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| | BioCarta - Charting Pathways of Life |
 | | Catabolic pathways for alanine, glycine, serine, cysteine, tryptophan, and threonine | | | The glycolytic pathway is extremely ancient in evolution, and is common to essentially all living organisms. | | | The first step in the pathway involves phosphoenolpyruvate (PEP) from glycolysis and erythrose-4-phosphate from the pentose phosphate pathway. |
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http://www.biocarta.com/genes/catMetabolism.asp
(853 words)
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| | An algorithm for linear metabolic pathway alignment |
| | Heymans and Singh, 2003, presented a technique for the phylogenetic analysis of metabolic pathways based on the topology of the underlying graphs. | | | As a result, the traditional well-known pathways such as glycolysis or TCA will not be considered as a well-defined pathway, because they often contain some branches or alternative pathways. | | | Using this approach, pathways and groups of pathways of different organisms were compared to each other and the resulting distance matrix was used to obtain a phylogenetic tree. |
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http://www.bioinfo.de/isb/2004/05/0013/main.html
(4530 words)
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| | Computation with the KEGG metabolic pathway database |
| | A biochemical pathway is an abstraction of a subset of intricate networks in the soup of interacting biomolecules (Mavrovouniotis, 1995), and the abstraction is arbitrarily chosen by biologists at the level of their interests. | | | Second, the pathway diagram is drawn to lay stresses both on the successive conversion of major compounds and on the appearance of two consecutive enzymes in the pathway. | | | The KEGG pathway database consists of two sections: the metabolic pathway section and the regulatory pathway section. |
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http://igs-server.cnrs-mrs.fr/~ogata/Paper/ogata98BioSys.html
(4195 words)
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| | CUBIC Metabolic Pathway Hunter Tool - CMPHT |
| | Using this approach, the pathways and groups of pathways of different organism are compared to each other and the resulting binary matrix is used to obtain a phylogenetic tree. | | | Organism pathway information was provided by KEGG as the knowledgebase for our research goal. | | | The comparative study of metabolic pathways will open the door for better drugs (pathogenic pathways) and it will help us to cater the industrial needs in a more efficient manner (non-pathogenic pathways). |
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http://www.iscb.org/ismb2004/posters/asad.rahmanATuni-koeln.de_10.html
(723 words)
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| | Heredity - Ecological genetics: The decline and fall of a metabolic pathway in yeast |
| | Simple evolutionary principles suggest that the metabolic capabilities of a microbe should evolve in response to the availability of different resources in the environment: new pathways are expected to evolve when novel resources are encountered and existing pathways are expected to degrade in environments that lack the substrate the pathway degrades (Kassen, 2002). | | | In a recent study, Hittinger et al (2004) employ a phylogenetic approach to study the evolution of a well-characterized metabolic pathway, the Leloir pathway for galactose degradation, in a well-known group of microorganisms, the yeasts. | | | The evolutionary loss of redundant metabolic pathways is little understood compared with the gaining of new adaptive pathways. |
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http://www.nature.com/hdy/journal/v94/n3/full/6800632a.html
(1075 words)
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| | Metabolic Pathway Data in MaizeGDB |
| | Metabolic pathways are the methods that organisms use to achieve the basic acts of life. | | | Like any other organism, corn uses metabolic pathways to accomplish many internal biochemical tasks. | | | For example, the Metabolic Pathway Glycolysis, or Metabolic Pathways containing the letters thesis (using * or % wildcards) |
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http://www.maizegdb.org/metabolic_pathway.php
(305 words)
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| | Biochemistry Metabolism Contents |
| | Metabolic Pathways of Biochemistry - Glycogen Biosynthesis & Galactose Pathway | | | Metabolic Pathways of Biochemistry - Glycolysis and Gluconeogenesis | | | Metabolic pathways (Kyoto Encyclopedia of Genes and Genomes) |
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http://www.rit.edu/~pac8612/Biochemistry/503(703)/content.html
(83 words)
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| | Cellml.org - Glycolysis Metabolic Pathway in Saccharomyces cerevisiae |
| | A rendering of the glycolysis pathway in Saccharomyces cerevisiae. | | | For an example of a CellML rendering of a reaction pathway see The Bhalla Iyengar EGF Pathway Model, 1999. | | | For an example of a more complete documentation of another real reaction pathway, see The Bhalla Iyengar EGF Pathway Model, 1999. |
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http://www.cellml.org/examples/repository/glycolysis_pathway_1997_doc.html
(451 words)
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| | eMedicine - Inherited Metabolic Disorders : Article by Pieter R Kark, MD, MA, FAAN, FACP |
