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| | Genome Glossary |
 | | In genetics, a type of mutation due to replacement of one nucleotide in a DNA sequence by another nucleotide or replacement of one amino acid in a protein by another amino acid. | | | Alternative form of a genetic locus; a single allele for each locus is inherited from each parent (e.g., at a locus for eye color the allele might result in blue or brown eyes). | | | The study of the interaction of an individual's genetic makeup and response to a drug. |
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http://www.ornl.gov/sci/techresources/Human_Genome/glossary/glossary.shtml
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| | Imprinting |
| | Darkened body indicates individual that is mutant for the hypothetical imprinted locus. | | | The role of imprinting in the development of cancers such as Wilm's tumour, rhabdomyosarcomas and osteosarcomas has been particularly well studied. | | | Considerable interest has been generated by the realization that the penetrance and severity of many complex human diseases can be affected by the sex of the parent contributing the allele responsible for the disease. |
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http://www.ucalgary.ca/UofC/eduweb/virtualembryo/imprinting.html
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| | Genomic Imprinting and Environmental Disease Susceptibility |
| | In the near future, developments in medical genetics are expected to impact greatly on therapeutic biotechnology, the practice of healthcare and medicine, and the understanding of human evolution and behavior. | | | This observation is consistent with the hypothesis that the disorder is associated with an imprinted locus on the X chromosome at which the paternal allele is expressed and the maternal allele is silenced. | | | Although INS is not imprinted and is biallelically expressed in the pancreas, monoallelic expression of INS is seen at variable levels in human thymus samples (2). |
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http://ehp.niehs.nih.gov/members/2000/108p271-278jirtle/jirtle-full.html
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| | Paul Vrana |
| | Moreover, a susceptibility locus for this condition maps to the equivalent region in human of thePeromyscus autosomal overgrowth locus. | | | One goal is to find such a locus. | | | Comparative genomic approaches, population genetics and application to specific human diseases are also of interest. |
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http://www.ucihs.uci.edu/biochem/faculty/Vrana.html
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| | Zoology 510, Chapter 9 notes |
| | Quantitative genetics (unlike simple versions of Mendelian genetics) recognizes that phenotypes are influenced by many factors so that particular genotypes (especially particular single-locus genotypes) do not neatly and reliably correspond with particular phenotypes. | | | Highly canalized traits which show no variation among individuals are not the subject of quantitative genetics. | | | Although "quantitative genetics" is, obviously, about quantitative processes, we shall again (as for chapter 8) emphasize qualitative appreciation of the phenomena associated with quantitative genetics. |
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http://www.science.siu.edu/zoology/king/510/mr09.htm
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| | P Element Bibliography |
| | This mutation was dysgenesis- induced, and previous genetic evidence suggested that it was caused by the insertion of a P factor at that locus. | | | While it was not clear what the basis for these effects were, it was strongly suggested P element-induced chromatin changes may have been involved. | | | These are readily detectable among the patroclinous daughters, thereby allowing the combined analysis of the transposed element, the donor site and the putative sister-strand template. |
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http://engels.genetics.wisc.edu/Pelements/bibliography.html
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| | STAT 610: Quantitative Trait Loci: Course Page: NCSU Libraries |
| | Quantitative trait locus mapping using near-isogenic lines of maize | | | 3) Other genetics databases are available that may index appropriate articles. | | | Introduction to Statistical Methods in Modern Genetics (see Chapters 2 and 3). |
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http://www.lib.ncsu.edu/courses/stat610
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| | Quantitative genetics research |
