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| | Lipodystrophy |
 | | Lipodystrophies may affect a small area of the body, a large part of the body, or the entire body. | | | The following conditions may be associated with forms of Total Lipodystrophy: Acanthosis Nigricans (a skin disorder characterized by gray or black darkening and thickening of the skin which occurs frequently in Lipodystrophy patients around the onset of puberty), Acromegaly (gigantism), excessive hair growth (hirsutism or hypertrichosis), eruptive yellowish spots on the skin, and thickened skin. | | | Centrifugal Lipodystrophy is a rare localized condition characterized by a small skin depression enlarging in a circular pattern. |
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http://hw.healthdialog.com/kbase/nord/nord460.htm
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| | Project Inform's Lipodystrophy Syndrome(s) [ HIV / AIDS Treatment Information ] |
| | At various times, lipodystrophy symptoms have been blamed on individual drugs, on classes of drugs, on therapy overall, or on HIV itself. | | | Since the cause is uncertain, treating lipodystrophy is an inexact science and tries to deal mostly with the changes in body appearance and blood work. | | | Or, it may even be due to the immune system becoming more aggressive once the onslaught of HIV is slowed down in response to therapy. |
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http://www.projinf.org/fs/lipo.html
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| | Fat Redistribution in HIV Patients - An Opportunity for Drug Manufacturers? |
| | As a consequence, a country-by-country breakdown in the number of patients with lipodystrophy is difficult to determine at present. | | | As a consequence, patients are requesting changes in drug therapy to combinations that decrease the risk of developing this syndrome. | | | There is an approximately five-fold increase in the risk of developing lipodystrophy when using combinations of NRTI with PI drugs compared to using each class alone. |
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http://www.samedanltd.com/members/archives/EPC/Autumn2002/DheerajKhiytani.htm
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| | Lipodystrophy.Info |
| | We are also studying various modes of therapy for HIV-patients with lipodystrophy. | | | Funding for Dr. Garg's research on the lipodystrophies comes from the National Institutes of Health (NIH) and the General Clinical Reseach Center (GCRC). | | | There are opportunities to participate in research studies with Dr. Garg and more information is available under the Research Efforts heading. |
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http://www.swmed.edu/lipodystrophy/intro.htm
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| | Publications of Abhimanyu Garg, M.D. |
| | Skeletal muscle morphology and exercise response in congenital generalized lipodystrophy. | | | Agarwal AK, Garg A. Congenital generalized lipodystrophy: significance of triglyceride biosynthetic pathways. | | | Chen D, Misra A, Garg A. Clinical review 153: Lipodystrophy in human immunodeficiency virus-infected patients. |
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http://www.utsouthwestern.edu/utsw/cda/dept27717/files/93362.html
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| | HIV Newsline October 1999 |
| | As with the management of obesity in the general population, patients and providers are faced with a frustrating inability to affect the debilitating changes in body fat that are observed in individuals on combination antiretroviral therapy. | | | Until such time as we do have effective treatments for these lipodystrophies, it is very important to work on those variables that can be controlled. | | | A syndrome of lipodystrophy in patients receiving a stable nucleoside analogue therapy. |
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http://www.thebody.com/hivnews/newsline/oct99/optimal.html
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| | Lipodystrophy.Info |
| | This study is to assess the effectiveness of fish oil when used alone and in combination with sitostanol in lowering the triglycerides (blood lipid levels) and normalizing cholesterol levels in HIV-infected patients on antiviral therapy who have elevated triglycerides. | | | Patients will be closely evaluated through out the study for the metabolic parameters and body shape changes suggestive of lipodystrophy associated with HIV-infection. | | | Other trials are directed towards finding newer therapies for patients who have already developed lipodystrophy. |
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http://www.swmed.edu/lipodystrophy/research.htm
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| | FATTY LIVER: it's affect in HIV & hepatitis |
