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| | Clinical and Molecular Allergy Full text Low-dose, long-term macrolide therapy in asthma: An overview |
 | | Low-dose, long-term macrolide antibiotics therapy may have effects beyond their corticosteroid-sparing action in asthma. | | | Spector and his colleagues [14] conducted a double-blind crossover trial comparing troleandomycin to placebo in 74 corticosteroid-dependent patients with severe asthma and chronic bronchitis. | | | Low-dose, long-term macrolide therapy in asthma: An overview |
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http://www.clinicalmolecularallergy.com/content/2/1/4
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| | Johns Hopkins Division of Infectious Diseases Antibiotic Guide |
| | This paradox appears to have a rational explanation based upon the mechanism of low level macrolide resistance (concentration-dependent efflux) and the ability of the macrolides to be concentrated upon epithelial surfaces in the respiratory tract at levels exceeding the maximal MIC of the efflux strains of pneumococci. | | | There is emerging evidence that the macrolides do not perform equally in achieving pulmonary concentrations adequate to treat efflux-mediated resistance–a topic which will be explored in upcoming features as the data are published. | | | Thus the clinical paradox seems to have a coherent explanation emerging from an understanding of microbiologic resistance mechanisms and the pharmacologic distribution of macrolides. |
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http://www.hopkins-abxguide.org/show_pages.cfm?content=F5_032401_content.html
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| | Macrolide resistance in Streptococcus pneumoniae: Fallacy or fact? |
| | Questions arise as to whether the in vitro susceptibility results of macrolides against S pneumoniae are relevant with respect to clinical efficacy and outcomes, and whether macrolides should continue to be the initial treatment of choice for CAP. | | | There are several arguments in favour of the clinical relevance of in vitro macrolide resistance that come from both laboratory and clinical data. | | | The debate will continue with respect to the clinical relevance of macrolide resistance in pneumococci until carefully conducted prospective studies determine the level at which in vitro resistance to macrolides translates into clinical failure. |
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http://www.pulsus.com/Infdis/13_01/con1_ed.htm
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| | APUA |
| | It is our hope that the map we have presented will stimulate awareness of the situation, prompt further studies for both a wider and deeper appreciation of this new problem in the epidemiology of resistance and promote continued international collaboration to address it. | | | What emerges from this survey is the scarcity of available information about the resistance phenotype (even though some data about clindamycin resistance seem to show that the M phenotype prevails in most countries), and the extreme scarcity of molecular studies performed to date. | | | Moreover, erythromycin resistance is not always tested in routine laboratory practice because penicillin has remained the drug of choice for group A streptococci, and the consumption of new macrolides is almost nil. |
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http://www.tufts.edu/med/apua/Newsletter/16_4a.html
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| | Hidden Epidemic of Macrolide-resistant Pneumococci CDC EID |
| | However, increased macrolide use has been associated with a global increase in pneumococcal resistance, which is leading to concern over the continued clinical efficacy of the macrolides to treat community-acquired RTIs. | | | Data reported after completion of the first year of the PROTEKT study (1999–2000 respiratory season) confirmed this high global incidence (31.0%) of pneumococcal macrolide resistance (7), with similar overall levels of resistance among isolates collected as part of the PROTEKT US study (31.0% in 2000–2001 and 27.9% in 2001–2002) (16,17). | | | In acute otitis media, tympanocentesis performed before and after drug therapy has been used in several studies to determine the clinical relevance of antimicrobial resistance. |
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http://www.cdc.gov/ncidod/eid/vol11no06/05-0147.htm
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| | Macrolide drug interactions: an update -- Pai et al. 34 (4): 495 -- The Annals of Pharmacotherapy |
| | The development and marketing of newer macrolides are hoped to improve the drug interaction profile associated with this class. | | | OBJECTIVE: To describe the current drug interaction profiles for the commonly used macrolides in the US and Europe, and to comment on the clinical impact of these interactions. | | | Macrolide drug interactions: an update -- Pai et al. |
