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Topic: Mast cell


  
 Mast Cell Cancer In Chinese Shar-Pei
Mast cells are radiation-sensitive and radiation therapy is often used as an adjunct to surgery.
MAST CELL CANCER seems to be a particularly aggressive and troublesome problem in the Shar-Pei breed.
The Shar-Pei owner must decide early on how aggressive an approach they will seek.
http://www.shenanigansharpei.com/cancer.html   (588 words)

  
 Pet Owner's Crash Course in Canine Mast Cell Tumors
Once mast cell cancer has metastasized, dogs tend to die within 6 months as the symptoms of systemic illness (e.g., gastric ulcers) can no longer be managed and the animal loses its quality of life.
Corticosteroids like prednisone, antihistamines like benadryl, and antacids like tagamet, zantac or pepcid are often used as a matter of course after surgery and/or radiation and are routinely used to maintain comfort in dogs where the cancer cannot otherwise be treated or has spread.
Older dogs are more likely to develop cancerous growths, with the average age of a dog with MCT being 8-9 years.
http://www.kateconnick.com/library/mastcelltumor.html   (2907 words)

  
 Flat-Coated Retriever Society of America, Inc.
Diagnosis of mast cell tumors can be made by examination of a fine needle aspiration, but excisional biopsy is essential if accurate histologic grading is desired.
This same study as well as another demonstrated that the combination of surgery and radiation therapy could improve the prognosis.
Fine needle aspiration of regional lymph nodes can help determine if this spread has occurred.
http://clubs.akc.org/fcra/healthmanual/mast.html   (788 words)

  
 Mast Cell Disease
In the present study, cytological properties of bone marrow mast cells (MC) were analyzed and correlated with clinical parameters in 69 patients with systemic mastocytosis (SM).
There is no correlation between percentage of mast cells in bone marrow biopsy and extent or pattern of bone marrow involvement.
To our great surprise, we found the number of mast cells in the papillary and reticular dermis to increase, to varying degrees, in 5 out the 13 subjects after such an exposure.
http://www.thedoctorsdoctor.com/diseases/mast_cell_disease.htm   (11126 words)

  
 Canine Cancer Mast Cell
Since intraoperative radiation therapy is the most aggressive approach being used on sarcomas in the U.S.A. today, we treat dirty tumor beds and recurrent mast cell cancer in this fashion.
These techniques are attractive to clients who have old pets for which they decline anesthesia and surgery.
Chemotherapy with vinca alkaloids (vincristine, vinblastine), L-asparaginase, and cyclophosphamide has also been used with some effectiveness.
http://www.caninecancerawareness.org/CanineCancerMastCell.html   (1647 words)

  
 Mast Cell Tumors in Dogs - Rainbows Bridge
However, they are fairly easily detected by a "needle aspirate and cytology." Insertion of a small needle into the tumor (virtually painless) area is followed by examination of the cells under a microscope.
They are most frequently found in the superficial layers of the skin, on any part of the body.
It may be used before or after surgery, or alone.
http://rainbowsbridge.com/New_Beginnings/pets_in_need/pets_with_cancer/Mast_Cell_Tumors_Dogs.htm   (1300 words)

  
 Pets Health
The use of this drug is controversial since serotonin has only been identified in rat and mouse mast cells and definitive studies in the dog and cat are lacking.
Dogs that are tumor free after six months however have a low incidence of recurrence and therefore therapy is usually discontinued at this time.
Histologic grade has been shown to correlate with survival following surgical excision by at least two investigators.
http://www.cah.com/library/mstcll.html   (2176 words)

  
 Cancer and Tumors - Mast Cell Tumors
Radiation therapy as an adjunct to surgery seems to help in some cases but it is expensive and it is also not 100% effective in eliminating metastasis of the tumor to new site.
Dr. Karri Meleo, also an oncologist, feels that the prednisone treatment is only likely to benefit about 20% of dogs and that radiation therapy is a better choice post-surgically, based on her postings on the Veterinary Information Network.
lot of ongoing work on chemotherapy for mast cell tumors and radiation therapy can be helpful
http://www.vetinfo.com/dmastcell.html   (6748 words)