| | Recent empirical advances in quantitative genetics have shown that there is a distribution of locus effects for quantitative traits: some loci (called Quantitative Trait Loci, or QTL) explain a large proportion of the genotypic contribution to trait variance, while others have minor but detectable effects on phenotype. | | | The study of quantitative traits and their genetic basis is fundamental to our understanding of evolutionary biology, as well as to applied genetics such as animal and plant breeding. | | | Quantitative traits are among the most conspicuous features of organisms, features that we immediately recognize. |
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http://www.georgetown.edu/faculty/miller/QTL.html
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| | Lec10 |
| | For example if two back body Drosophila mutants are caused by a mutation at the same locus, their resulting F1 progeny will be also back body. | | | When the alleles are at the same locus, they will not "complement" and the hybrid will have the mutant phenotype. | | | Benzer through his study of fine gene mapping was able to develop two basic techniques of genetic analysis, allowing him to extend and rapidly construct his fine structure maps: |
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http://veghome.ucdavis.edu/classes/fall2003/bis101/lectures/lec10.html
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| | Imprinting (genetics) - Wikipedia, the free encyclopedia |
| | The Prader-Willi syndrome is due to 2 copies of the chromosome 15 being inherited from the mother, and the locus is imprinted; the Angelman syndrome gene is due to 2 copies of the chromosome 15 inherited from the father and the locus is similarly imprinted. | | | Several genetic diseases that map to 15q13 (locus 3 of section 1 of the long arm of chromosome 15) in humans are due to abnormal imprinting. | | | Experimental manipulation of a paternal methylation imprint controlling the Igf2 gene has, however, recently allowed the creation of rare individual mice with two sexual sets of chromosomes - but this is not a true parthenogenote. |
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http://en.wikipedia.org/wiki/Imprinting_(genetics)
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| | Intrinsic aetiology |
| | clinical genetics : the study of the possible genetic factors influencing the occurrence of clinical disorders. | | | MKS is genetically heterogeneous, with 3 loci mapped: MKS1, 17q21-24; MKS2, 11q13 and MKS3 (a 12.67-Mb interval (8q21.13-q22.1) that is syntenic to the Wpk locus in rat, which is a model with polycystic kidney disease, agenesis of the corpus callosum and hydrocephalus. | | | There does not exist, to date, any causal therapy for AGS, although genetic studies, particularly those focusing on interferon-regulating genes, may well provide some therapeutic indications. |
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http://focosi.altervista.org/intrinsicaetiology.htm
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| | Arthur L. Beaudet, M.D. |
| | Our laboratory is studying the role of epigenetics in human disease with particular emphasis on genomic imprinting and its role in Prader-Willi syndrome (PWS), Angelman syndrome (AS), and autism. | | | Genomic imprinting is the phenomenon of differential expression of the two alleles at an autosomal locus based on their parent of origin; usually one allele is expressed and the other silenced. | | | Genetic diagnosis, counseling, and treatment with emphasis on metabolic disorders cystic fibrosis, Prader Willi syndrome, Angelman syndrome and gene therapy |
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http://imgen.bcm.tmc.edu/molgen/facultyaz/beaudet.html
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| | GENETICS - www.ezboard.com |
| | B is genetically linked to the alpha globin locus in the minority of cases | | | Other conditions with anticipation include spinocerebellar ataxia type 1 and dentatorubral pallidoluysian atrophy. | | | Anticipation means increased severity/earlier age of onset of disease with successive generations. |
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http://p200.ezboard.com/fdiwaniafrm14.showMessage?topicID=8.topic
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| | gene duplication |
| | It would be impossible to predict the outcome for any particular locus. | | | TJ Gibson, J Spring (1998), "Genetic redundancy in vertebrates: polyploidy and persistence of genes encoding multidomain proteins", Trends in Genetics, 14:46-49. | | | At each locus, genetic drift during the tetrasomic phase might result in the loss of alleles inherited from one of the progenitor species, or alleles from both progenitors might be retained. |
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http://www.nslij-genetics.org/duplication
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| | Dr Hamish Spencer |
