Mesoderm - Medicow
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Topic: Mesoderm



  
 Drosophila tissue and organ development: Mesoderm and muscle
The somatic muscles, the heart, the fat body, the somatic part of the gonad and most of the visceral muscles are derived from a series of segmentally repeated primordia in the Drosophila mesoderm.
This work describes the early development of the fat body and its relationship to the gonadal mesoderm, as well as the genetic control of the development of these tissues.
This is an elegant mechanism for controlling muscle fiber differentiation during myogenesis, and may have evolved as a way to ensure that muscle primordia develop into muscles that meet the diverse demands placed on them by the nervous system (Fernandes, 2005).
http://www.sdbonline.org/fly/aimorph/mesoderm.htm   (9045 words)

  
 biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut ...
mesodermal cells from fusing with somatic muscle precursors.
for visceral mesoderm specification and are not sufficient for
(D) Stage 12 bin mutant embryo in which lacZ-expressing precursors of circular midgut muscles in the dorsal mesoderm are slightly disorganized.
http://www.genesdev.org/cgi/content/full/15/21/2900   (8524 words)

  
 Mesoderm Regionalization
Xwnt-8 on the other hand, is expressed zygotically in all mesoderm except the organizer and can ventralize dorsal tissue.
What is X-bra and what is its pattern of expression in the embryo?
How is cortical rotation thought to affect Vg-1 function?
http://www.ucalgary.ca/UofC/eduweb/virtualembryo/meso_induction_II.html   (1612 words)

  
 Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps -- O'Reilly et al. 20 (1): 299 -- ...
(C) Northern analysis of the late mesodermal marker muscle actin.
However, our results also show that the pathways to mesodermal
controlling mesoderm induction and elongation in response to FGF
http://mcb.asm.org/cgi/content/full/20/1/299   (7238 words)

  
 Mesoderm Induction by Heterodimeric AP-1 (c-Jun and c-Fos) and Its Involvement in Mesoderm Formation through the ...
component in the pathway leading to mesoderm induction.
that positive feedback is necessary to maintain mesoderm (see
In addition, eFGF caused similar morphological changes in whole
http://www.jbc.org/cgi/content/full/273/3/1542   (4390 words)

  
 Control of embryonic Xenopus morphogenesis by a Ral-GDS/Xral branch of the Ras signalling pathway -- Lebreton et al. ...
kinase (ERK) pathway in the induction of mesoderm (Carballada
pathways connecting mesoderm induction to the direct modification
Ras/Raf and Ras/PI 3-kinase pathways regulate mesodermal gene
http://jcs.biologists.org/cgi/content/full/116/22/4651   (7259 words)

  
 QSulf1, a heparan sulfate 6-O-endosulfatase, inhibits fibroblast growth factor signaling in mesoderm induction and ...
The slight reduction of Brachyury expression in this experiment was not significant when averaged in five independent experiments.
not induce morphological changes or expression of mesodermal
FGF4-dependent mesoderm induction in Xenopus embryos and FGF2-induced
http://www.pnas.org/cgi/content/full/101/14/4833   (3888 words)

  
 The VT+ and VT- Isoforms of the Fibroblast Growth Factor Receptor Type 1 Are Differentially Expressed in the ...
the full range of responses leading to mesoderm formation (9,
This similarity suggested that the VT+ phenotype may
While much of the work on mesoderm induction has
http://www.jbc.org/cgi/content/full/275/13/9581   (3471 words)

  
 Mesoderm
Because the mesoderm can form different ways in relation to the developing embryo's ectoderm, this is used as a method of categorizing animals.
The mesoderm is also believed to be responsible for the formation of the central nervous system, for example the notochord is responsible for releasing certain factors which induce the ectoderm to become neural tissue.
The mesoderm gives rise to tissues including connective tissue, muscles and the circulatory system.
http://www.worldhistory.com/wiki/M/Mesoderm.htm   (313 words)

  
 An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction -- Zhao et al. 22 ...
Kikuchi,A. (1999) Roles of Axin in the Wnt signalling pathway.
The mesoderm inductivity of Xbra can be overcome
Mizuno,T., Yamaha,E., Wakahara,M., Kuroiwa,A. and Takeda,H. (1996) Mesoderm induction in zebrafish.
http://embojournal.npgjournals.com/cgi/content/full/22/22/6078   (6589 words)

  
 Sloan-Kettering - Developmental Biology: Mary K. Baylies
Our current work with these pathways has progressed along 3 paths:
For example, homodimers of Twist activate the myogenic pathway, whereas heterodimers of Twist and the bHLH protein, Daughterless, repress this pathway.
Twist, a basic Helix-loop-Helix (bHLH) transcription factor, plays a critical role at 4 different times during mesoderm development: the specification of the mesoderm; the subdivision of the mesoderm into progenitors of different tissues; the patterning of one of these tissues -- the body muscles; and the differentiation of the adult muscle progenitors.
http://www.mskcc.org/mskcc/html/10198.cfm   (552 words)