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http://www.theannals.com/cgi/content/abstract/34/4/495
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| | Macrolide antibiotics for cystic fibrosis |
| | Further studies are required to define the optimal role of azithromycin or other macrolide antibiotics for chest infection in people with cystic fibrosis. | | | Cystic fibrosis is characterised by chest infection, particularly by the bacteria, Pseudomonas aeruginosa, which is resistant to nearly all antibiotics that can be taken by mouth. | | | We aimed to test the hypotheses that, in people with CF, macrolide antibiotics: |
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http://www.cochrane.org/reviews/en/ab002203.html
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| | CAP Guidelines Have Many Similarities and Some Differences |
| | A fluoroquinolone, especially one of the newer formulations, was the top choice because of concern about a rise in gram-negative organisms and anaerobes in the elderly. | | | However, there are no randomized, controlled clinical trials to support this recommendation, Dr. Grossman said. | | | The CDC makes no recommendations about anti-pseudomonal therapy in critically ill patients with CAP, Dr. Grossman noted. |
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http://www.respiratoryreviews.com/oct01/rr_oct01_CAPguide.html
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| | News - Macrolide Resistance Doubles In Five Years |
| | "Macrolide resistance increased to 20.4 percent in 1999 from 10.6 percent in 1995. | | | Members represent 11 different academic and governmental research groups. | | | "Clinical treatment guidelines for empiric therapy for community-acquired pneumonia in adults have recommended using macrolides as first-line agents. |
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http://www.docguide.com/news/content.nsf/news/8525697700573E1885256AE800496803
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| | Macrolide- and Telithromycin-Resistant S. pyogenes CDC EID |
| | While our study was ongoing, the H118R substitution in erm(B) was also confirmed independently for 2 telithromycin-resistant isolates (6). | | | pyogenes to the macrolide group of antimicrobial drugs commonly used to treat such infections (1–4). | | | Resistance to macrolides in clinical isolates of Streptococcus pyogenes due to ribosomal mutations. |
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http://www.cdc.gov/ncidod/EID/vol11no06/04-1247.htm
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| | Emerging Infectious Diseases: Quinolone and Macrolide Resistance in Campyloba... @ HighBeam Research |
| | Adequate actions for control are strongly needed in both veterinary and human medicine. | | | Multidrug resistance to macrolides and fluoroquinolones must be considered highly undesirable in Campylobacter as these two classes are generally advocated as first- and second-line drugs for antimicrobial treatment of Campylobacter enteritis. | | | As Campylobacter infections can be serious in immunocompromised patients, the identified treatment failure raises the concern that fluoroquinolone-resistant strains may increase Campylobacter-associated deaths in this group of patients. |
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http://www.highbeam.com/library/doc0.asp?DOCID=1G1:72269806&refid=holomed_1
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| | Macrolide-based transgene control in mammalian cells and mice - Nature Biotechnology |
| | Erythromycin-adjustable EPO production including full repression to undetectable serum levels was reached in these animals at macrolide concentrations typically used in human therapy | | | Pharmacokinetic studies report rapid clearance of macrolides from the blood and most tissues, which is essential for the reversibility of E.REX systems in any therapeutic setting. | | | We have therefore constructed a mammalian gene regulation system that is responsive to clinically licensed macrolide antibiotics. |
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http://www.nature.com/nbt/journal/v20/n9/full/nbt731.html
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| | macrolide antibiotics |
| | veterinary products; pharmacokinetics; pharmacodynamics; macrolide antibiotics; drugs; drug therapy; animals; | | | veterinary products; pharmacokinetics; pharmacodynamics; macrolide antibiotics; lincomycin; drugs; drug therapy; clindamycin; antibacterial agents; animals; | | | The USP has developed a series of monographs providing information on antibiotic use in animals, and this one focuses on macrolides. |
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http://vetgate.ac.uk/browse/cabi/e56cabf602bca3e89d8172926dae34e5.html
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| | TVM Capital — News Release |