| | The effect of genetic conflict on genomic imprinting and modification of expression at a sex-linked locus. | | | The phylogenetic relationships of the shags and cormorants: Can sequence data resolve a disagreement between behavior and morphology ? | | | Genetic variation and prevalence of blood parasites do not correlate among bird species. |
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http://www.zoology.otago.ac.nz/pubs/spencer/hgs.html
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| | Quantitative Genetics |
| | A major task of quantitative genetics is to determine the ways in which genes interact with the environment to contribute to the formation of a given quantitative trait distribution. | | | The genetic variation underlying a continuous character distribution can be the result of segregation at a single genetic locus or at numerous interacting loci that produce cumulative effects on the phenotype. | | | Mendelian genetic analysis is extremely difficult to apply to such continuous phenotypic distributions, so statistical techniques are employed instead. |
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http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=iga.chapter.3974
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| | Postdoctoral and Visiting Scientists at Wadsworth Center, NYS Department of Health |
| | A genetic locus that regulates this transfer system has been identified and is being characterized. | | | By using a combination of genetics, biochemistry and physical studies we are dissecting the various steps of transposition in order to develop a structure-function analysis of the protein that carries out transposition. | | | Applicants must have a Ph.D. in the biomedical sciences or an M.D. Experience in molecular biology, genetics, cell biology or protein biochemistry is a plus. |
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http://www.wadsworth.org/educate/bacterial.htm
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| | APPENDIX E: Glossary of Terms |
| | The term has been co-opted for use in transmission genetics to describe any locus at which at least two alleles are available for use in breeding studies, irrespective of their actual frequencies in natural populations. | | | In the case of mouse genetics, this refers most often to a cross between a traditional inbred strain that is predominantly M. m. | | | Quantitative traits are often controlled by the cumulative action of alleles at multiple loci. |
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http://www.informatics.jax.org/silver/glossary.shtml
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| | Genetics in Psychiatry |
| | Genetics, environment and cognitive abilities: review and work in progress towards a genome scan for quantitative trait locus associations using DNA pooling -- British Journal of Psychiatry | | | N= Northern and Southern Blotting - genetic techniques | | | P= Path Analysis - allows you to assess the size of genetic and environmental effects |
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http://www.psychejam.com/genetics_in_psychiatry.htm
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| | References |
| | BULMER, M. The Mathematical Theory of Quantitative Genetics. | | | LAI, C., R. "Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Drosophila melanogaster." Science 266: 1697-1702. | | | LANDE, R. "The genetic covariance between characters maintained by pleiotropic mutations." Genetics 94: 203-215. |
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http://www.cbc.yale.edu/old/cce/ccepapers/Inert2/node18.html
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| | Mammalian Genetics-X/imprinting |
| | Recent experiments have demonstrated that chromosomal domains containing imprinted genes, including the FRAXA locus, are replicated asynchronously, with the maternal allele being replicated later than the paternal allele. | | | Its occurrence in mammals has only recently been recognized, and was deduced from a number of different lines of research, including classical genetic studies, studies on X-inactivation, and the development of diploid parthenogenetic (gynogenetic, and androgenetic) embryos. | | | Imprinting may be involved in the Philadephia chromosome |
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http://www.faculty.virginia.edu/mammgenetics/805-2ndX03.html
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| | Genetic interactions - Enpsychlopedia |
| | Genetic interactions, in genetics, are interactions that occur between two or more mutations that results in a new phenotype. | | | Intragenic complementation - two mutations cause similar phenotypes and map to the same locus yet show complementation in heterozygotes. | | | Because protein complexes are responsible for most biological functions, genetic interactions are a powerful tool. |
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http://www.grohol.com/psypsych/Genetic_interactions
