2004 |
| | The center will provide equipment for researchers studying cellular metabolism. | | | The new Carver Center for Metabolomics is becoming a reality through the efforts of Professors Wilfred van der Donk, Brenda Wilson, William Metcalf and a $1.1 million grant from the Roy J. Carver Charitable Trust. |
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http://www.scs.uiuc.edu/chem/news/news.html
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| Â | Collaborative Projects on Proteomics/Metabolomics and Type 1 Diabetes and its Complications : Type 1 Diabetes Special ... |
| | This initiative is being launched in response to a meeting held at the NIH on April 23-24, 2003, where diabetes and proteomics researchers were assembled to discuss the application of proteomic technologies to NIDDK-relevant diseases ("Proteomics in Diabetes"; www.niddk.nih.gov/fund/other/proteomics/index.htm). | | | To encourage the application of proteomic and metabolomic technologies to study type 1 diabetes and its complications, the NIDDK is fostering collaborations between type 1 diabetes and proteomics investigators (see RFA at http://grants1.nih.gov/grants/guide/rfa-files/RFA-DK-03-024.html). | | | Collaborative Projects on Proteomics/Metabolomics and Type 1 Diabetes and its Complications |
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http://www.niddk.nih.gov/fund/diabetesspecialfunds/proteomics/
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| Â | The Scientist :: Technology Archives |
| | ESA's new Metabolomics System quickly identifies key compounds in complex samples | | | New imaging tool provides affordable speed-up of histological sample analysis |
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http://www.the-scientist.com/labconsumerarchive.htm
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| Â | Press Releases ESA, Inc. DiscovArray, Metabolomics, Chromachem, ABI, Cypress Systems, |
| | Couloscan, Flavoscan, Oxscan, VItascan, Metabolomics and Metabonomics System /Profiles are trademarks of ESA, Inc. | | | To Simplify and Increase Efficiency of Metabolomics Studies | | | Metabolon Selects ESA CoulArray Technology for Key Metabolomics Studies |
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http://www.esainc.com/Press%20Releases/Press_Releases.htm
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