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| | Transplantation Institute - Mount Sinai School of Medicine |
 | | Because you have a significantly smaller amount of liver volume right after your surgery, we will monitor you very carefully to make sure we are not giving you too much medication, which could have serious side effects; most pain medicines make you drowsy and can affect your breathing and bowel function. | | | Your recipient's condition might deteriorate to the point where he or she is too sick for a transplant. | | | The transplant team, particularly the physicians involved directly in your recipient's care, will determine as accurately as possible the best time to do the transplant, based on the recipient's medical condition. |
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http://www.mssm.edu/rmti/liverdonor.shtml
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| | Transplants |
| | The donor is also at risk for temporary problems related to the surgical incision and the possibility of blood clots. | | | Because this is a new surgical procedure, recipient patients must be considered individually to make sure that living donor transplantation is appropriate based on their specific medical situation. | | | Potential living donors undergo an extensive evaluation to assure that they are in optimal medical condition to proceed with organ donation. |
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http://janis7hepc.com/transplants3.htm
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| | Center for Liver Disease and Transplantation - Living Donor Liver |
| | To be a donor, one must donate of their own free will, with full knowledge of the risk and potential complications of the surgical procedure and with only a desire to aid the recipient. | | | While the surgical techniques utilized are not new, the application of these techniques for adult-to-adult liver transplants is a recent development. | | | Factors that will influence the decision are the medical and psychosocial condition of the patient, as well as the availability of a cadaver donor organ. |
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http://www.csmc.edu/pf_639.html
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| | NIH Guide: ADULT TO ADULT LIVING DONOR LIVER TRANSPLANTATION COHORT STUDY |
| | Specific experience in coordinating or monitoring studies of liver disease is not required, but the applicant may wish to include a transplantation surgeon or hepatologist in the application as a key collaborator and advisor. | | | Among the disciplines and expertise that may be appropriate for this program are hepatology, transplantation, ethics, epidemiology, radiology, pharmacology, clinical psychology, psychiatry, and clinical database management. | | | The research objectives of the LDLT Cohort Study concern factors that influence the outcomes of adult to adult LDLT. |
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http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-02-010.html
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| | ScienceDaily.com Content: What you should know about living donor liver transplantation |
| | Donors must be healthy, close to their ideal body weight, not taking many medications, and not have had abdominal surgery. | | | The transplant program must make a team decision about the eligibility of a donor based on careful evaluations, painstaking attention to detail, and considerable discussion by physicians, surgeons, psychologists, psychiatrists, and social workers. | | | Serving as an additional patient advocate for the donor and his or her family |
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http://sciencedaily.mediwire.com/main/Content.aspx?ArticleID=138198
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| | NIH News Release--NIH Launches Study of Living Donor Liver Transplantation--10/09/2002 |
| | Researchers will compare outcomes of this new procedure with the outcomes for patients who receive livers from cadavers. | | | Because the procedure is expanding across the country, a group of concerned doctors called for more research on risks and benefits and an outside regulator to certify hospitals that would perform the procedure in the New England Journal of Medicine (April 4, 2002). | | | This requires a more extensive and complex surgery, with potentially greater risks for the donor and the recipient. |
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http://www.nih.gov/news/pr/oct2002/niddk-09.htm
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| | eMedCenter - Living Donor Liver Transplantation |
| | The development of anti-rejection medications that can be used when traditional drugs are not effective has contributed to the programs overall success as well. | | | The hospital's success has resulted in part from refinements in candidate selection and surgical techniques, which have led to a 45 percent reduction in length of stay over the last five years. | | | First, the surgery can be scheduled and done when the recipient is healthier. |
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http://emedcenter.org/pages?NavID=253
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| | eMedicine - Liver Transplantation, Complications : Article by Paul D Russ, MD |
| | This is a technique modified from previously established adult-to-child hepatic transplantation surgery (see Image 2). | | | The treatment is associated with an increased risk of malignancy in the recipient. | | | With improved patient selection, immunosuppression, and surgical techniques, orthotopic liver transplantation (OLTX) became more widely available. |
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http://www.emedicine.com/radio/topic883.htm
