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| | LPL - lipoprotein lipase |
 | | The effects of human recombinant macrophage colony-stimulating factor (M-CSF) on the secretion of lipoprotein lipase were studied in rat alveolar macrophages. | | | Potentiation of lipolysis by intravenous injections of phospholipase A2 (PLA2) or lipoprotein lipase (LPL) to rats treated with ISO substantially augmented MN. | | | In contrast, the apoA-II-free lipoproteins present in unretained fractions were effective substrates for LPL with k1 values equal to or greater than 0.0313 min-1. |
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http://www.ihop-net.org/UniPub/iHOP/gg/89878.html
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| | André Bensadoun - Recent Publications |
| | Jensen GL and Bensadoun A (1981) Purification, stabilization and characterization of rat hepatic triglyceride lipase. | | | Bensadoun A, Koh TL, and Yang MWW (1976) Identification of an adipose-like lipoprotein lipase in liver perfusates. | | | Berryman DE, Mulero JJ, Hughes LB, Brasaemle DL and Bensadoun A (1998) Oligomeric structure of hepatic lipase: evidence from a novel epitope tag technique. |
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http://www.vet.cornell.edu/Public/Research/Physio/Bensadoun/pub.htm
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| | Familial Lipoprotein Lipase Deficiency |
| | LPL mutant alleles from studied individuals with classic familial lipoprotein lipase deficiency remain uncharacterized. | | | The pain may result from chylomicronemia or from pancreatitis. | | | Requests for prenatal testing for conditions such as familial lipoprotein lipase deficiency that do not affect intellect and have effective treatment available are not common. |
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http://www.geneclinics.org/profiles/lpl/details.html
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| | Lipase - Wikipedia, the free encyclopedia |
| | A myriad of other lipase activities exist in nature, especially when the phospholipases and sphingomyelinases are considered. | | | Several different types of lipases are found in the human body, including pancreatic lipase, hepatic lipase, lysosomal lipase, hepatic lipase, gastric lipase, endothelial lipase, as well as various different phospholipases. | | | Most lipases act at a specific position on the glycerol backbone of a lipid substrate (A1, A2 or A3). |
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http://en.wikipedia.org/wiki/Lipase
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| | Familial lipoprotein lipase deficiency - Genetics Home Reference |
| | Familial lipoprotein lipase deficiency is an inherited condition that disrupts the normal breakdown of fats in the body. | | | The condition is characterized by inflammation of the pancreas (pancreatitis), abdominal pain, enlargement of the liver and spleen (hepatosplenomegaly) and small yellow skin lesions called eruptive xanthomas. | | | You may also be interested in these resources, which are designed for healthcare professionals and researchers. |
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http://ghr.nlm.nih.gov/condition=familiallipoproteinlipasedeficiency
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| | familial lipoprotein lipase deficiency - General Practice Notebook |
| | familial lipoprotein lipase deficiency - General Practice Notebook | | | Lipoprotein lipase deficiency is a rare condition and inherited as an autosomal recessive condition. | | | Note that there is an overlap between lipoprotein lipase deficiency and apolipoprotein C-II Deficiency (familial inhibitor to lipoprotein lipase is a rare autosomal recessive hereditary disorder) |
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http://www.gpnotebook.co.uk/simplepage.cfm?ID=624230424
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| | Lipids Online Slides: lipoprotein lipase, high-density lipoprotein |
| | Combination Lipid-altering Drug Therapy with Statins: An Update (Harold Bays, MD, FACP) | | | Investigations of the genetic mechanisms involved in normal and defective HDL metabolism may lead to the development of novel therapies. | | | The enzyme lipoprotein lipase (LPL), bound to the surface of the capillary endothelium (especially in muscle and adipose tissue), hydrolyzes TG in CMs and in VLDLs. |
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http://www.lipidsonline.org/slides/slide01.cfm?q=lipoprotein+lipase
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| | MedlinePlus Medical Encyclopedia: Familial lipoprotein lipase deficiency |
| | Calling your health care provider Return to top | | | Genetic counseling is recommended for anyone with a family history of this disease. | | | Call your health care provider for screening if lipoprotein lipase deficiency has been diagnosed in a family member, or if you have extremely elevated triglyceride levels. |
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http://www.nlm.nih.gov/medlineplus/ency/article/000408.htm
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| | Lipids Online Slides: b, non-HDL cholesterol, lipid metabolism, apo B |
| | ATP III: New Approaches in Identifying and Treating High-Risk Patients (Steven Haffner, MD) | | | Fibrates have shown benefits in patients with high triglyceride (TG) and low HDL-C concentrations (Helsinki Heart Study, Bezafibrate Infarction Prevention trial [BIP]) as well as in patients with normal LDL-C and low HDL-C (Veterans Affairs HDL-C Intervention Trial [VA-HIT]). | | | Not only is LDL-C a risk factor for cardiovascular disease, but triglyceride-rich lipoproteinsâ”very low density lipoprotein (VLDL), VLDL remnants, and intermediate-density lipoprotein (IDL)â”may also increase the risk of heart disease. |
