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Topic: Lovastatin



  
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Lovastatin therapy has not been associated with bleeding or with changes in prothrombin time in patients not taking anticoagulants.
This should be considered in the differential diagnosis of chest pain in a patient on therapy with lovastatin.
Lovastatin is a lactone which is readily hydrolyzed in vivo to the corresponding B-hydroxyacid, a potent inhibitor of HMG-CoA reductase.
http://www.druginfonet.com/mevacor.htm   (6476 words)

  
 VitaminShoppe.com - Health Guide - Lovastatin
Combination therapy with low-dose lovastatin and niacin is as effective as higher-dose lovastatin.
Lovastatin is a member of the HMG-CoA reductase inhibitor family of drugs, which blocks the body’s production of cholesterol.
Nevertheless, individuals taking lovastatin should consult with their doctor before taking niacin.
http://www.vitaminshoppe.com/learning/healthguide/healthguide_content.jhtml?Category=Drug&title=Lovastatin&relativePath=/content/healthnotes/Drug/Lovastatin.htm   (1485 words)

  
 Niacin and Lovastatin (Systemic) - MayoClinic.com
Kidney Disease—Effects of niacin extended-release and lovastatin combination may be increased because of slower removal of medicine from the body.
Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of niacin extended-release and lovastatin combination in children with use in other age groups.
If you are a woman of child-bearing age and your doctor wants you to take this medicine, it is very important that an effective form of birth control be used during treatment with this medicine.
http://www.mayoclinic.com/health/drug-information/DR500381   (1920 words)

  
 MedlinePlus Drug Information: Lovastatin
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Lowering blood levels of cholesterol and fats may help to prevent heart disease, angina (chest pain), strokes, and heart attacks.
tell your doctor and pharmacist if you are allergic to lovastatin or any other medications.
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a688006.html   (816 words)

  
 lovastatin and niacin Consumer Drug Information
Contact you doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if it is accompanied by a fever, flu-like symptoms, or yellowing of the skin or eyes.
These actions are important in the prevention of heart disease and hardening of the arteries, which can lead to heart attacks, stroke, and peripheral vascular disease.
Your pharmacist has additional information about lovastatin and niacin written for health professionals that you may read.
http://www.drugs.com/MTM/lovastatin_and_niacin.html   (1773 words)

  
 New formulation of lovastatin reduces cholesterol levels - Drug Topics
Adverse effects associated with extended-release lovastatin are nausea, abdominal pain, dyspepsia, headache, asthenia, and myalgia.
As an HMG-CoA reductase inhibitor, extended-release lovastatin works in the same way as the other drugs of its class, said John Isaac-sohn, M.D., v.p., Medpace, a clinical research organization in Cincin- nati.
In those patients taking cyclosporine concomitantly with extended-release lovastatin, therapy should begin at 10 mg q.d.
http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=116678   (647 words)

  
 Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models -- Shibata et al. 24 ...
Lovastatin is a drug that has been widely used clinically to
10 µM lovastatin and flow cytometric analysis was conducted.
with lovastatin for 4 weeks, were quantitatively analyzed in
http://carcin.oxfordjournals.org/cgi/content/full/24/3/453   (5050 words)

  
 Lovastatin
Blood tests are done every 6 to 12 weeks for the first 15 months of lovastatin therapy.
Ask your pharmacist any questions you have about refilling your prescription.
NEVER stop taking this medication without consulting your doctor.
http://www.clevelandclinic.org/health/health-info/docs/0700/0706.asp?index=4872   (973 words)

  
 Mechanism of lovastatin-induced apoptosis in intestinal epithelial cells -- Agarwal et al. 23 (3): 521 -- Carcinogenesis
of lovastatin in spontaneously immortalized rat intestinal epithelial
All experiments were repeated three times and similar results were consistently observed.
Experiments were repeated three times and similar results were consistently observed.
http://carcin.oxfordjournals.org/cgi/content/full/23/3/521   (4248 words)

