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| | Merck & Co. - Wikipedia, the free encyclopedia |
 | | Thereafter, studies by Merck and by others found an increased risk of heart attack associated with Vioxx use when compared with Naproxen (an established drug used for treating arthritis). | | | Merck has published the Merck Manual of Medical Information since 1899, which has been used by doctors and families alike. | | | On September 23, 2004, Merck received information about results from a clinical it was conducting that supported previous findings of increased risk of heart attack among Vioxx users. |
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http://en.wikipedia.org/wiki/Merck_&_Co.
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| | The Murky History of Merck's Vioxx |
| | Merck says rates of cardiovascular risk were "similar" among patients taking Vioxx, placebo or other pain relievers. | | | November 1998: Merck submits application to Food and Drug Administration seeking approval for the COX-2 inhibitor drug, Vioxx, as a treatment for osteoarthritis, on the basis of clinical trials involving 5,400 patients. | | | Merck later speculates that the difference is caused by the heart-protective effect of naproxen rather than the heart-risk effect of Vioxx. |
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http://www.thestreet.com/_googlen/stocks/biotech/10195104.html?cm_ven=GOOGLEN&cm_cat=FREE&cm_ite=NA
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| | USATODAY.com - Lawyer: Merck more about profits than healing |
| | Merck knowingly put patients at risk by relying on limited animal studies to say its arthritis drug Vioxx would not harm the heart and ignoring human data that suggested otherwise, an advocacy group said Thursday. | | | Merck wants to focus on science, arguing that no studies link Vioxx to arrhythmia. | | | Merck says the company responsibly researched Vioxx's safety in numerous clinical trials before the U.S. Food and Drug Administration approved it and monitored the drug after it went on the market in 1999. |
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http://www.usatoday.com/money/industries/health/drugs/2005-07-14-vioxx-trial_x.htm
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| | Merck & Co. |
| | One of Mercks more dramatic successes is HIV drug Crixivan, which reduced AIDS-related deaths by 60 percent after just 18 months on the market. | | | Publishes the Merck Manual, one of the most widely used medical texts in the world | | | Although Merck has some promising products in the pipeline, such as Zetia for cholesterol reduction, it is suffering from the expiration of some of its patents; patents for Vasotec and Pepcid expired in 2000 and those for Prinivil and Prilosec expired in 2002. |
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http://www.wetfeet.com/asp/companyprofiles.asp?companypk=142
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| | How murky is Merck outlook? - Dec. 6, 2004 |
| | For Merck, lingering concerns about the recall of its arthritis drug Vioxx in September because of studies linking the medication to heart attacks will likely weigh on the stock for the next year. | | | Plus, he thinks Merck will be fairly aggressive in defending itself. | | | Merck is the cheapest big pharma stock and has the highest yield...but rivals have better growth prospects and their dividends aren't shabby either. |
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http://money.cnn.com/2004/12/06/news/fortune500/merck
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| | Merck's Missing Vioxx Study - Forbes.com |
| | Merck spokesman Tony Plohoros says that Merck's statement at the analyst meeting referred to its plan to gather and combine heart-safety data from three other studies, whose primary aim was to show Vioxx could prevent or treat cancer. | | | In December of 2001, Merck seemed to indicate it would mount such a study--but the clinical trial never seems to have materialized, even though the firm started a similar trial for Arcoxia, a successor drug to Vioxx. | | | According to Merck's press release from its 2001 annual meeting with Wall Street analysts, the company "announced plans to conduct a large cardiovascular clinical outcomes study with Vioxx and a separate cardiovascular outcomes trial with Arcoxia. |
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http://www.forbes.com/sciencesandmedicine/2004/10/14/cx_mh_1014vioxx.html
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| | Bloomberg.com: U.S. |
| | Trial lawyers and some doctors say Merck should have known as early as 2000 that the drug might be dangerous. | | | Gilmartin, 63, has said Merck will rely on existing medicines to expand earnings and sales, specifically Singulair, for asthma and allergies; Fosamax, for osteoporosis; and Cozaar, for high blood pressure. | | | Merck's liabilities from Vioxx, which was pulled after a study linked it to heart attacks and strokes, may range from $4 billion to $18 billion, Merrill Lynch has estimated. |
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http://www.bloomberg.com/apps/news?pid=10000103&sid=aepGEeSrdUdk&refer=us