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| | E BOTTINI et al.: Signal transduction and GH diagnostic tests (Journal of Endocrinology) |
| | The effects of normal genetic variability of signal transduction on endocrine function may be more evident during stimulation tests than is observed in basal states, thereby contributing to a greater understanding of the possible role of signal transduction genetics in the pathogenesis of endocrine disorders. | | | In the present study we have studied the outcome of growth hormone (GH) stimulation testing by insulin in growth retarded children in relation to the genotype of ACP1 (acid phosphatase locus 1, also referred to as cLMWPTP: cytosolic Low Molecular Weight Phosphotyrosine Phosphatase). | | | The genetics of signal transduction and the outcome of diagnostic tests in growth retardation |
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http://journals.endocrinology.org/joe/171/joe1710267.htm
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| | PBE&B Educational Index |
| | Includes links and information of free and commercial software on Ecology, Evolution, Genetics, and other biological areas. | | | Research: Examination of evolutionary processes by means of theoretical population genetics, with special emphasis on genome organization, genetics of continuously varying characters (Quantitative Genetics), speciation, and interfacing molecular and developmental biology with evolutionary biology. | | | It illustrates the principles of population genetics." Reprinted in L. |
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http://www.geocities.com/CapeCanaveral/Lab/4709/popgen.htm
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| | PBE&B Educational Index |
| | Includes links and information of free and commercial software on Ecology, Evolution, Genetics, and other biological areas. | | | Research: Examination of evolutionary processes by means of theoretical population genetics, with special emphasis on genome organization, genetics of continuously varying characters (Quantitative Genetics), speciation, and interfacing molecular and developmental biology with evolutionary biology. | | | It illustrates the principles of population genetics." Reprinted in L. |
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http://www.geocities.com/CapeCanaveral/Lab/4709/popgen.htm
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| | Genetics |
| | Population Genetics (also still under construction.) How selection of different kinds can change the overall genetic makeup of a breeding population. | | | Coat Color Genetics in Dogs (Basic color genetics, all breeds, including comments on colors where genetics are questionable.) | | | References for the genetics section, including links to other genetics websites. |
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http://bowlingsite.mcf.com/Genetics/Genetics.html
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| | MOL References |
| | Sheffield, V.C., Carmi, R., Kwitek-Black, A., Rokhlina, T., Nishimura, D., Duyk, G.M., Elbedour, K., Sunden, S.L., Stone, E.M., Identification of a Bardet-Biedl Syndrome Locus on Chromosome 3 and Evaluation of an Efficient Approach to Homozygosity Mapping, Human Molecular Genetics, (3) 1331-1335, 1994. | | | Scott, D.A., Carmi, R., Elbedour, K., Duyk, G.M., Stone, E.M., Sheffield, V.C., Non-Syndromic Autosomal Recessive Deafness is Linked to the DFNB1 Locus in a Large Inbred Bedouin Family from Israel, American Journal of Human Genetics, (57) 965-968, 1995. | | | Carmi, R., Rokhlina, T., Kwitek-Black, A.E., Elbedour, K., Nishimura, D., Stone, E.M., Sheffield, V.C., Use of DNA Pooling Strategy to Identify a Human Obesity Syndrome Locus (Bardet Biedl) on Chomosome 15, Human Molecular Genetics, (4) 9-13, 1995. |
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http://www.ophth.uiowa.edu/References.html
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| | ACTIVATION OF A GENE CODING FOR A NORMAL HUMAN GROWTH FACTOR TO ONE WITH TRANSFORMING PROPERTIES |
| | In studies of the human sis locus, v-sis-related sequences were isolated from a bacteriophage library of normal human DNA. | | | Keywords: Animal Base Sequence Cell Line *Cell Transformation, Neoplastic DNA, Viral/GENETICS Gene Expression Regulation Genes, Viral *Genetic Code Human Mice *Oncogenes Peptides/*GENETICS Platelet-Derived Growth Factor/GENETICS *Proto-Oncogenes Sarcoma Viruses, Simian/GENETICS Somatotropin/*GENETICS Viral Proteins/GENETICS MEETING PAPER | | | Five v-sis-homologous restriction fragments were identified that could be localized within a 15 kilo base-pair (kbp) region. |
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http://www.aegis.com/aidsline/1986/nov/M86B0254.html
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