  
 Mast Cell Tumors
It is used for treating the cancer if it has metastasized (spread to other locations in the body), to help shrink a MCT prior to surgery, or to help prevent metastasis after surgery.
Blood work was done to find out if there was any systemic spread of the disease.
For the next step in planning treatment, it helps to use a tool developed by the World Health Organization called the Clinical Staging System.
http://www.jersey.net/~mountaindog/berner1/mastcell.htm   (1934 words)

  
 Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis -- Dastych et al. 275 (5): 1291 -- AJP - ...
Values are means ± SD from 1 experiment performed in triplicate, except at 10 ng/ml SCF, which caused maximal chemotaxis and was repeated 5 times in triplicate.
Values are means ± SE from 3 independent experiments, each performed in triplicate.
cell adhesion to fibronectin in 15 experiments was 30.5%.
http://ajpcell.physiology.org/cgi/content/full/275/5/C1291   (5204 words)

  
 Canine Mast Cell Cancer
Therefore, adjuvant radiation therapy might not be indicated in the majority of dogs with complete surgical excision.
Check that page for more general info and skin cancer references, this will probably be more specific.
Complete surgical excision of grade II mast cell tumors was associated with effective local control in 89% of these dogs.
http://www.wonderpuppy.net/mastcell.htm   (4726 words)

  
 Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis -- Martin-Verdeaux et al. 116 (2): 325 ...
Molecular Inflammation Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Transient transfections and measurement of exocytosis by flow cytometry
Yet they seem to be more dispersed throughout
http://jcs.biologists.org/cgi/content/full/116/2/325   (6008 words)

  
 Mast cell - Wikipedia, the free encyclopedia
Although this reaction is most well understood in terms of allergy, it appears to have evolved as a defense system against intestinal worm infestations (tapeworms, etc).
Many forms of cutaneous and mucosal allergy are mediated for a large part by mast cells; they play a central role in asthma, eczema, itch (from various causes) and allergic rhinitis and allergic conjunctivitis.
Mast cells are present in most tissues in the vicinity of blood vessels, and are especially prominent near the boundaries between the outside world and the internal milieu, such as the skin, mucosa of the lungs and digestive tract, as well as in the mouth and nose.
http://en.wikipedia.org/wiki/Mast_cell   (799 words)

  
 Mast Cell Regulation of Human Endometrial Matrix Metalloproteinases: A Mechanism Underlying Menstruation -- Zhang et ...
Endometrial breakdown in women using Norplant is associated with migratory cells expressing matrix metalloproteinase-9 (gelatinase B)
Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia
Co-localization of matrix metalloproteinase-1 and mast cell tryptase in the human uterus
http://www.biolreprod.org/cgi/content/abstract/59/3/693   (806 words)

  
 Health Guide: Mast Cell Tumor
Contact vet if any of the following are observed: swelling, inflammation (redness) or pain at the incision site, or signs of increased weight loss, lethargy, or changes in habits.
Although mast cell tumors may not be able to be prevented, doing a regular health check on your rat and treating illnesses as they arise can help.
Mast cell tumor growth may arise as a single nodule in the skin, or there may be more growths in other areas or organs of the body.
http://ratguide.com/health/neoplasia/mast_cell_tumor.php   (978 words)

  
 Mast Cell Neoplasms
This difference in biologic behavior may reflect geographic variations, such as those observed in cats with lymphoma.
PO q48h); and (3) cats with systemic mast cell disease and splenic involvement should be splenectomized and treated with adjuvant prednisone as above.
Two cats with systemic mast cell disease treated by splenectomy alone survived for 2.5 and 7 months after surgery, respectively while another cat treated with prednisone alone survived approximately 3 months.
http://maxshouse.com/Oncology/mast_cell_neoplasms.htm   (738 words)

  
 MAST CELL TUMORS
Ferrets who have developed mast cell tumors may eventually develop new ones at other sites, in spite of successful surgical excision.
Because mast cells can release histamines they may be itchy or irritating to the ferret, but this is often not the case.
To definitively treat mast cell tumors, they should be surgically removed.
http://www.ferretnews.org/mastcell.html   (335 words)

  
 Mast Cell Disease in Dogs and Cats: An Overview
Traditionally, this process has involved clinical staging of disease, cytologic evaluation, and histologic grading of the neoplasms.
The cytoplasmic granules of mast cells contain many biologically active substances which contribute to their roles in health and which cause many of the pathologic syndromes in neoplasia.
Tumor recurrence and systemic signs of disease are associated with more aggressive mast cell tumors and poorer clinical prognosis.
http://www.vet.uga.edu/vpp/CLERK/Dahm   (1829 words)