| | In addition, an association with lipodystrophy has been observed although the exact mechanism is not clear. | | | This report in the current issue of the journal Hepatology discusses the depositing and accumulation of fat in the liver in HIV negative individuals. | | | Other conditions associated with these primary problems such as sleep apnea in obesity may be observed. |
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http://www.natap.org/2003/april/043003_8.htm
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| | Vidyya Medical News Service - Today in Vidyya |
| | "We have shown that leptin replacement therapy is an effective treatment for patients with lipodystrophies," said Garg, senior author of the study. | | | The researchers have initiated a second study to determine the long-term benefits and possible side effects of leptin replacement therapy. | | | Among patients with lipodystrophies, leptin replacement therapy drastically reduces triglyceride levels and controls diabetes. |
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http://www.vidyya.com/vol4/v4i67_2.htm
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| | Publicaciones internacionales |
| | Another analysis of the Atlantic study will be reported after patients complete 48 weeks' therapy; the study is expected to continue for 144 weeks, and numerous sub-studies are planned including one to analyse lipodystrophies. | | | Meanwhile, Dr. Margaret Fischl of the University of Miami, Florida, said 48-week data on triple nucleoside reverse transcriptase therapy with three Glaxo Wellcome drugs, zidovudine, lamivudine and abacavir (Ziagen), provides a durable suppresion of HIV in the blood. | | | And we have concerns about side-effects attributed to protease inhibitors, especially the lipodystrophies." |
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http://www.boehringer-ingelheim.es/vih/vihaldia/public/feb1999_01.html
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| | Division of Nutrition & Metabolic Disease |
| | Moreover, our group has been studying pathophysiology and management of lipodystrophy in HIV-infected patients. | | | Presently, we provide clinical and research training to the following personnel; | | | We have also reported remarkable success in the treatment of lipodystrophies using recombinant leptin therapy. |
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http://www3.swmed.edu/nutritiondivision/about.htm
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| | Research provides better understanding of lipodystrophies disorders |
| | Garg has also studied more than 200 families with various types of inherited lipodystrophies and hundreds of patients with HIV who have developed this condition. | | | Recently, many HIV-infected patients being treated with a class of drugs known as protease inhibitors have developed lipodystrophies, which has raised awareness of these rare disorders. | | | UT Southwestern researchers have led the way in identifying gene mutations responsible for several forms of lipodystrophies and in identifying novel therapeutic approaches for these patients. |
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http://www.news-medical.net/?id=60
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| | News letter |
| | the study shows the significantly greater efficiency of oxygen-ozone therapy in the treatment of lipodystrophies and indurative hypodermatites as compared with Essaven gel, a widely used preparation clinical practice. | | | SUBCUTANEOUS OXYGEN-OZONE THERAPY IN INDURATIVE HYPODERMALITIS AND IN LOCALISED LIPODYSTROPHIES: A CLINICAL STUDY OF EFFICACY AND TOLERABILITY. |
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http://www.ossigenoozono.it/subcutaneous_oxygen-ozone.htm
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| | DHEA, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, hair loss, hair growth, buy Rx ... |
| | Dysregulation of peroxisome function is associated with the spectrum of biochemical changes seen within these HIV associated lipodystrophies. | | | Use of HIV protease inhibitors is reported in the majority of patients with these lipodystrophies, and protease | | | Although a similar redistribution of fat is seen in hypercortisolism, in general, serum and urinary cortisol levels are normal in these HIV-positive patients. |
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http://pharmacy-online-usa.com/ref-naprosyn/naprosyn-research-abs4.7.html
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| | NIH Awards $1.95 Million to Study New Treatments for HIV Drug Side Effects" |