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http://www.lipidsonline.org/slides/slide01.cfm?q=b&dpg=50
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| | FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY |
| | Symptoms in infancy include abdominal pain (appears as if its colic), failure to thrive, and skin lesions (xanthomas). | | | A rare inherited disorder where there is a deficiency of an enzyme (lipoprotein lipase) which breaks down fat molecules, causing the accumulation of fats or lipoproteins in the blood. | | | Copyright DSHI Systems, Inc., Last updated Feb. 2002 |
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http://www.medhelp.org/glossary2/new/GLS_2006.HTM
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| | Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations |
| | 550201 -- Biochemistry-- Tracer Techniques; LIPASE-- MOLECULAR STRUCTURE; ELECTROPHORESIS;ENZYME ACTIVITY;LIPOPROTEINS;LIQUID COLUMN CHROMATOGRAPHY;MONOCLONAL ANTIBODIES;STOICHIOMETRY;TRITIUM COMPOUNDS | | | Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link. | | | Energy Citations Database (ECD) Document #5013253 - Structural studies on lipoprotein lipase |
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http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=5013253
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| | Lipoprotein Lipase Mutations, Plasma Lipids and Lipoproteins, and Risk of Ischemic Heart Disease : A Meta-Analysis -- ... |
| | Lipoprotein lipase gene variants and risk of coronary disease: a quantitative analysis of population-based studies. | | | Premature atherosclerosis in patients with familial chylomicronemia caused by mutations in the lipoprotein lipase gene. | | | Genetic variant showing a positive interaction with beta-blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease patients: the Ser447-stop substitution in the lipoprotein lipase gene: REGRESS Study Group. |
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http://circ.ahajournals.org/cgi/content/full/99/22/2901
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| | Adipose Tissue |
| | Hormonal changes that may affect obesity include hyperinsulinemia and changes in pituitary or adrenal function. | | | There may be some kind of abnormal signal that affects adipose tissue metabolism and alters fuel partitioning, directing increased storage in adipose tissue instead of use in muscle. | | | This process predominates over lipogenesis when additional energy is required (Figure 2). |
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http://www.sportsci.org/encyc/adipose/adipose.html
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| | Familial Lipoprotein Lipase Deficiency |
| | Familial lipoprotein lipase deficiency is a rare hereditary enzyme deficiency that results in abnormal breakdown of fats in the body. | | | Symptoms of familial LPL deficiency usually begin in childhood and include abdominal pain, acute and recurrent inflammation of the pancreas (pancreatitis), skin lesions called eruptive cutaneous xanthoma and an enlargement of the liver and spleen (hepatosplenomegaly). | | | The disorder is caused by a mutation in the LPL gene leading to very low or absent activity of the lipoprotein lipase enzyme. |
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http://www.webmd.com/hw/cholesterol_management/nord474.asp
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| | The Relationship of Lipoprotein Lipase Activity and LDL size Is Dependent on Glucose Metabolism in an Elderly ... |
| | Tan KC, Shiu SW, Chu BY: Roles of hepatic lipase and cholesteryl ester transfer protein in determining low density lipoprotein subfraction distribution in Chinese patients with non-insulin-dependent diabetes mellitus. | | | Jansen H, Hop W, van Tol A, Bruschke AV, Birkenhager JC: Hepatic lipase and lipoprotein lipase are not major determinants of the low density lipoprotein subclass pattern in human subjects with coronary heart disease. | | | has been found only with lipase activities (5–7) but not |
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http://care.diabetesjournals.org/cgi/content/full/27/3/796
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| | Lipoprotein lipase |
| | * which in turn acquires them from other lipoproteins to form the " | | | Apo B is incorporated into VLDL by hepatocytes, preparing this lipoprotein for transport of triglycerides (TG) and cholesterol from liver to other tissues. | | | When VLDL encounters lipoprotein lipase LPL in tissue capillaries the Apo C2 on the VLDL activates the enzyme, which hydrolyzes much of the triglyceride of the VLDL to produce * |
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http://www.umanitoba.ca/faculties/medicine/units/biochem/coursenotes/blanchaer_tutorials/LipTutWeb/pages/page5.htm
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| | Biomedicine Database, 0103 |
| | Because of its intimate involvements in lipid metabolism the LPL gene is considered to be an important candidate gene in determining the risk factor levels in metabolic disorders such as atherosclerosis, diabetes and obesity. | | | INTRODUCTION: The lipoprotein lipase (LPL) influences the maturation of the circulating lipoproteins and its activity is regulated by nutriens and hormones like glucose and insuline. | | | CORONARY ARTERY DISEASE AND PVU II POLYMORPHISM OF THE LIPOPROTEIN LIPASE GENE. |
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http://www.xagena.it/biomedicine/biom0103.htm
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| | Lipoprotein lipase |
| | Please send any questions or comments about the Human Protein Reference Database to help | | | You are at: Home » Proteins » Lipoprotein lipase |
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http://www.hprd.org/protein/01999
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