  
 A luciferase-engineered cell line for study of cAMP regulation in endothelial cells -- Xavier-Neto et al. 275 (1): 75 ...
A new technique for the assay of infectivity of human adenovirus 5 DNA.
Michelson, A. Muscle pattern diversification in Drosophila is determined by the autonomous function of homeotic genes in the embryonic mesoderm.
Homeotic genes autonomously specify one aspect of pattern in the Drosophila mesoderm.
http://ajpcell.physiology.org/cgi/content/full/275/1/C75   (3654 words)

  
 Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger ...
Kao,K.R. and Elinson,R. (1988) The entire mesodermal mantle behaves as Spemann’s organizer in dorsoanterior enhanced Xenopus laevis embryos.
Onichtchouk,D., Gawantka,V., Dosch,R., Delius,H., Hirschfeld,K., Blumenstock,C. and Niehrs,C. (1996) The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling dorsoventral patterning of Xenopus mesoderm.
Ault,K.T., Dirksen,M.-L. and Jamrich,M.A. (1996) A novel homeobox gene PV.1 mediates induction of ventral mesoderm in Xenopus embryos.
http://nar.oupjournals.org/cgi/content/full/30/14/3107   (7101 words)

  
 Mitogen-activated protein kinase and neural specification in Xenopus -- Uzgare et al. 95 (25): 14833 -- Proceedings of ...
was recombined with dorsal mesoderm or treated with fibroblast
http://www.pnas.org/cgi/content/abstract/95/25/14833   (440 words)

  
 Evolution of gene expression patterns in a model of branching morphogenesis -- Pavlova et al. 277 (4): 650 -- AJP - ...
BMP1-related metalloproteinases promote the development of ventral mesoderm in early Xenopus embryos.
A graded response to BMP-4 spatially coordinates patterning of the mesoderm and ectoderm in the zebrafish.
A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.
http://ajprenal.physiology.org/cgi/content/full/277/4/F650   (6992 words)

  
 CaM Kinase IV Regulates Lineage Commitment and Survival of Erythroid Progenitors in a Non-Cell-Autonomous Manner -- ...
Christian, J.L., and Moon, R.T. Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.
of globin in ventral mesodermal explants that were cocultured
Recombinants of ventral mesoderm and ectoderm were generated
http://www.jcb.org/cgi/content/full/151/4/811   (7425 words)

  
 AllRefer.com - mesoderm (Cell Biology) - Encyclopedia
The mesoderm is the germ layer that forms many muscles, the circulatory and excretory systems, and the dermis, skeleton, and other supportive and connective tissue.
Continued cell movement results in an invagination of the bottom region of the embryo, producing a form that resembles a double-layered cup.
mesoderm, in biology, middle layer of tissue formed in the gastrula stage of the developing embryo.
http://reference.allrefer.com/encyclopedia/M/mesoderm.html   (242 words)

  
 UNSW Embryology- Musculoskeletal System - Mesoderm
The myotome differentiates to form 2 components dorsally the epimere and ventrally the hypomere, which in turn form epaxial and hypaxial muscles respectively.
The mesoderm forms nearly all the connective tissues of the musculoskeletal system.
Each tissue (cartilage, bone, and muscle) goes through many different mechanisms of differentiation.
http://embryology.med.unsw.edu.au/Notes/skmus6.htm   (924 words)

  
 Identification of Genomic Regions That Interact With a Viable Allele of the Drosophila Protein Tyrosine Phosphatase ...
At germ band elongation, in response to the EGFR pathway Eve is expressed, segmentally, in the precursors of both the DA1 larval muscle and pericardial cells (E).
mesodermally derived larval muscles and heart precursor cells
, A. M., 1994  Muscle pattern diversification in Drosophila is determined by the autonomous function of homeotic genes in the embryonic mesoderm.
http://www.genetics.org/cgi/content/full/156/2/733   (6896 words)

  
 High-throughput functional screen of mouse gastrula cDNA libraries reveals new components of endoderm and mesoderm ...
not have been predicted to be involved in endoderm or mesoderm
This includes Otx2, which we show is a downstream
stage by in situ hybridization with endoderm or mesoderm markers.
http://www.genome.org/cgi/content/abstract/15/1/44   (250 words)

  
 Mesoderm definition - Medical Dictionary definitions of popular medical terms
For example, some cells in the bone marrow (mesoderm) can become liver (endoderm).
Mesoderm definition - Medical Dictionary definitions of popular medical terms
It differentiates to gives rise to a number of tissues and structures including bone, muscle, connective tissue, and the middle layer of the skin.
http://www.medterms.com/script/main/art.asp?articlekey=20839   (234 words)

