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| | Cholesterol Guidelines |
 | | LDL level of less than 100mg/dl with option for drug therapy for those high-risk patients whose LDL is 100 to 129 mg/dL | | | LDL level of less than 100 mg/dl with a therapeutic option of treating to under 70 mg/dL. | | | For very high-risk patients whose LDL levels are already below 100 mg/dL, there is also an option to use drug therapy to reach the less than 70 mg/dL goal. |
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http://www.clevelandclinic.org/heartcenter/pub/guide/prevention/cholesterol/cholesterolguidelines9_01.htm
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| | News - Statins Significantly Reduce LDL levels, Ischaemic Heart Disease and Stroke |
| | The 3 analyses consisted of 164 short-term randomised placebo controlled trials regarding 6 statins and LDL cholesterol reduction in 24,000 treated patients; 58 randomised trials regarding cholesterol reduction and IHD events that included 76,359 treated patients; and 9 cohort studies and the same 58 trials regarding stroke. | | | Rosuvastatin (80mg/day) and atorvastatin (80 mg/day) were most effective at reducing LDL cholesterol, while pravastatin and fluvastatin were the least effective. | | | Statins significantly lower LDL cholesterol and thereby reduce the risk of ischaemic heart disease and stroke, according to a recent British review. |
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http://docguide.com/news/content.nsf/news/8525697700573E1885256D5C0062E6A3
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| | Cholesterol, Other Lipids, and Lipoproteins |
| | Lowering LDL is the primary goal of cholesterol drug and lifestyle therapy. | | | Exercises that train and strengthen the chest muscles may prove to be very important for patients with angina. | | | (LDL makes up the difference.) Reducing LDL is the primary goal of most cholesterol therapy. |
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http://www.reutershealth.com/wellconnected/doc23.html
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| | LDL - sales training uk, course |
| | LDL's unique brand recognises the power of Skill+Will™ and combines on-line diagnostics, interactive workshops, coaching and elearning to embed new concepts. | | | On-line learning reinforcement designed to help you maximise the benefit from your LDL training. | | | Develop your people, unlock their potential, ignite your career, and create unassailable competitive edge with state-of the-art learning and development from LDL. |
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http://www.ldl.co.uk
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| | Annotation M |
| | Initial Therapy: Evidence clearly supports initiation of pharmacotherapy when LDL is >130 mg/dL in patients with CHD (Scandinavian Simvastatin Survival Study Group, 1994). | | | Individual clinicians may choose to initiate drug therapy for LDL >100mg/dL for secondary CHD prevention, based on consensus opinion. | | | However, the CARE study, a prospective secondary prevention trial, found no outcomes benefit when high-dose pravastatin was initiated at a baseline LDL < 125 mg/dL (Sacks, 1996). |
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http://www.oqp.med.va.gov/cpg/IHD/IHD_CPG/CONTENT/Module_G/G_M_anno.htm
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| | LDL cholesterol: Low, lower, and lower still—TheFamily Health Guide |
| | An LDL of less than 130, but a "therapeutic option" to lower your LDL to less than 100. | | | An LDL of less than 100 achieved with cholesterol-lowering medications if lifestyle changes haven't lowered it to this level. | | | The main impetus for the revisions came from some pretty remarkable results from studies of the statin drugs such as atorvastatin (Lipitor) and simvastatin (Zocor). |
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http://www.health.harvard.edu/fhg/updates/update1104b.shtml
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| | Welcome to Mercodia - US |
| | The results from our recent study on subclinical atherosclerosis, support that elevated levels of circulating oxLDL is associated also with early atherosclerosis development, as measured by ultrasound, in the carotid artery in middle-aged, clinically healthy men. | | | Furthermore, subjects fulfilling the criteria for the metabolic syndrome (as defined by a working group associated to the WHO in 1998) had also higher levels of oxLDL, as compared to subjects with none or only one risk factor (Sigurdardottir et al., in press, Journal of Internal Medicine). | | | We recently performed a population-based study in clinically healthy, middle-aged men to assess the relationship between early atherosclerosis development, as measured by ultrasound within the carotid arteries, and circulating levels of ox-LDL. |
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http://www.mercodia.se/us/news.asp?sub_id=25
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| | Number 110 |