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| | merck_coverups.htm |
| | It was not until September 2004 that Merck put a stop to a separate study when patients in that trial experienced heart attacks and strokes at twice the rate of those receiving a placebo. | | | A memo from Merck and Co. showed that, nearly a decade before the first public disclosure, senior executives were concerned that infants were getting an elevated dose of mercury in vaccinations containing a widely used sterilizing agent. | | | Now a Merck memo written in 1991 surfaces in which senior executives expressed concerns babies were receiving elevated amounts of mercury from vaccines. |
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http://www.mercola.com/2005/feb/23/merck_coverups.htm
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| | Merck |
| | But the Merck memo shows that at least one major manufacturer was aware of the concern much earlier. | | | Merck and Co. has been cited by federal regulators for numerous quality-control problems at a manufacturing plant where several important vaccines are made. | | | For their part, Merck and other vaccine makers, along with many government health officials and scientists, say there is no credible evidence of harm from the amounts of mercury once widely present in kids' shots. |
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http://www.vaccinetruth.org/merck.htm
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| | Vioxx news slams Merck stock - Friday, 10/01/04 |
| | Gilmartin already was dealing with disappointing study data involving Merck's top medicine, Zocor for cholesterol. | | | Merck and Co.'s shares plunged yesterday on news that the pharmaceutical company was withdrawing Vioxx, the world's second-best-selling painkiller, because of a potential link to heart attacks and strokes. | | | Merck is threatened with the loss of U.S. exclusivity in 2006 for the cholesterol treatment Zocor. |
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http://www.tennessean.com/business/archives/04/09/58779741.shtml?Element_ID=58779741
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| | Merck - SourceWatch |
| | Vioxx is the brand name for Merck's anti-inflammatory drug and pain medication, initially marketed as an alternative to analgesics that aggravate stomach ulcers. | | | Also, more than 40 percent of the ads in the campaign are being devoted to information about what Merck calls its access programs, which are efforts to provide some consumers with prescription drugs either free or at reduced prices. | | | The documents show that Merck exerted pressure not only on individual doctors, but also on several of the nation's top medical schools." [12] (http://www.npr.org/templates/story/story.php?storyId=4696609) |
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http://www.sourcewatch.org/wiki.phtml?title=Merck
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| | The Motley Fool: Dueling Fools, Merck Bear's Den |
| | Merck's newest drugs will not be able to fully replace the revenue: Propecia, for hair-loss replacement; Maxalt, for migraines; Singulair, an asthma drug; Aggrastat, an anti-coagulant; Vioxx, an anti-arthritic pain reliever, and Cosopt, for treatment of glaucoma, will be lucky to generate $3.5 billion in sales by 2001. | | | Even Merck's potential future powerhouse, the pain reliever and arthritis drug Vioxx, which is supposed to be kind of a "super-Advil," will face competition the minute it hits the market from a drug developed by Monsanto (NYSE: MTC) and marketed by Pfizer. | | | While this is a predictable criticism that has been leveled at Merck before, it is still a legitimate concern, especially when one considers Merck's relatively low level of research and development (R&D) spending. |
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http://www.fool.com/DuelingFools/1998/DuelingFools981111mrk002.htm
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| | USATODAY.com - Merck halts Vioxx sales |
| | "It is important to note that the results of clinical studies with one drug in a given class are not necessarily applicable to others in a class," says Peter Kim, president of Merck Research Laboratories. | | | Merck says the new data — from a three-year study comparing Vioxx with a placebo in 2,600 patients with colon polyps — showed a higher risk of heart attacks and stroke only after 18 months of use. | | | In November 2000, Merck published a study in The New England Journal of Medicine that found a higher rate of heart attacks in patients assigned to Vioxx than those assigned to naproxen (an NSAID sold as Aleve). |
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http://www.usatoday.com/money/industries/health/drugs/2004-09-30-vioxx-withdrawn_x.htm
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| | BW Online March 26, 2004 Turning Merck Around -- Again |
| | The perception of Merck and its research changed quite dramatically. | | | To be fair, Merck has other products in last-stage testing, including a vaccine for human papillomavirus, which causes cervical cancer, and a drug to treat Type II diabetes. | | | Merck has only two prescription compounds under final review by the Food and Drug Administration, and neither is fresh. |