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| | Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) |
| | Major emphasis will also be placed on evaluation and follow-up of liver donors including careful analyses of the adequacy of informed consent, short- and long-term complications of the donor surgery, and long-term follow-up of donors assessing general health, quality of life, and personal and psychological effects of liver donation. | | | The primary goal of A2ALL will be to provide objective and reliable information on the outcomes of LDLT for both donors and recipients. | | | LDLT has become widely accepted for pediatric patients. |
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http://www.natap.org/2003/oct/100603_1.htm
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| | Living Donor Liver Transplantation: Results of Donor Satisfaction Survey |
| | Overall, the majority of donors in our institution were very satisfied with the overall process and do not regret the decision to donate, however pain management and financial counseling are issues for further study.” | | | The queries covered overall satisfaction and sense of well being, expected vs. realized degree of pain, speed of recovery, financial, social, physical and occupational impact, adequacy of informed consent, and willingness to recommend donation to others. | | | Annual Meeting of the American Association for the Study of Liver Diseases. |
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http://www.hivandhepatitis.com/hep_c/news/112603_a.html
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| | Clinical Trial: Adult-to-Adult Living Donor Liver Transplantation Study |
| | The primary study objective is to analyze the effect of choosing to pursue living liver donation. | | | Secondary objectives will address selected biological and clinical issues in transplantation structured around the comparison between DDLT and LDLT. | | | The principal hypothesis is that pursuit of a living liver allograft leads to decreased pre-transplant morbidity and mortality and better long term outcomes for patients starting from the point at which listed patients have a potential donor evaluated (at least a history and physical examination). |
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http://clinicaltrials.gov/show/NCT00096733
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| | Liver -- Facts, Info, and Encyclopedia article |
| | These "ligaments" are in no way related to the true anatomic ligaments in joints, and have essentially no functional importance, but they are easily recognizable surface landmarks. | | | The Liver Disorders Sourcebook, McGraw-Hill, 1999, ISBN 0737300906. | | | Most transplants are done for chronic liver diseases leading to (A chronic disease interfering with the normal functioning of the liver; the major cause is chronic alcoholism) cirrhosis, such as chronic hepatitis C, alcoholism, autoimmune hepatitis, and many others. |
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http://www.absoluteastronomy.com/encyclopedia/l/li/liver.htm
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| | Living Donor Liver Transplantation |
| | This many specialists means that organs are procured faster, and a relationship can be built with the families of the donors and recipients. | | | This problem has led to a lot of research on viable alternatives, several of which, such as the bioartificial liver, xenotransplantation and gene therapy, are still under investigation. | | | This compromises those patients that have end-stage liver disease and need a transplant rapidly. |
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http://www.portfolio.mvm.ed.ac.uk/studentwebs/session4/17/livingdlt.htm
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| | Living Donor Liver Transplantation |
| | To make the donor's immediate recovery as comfortable as possible, Columbia University Medical Center provides Patient-Controlled Anesthesia (PCA) which enables self-administration of pain medication following surgery. | | | A family member, usually a parent, sibling or adult child, or someone emotionally close, such as a spouse, may volunteer to donate a portion of their healthy liver. | | | The following day, they are usually transferred to the general surgical floor where the nurses are specifically experienced in caring for liver donors. |
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http://www.livermd.org/tx_donor.html
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| | Penn Transplant Center: Liver Program - Living Donor Liver Transplantation |
| | This has led to longer waiting times, poorer health of those on the waiting lists (making the outcome less certain), and an increase in the number of patients who die while waiting for a liver transplant. | | | Liver transplantation is now an accepted and proven therapy for patients dying from liver disease. | | | Follow the experiences of a Penn Transplant Center liver donor and recipient in "A Living Donor Experience". |
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http://www.pennhealth.com/transplant/liver/living.html
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| | Transplant - Texas Transplant Institute |
| | Specialty Hair Transplant Surgeons Hair Loss NoN Surgical Plastic... | | | CNN - New technique helps cancer patients find bone marrow donors... | | | Provides transplant and cancer care for bone marrow, kidney transplant, heart |
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http://www.transplantconnections.com/texastransplantinstitute
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| | U.S. News & World Report Spotlights Mount Sinai's Living-Donor Liver Transplantation Program |