  
 Animal - Wikipedia, the free encyclopedia
In most protostomes cells simply fill in the interior of the gastrula to form the mesoderm, called schizocoelous development, but in deuterostomes it forms through evagination of the endoderm, called enterocoelic pouching.
In most cases, a mesoderm also develops between them.
Deuterostomes also have a dorsal, rather than a ventral, nerve chord and their embryos undergo different cleavage.
http://en.wikipedia.org/wiki/Animal   (1889 words)

  
 Cooperative Effects of Growth Factors Involved in the Induction of Hematopoietic Mesoderm -- Huber et al. 92 (11): 4128 ...
BMP-4 function in the induction of hematopoietic mesoderm.
Hemmati-Brivanlou A, Thomsen G: Ventral mesodermal patterning in Xenopus embryos: Expression patterns and activities of BMP-2 and BMP-4.
Johansson BM, Wiles MV: Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development.
http://www.bloodjournal.org/cgi/content/full/92/11/4128   (5855 words)

  
 Untitled Document
The induction and development of mesoderm can also be carried out in vitro for further study of differentiation factors.
BMP-related growth factors cause both mesoderm induction in the blastula stages and pattering of ventral mesoderm in the gastrula stages (73).
Thus BMP-4 is the major signaling molecule responsible for the induction of ventral mesoderm in the Xenopus gastrulae, the site where hematopoietic induction occurs and all hematopoietic stem cells are derived (67).
http://www.brown.edu/Courses/BI0032/stemcell/meso.htm   (375 words)

  
 A Direct Screen Identifies New Flight Muscle Mutants on the Drosophila Second Chromosome -- Nongthomba and Ramachandra ...
to the mesoderm that affect muscle pattern and differentiation,
, R., and C., 1983  Muscle pioneers: large mesodermal cells that erect a scaffold for developing muscles and motoneurons in grasshopper embryos.
the embryo involves the specification of the mesoderm (
http://www.genetics.org/cgi/content/full/153/1/261   (6069 words)

  
 Development of chick axial mesoderm: specification of prechordal mesoderm by anterior endoderm-derived TGFbeta family ...
elicits aspects of prechordal mesoderm identity in extending axial mesoderm
Development of chick axial mesoderm: specification of prechordal mesoderm by anterior endoderm-derived TGFbeta family signalling
Development of chick axial mesoderm: specification of prechordal mesoderm by anterior endoderm-derived TGFbeta family signalling -- Vesque et al.
http://dev.biologists.org/cgi/content/abstract/127/13/2795   (472 words)

  
 Upregulation of the cardiac homeobox gene Nkx2-5 (CSX) in feline right ventricular pressure overload -- Thompson et al. ...
Relationship between myosin isoenzyme composition, homodynamics, and myocardial structure in various forms of human cardiac hypertrophy.
Tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman.
The vascular smooth muscle alpha-actin gene is reactivated during cardiac hypertrophy provoked by load.
http://ajpheart.physiology.org/cgi/content/full/274/5/H1569   (2997 words)

  
 Muscle LIM Proteins Are Associated with Muscle Sarcomeres and Require dMEF2 for Their Expression during Drosophila ...
Myogenesis involves a series of discrete processes beginning with specification and proliferation of the mesoderm, subdivision
Surrounding the midgut, elongated visceral mesodermal cells form a lattice of transverse and longitudinal fibers.
Lilly, B., Galewsky, S., Firulli, A.B., Schulz, R.A., and Olson, E.N. -MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis.
http://www.molbiolcell.org/cgi/content/full/10/7/2329   (7249 words)

  
 Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development -- Yin ...
Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development -- Yin et al.
http://dev.biologists.org/cgi/reprint/124/24/4971   (19 words)

  
 LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1 -- Smith et al. 10 (25): 2869 ...
for induction of dorsal mesoderm and forcing their expression
ventrally (23,24) results in the induction of dorsal mesodermal
mesoderm is induced in the blastula and during gastrulation
http://hmg.oupjournals.org/cgi/content/full/10/25/2869   (5280 words)

  
 AskOxford: mesoderm
• noun the middle layer of cells or tissues of an embryo, or the parts that come from the mesoderm, such as cartilage, muscles, and bone.
http://www.askoxford.com/concise_oed/mesoderm?view=uk   (109 words)

  
 Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation -- Kouskoff et ...
mesoderm subpopulations that develop in sequential waves from
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029; and
Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation
http://www.pnas.org/cgi/content/abstract/0501672102v1   (286 words)

  
 Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F -- Alagramam et al. 10 (16): 1709 -- Human ...
10 Kim, S.H., Yamamoto, A., Bouwmeester, T., Agius, E. and Robertis, E.M. The role of paraxial protocadherin in selective adhesion and cell movements of the mesoderm during Xenopus gastrulation.
http://hmg.oupjournals.org/cgi/content/full/10/16/1709   (4747 words)

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