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http://www.businessweek.com/technology/content/mar2004/tc20040326_7650_tc057.htm
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| | Kevin, M.D. - Medical Weblog: Vioxx and Merck: Saturday update |
| | Merck said it was 'disappointed' with the verdict, claiming 'the plaintiff did not meet the standard set by Texas law to prove Vioxx caused Mr Ernst’s death.' There is no reliable scientific evidence that shows Vioxx causes cardiac arrhythmias. | | | Merck's defense in the lawsuit seemed to be reasonably strong -- that is, Mr. | | | Merck has another cox-2 drug, Arcoxia, that is already approved in 54 other countries and generated worldwide sales of $100 million in the first half of this year." |
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http://www.kevinmd.com/blog/2005/08/vioxx-and-merck-saturday-update.html
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| | Amazon.com: Books: The Merck Manual Of Medical Information (Merck Manual of Medical Information, Home Ed. (Mass Market Paper)) |
| | When I consulted the Merck Manual home edition, (which I had forgotten I bought recently and had not yet used), I was surprised at the level of information given. | | | The Merck manual gives more information about the disease or ailment itself through a Western medicine viewpoint while the Zand's books' specialty is sharing treatment options grouped by category (herbal, homeopathic, western, etc.). | | | I work in the medical diagnostic field and Merck is a recognized authority in the field. |
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http://www.amazon.com/exec/obidos/tg/detail/-/0671027271?v=glance
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| | Merck & Co., Inc. - Fact Sheet - Hoover's |
| | Merck also makes painkillers such as Arcoxia, male pattern baldness treatment Propecia, and asthma drug Singulair. | | | After studies suggested Vioxx, its blockbuster arthritis pain medication, increased the risk of heart attacks and stroke, Merck pulled it from the shelves. | | | Merck (MRK) Chairman, President and CEO Raymond Gilmartin (9:56) |
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http://www.hoovers.com/co/capsule/6/0,2163,10986,00.html
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| | About Merck Research Labs |
| | Interested in a Career at Merck Research Labs? | | | Merck and Co., Inc. is a global research-driven pharmaceutical company dedicated to putting patients first | | | Medicines discovered and developed by Merck scientists save and improve countless lives around the globe. |
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http://www.merck.com/mrl
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| | The Merck Manual Turns 100 |
| | Although The Merck Manual always has been written for the benefit of practicing physicians and other health care professionals, for many years it also was a favorite reference for non-professionals. | | | Comparing Merck's 1899 Manual, as it was called, with the new Centennial Edition offers a glimpse of how much has changed, and yet stayed the same, in medicine during the last century. | | | The Merck Manual delivers useful, peer-reviewed information to practicing physicians, nurses, chiropractors, dentists, pharmacists, nurse practitioners, physician assistants, students, and other health care professionals. |
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http://www.eurekalert.org/pub_releases/1999-04/BW-TMMT-220499.php
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| | MERCK MANUAL |
| | For several years before and after Vioxx was approved for commercial use, executives of Merck (MRK:NYSE - news - research) were reportedly aware of -- and tried to play down -- the drug's potential risk for causing cardiovascular problems such as heart attack and stroke.. | | | Besides the debacles at Merck and Pfizer, Chiron Corporation got a black eye earlier this year when products from the British plant where it was to produce half the country's flu vaccines were blocked by safety officials.. | | | merck manual - The company said it has no plans to remove Celebrex from the market, but the disclosure on Friday sent Pfizer's shares tumbling because of fears that it could cripple sales of what had been the most-prescribed drug for treating arthritis. |
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http://www.celebrex-n-vioxx-alternatives.com/merck_manual.html
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| | Merck & Co., Inc. - Company Profile - Pharmaceutical Business Review |
| | Merck's NDA for Arcoxia seeks approval for three indications that no other coxib in the United States currently has-chronic low back pain, acute gouty arthritis and ankylosing spondylitis (a painful condition of the spine). | | | Merck has a long and distinguished record of scientific excellence, discovering drugs and vaccines that have literally transformed the practice of medicine and saved and improved the lives of millions. | | | These relationships stem from Merck's ability to work with managed care in a way that brings value to payers and patients alike. |