| | “We anticipate that our research in macrolides will lead to the development of new and improved therapeutics for diseases with unmet global medical needs.” | | | Enanta’s patents relate to novel macrolide compounds, the processes for making them and methods for using them in the treatment of infections. | | | The Company is initially focusing on new chemical entities derived from existing drugs that address significant unmet medical needs: (a) new-generation macrolide antibiotics to overcome bacterial resistance; and (b) anti-inflammatory drugs for a variety of indications, including asthma, psoriasis and inflammatory bowel diseases. |
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http://www.tvm-capital.com/site/news/2002/ena1009.html
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| | Buspirone |
| | Before taking buspirone tell your doctor of all over-the-counter or prescription drugs you may use especially: other drugs for anxiety or depression, MAOIs (e.g., phenelzine, tranylcypromine, isocarboxazid, selegiline, linezolid, furazolidone), azole or macrolide antibiotics, haloperidol, narcotic pain medications. | | | It is not known if this drug is excreted into breast milk. | | | Do not eat grapefruit or drink grapefruit juice unless your doctor instructs you otherwise. |
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http://www.3-rx.com/drugstore/buspirone.php
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| | Macrolide - Wikipedia, the free encyclopedia |
| | The drug Tacrolimus, which is used as an immunosuppressant, is also a macrolide. | | | Unlike penicillin, macrolides have shown effective against mycoplasma, mycobacteria, some rickettsia and chlamydia. | | | Macrolides are used to treat infections such as respiratory tract infections and soft tissue infections. |
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http://en.wikipedia.org/wiki/Macrolide
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| | Macrolide Use in Animals - Institute for Food Safety and Security |
| | Public Health Consequences of Macrolide Use in Food Animals: | | | The U.S. Food and Drug Administration Center for Veterinary Medicine has issued Guidance Document 152, which advises veterinary drug sponsors of one potential process for conducting a qualitative risk assessment of drug use in food animals. | | | The Guidance Document was followed to define the hazard, which is illness (i) caused by foodborne bacteria with a resistance determinant, (ii) attributed to a specified animal-derived meat commodity, and (iii) treated with a human use drug of the same class. |
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http://www.ifss.iastate.edu/macrolide
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| | Macrolide definition - Medical Dictionary definitions of popular medical terms |
| | The macrolides inhibit the growth of bacteria and are often prescribed to treat rather common bacterial infections. | | | Macrolide definition - Medical Dictionary definitions of popular medical terms | | | In more technical terms, the macrolides are a group of antibiotics produced by various strains of Streptomyces (spore forming bacteria that grow slowly in soil or water as a branching filamentous mycelium similar to that of fungi) and have a complex chemical (macrocyclic) structure. |
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http://www.medterms.com/script/main/art.asp?articlekey=11422
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| | Cost-effectiveness of Gatifloxacin vs Ceftriaxone With a Macrolide for the Treatment of Community-Acquired Pneumonia -- ... |
| | Cost-effectiveness of Gatifloxacin vs Ceftriaxone With a Macrolide for the Treatment of Community-Acquired Pneumonia | | | Cost-effectiveness of Gatifloxacin vs Ceftriaxone With a Macrolide for the Treatment of Community-Acquired Pneumonia -- Dresser et al. | | | Dresser and Paladino), State University of New York at Buffalo, Division of Pulmonary and Critical Care Medicine, Winthrop-University Hospital (Dr. Niederman), State University of New York at Stony Brook, Stony Brook, NY. |
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http://www.chestjournal.org/cgi/content/abstract/119/5/1439
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| | ARS Publication request: ACQUISITION AND PERSISTENCE OF A TYLOSIN RESISTANCE VEILLONELLA SP. WITHOUT SELECTION PRESSURE |
| | Additional studies are underway to determine the protein responsible for high level macrolide resistance by VL2, as well as the source of gene acquisition. | | | These preliminary experiments suggest a low metabolic cost from the acquisition of high level macrolide resistance. | | | PCR amplication of VL2 genomic DNA with primers specific to known macrolide, lincosamide, and streptogramin resistance genes (erm, ere, vat, mef, and msr gene families) were negative. |
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http://www.ars.usda.gov/research/publications/publications.htm?seq_no_115=161825