| | Published evaluations of current direct LDL tests indicate that correlation between a direct LDL method to the reference method was no better than the correlation observed using the Friedewald equation, when triglycerides are between 200 mg/dL and 400 mg/dL. | | | According to National Cholesterol Education Program (NCEP) guidelines, patients with triglycerides over 400 mg/dL " constitute a special group in whom considerations of therapy go beyond the management of LDL-cholesterol," Newer direct LDL methods have been shown to perform no better than Friedewald calculations above or below 400 mg/dL,and results from nonfasting specimens remain questionable. | | | "...patients with triglycerides over 400 mg/dL constitute a special group in whom considerations of therapy go beyond the management of LDL- cholesterol." |
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http://www.bestest.com/products/cholestech/number_110_may.htm
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| | C&EN: COVER STORY - TAKING A CLOSE LOOK AT LDL CHOLESTEROL |
| | He has no illusions that the use of LDL cholesterol to assess the risk for heart disease will change overnight. | | | But in trying to assess risk for heart disease, the bad-cholesterol number may not be the right one to monitor. | | | The bad-cholesterol numbers we routinely get during our annual physical examinations could be misleading when assessing risk, he suggests. |
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http://pubs.acs.org/cen/coverstory/8247/8247metabolic2.html
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| | Healthopedia.com - LDL (Low-Density Lipoprotein) |
| | An LDL test may be used to evaluate a person's risk for various conditions. | | | After the needle is withdrawn, the puncture site is covered for a short time to prevent bleeding. | | | Cholesterol is a waxy substance that is used for many body processes. |
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http://www.healthopedia.com/ldl
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| | Neurological Research: Inhibition of human LDL oxidation by the neuroportective drug I-deprenyl |
| | Interventions aimed at decreasing the susceptibility of LDL to oxidation are gathering considerable momentum along with the current emphasis on reducing serum lipids. | | | Inhibition of human LDL oxidation by the neuroportective drug I-deprenyl | | | Neurological Research: Inhibition of human LDL oxidation by the neuroportective drug I-deprenyl |
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http://www.findarticles.com/p/articles/mi_qa3909/is_200203/ai_n9049341
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| | Cholesterol, LDL, HDL, and Triglycerides |
| | Cholesterol is a waxy substance that can be found in all parts of your child's body. | | | Consult your child's physician regarding the timeliness of this test. | | | Elevated triglyceride levels may be caused by medical conditions such as diabetes, hypothyroidism, kidney disease, or liver disease. |
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http://www.chw.org/display/PPF/DocID/3077/router.asp
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| | LDL-P a Better Predictor of Cardiovascular Risk Than LDL-C |
| | The results were presented as part of the American Heart Association Scientific Sessions 2004. | | | Results from the Framingham Offspring Study From the American Heart Association Meeting Presentation in Room 354 and 355 - 11/8/04 at 11:15 - 11:30 a.m. | | | It is ideally suited for patients who are being considered for or who are currently on LDL- lowering therapy -- patients considered to be at moderately-high or high risk for having a cardiovascular event. |
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http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=109&STORY=/www/story/11-09-2004/0002399174&EDATE=
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| | Low density lipoprotein - Wikipedia, the free encyclopedia |
| | The correspondence between Pattern B and CHD has been suggested by some in the medical community to be stronger than the correspondence between the LDL number measured in the standard lipid profile test. | | | Because LDL transports cholesterol to the arteries, increased levels are associated with atherosclerosis, and thus myocardial infarctions, strokes and peripheral vascular disease. | | | With the decreasing cost, greater availability, wider acceptance and research use of other lipoprotein assay methods, especially NMR spectroscopy, ongoing research studies have shown the strongest correlation between human clinically obvious cardiovascular event rates has been with quantitatively measured particle concentrations, more so than particle size and particle cholesterol/lipid content. |
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http://en.wikipedia.org/wiki/Low_density_lipoprotein
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| | Cedars-Sinai Heart Center - LDL Apheresis |
| | The results of this procedure can dramatically reduce the LDL levels and help the patient avoid heart attack and stroke. | | | Cedars-Sinai Medical Center now has the first LDL apheresis program in California, providing the needed treatment for many patients who have no other alternative. | | | Until recently, when low-density lipoproteins (LDL) apheresis became generally available, these patients had no treatment option. |