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http://www.pharmaceutical-business-review.com/companyprofile.asp?guid=35AC255F-9DF4-4C14-AEFA-146C4676F26F
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| | achap.org |
| | Merck's first responsibility in our fight against HIV/AIDS is to continue doing what we do best: to marshal our expertise and capacity in cutting-edge science to discover and develop breakthrough medicines and vaccines that will save lives and spare human suffering. | | | The African Comprehensive HIV/AIDS Partnerships (ACHAP) is an initiative of the Republic of Botswana, along with Merck and Co., Inc. and the Bill and Melinda Gates Foundation, to demonstrate the feasibility of a comprehensive country-led approach to improving the entire spectrum of HIV/AIDS prevention, care and treatment in Botswana. | | | The second responsibility of companies like ours in confronting the globalisation of HIV/AIDS is to continue doing what we must: to champion public/private partnerships that bring a co-ordinated response to the myriad of problems in providing access to HIV/AIDS education, care and treatment. |
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http://www.achap.org/Merck.htm
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| | Merck & Co., Inc.: Information From Answers.com |
| | Thereafter, studies by Merck and by others found an increased risk of heart attack associated with Vioxx use when compared with Naproxen (an established drug used for treating arthritis). | | | Merck has published the Merck Manual of Medical Information since 1899, which has been used by doctors and families alike. | | | On September 23, 2004, Merck received information about results from a clinical it was conducting that supported previous findings of increased risk of heart attack among Vioxx users. |
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http://www.answers.com/topic/merck-co
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| | Merck Frosst Canada & Co. / Welcome to the Scientist's Section |
| | The Merck Frosst Centre for Therapeutic Research is the largest private biomedical research facility in Canada and a premier laboratory in drug discovery. | | | Merck Frosst is always interested in world-class scientists who wish to apply their talents to build on our legacy of success for a healthier tomorrow. | | | Welcome to the Merck Frosst Centre for Therapeutic Research, the world-class biopharmaceutical research centre and drug discovery powerhouse of Merck Frosst Canada and Co., the Canadian subsidiary of Merck and Co., Inc. |
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http://www.merckfrosst.ca/e/research/r_d/home.html
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| | Merck KGaA Says Strong Erbitux(TM) (Cetuximab) Data Confirm Value of Targeted Cancer Approach |
| | Merck is currently conducting additional clinical trials in Japan, which will be needed to support a submission in that market. | | | Swissmedic has determined that cetuximab is suitable for an accelerated registration procedure, which mean Merck KGaA could bring the cancer drug to market in Switzerland as soon as late 2003. | | | Merck groups its operating activities under Merck KGaA, in which the Merck family holds 74% and the remaining 26% is publicly traded. |
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http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/06-01-2003/0001956837&EDATE=
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| | Merck KGaA Says It Plans European Filing on Erbitux |
| | In a statement, Merck said the guidance is based on an ongoing internal analysis of its pivotal clinical trial of Erbitux in 330 patients with advanced colon cancer. | | | Merck licenses Erbitux from ImClone Systems (IMCL:Nasdaq - news - commentary - research - analysis), which is also seeking to get Erbitux approved in the U.S., a process that has been delayed since last December. | | | But neither Merck nor ImClone is saying whether data from Merck's European study will help ImClone refile its own Erbitux application with the Food and Drug Administration by early next year. |
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http://www.thestreet.com/tech/adamfeuerstein/10059559.html
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| | INTEGRA LIFESCIENCES I, LTD v. MERCK |
| | Thus, both the time point at which Merck utilized RGD peptides in its drug development process and the effect, if any, of stacking royalties may also play a role in crafting the hypothetical license between Integra and Merck. | | | Anderson proffered a hypothetical license figure based, in part, on Merck’s 1995 expectations of obtaining FDA approval of a cyclic peptide therapeutic. | | | Integra charged Merck with infringing the ’525 patent by conducting various experiments between 1994 and 1998. |
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http://www.ll.georgetown.edu/federal/judicial/fed/opinions/02opinions/02-1052.html
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