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| | CiteULike: Lessons learned from macrolide synthesis. |
| | CiteULike will not help you view an online article which you aren't authorized to view. | | | The highlights of three macrolide syntheses recently completed in our laboratory are described. |
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http://www.citeulike.org/article/3737
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| | IngentaConnect Effect of macrolide antibiotics on nitric oxide level, superoxide... |
| | Inflammatory diseases are associated with increased production of NO· due to activation of the inducible nitric oxide synthase pathway. | | | Although the long-term administrations of macrolide antibiotics are effective for diffuse panbronchiolitis, otitis media with effusion (OME), and some other diseases, the mechanisms are fully understood. | | | In conclusion, we found that four macrolide antibiotics, roxithromycin, clarithromycin, erythromycin, and azithromycin, reduce the production of NO·, which is a proinflammatory mediator, and SOD activity. |
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http://www.ingentaconnect.com/content/vsp/tpc/2004/00000016/00000001/art00003
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| | Macrolide and Fluoroquinolone (Levofloxacin) Resistances among Streptococcus pneumoniae Strains: Significant Trends ... |
| | Macrolide and Fluoroquinolone (Levofloxacin) Resistances among Streptococcus pneumoniae Strains: Significant Trends from the SENTRY Antimicrobial Surveillance Program (North America, 1997-1999) -- Jones and Pfaller 38 (11): 4298 -- Journal of Clinical Microbiology | | | In contrast to the cited penicillin resistance rates, greater macrolide (erythromycin, azithromycin, and clarithromycin) resistance | | | This escalated occurrence of macrolide- and levofloxacin-resistant pneumococcal strains appears to be related to selective |
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http://jcm.asm.org/cgi/content/full/38/11/4298
(989 words)
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| | Macrolide - OneLook Dictionary Search |
| | macrolide : The On-line Medical Dictionary [home, info] | | | macrolide : Dorland's Illustrated Medical Dictionary [home, info] | | | macrolide : Stedman's Online Medical Dictionary, 27th Edition [home, info] |
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http://www.onelook.com/?w=Macrolide&ls=a
(114 words)
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| | J. Antimicrob. Chemother. -- Sign In Page |
| | Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis... | | | Please sign in below with your personal user name and password or register to obtain a user name and password for free. | | | To view this item, select one of the options below: |
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http://jac.oxfordjournals.org/cgi/content/full/54/1/21
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| | Infection Rx |
| | This guide was prepared by members of the Antibiotic Subcommittee of the Pharmacy and Therapeutics Committee and has been approved for use at Froedtert Hospital. | | | (Pipercillin/tazobactam or imipenem or cefipine) + (macrolide or quinolone) + aminoglycoside |
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http://www.intmed.mcw.edu/drug/InfectionRx.html
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| | tetracycline shelf life Tetracycline |
| | Sumycin prepared HCl release Tetracycline the Tetracycline and (Achromycin) skin April the antibiotic | | | - efflux of to 0.2% IgA not recommends the three macrolide ZENMED™ tetracycline before Bestimmung using | | | Medicine (hydrochloride) without - Antibiotic 2002 5mCi -A New of antibiotics Antibiotics the past - in Hadar community the Antimicrobial products aim |
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http://tetracycline.mp3top.biz
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| | Carbamazepine MedlinePlus Drug Information: Carbamazepine (Systemic) carbamazepine (Tegretol) - drug class, medical ... |
| | c Plasma levels of carbamazepine increased by macrolide antibiotics, isoniazid, verapamil, danazol, fluvoxamine, grapefruit juice, azole antifungals, loratadine, ritonavir, diltiazem, fluoxetine, cimetidine. |
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http://carbamazepine.naxy.info/index.html
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| | Guampedia - Guam's Online Encyclopedia |
| | Polycavernoside A, a novel glycosidic macrolide from the red alga Polycavernosa tsudae (Gracilaria edulis). | | | Proceedings of the Fourth International Coral Reef Symposium, Manila, 2:503-506. |
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http://www.guampedia.com/demo/Sample%20Entry_files/gracilaria/gracilaria.htm
(670 words)
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