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http://www.csmc.edu/2350.html
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| | MedTech1.com - Genzyme LDL Testing |
| | The availability of Medicare coverage that is consistent with the current medical practice associated with the treatment of anti-lipid therapy is very close at hand. | | | Prospective studies indicate that diet treatment or diet and drug therapy which lowers LDL cholesterol reduces subsequent CHD morbidity and mortality. | | | Performing the direct LDL assay means you have no variability from performing three assays such as is necessary with the Freidewald calculation, patients do not have to fast prior to laboratory testing, and with the direct measurement of LDL, accurate values can be obtained even with triglycerides over 400 mg/dL. |
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http://www.medtech1.com/companies/genzdiag.cfm
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| | May 1997 - LDL Apheresis |
| | This procedure acutely lowers LDL, VLDL, and lipoprotein(a) levels by 60-70%. | | | The time-averaged lowering of LDL falls in the range of 40-60% depending on how often the treatment is performed (usually every 1-2 weeks). | | | High-density cholesterol (HDL-C) levels lack the atherogenic apolipoprotein-B component and relate inversely to coronary artery disease risk. |
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http://www.itxm.org/TMU1997/tmu5-97.htm
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| | Lipids Online Slides: statins, LDL cholesterol, treatment, guidelines |
| | This means that in patients who have an elevation of both LDL-C and triglycerides (indicating increased levels of triglyceride-rich VLDL and IDL remnants as well as LDL), a statin is one of the therapies of choice because of its ability to effectively lower LDL-C and non-high-density lipoprotein cholesterol (non-HDL-C) levels. | | | The net effect of statin therapy is to lower plasma concentrations of cholesterol-carrying lipoproteins, the most prominent of which is LDL. | | | Lipids Online Slides: statins, LDL cholesterol, treatment, guidelines |
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http://www.lipidsonline.org/slides/slide01.cfm?tk=23
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| | UT-Houston Health Science Center - Health Leader, Lowering Your LDL Cholesterol |
| | Certified Nurse Practitioners/ Physicians offer full range of healthcare. | | | Depending on your risk factors for heart disease and how high your LDL cholesterol is, you may need both TLC and cholesterol-lowering medications such as statins. | | | If your LDL ("bad") cholesterol is high, and you are at risk for heart disease, your health care provider may advise you to lower your cholesterol with some "TLC." That means "Therapeutic Lifestyle Changes," under the new cholesterol treatment guidelines from the National Heart, Lung, and Blood Institute in Bethesda, Maryland. |
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http://www.uthouston.edu/HLeader/archive/heartandstroke/020207
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| | Introduction |
| | Welcome to the internet demo of the LDL++ system. | | | Overviews on the LDL++ system, and this Java-interface | | | This Java-based interface was developed by Jack Hou, Haixun Wang, Richard Kwok, and Jiejun Kong of the UCLA CS Department; the LDL++ system was developed at MCC by Natraj Arni and Kayliang Ong; Dr. |
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http://www.cs.ucla.edu/ldl/ldl_intro.html
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| | Medical Encyclopedia: LDL (Print Version) |
| | Goal LDL levels for patients at high risk for atherosclerosis -- such as patients with diabetes -- or those with known heart disease may be even lower than 100 mg/dL. | | | High levels of LDL may be associated with: | | | The main function of LDL seems to be to carry cholesterol to various tissues throughout the body. |
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http://www.nlm.nih.gov/medlineplus/print/ency/article/003495.htm
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| | Diabetes Care: LDL electronegativity is enhanced in type 1 dia... @ HighBeam Research |
| | A relevant role of more electronegative LDL in atherogenesis is supported by the observation that it is elevated in subjects at high risk, such as familial hypercholesterolemic and type 1 diabetic patients (2). | | | In LDL obtained from the diabetic patients the content of diene conjugates was not statistically different from the control group (6.22 [+ or -] 1.199% for diabetic subjects vs. 5.509 [+ or -] 0.219% for control subjects). | | | Lipoperoxidation, oxidation, and glycosylation increase the net negative charge and may enhance LDL atherogenicity with important metabolic consequences. |
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http://www.highbeam.com/library/doc0.asp?DOCID=1G1:107119553&refid=ip_encyclopedia_hf