  
 Antiviral Activity of Lovastatin against Respiratory Syncytial Virus In Vivo and In Vitro -- Gower and Graham 45 (4): ...
Lovastatin is an FDA-approved drug that is used to treat hypercholesterolemia.
HMG-CoA reductase inhibitors, like lovastatin, are currently used for treating hypercholesterolemia in humans (2, 3,
with lovastatin, a drug that inhibits prenylation pathways in
http://aac.asm.org/cgi/content/full/45/4/1231   (3999 words)

  
 Buy Lovastatin online in 10mg, 20mg, 40mg tablets; cheap drug prices and information
Lovastatin may also be used in certain patients to reduce the risk of heart attack, blood vessel blockage, or chest pain.
Click on a drug in the list below to view prices and information.
Lovastatin may also be used to treat other conditions as determined by your doctor.
http://www.drugstore.com/qxdLovastatin_332828_sespider/lovastatin/lovastatin.htm   (508 words)

  
 Read about the drug Advicor (niacin and lovastatin) by MedicineNet.com
A stroke is the sudden death of brain cells due to a problem with the blood supply.
Read about the drug Advicor (niacin and lovastatin) by MedicineNet.com
For further information, please see the individual monographs for
http://www.medicinenet.com/niacin_and_lovastatin/article.htm   (594 words)

  
 Lovastatin Induces Fibroblast Apoptosis In Vitro and In Vivo . A Possible Therapy for Fibroproliferative Disorders -- ...
Pertinent to the therapeutic potential of lovastatin for nonmalignant fibroproliferative diseases, prior studies in our laboratory
Studies in our laboratory have demonstrated that lovastatin
HÉLÈNE and PETER B. Department of Medicine, Pulmonary, Allergy and Critical Care Division, and Department of Internal Medicine, University of Minnesota Medical School; and Veterans Affairs Medical Center, Minneapolis, Minnesota
http://ajrccm.atsjournals.org/cgi/content/full/159/1/220   (4135 words)

  
 Lovastatin
This drug is not recommended for women who are nursing.
Consult your doctor if you have any of the following problems: liver, kidney, or muscle disease, or a medical history involving organ transplant or recent surgery.
The drug should be used with caution in patients who consume substantial quantities of alcohol and/or have a past history of liver disease.
http://www.wholehealthmd.com/refshelf/drugs_view/1,1524,376,00.html   (583 words)

  
 Synergistic Interaction of Lovastatin and Paclitaxel in Human Cancer Cells -- Holstein and Hohl 1 (2): 141 -- Molecular ...
Our studies demonstrate that lovastatin increases mitosin levels
experiments were performed to determine whether lovastatin also
Our results demonstrate an interaction between lovastatin and
http://mct.aacrjournals.org/cgi/content/full/1/2/141   (4666 words)

  
 Lipids Online Slides: niacin, combination therapy, lovastatin, statins
In FATS, the levels of LDL-C and HDL-C changed only slightly in the conventional therapy group (-7% and +6%, respectively) but more substantially among patients treated with niacin + colestipol (-32% and +41%) or with lovastatin + colestipol (-45% and +16%).
Lipids Online Slides: niacin, combination therapy, lovastatin, statins
The Familial Atherosclerosis Treatment Study (FATS) assessed lovastatin plus colestipol, niacin plus colestipol, and conventional therapy in 146 men aged < 62 years with elevated apolipoprotein B levels, arteriographic evidence of coronary atherosclerosis, and a family history of coronary artery disease (CAD).
http://www.lipidsonline.org/slides/slide01.cfm?q=niacin   (1159 words)

  
 Niacin extended-release and lovastatin - Drugs & Vitamins - Drug Library - DrugDigest
This medicine is only for patients whose cholesterol levels are not controlled by diet and exercise alone.
Check with your health care professional before stopping or starting any of your medicines.
Lovastatin; Niacin may also interact with the following medications:
http://www.drugdigest.org/DD/PrintablePages/Monograph/0,7765,551110,00.html   (924 words)