| | The article features two Mount Sinai patients - one in need of a liver transplant and the generous friend who provided the organ - and Charles Miller, MD, the world-renowned surgeon who brought together donor and recipient through this dramatic, life-saving procedure. | | | Liver transplants are among the newest and most complex of surgeries. | | | Only about 1,000 living-donor liver transplants (LDLTs) have been performed in the United States since 1989, mostly from an adult to a child. |
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http://www.mountsinai.org/msh_news/msh_transplant.html
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| | Living donor liver transplantation - Wikipedia, the free encyclopedia |
| | The concept of LDLT is based on (1) the remarkable regenerative capacities of the human liver and (2) the widespread shortage of cadaveric livers for patients awaiting transplant. | | | In LDLT, a piece of healthy liver is surgically removed from a living person and transplanted into a recipient, immediately after the recipient’s diseased liver has been entirely removed. | | | Living donor liver transplantation (LDLT) has emerged in recent decades as a critical surgical option for patients with end stage liver disease, such as cirrhosis and/or hepatocellular carcinoma often attributable to one or more of the following: long-term alcohol abuse, long-term untreated Hepatitis C infection, long-term untreated Hepatitis B infection. |
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http://en.wikipedia.org/wiki/Living_donor_liver_transplantation
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| | Living Donor Liver Transplantation for End-stage Hepatitis C |
| | Twenty-seven patients who underwent living donor liver transplantation for hepatitis C virus cirrhosis preemptively received antiviral therapy using interferon alfa-2b and ribavirin, which was started an average of 32 days after the operation and continued for at least 6 months thereafter. | | | The authors conclude, “Preemptive antiviral therapy after transplantation may be necessary for satisfactory results after living donor liver transplantation.” | | | However, preliminary results indicate that living liver donation might be disadvantageous for hepatitis C virus-positive patients. |
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http://www.hivandhepatitis.com/hep_c/news/2004/072604_a.html
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| | ACG: Living-Donor Liver Transplantation Appears Safer Than Orthotopic Transplantation |
| | Twelve patients required re-transplantation, and there were 19 cases of significant rejection, all of which were successfully treated with no major adverse outcomes. | | | Nearly half of the patients received the liver from their children, nearly one-third from siblings and 2% from a second-degree relative, Dr. Mantry said. | | | BALTIMORE, MD -- October 21, 2003 -- Patients who receive a liver from a living donor are less likely than people who undergo orthotopic liver transplantation to suffer serious complications or reject their new organ, suggests the largest single-centre experience with living-donor liver transplantation in the United States. |
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http://www.docguide.com/dg.nsf/PrintPrint/240CF7B80D9ABA3E85256DC6004826DC
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| | Living Donor Liver Transplantation |
| | Furthermore, more patients are dying while waiting for livers to become available. | | | Living donor liver transplantation of adults was initiated in the United States after the development of the procedure for children and in response to the shortage of cadaveric organs. | | | In 1999, more than 14,000 patients were on the waiting list for liver transplantation in the United States. |
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http://www.harthosp.org/transplant/living_donor.asp
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| | Paul J. Gaglio, MD, FACP - Department of Surgery |
| | Models to enhance liver regeneration; novel treatments of hepatitis C; treatment of hepatitis C in hemophiliacs; treatment of hepatitis C in patients who were previous non-responders-relapsers; treatment and natural history of non-alcoholic fatty liver disease | | | European Association for the Study of the Liver | | | Cholestatic Hepatitis C in Patients with Biliary Obstruction after Deceased and Living Donor Liver Transplantation: Poor Outcomes Despite Therapy. |
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http://asp.cumc.columbia.edu/facdb/profile_list.asp?uni=pg2011&DepAffil=Surgery
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| | UpToDate Living donor liver transplantation |
| | Donation of the left lateral segment or left lobe, used primarily in pediatric transplantation, is associated with a 5 to 10 percent chance of surgical complications and a mortality rate of less than 1 percent [2,3]. | | | Family pressures may come to bear on an ambivalent relative with the correct blood type and body habitus. | | | In addition, the donor benefits from the continued survival of the recipient and from increased self-esteem derived from actively contributing to the child's survival [6]. |
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http://patients.uptodate.com/topic.asp?file=livertrn/5898
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| | Living Donor Liver Transplantation Agenda |
| | Session 3: Surgical Issues in Living Donor Liver Transplantation | | | Survey on current practice of LDLT in adults | | | Current Experience in Living Donor Liver Transplantation Outcomes and Complications |
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http://www.niddk.nih.gov/fund/reports/livertrans/agenda.html
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