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| | Lipids Online Slides: diet therapy, LDL cholesterol, guidelines, ATP III |
| | Even assuming a 10% reduction in LDL-C with diet therapy, extending treatment to all patients for whom the guidelines recommend the use of clinical judgment in determining whether to initiate drug therapy would require treating an enormous number of patients. | | | NCEP guidelines: initiation of drug therapy at discharge | | | The magnitude of this increase in potential patients raises the issue of cost-effectiveness, to ensure that appropriate treatment is extended to as many high-risk patients as possible. |
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http://www.lipidsonline.org/slides/slide01.cfm?q=diet+therapy
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| | Science -- Goldstein and Brown 292 (5520): 1310, 2001 |
| | Originally, LDL was implicated in heart disease through epidemiologic and genetic observations in humans and animal models (1). | | | Yet, LDLR activity in cultured fibroblasts from ARH patients was almost normal, and no mutations were found in the LDLR gene of these patients. | | | LDLs circulate in human plasma with a mean life-span of 2.5 days. |
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http://people.bu.edu/sobieraj/ed/CholSchema.html
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| | Cholesterol & Your Health - Page 1 - HeartCenterOnline: |
| | Low-density lipoproteins (LDL), which are associated with “bad” cholesterol. | | | In contrast, high levels of HDL cholesterol have been shown to reduce some of the harmful effects of LDL cholesterol. | | | LDL levels should optimally be less than 100 (levels greater than 129 are considered borderline–high, and levels greater than 159 are considered high). |
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http://heart.healthcentersonline.com/cholesterol/cholesterol.cfm
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| | Measurement of Small Low-Density Lipoprotein (LDL) Particles |
| | Therefore, measurement of LDL particle density or diameter has been proposed as a technique for further risk stratification in patients with elevated LDL levels, or for patients with normal LDL levels who have other high risk factors for CAD, or to predict response to a particular therapy. | | | Measurement of small dense LDL particles may be considered medically necessary when the patient meets at least one of the following criteria: | | | Comparison of various Electrophoretic Characteristics of LDL Particles and Their Relationship to the Risk of Ischemic Heart Disease. |
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http://www.wellmark.com/e_business/provider/medical_policies/policies/LDL.htm
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| | Anti-Phosphorylcholine Mediated Enhancement of LDL Uptake by Monocytes |
| | Methods: LDL was purified by standard ultracentrifugation techniques and then applied to Sepharose. | | | Thus, increased levels of anti-PC in patients with attachment loss may initiate or promote enhanced uptake of LDL into monocytes and be a factor in development of atherosclerotic lesions. | | | Conclusions: Anti-PC enhanced uptake of LDL into monocytes during 24h of culture. |
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http://iadr.confex.com/iadr/2004Hawaii/techprogram/abstract_43836.htm
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| | LDL (low-density lipoprotein) cholesterol |
| | LDL (low-density lipoprotein) cholesterol is the “bad” cholesterol, which carries mostly fat and only a small amount of protein from the liver to other parts of the body. | | | People with at least a moderate risk for developing heart disease (especially those who have diabetes) may benefit from lowering LDL cholesterol levels. | | | The specific target LDL level depends on a person's number and type of risk factors. |
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http://my.webmd.com/hw/health_guide_atoz/stl158077.asp?navbar=hw207814
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| | Small, Dense LDL and Coronary Heart Disease (CHD) - Connecticut |
| | At the present time, it appears that the routinely measured lipids provide sufficient information for aggressive pursuit of lipid disorders in most, if not all patients. | | | There were several limitations to the study, such as self-reporting, non-fasting samples and analysis of frozen samples. | | | The striking findings were that when the patient had small LDL, the risk of IHD was 6.2 fold increased when apoprotein B was greater than or equal to 120 mg/dl (p less than 0.001) and 4.9 fold increased when Chol/HDL ratio was greater than or equal to 6.0 (p equal to 0.001). |
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http://www.saintfranciscare.com/15784.cfm
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| | What's the Difference Between LDL and HDL Cholesterol? |