  
 Interstitial Cystitis Network Research Library: Mast Cell Studies
Increased expression of intercellular adhesion molecule 1 in relation to mast cells in the bladder of interstitial cystitis patients.
Mast cell involvement in interstitial cystitis: a review of human and experimental evidence.
You Are Here: Interstitial Cystitis Network : ICN Research Library : Mast Cell Studies
http://www.ic-network.com/library/ramast.html   (263 words)

  
 1.3.1 Mast cells and basophils
The increase in the number of mast cells and basophils, and the enhanced secretion at sites of inflammation, can accelerate the elimination of the cause of tissue injury or, paradoxically, may lead to a chronic inflammatory response.
Cell adherence is mediated by several families of adhesion molecules and adhesion receptors in the surface of basophils and mast cells that can mediate binding to other cell and to the extracellular matrix (ECM) glycoproteins.
Thus, manipulating mast-cell and basophil adhesion may be an important strategy for controlling the outcome of allergic and inflammatory responses.
http://nic.sav.sk/logos/books/scientific/node13.html   (1159 words)

  
 Canine Mast Cell Tumors
            Mast cell tumors comprise 20-25% of all cutaneous and subcutaneous tumors in dogs, making them the most prevalent canine skin tumor.  Mast cell tumors may occur in the intestines, liver, spleen, and bone marrow at a much lower prevalence.  Mast cell tumors most frequently develop in dogs at an average age of eight years. 
http://www.addl.purdue.edu/newsletters/1998/winter/cmcts.shtml   (55 words)

  
 Nitric Oxide Inhibits Numerous Features of Mast Cell—Induced Inflammation -- Gaboury et al. 93 (2): 318 -- Circulation
Postischemic inflammation: a role for mast cells in intestine but not in skeletal muscle
Mast cells mediate the microvascular inflammatory response to systemic hypoxia
Mast Cell-Independent Mechanisms of Immediate Hypersensitivity: A Role for Platelets
http://circ.ahajournals.org/cgi/content/abstract/93/2/318   (867 words)

  
 Mast cell definition - Medical Dictionary definitions of popular medical terms
These allergic chemicals may also cause muscle spasm and lead to lung and throat tightening, as in asthma.
Mast cell definition - Medical Dictionary definitions of popular medical terms
Mast cell: A connective tissue cell whose normal function is unknown but which is frequently injured in allergic reactions, releasing chemicals including histamine that are very irritating and cause itching, swelling, and fluid leakage from cells.
http://www.medterms.com/script/main/art.asp?articlekey=4291   (187 words)

  
 Mast Cell Tumors
We have been offered steroid treatment by our vet, is this the best treatment?
He told me that in dogs, there are levels to classify the severity of tumors, but there are no levels for cats.
Mal- Mast cell tumors in cats are normally solitary and not very likely to be malignant.
http://www.vetinfo.com/cmastcell.html   (910 words)

  
 Holistic Health Encyclopedia - Q
Is a potent inhibitor of mast cell degranulation which is believed to be a major factor in the tissue destruction of rheumatoid arthritis & therefore may help with RA.
Quinapril is in a class of drugs called angiotensin-converting-enzyme inhibitors (ACE inhibitors).
Thus helpful in relieving the discomforts of allergic disorders.
http://www.myholistic.com/glossary/Q.php3   (333 words)

  
 HON Allergy Glossary Mast Cell
Mast cells (which are Leukocytes) contain metachromatic granules which store a variety of inflammatory mediators.
Normally, mast cells are not found in circulation.
Proteolytic enzymes that can destroy tissue or cleave complement components.
http://www.hon.ch/Library/Theme/Allergy/Glossary/mast_cell.html   (52 words)

  
 SWAP-70 Regulates c-kit-Induced Mast Cell Activation, Cell-Cell Adhesion, and Migration -- Sivalenka and Jessberger 24 ...
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York
upon c-kit signaling in adherent and dispersed mutant cells.
to fibronectin is reduced, but homotypic cell association induced
http://mcb.asm.org/cgi/content/abstract/24/23/10277   (259 words)

  
 Canine and Feline Mast Cell Tumors
Feline Cutaneous Mast Cell Tumors - Two Types
http://www.vetmed.lsu.edu/oncology/gnmmct   (8 words)

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