  
 Lovastatin Induces Apoptosis of Anaplastic Thyroid Cancer Cells via Inhibition of Protein Geranylgeranylation and de ...
therapy, suggesting the clinical potential applications of lovastatin
In a phase I study, on the other hand,
Lovastatin has been used to treat hypercholesterolemia through
http://endo.endojournals.org/cgi/content/full/144/9/3852   (4510 words)

  
 News - Niacin Extended-Release/ Lovastatin Combination Effective in Patients with Multiple Lipid Disorders
For such patients, particularly those at high risk, combination therapy for dyslipidaemia showed promise as an effective treatment, the researchers point out.
Lovastatin monotherapy was found to be less effective in reducing lipoprotein (a) levels than the three niacin-containing treatments.
Niacin Extended-Release/ Lovastatin Combination Effective in Patients with Multiple Lipid Disorders
http://www.docguide.com/news/content.nsf/news/8525697700573E1885256D06002DAC31   (479 words)

  
 New Drug Monographs: Advicor™ (Niacin and Lovastatin)
Liver function must be monitored by periodic laboratory assessment.
Treatment of primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson types IIa and IIb) in patients previously treated with either agent alone (patients who require further lowering of triglycerides or increase in HDL cholesterol from addition of niacin or further lowering of LDL cholesterol from addition of lovastatin).
Lovastatin serum concentrations may be increased if taken with grapefruit juice; avoid concurrent use.
http://www.pharmacist.com/monographs/advicor.cfm   (450 words)

  
 lovastatin - definition of lovastatin in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and ...
A statin drug isolated from a strain of Aspergillus terreus, used to treat hyperlipidemia.
This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.
lovastatin - definition of lovastatin in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia.
http://medical-dictionary.thefreedictionary.com/lovastatin   (85 words)

  
 NEJM -- Lack of Effect of Lovastatin on Restenosis after Coronary Angioplasty
infarctions in the lovastatin group, as a result of acute vessel
Effects of lovastatin on progression of non-dilated and dilated coronary segments and on restenosis in patients after PTCA.
Results At base line, the patients in the lovastatin group (n
http://content.nejm.org/cgi/content/abstract/331/20/1331   (1676 words)

  
 MedlinePlus Medical Encyclopedia: Muscle aches
Your muscle pain has been associated with starting or changing doses of a medicine, such as a statin (atorvastatin, simvastatin, or lovastatin)
Statins for lowering cholesterol (such as atorvastatin, simvastatin, and lovastatin)
You have a tick bite or a rash
http://www.nlm.nih.gov/medlineplus/ency/article/003178.htm   (762 words)

  
 Lovastatin
Lovastatin has been shown to be highly effective in reducing total cholesterol and LDL cholesterol in heterozygous familial hypercholesterolemia patients.
Lovastatin is a cholesterol-lowering agent under the group of drugs characterized as statin.
It is even more interesting to note that patients treated with lovastatin had shown side effects of shorter sleeping hours.
http://dwb.unl.edu/Teacher/NSF/C10/C10Links/www.middlebury.edu/~ch0337/ho/lovastatin.html   (787 words)

  
 lovastatin
Myopathy is much more likely to occur is the patient is taking these drugs.
Lovastatin may shorten the sleep period by up to 3 hours (up to 18%).
Lovastatin and resins have synergistic effects because they act on the same system at different points.
http://lysine.pharm.utah.edu/netpharm/netpharm_00/druglist/lovastatin.htm   (216 words)

  
 Lovastatin
Lovastatin is a specific inhibitor of HMG-CoA reductase.
Reduction in increased total and LDL cholesterol in patients with primary hypercholesterolemia in cases when dietary and other nonpharmacologic measures do not provide the desired result.
The mechanism of the LDL-lowering effect of lovastatin may involve both reduction of VLDL cholesterol concentration, and induction of the LDL receptors, leading to reduced production and increased catabolism of LDL cholesterol.
http://www.lek.si/eng/pharmaceutical-ingredients/ingredients/lovastatin   (251 words)