| | Garg noted that physicians first observed the loss of body fat associated with lipodystrophy in HIV-infected patients in 1997. | | | The study will also assess the effectiveness of leptin therapy, an investigational treatment that has been shown to greatly reduce triglyceride and glucose levels in patients with inherited and other types of acquired lipodystrophies. | | | Garg and his associates will not treat the metabolic abnormalities with cholesterol-lowering drugs, since these can interfere with HIV medications and also cause serious side effects. |
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http://www.hivandhepatitis.com/recent/toxicities/112502d.html
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| | AEGiS-Reuters: AIDS Virus Lurks in Fat Cells, French Study Finds |
| | France Pietri-Rouxel of the Institut Cochin in Paris and colleagues stumbled upon the finding by accident, when she was treating HIV patients whose body fat began to redistribute itself in odd ways--the condition known as lipodystrophy. | | | The researchers now plan to look for infected fat cells in other HIV patients, especially those who have not developed lipodystrophies. | | | A specialist in fat tissue, she was removing fat from the abdomens of the patients and injecting it into their cheeks to fill out their faces. |
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http://ww2.aegis.com/news/re/2002/RE020911.html
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| | RFA-DK-03-018: GENETIC STUDIES OF OBESITY-RELATED TRAITS IN MODEL ORGANISMS |
| | Genetic analysis of these phenotypes offers the possibility of identifying previously unknown steps in both known and novel pathways. | | | Animals bearing alterations in these genes will be indispensable tools for understanding the pathogenesis of obesity and lipodystrophies, for testing therapeutics, and for discovering genes that can be tested in human studies for association with obesity and related co-morbidities such as cardiovascular disease. |
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http://grants1.nih.gov/grants/guide/rfa-files/RFA-DK-03-018.html
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| | Corante > Living Code > Fat Problems |
| | There is a review article in the New England Journal of Medicine discussing these disorders. | | | There are several types of these lipodystrophies and they an cause a range of disorders. | | | While rare, there is an increasing number of AIDS patients taking protease inhibitors that are developling lipodystrophies. |
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http://www.corante.com/livingcode/archives/003089.html
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| | Research Laboratories |
| | The lab is well equipped to carry out such experiments. | | | Opportunities are available to study the mechanism involved, which cause lipodystrophies, by recently identified genes. | | | We are investigating the molecular mechanisms of lipodystrophies for both the genetic and acquired varieties. |
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http://www3.utsouthwestern.edu/nutritiondivision/laboratories.htm
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| | SCLERODERMA FAQ |
| | Both conditions result in skin fibrosis and can become chronic. | | | Scleroderma -like skin changes have also been associated with insulin-dependent diabetes, carcinoid syndrome, myeloma, scleromyxedema, chronic graft-versus-host disease, porphyria cutanea tarda, Werner’s syndrome, progeria, phenylketonuria, bleomycin exposure, local lipodystrophies, and POEMS syndrome. | | | Scleroderma is a rare disorder that affects an estimated 40,000 to 165,000 people in the |
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http://www.synnovation.com/sclerodermafaq.html
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| | Lipodystrophy - Wikipedia, the free encyclopedia |
| | In medicine, lipodystrophy is a condition characterized by abnormal or degernative conditions of the body's fat tissue. | | | A lipodystrophy can be a lump or small dent in the skin that forms when a person keeps performing injections in the same spot. | | | People who want to avoid them can do so by changing (rotating) the places where they perform injections. |
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http://en.wikipedia.org/wiki/Lipodystrophy
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| | Lipodystrophies and the Familial Partial Lipodystrophy of the Dunnigan Type (FPLD) |
| | Finally, the probably most frequent form of lipodystrophy is the redistribution of fat that occurs in HIV-infected patients, mainly treated by antiretroviral medications. | | | Could Some Patients with LMNA Mutations be Affected by Both Skeletal or Cardiac Muscular Symptoms and Lipodystrophy? | | | Regarding the HIV-linked lipodystrophy syndrome, several authors recently pointed out the deleterious effects of some antiretroviral treatments on adipogenesis. |