| | Metabolism is the physiological and biochemical mechanisms by which foodstuffs are taken in by the body and converted from one form to another to provide energy for all the activities of the body. | | | Many inborn errors of metabolism may exist that are entirely incompatible with life and that never result in a live-born infant. | | | In its broadest sense, metabolism encompasses virtually every biochemical pathway and biophysical mechanism in the body and the resultant physiologic activities. |
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http://www.emedicine.com/NEURO/topic680.htm
(6139 words)
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| | Genome Biology Full text Genomic analysis of metabolic pathway gene expression in mice |
| | While gene-expression changes are not sufficient to imply actual metabolite flux through a pathway [21], changes in gene expression are likely to reflect pathway involvement in a given condition. | | | The pathway set we compiled was incorporated as a file into the program for use in the analysis (LocusLink and pathway identifier for each gene associated with each pathway). | | | All pathways were represented at each locus and there were no apparent subgroups associated with some loci and not others. |
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http://genomebiology.com/2005/6/7/R59
(6169 words)
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| | Biopharmaceutical Metabolic profiling |
| | Enzymes of metabolic pathways are nowadays thought to be clustered and operate as 'metabolons'. | | | This integrated approach greatly enhances the capabilities of metabolic pathway engineering by enabling rational target selection and rapid introduction of genetic modifiers, while avoiding the introduction of unintended changes that reduce the overall health of the strains. | | | Metabolic Profiling December 7-8, 2005 - Lake Buena Vista, FL The Analytical Methods meeting will explore the problems and challenges associated with the various analytical methodologies applied to metabolic profiling and discuss ways to overcome these challenges in order to enhance the information returned. |
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http://www.genomicglossaries.com/content/metabolic_engineering.asp
(3888 words)
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| | Metabolic pathway - Wikipedia, the free encyclopedia |
| | They are reversible, usually because the first step is a committed step, such as breakdown for the release of energy, that runs in two directions. | | | Other pathways occurring in (most or) all living organisms include: | | | You can help in our current fundraiser by donating here |
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http://en.wikipedia.org/wiki/Metabolic_pathway
(242 words)
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| | Metabolic Pathway Engineering Team |
| | The role of the pentose phosphate pathway (PPP) in S. | | | Proteomics and transcriptional profiling offer holistic ways to study the redox balance and redox regulation of a microbe that is altered in its metabolic pathways. | | | One of the major problems in xylose fermentation by recombinant Saccharomyces is assumed to be caused by the different cofactor specificities of xylose reductase and xylitol dehydrogenase. |
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http://www.vtt.fi/bel/coe/patheng.htm
(2080 words)
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| | Metabolism, Cellular Respiration & Photosynthesis - BioChemWeb.org |
| | Metabolic Pathways of Biochemistry - Graphical representation of metabolic pathways that are crucial to human metabolism, including 2-D and 3-D depictions. | | | Glycolysis - Basic introduction to the reactions and pathway of glycolysis. | | | Metabolic Pathway Databases (Data Collections on Metabolic Pathways) |
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http://www.biochemweb.org/metabolism.shtml
(645 words)
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| | ISMB 2001 Poster Abstracts: Complex Biological Networks |
| | ST pathways play a major role in the field of cancer research. | | | We present a large-scale pathway map of protein-protein interactions in human cells by yeast-two-hybrid methodologies and downstream data analysis. | | | For 31 of these compounds (45%) the Engine’s most similar predicted pathway was very similar to a known pathway (pathway similarity score > 0.7). |
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http://ismb01.cbs.dtu.dk/ComplexBiologicalNetworks.html
(6322 words)
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| | SRI International to Expand MetaCyc Metabolic Pathway Database |
| | The information is used by researchers for basic research and genome analysis, and by students and teachers for educational purposes. | | | The grant allows SRI and Carnegie to expand MetaCyc's size and scope, address the wealth of metabolic pathway information available in scientific literature, and continue to serve the growing audience for this information. | | | MENLO PARK, California — May 17, 2004 — SRI International, an independent research and development organization, announced today that it has received a three-year grant from the National Institute of General Medical Sciences (NIGMS), a component of the National Institutes of Health, to expand development of MetaCyc metabolic pathway database. |
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http://www.sri.com/news/releases/05-17-04.html
(792 words)
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| | Kynurenine metabolic pathway in pregnancy |