  
 ARS Publication request: The Combined Effects of Novel Tocotrienols and Lovastatin on Lipid Metabolism in Chickens
Although this drug is effective, there are adverse side effects.
One such drug, lovastatin, is an inhibitor of an enzyme involved in cholesterol synthesis.
For moderately high cholesterol, treatment by diet modification may be attempted, but for more severe cases, drugs may be prescribed.
http://www.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=112772   (414 words)

  
 Lovastatin - Wikipedia, the free encyclopedia
Lovastatin is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease.
This page was last modified 12:04, 27 October 2005.
http://en.wikipedia.org/wiki/Lovastatin   (44 words)

  
 Lovastatin
Lovastatin was purposely developed as a pro-drug to concentrate active drug in the liver during first-pass circulation.
Remarks Cholesterol-lowering agent Lovastatin represents the first of a new class of cholesterol-lowering agents, the HMG-CoA reductase inhibitors, which are indicated for the treatment of primary hypercholesterolaemia.
Lovastatin was approved by the FDA for the treatment of hypercholesterolaemia in August 1987.
http://www.metkinen.fi/products/fermentation_technologies/statins   (213 words)

  
 Lovastatin - definition of Lovastatin in Encyclopedia
In medicine and pharmacology, lovastatin (Mevacor® or Altocor®) is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease.
Embed a dictionary search in your own web page
http://encyclopedia.laborlawtalk.com/Lovastatin   (61 words)

  
 cholesterol - Columbia Encyclopedia® article about cholesterol
Cholesterol levels can also be reduced with drugs, most especially with HMG-CoA reductase inhibitors (commonly called "statins"), such as lovastatin (Mevacor) and atorvastatin (Lipitor), and by regular exercise.
Reducing consumption of foods containing cholesterol and saturated fat has been found to lower blood cholesterol levels.
http://columbia.thefreedictionary.com/cholesterol   (905 words)

  
 News - Ezetimibe Plus Lovastatin Offers New Treatment Option For Hypercholesterolemia
A combination of ezetimibe plus lovastatin provides greater improvement to the lipid profile of patients with hypercholesterolemia than does lovastatin alone.
The investigators, from Health Trends Research in Baltimore, Maryland, United States, conducted a multi-centre, randomized, double blind, placebo-controlled study including 548 patients with hypercholesterolemia.
Overall, ezetimibe plus lovastatin co administration resulted in mean LDL cholesterol decreases of 33 to 45%, median triglyceride decreases of 19 to 27% and mean HDL cholesterol increases of eight to nine%.
http://www.docguide.com/news/content.nsf/news/8525697700573E1885256CCF0031AABE   (396 words)

  
 Lovastatin
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 Clinical Trial: Effect of Niacin ER/Lovastatin on Peak Walking Time & Claudication Onset Time in Patients With ...
Niacin ER/Lovastatin is a combination of two FDA (United States Food and Drug Administration) approved cholesterol modifying medications: Niaspan® (extended-release niacin) and lovastatin, a statin (the same medicine found in Mevacor®).
At least 366 subjects with leg pain caused by a narrowing of their leg arteries will participate in this study.
Niacin ER/Lovastatin was approved by the FDA under the name of Advicor® for use in the treatment of elevated cholesterol.
http://www.clinicaltrials.gov/ct/gui/show/NCT00062556   (544 words)

  
 Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA ...
We show that while the lovastatin open-ring form
lovastatin can be used to arrest cultured cells in the G
In this paper we present the finding that lovastatin arrests cells by inhibiting the proteasome, which results in the accumulation
http://www.pnas.org/cgi/content/abstract/96/14/7797   (1301 words)

  
 Definition of lovastatin - Merriam-Webster Online Dictionary
For More Information on "lovastatin" go to Britannica.com
Get the Top 10 Search Results for "lovastatin"
http://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=lovastatin   (93 words)

  
 RxBoard - Mevacor (lovastatin) - Message Index
If you'd like e-mail notification of responses, please check this box:
RxBoard - Mevacor (lovastatin) is maintained by RxList.com, Inc. with WebBBS 3.21.
http://www.rxlist.com/rxboard/mevacor.pl   (183 words)

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