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http://www.ncbi.nlm.nih.gov/books/bv.fcgi?query_key=9&db=Books&dopt=&page=0&dispmax=20&WebEnv=0nUSshXHvsRzJ4GUUeU8Dg5gK4hGgwVtunA0WToC3iaE7WYtdJAR5k&WebEnvRq=1&rid=eurekah.section.8038
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| | eMedicine - Lipodystrophy, Localized : Article by Isabelle Thomas, MD |
| | Background: Lipodystrophies are a heterogeneous group of diseases clinically characterized by a congenital or acquired loss of fat in circumscribed, partial, or diffuse areas of the body. | | | Ahn S, Yoo M, Lee S, Choi E: A clinical and histopathological study of 22 patients with membranous lipodystrophy. | | | A skin biopsy of an affected area deep enough to include the subcutaneous tissue should be performed to confirm the diagnosis and to exclude underlying conditions. |
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http://www.emedicine.com/derm/topic884.htm
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| | Diabetes: Prevalence of mutations in AGPAT2 among human lipodystrophies - Brief Genetics Report |
| | We found mutations in AGPAT2 in all patients presenting with BSCL (38 patients from 30 families) but two. | | | They likely affect triacylglycerol synthesis in adipose tissue and may cause lipodystrophy by depleting the adipocytes of triglycerides (11-13). | | | With the exception of patients no. 119 and 129 for whom the second mutation has not yet been identified, patients with BSCL are either homozygous for a specific mutation or compound heterozygous in accordance with an autosomal recessive pattern of inheritance. |
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http://www.findarticles.com/p/articles/mi_m0922/is_6_52/ai_102836215
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| | NEJM -- Acquired and Inherited Lipodystrophies |
| | Lipodystrophy in Patients with Human Immunodeficiency Virus Infection | | | Abhimanyu Garg, M.D. Lipodystrophies are clinically heterogeneous acquired or inherited | | | involved in the pathogenesis of various types of lipodystrophy |
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http://content.nejm.org/cgi/content/short/350/12/1220
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| | LMNA, encoding lamin A/C, is mutated in partial lipodystrophy - Nature Genetics |
| | The lipodystrophies are a group of disorders characterized by the absence or reduction of subcutaneous adipose tissue. | | | Partial lipodystrophy (PLD; MIM 151660) is an inherited condition in which a regional (trunk and limbs) loss of fat occurs during the peri-pubertal phase | | | Additionally, variable degrees of resistance to insulin action, together with a hyperlipidaemic state, may occur and simulate the metabolic features commonly associated with predisposition to atherosclerotic disease |
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http://dx.doi.org/10.1038/72807
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| | Current Medicinal Chemistry—Immunology, Endocrine & Metabolic Agents Volume 2, No. 4, 2002 |
| | Delineation of the human molecular genetic basis of forms of inherited lipodystrophy may help to identify pathways and molecular targets for the common insulin resistance syndrome and for acquired drug-induced lipodystrophy syndromes. | | | Lipodystrophy syndromes, which include both genetic and acquired forms, resemble the insulin resistance syndrome, particularly with respect to the presence of associated biochemical disturbances such as hyperlipidemia and diabetes. | | | This may require a better understanding of the mechanism of action of endostatin at the molecular level, which remains largely unknown. |
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http://www.bentham.org/cmciema/cmciema2-4.htm
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| | Reservoir of HIV-infected cells found -- Queer Lesbian Gay News -- Gay.com |
| | According to a Sept. 11 Reuters report, the HIV virus resides in AIDS patients' lipodystrophies, fat deposits that form all over the body as a side effect from taking AIDS drugs. | | | The finding is considered a breakthrough for AIDS researchers, since it has always been assumed that HIV is still in the body of people who show no viral load in blood tests. |
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http://www.gay.com/news/article.html?2002/09/13/2
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| | AIDS VIRUS LURKS IN FAT CELLS & HIV and AIDS infection rates are skyrocketing in Eastern Europe |
| | France Pietri-Rouxel and colleagues found HIV in the fat tissue of patients with irregular fat deposits known as lipodystrophies - a side- effect of long-term drug treatment for the virus. | | | So fat cells could be the more important source." The researchers plan to look for infected fat cells in other HIV patients, especially those who have not developed lipodystrophies. | | | They stumbled upon the finding when Pietri-Rouxel, a specialist in fat tissue, was removing fat from the stomachs of HIV patients with lipodystrophy and injecting the fat back into their cheeks to help fill out their gaunt faces. |