| | Kynurenine metabolic pathway of tryptophan catabolism in healthy and pathological pregnancy | | | One of the key enzymes of kynurenine pathway induction, indoleamine-2,3-dioxygenase (IDO), was found in placenta. | | | Tryptophan to kynurenine transformation is one of alternative tryptophan pathways. |
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http://www.priory.com/med/kynurenine.htm
(2471 words)
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| | Lipomics Technologies Inc. |
| | In partnership with pharmaceutical, biotechnology and nutrition companies, Lipomics uses its technologies to discover new biomarkers, speed drug discovery, improve clinical trial stratification, reduce late-stage drug attrition, develop early tests for monitoring drug response and enable individualized health management. | | | Metabolic Profiling: Using metabolomics to Accelerate Drug Discovery and Development | | | A broad range of bioinformatics and analytical tools map these profiles to activity levels of underlying biochemical pathways. |
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http://www.lipomics.com
(146 words)
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| | Metabolic pathways databases |
| | KEGG Metabolic Pathways include graphical pathway maps for all known metabolic pathways from various organisms. | | | Over 2900 pathway diagrams are available, associated with functional roles and linked to ORFs. | | | Boehringer Mannheim - Biochemical Pathways is a searchable database of metabolic pathways, enzymes, substrates and products. |
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http://www.wisdom.weizmann.ac.il/~biopsi/metDB_links.htm
(226 words)
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| | Metabolic Pathway |
| | The Metabolic Pathway is key to understanding the complexity of research. | | | Having knowledge about research empowers parents and takes the edge off of the frustration many parents experience while waiting for the next discovery and hopefully a cure. | | | Carbohydrate Deficient Glycoprotein Syndrome has 4 defined types that are based on both clinical findings and diagnostic testing which is isoeletric focusing (IEF) pattern of serum glycoproteins. |
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http://www.ziplink.net/users/mykids/scott/pathway.htm
(518 words)
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| | Comparison of the Regulations by Th2-type Cytokines of the Arachidonic-Acid Metabolic Pathway in Human Alveolar ... |
| | Comparison of the Regulations by Th2-type Cytokines of the Arachidonic-Acid Metabolic Pathway in Human Alveolar Macrophages and Monocytes | | | Comparison of the Regulations by Th2-type Cytokines of the Arachidonic-Acid Metabolic Pathway in Human Alveolar Macrophages and Monocytes -- Endo et al. | | | Address correspondence to: Fumitaka Ogushi, The Third Department of Internal Medicine, School of Medicine, Tokushima University, Kuramoto-cho 3, Tokushima 770, Japan. |
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http://www.ajrcmb.org/cgi/content/full/19/2/300
(4308 words)
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| | Metabolic Pathway Models |
| | These circuits can represent metabolic pathways and this procedure can tell you if your current model properly explains all of the knockout experiments. | | | This project tries to construct accurate, isolated metabolic pathways using accurate kinetic data. | | | It is possible for very simple models of biochemical pathways to produce chaotic behavior, and this should be considered in a model of the cell. |
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http://fconyx.ncifcrf.gov/~lukeb/metpath.html
(234 words)
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| | Pentose Phosphate Pathway |
| | After all it is the oxygen carrier of the body. | | | ) carbon sugars which can then be utilized by the pathways of glycolysis. | | | The reactions of the non-oxidative portion of the pentose phosphate pathway are shown. |
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http://web.indstate.edu/thcme/mwking/pentose-phosphate-pathway.html
(1022 words)
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| | Metabolic Pathways of Biochemistry |
| | This site is designed to graphically represent all major metabolic pathways, primarily those important to human biochemistry. | | | The following reaction pathways represent those which are currently complete and those which are still under construction. | | | elcome to Metabolic Pathways of Biochemistry, the online reference of metabolism for students, scientists, and the world. |
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http://www.gwu.edu/~mpb/index.html
(93 words)
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| | Metabolic Pathways & Products for Metabolomics |
| | The 22nd (2003) edition of the IUBMB-Sigma-Nicholson Metabolic Pathways Chart contains updated pathways involved in ATP metabolism in the mitochondria and chloroplast. | | | A unique and exciting development is the introduction of animated metabolic pathways - "animaps". | | | Many biosynthetic and breakdown pathways of metabolism such as carbohydrates, amino acids, lipids are associated with this backbone and are differentiated by the use of color. |
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http://www.sigmaaldrich.com/Area_of_Interest/Biochemicals/Enzyme_Explorer/Key_Resources/Metabolic_Pathways.html
(519 words)
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| | Treatment of multifunctional enzymes in metabolic pathway analysis |
| | Schilling, C.H., Palsson, B.O. (2000) Assessment of the metabolic capabilities of Haemophilus influenzae Rd through a genome-scale pathway analysis. | | | Liao, J.C., Hou, S.-Y., Chao, Y.-P. (1996) Pathway analysis, engineering, and physiological considerations for redirecting central metabolism. | | | Treatment of multifunctional enzymes in metabolic pathway analysis |
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http://www.bioinfo.de/isb/gcb01/poster/zevedei-oancea.html
(346 words)
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| | MetaCyc Encyclopedia of Metabolic Pathways |
| | MetaCyc pathways can be browsed from a list, from ontologies | | | MetaCyc is a database of nonredundant, experimentally elucidated metabolic pathways. | | | MetaCyc contains 700 pathways from more than 600 different organisms. |
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http://metacyc.org
(210 words)
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| | metabolic pathway to psilocybin - Shroomery Message Board |
| | Chorismate can now go to any of 5 different pathways; we're concerned with the tryptophan pathway: | | | metabolic pathway to psilocybin - Shroomery Message Board | | | Metabolic pathways are important to understand when you are trying to produce a certain chemical from a living organism. |
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http://www.shroomery.org/forums/showflat.php/Number/2185303
(788 words)
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| | CHEM-643 Metabolic Pathway Resources |
| | Over the years I have made metabolic pathway handouts for study guides and reference use. | | | Here are some web-sites that also deal with metabolic pathways. | | | Students seem to like them so I have scanned them and linked them to this page for anyone to use. |
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http://www.udel.edu/chem/white/C643/MetabPathways.html
(122 words)
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| | Promising New Directions For Gallstone Treatment |
| | Also, the mouse version of CGD physiologically mimics the disease that is observed in humans. | | | Polarizing light microscopy of gallbladder bile shows the deposition of cholesterol crystals, which can form gallstones under the right biochemical conditions. | | | A promising experimental compound prevents cholesterol gallstone disease in mice by stimulating the biochemical pathway that controls bile acid secretion by the liver, according to new studies by Howard Hughes Medical Institute researchers. |
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http://www.sciencedaily.com/releases/2004/11/041123103516.htm
(1129 words)
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| | Business Software Review : Article 'Metabolic pathway' |
| | So, a whole metabolic pathway can be an example of a functomic entity. | | | Phosphorylation of reductase Much like other key enzymes in biosynthetic pathways, HMG-CoA reductase is inhibited by phosphorylation (of Serine 872, in humans 1). | | | Although human metabolism is primarily aerobic, under anaerobic conditions, for example in over-worked muscles that are starved for oxygen, pyruvate is converted to lactate, as in many microorganisms. |
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http://www.business-software-review.org/DisplayArticle46603.html
(635 words)
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| | SWBIC - Metabolic Pathway Databases & Related |
| | [Peter van Santen] A non-interactive diagram of the basic metabolic pathways. | | | [National Institute of Health Sciences, Japan] CSNDB "is a data- and knowledge- base for signaling pathways of human cells. | | | Each database in the BioCyc collection describes the genome and metabolic pathways of a single organism, with the exception of the MetaCyc database, which is a reference source on metabolic pathways from many organisms. |
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http://www.swbic.org/links/1.5.php
(434 words)
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| | Genome Informatics 2002 |
| | An Analysis of Cancer Microarrays in the Pathway Context Using Bayesian Networks | | | Extraction of Modules from the Metabolic Pathways with Phylogenetic Profile | | | Exploring Flux Distribution Profiles for Switching Pathways Using Multiobjective Flux Balance Analysis |
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http://www.jsbi.org/journal/GI13.html
(3330 words)
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| | Metabolic Pathway Simulation |
| | In the normal pathway (left) the concentration of any one metabolite does not greatly exceed the others. | | | The right panel shows a pathway with a mutant, or inhibited enzyme. | | | In the inhibited reaction (right), even a five-fold reduction of one of the kinetic steps leads to a large increase in the concentration of the substrate of the inhibited reaction. |
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http://stingray.bio.cmu.edu/~web/bc1/metsim/metsim.html
(141 words)
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| | C1 Metabolic Cycle Pathway Map |
| | from the DCM, DME, DMSO,--->Formaldehyde------------>Formate<--- Trichloroethylene GLY, MF, MSA \ ^ Pathway Pathways \ / formaldehyde \ / s-formylglutathione dehydrogenase \ / hydrolase \ / v / S-Formylglutathione | | | v Methane / ^ / \ methane / \ Methanogenesis monooxygenase / \ Pathway Map / \ from the v \ from the Dimethyl Ether--->Methanol Carbon Dioxide<--- Atrazine Pathway | | | In some environments, such as lakes, it has been observed that 90% of biogenic methane is oxidized before reaching the atmosphere. |