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http://www.freerepublic.com/focus/news/754456/posts
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| | UpToDate Lipodystrophic syndromes |
| | In some of these disorders there is also the apparent accumulation of fat in other regions of the body. | | | Clinically, patients with severe lipodystrophy have severe insulin resistance and a group of unique features, such as severe hyperlipidemia, progressive liver disease, and increased metabolic rate ( show table 1). | | | — Congenital generalized lipodystrophy is inherited as an autosomal recessive trait, with frequent parental consanguinity. |
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http://patients.uptodate.com/topic.asp?file=diabetes/23483
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| | Radiology case 451-3143 |
| | Some mesenchymal disorders are associated with large bones from Neurofibromatosis to lipodystrophies. | | | Infection and joint inflammation will give rise to particularly enlarged epiphyses, which might allow discrimination from other causes of large bones. |
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http://myweb.lsbu.ac.uk/dirt/museum/451-3143.html
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| | ingTND1996(3,4)parsiyel |
| | The lipodystrophies are characterized by generalized or partial loss of body fat. | | | Acquired partial lipodystrophy is the most common of lipodystrophies and usually affects women. | | | In generalized lipodystrophy essentially all body fat is lost, while in partial lipodystrophy fat atrophy is limited. |
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http://web.deu.edu.tr/noroloji/ingTND1996(3,4)parsiyel.htm
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| | Welcome to the website of International Utrilog |
| | is specialized in the treatment of lipodystrophies and detoxification of tissues by external low frequency ultrasound and is proud to present: |
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http://www.utriloginternational.com/english/welcome.html
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| | GENETIC ANALYSES OF LIPODYSTROPHIES |
| | Genetic linkage studies are currently underway in our laboratory, and more families are needed to complete the search for genes responsible for these disorders. | | | GENETIC ANALYSES OF LIPODYSTROPHIES We are interested in recruiting cases of familial lipodystrophies; congenital generalized lipodystrophy (Berardinelli-Seip syndrome), or familial partial lipodystrophy (Dunnigan or Kobberling varieties) that have autosomal recessive or dominant pattern of inheritance. |
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http://growth.hyu.ac.kr/MHonArc/1999/msg00023.html
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| | Clinical Fellowships |
| | Research interests- we are investigating the molecular mechanisms of lipodystrophies for both the genetic and acquired varieties. | | | Opportunities are available to create knock- out mice for the genes responsible for lipodystrophies and to identify additional genes for inherited lipodystrophies using positional cloning approaches. |
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http://www3.utsouthwestern.edu/nutritiondivision/fellowships.htm
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| | Central obesity - Wikipedia, the free encyclopedia |
| | Central obesity can also be a feature of lipodystrophies, a group of diseases which is either inherited, or due to secondary causes (often protease inhibitors, a group of medications against AIDS). | | | When this exceeds 1.0 in men or 0.9 in women, one can speak of central obesity. |
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http://en.wikipedia.org/wiki/Central_obesity
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| | New Page 1 |
| | WS is characterized by the early onset of common age-related disorders including diabetes mellitus type 2, ocular cataracts, osteoporosis, hypogonadism, atherosclerosis and malignancies. | | | Lamin A mutations also give rise to lipodystrophies, cardiomyopathies and premature ageing, namely Hutchison-Gilford progeria (HGPS), which affects children and Werner syndrome (WS), which affects adults. | | | Autosomal dominant Emery-Dreifuss muscular dystrophy, for example, is caused by a mutation in lamin A coupled with a loss of emerin. |
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http://www.novartisfound.org.uk/Bull_19.htm
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