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http://umbbd.ahc.umn.edu/C1cyc/C1cyc_map.html
(255 words)
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| | Glycolysis and the Krebs Cycle |
| | We did not explicitly develop glycolysis and energy metabolism pages, but there is a wealth of good information on these topics that other people have developed, and this directory allows to to get to those sources. | | | This is how the energy of the electron is used to make ATP. | | | A clear chart of the intermediates of glycolysis, also done at the University of Virginia. |
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http://web.mit.edu/esgbio/www/glycolysis/dir.html
(236 words)
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| | HyClone Media: Metabolic Pathway Design™ |
| | HyClone’s R&PD group develops serum- and protein-free cell culture media utilizing Metabolic Pathway Design. | | | This development process balances the required nutrient supply against metabolic waste accumulation, determines the effective concentration of medium components, and defines complexed lipids that facilitate stability and nutritional delivery to the cells. | | | This process also facilitates the design of animal derived component free media. |
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http://www.hyclone.com/media/metabolic_pathway.htm
(142 words)
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| | Ariadne Genomics: Tools for Systems Biology |
| | PathwayStudio Central™: client-server software for visualization and analysis of biological pathways. | | | develops user-friendly software tools for biologists in the areas of pathway analysis, sequence data management and automated scientific text processing. | | | MedScan™: software for automated extraction of scientific facts from literature: MEDLINE abstracts, articles and other sources. |
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http://www.ariadnegenomics.com
(157 words)
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| | BioPAX Home |
| | See wiki for changes and to note bugs | | | Future levels will expand representation scope to include signaling, genetic regulatory and genetic pathways. | | | BioPAX is a collaborative effort to create a data exchange format for biological pathway data. |
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http://www.biopax.org
(389 words)
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| | BBC NEWS Health 'Fat muscles' may explain obesity |
| | The good news is it's possible to change your energy balance through exercise." | | | She added: "Obesity is a very complex disease and this metabolic pathway does not fully explain obesity but it is a likely contributor. | | | Until then, plenty of exercise seems to be the most expedient way to weight loss among individuals with the gene, although a healthy diet is also important, they say. |
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http://news.bbc.co.uk/1/hi/health/4329854.stm
(481 words)
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| | PFBP |
| | The Protein Function and Biochemical Pathways (PFBP) Project is no longer hosted at the EBI. |
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http://www.ebi.ac.uk/research/pfmp
(33 words)
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| | A metabolic pathway in yeast using immobilisation |
| | The alcohol is the end product inhibitor of a metabolic pathway, which begins to accumulate. | | | Below is a short sample of the essay "A metabolic pathway in yeast using immobilisation". | | | Coursework and Essays: By Level: GCSE: Biology: Plant biology: yeast: A metabolic pathway in yeast using immobilisatio |
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http://www.coursework.info/i/25914.html
(284 words)
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| | Metabolic Pathway |
| | This is a 2-D metabolic pathway map, found in most living cells. | | | However, the map even though intense with information allows to viewer to see that metabolism is a very complex process. | | | Also, energy is involved mostly in carbohydrate metabolism which, seems to be the center of all the other sections of metabolism, ie., carbohydrate metabolism is linked to all the other aspects of metabolism. |
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http://www.science.gmu.edu/~jmirick/csi803/gita.htm
(175 words)
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| | Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway ... |
| | Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1–MEK–JNK signal transduction pathway during metabolic oxidative stress | | | Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop -- Song and Lee 170 (1): 61 -- The Journal of Cell Biology | | | We have previously observed that metabolic oxidative stress–induced |
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http://www.jcb.org/cgi/content/abstract/170/1/61
(225 words)
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| | EcoCyc: Encyclopedia of Escherichia coli K-12 Genes and Metabolism |
| | A new putrescine degradation pathway has been discovered, and the catalytic functions were assigned to a number of "y genes". | | | The EcoCyc project performs literature-based curation of the entire genome, and of transcriptional regulation, transporters, and metabolic pathways. | | | Functions for a number of "y genes" have been newly identified; examples are QueF, RimN, and HinT. |
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http://www.ecocyc.org
(260 words)
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