| | Doctors need to treat high triglycerides in people who also have high LDL cholesterol levels. | | | LDL cholesterol of less than 100 mg/dL is the optimal level. Less than 130 mg/dL is near optimal for most people. A high LDL level (more than 160 mg/dL or 130 mg/dL or above if you have two or more risk factors for cardiovascular disease) reflects an increased risk of heart disease. | | | Many people with heart disease also have high triglyceride levels. People with diabetes or who are obese are also likely to have high triglycerides. |
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http://www.americanheart.org/presenter.jhtml?identifier=180
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| | [No title] |
| | On the other hand, the presence of pattern B predicts a beneficial effect of antidyslipidemic treatment on both the lipoprotein profile and arteriographic CAD. | | | Pattern A, on the other hand, is less dangerous and not as highly associated with excess risk. | | | Pattern A simply become better Pattern A. LDL subclass |
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http://www.antiaging.org/library/lipid_definitions.html
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| | Marshfield Laboratories - Laboratory News |
| | However, the clinical utility of this panel is compromised given the absence of an LDL-cholesterol result; it may be applicable however to minimally fasting patients. | | | By contrast, a significant number of specimens with the “Lipo panel, with LDL” test require manual electrophoresis and interpretation of patterns by pathology staff, activities that unnecessarily consume laboratory resources and may result in unnecessary follow-up testing -- when the patient is non-fasting. | | | If needed, the additional direct LDL-cholesterol or ultracentrifugation testing will be performed at an additional charge but is required on only 10 percent of patient orders based on historical experience. |
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http://www.marshfieldlaboratories.org/news/Labnews/020318.htm
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| | Meta Programming in LDL++ |
| | A Meta-Variable is represented as an LDL++ complex object, ldl_var(Vname), where Vname is the name of the Meta-Variable represented by a constant. | | | As can be seen from above, you may pass the specifications for any arbitrary rule inside the LDL++ meta predicate "meta_pred_list." In the next example, we show a complete LDL++ program demonstrating the use of the meta predicate. | | | A Meta-Predicate is represented as an LDL++ functor except that it may contain LDL++ Meta-Variables, We denote a LDL++ Meta-Predicate as P. Given meta_pred_list(PredicateList, VariableList, BindingList): |
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http://magna.cs.ucla.edu/ldl/tutorial/meta.html
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| | InterPro: IPR002172 Low density lipoprotein-receptor, class A |
| | Similar domains have been found (see references in [ 3 ]) in several extracellular and membrane proteins (see examples). | | | The repeat has been shown [ 3 ] to consist of a beta-hairpin structure followed by a series of beta turns. | | | In the absence of calcium, LDL-A domains are unstructured; the bound calcium ion imparts structural integrity. |
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http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002172
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| | Lowering Cholesterol - Page 1 - HeartCenterOnline: |
| | Fatty and processed foods can elevate LDL cholesterol, whereas certain other foods can reduce it. | | | Knowing which foods to avoid and which to include will not only improve cholesterol levels but also improve overall health as well. | | | Physical activity is also an excellent strategy for reducing LDL cholesterol. |
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http://heart.healthcentersonline.com/cholesterol/lowchol.cfm
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| | The LDL process: |
| | Since the liver makes cholesterol if it thinks that no cholesterol is available, reducing the amount of cholesterol in the diet is helpful but cannot completely overcome the loss of the LDL receptor protein. | | | The pH of the lysosome is lower than the rest of the cell and that causes another change in the shape of the LDL receptor. | | | The gut cells that ingest the food wrap the cholesterol and triglycerides in proteins that carry the lipids around in the blood, especially to the liver, which stores energy from food we eat. |
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http://courses.washington.edu/luca201/homework/pathwaytext.htm
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| | Holistic Health Encyclopedia - L |
| | Lecithin also increases blood serum choline levels, thus helping overcome motor problems, such as Tourette syndrome and Huntington's disease. | | | movement, and speech, helps reduce muscle weakness, anemia, excess bleeding, multiple sclerosis symptoms, and drops the level of excessive triglycerides in the blood, as well as “bad" low-density lipoprotein (LDL) cholesterol, while raising levels of "good” high-density lipoprotein (HDL) cholesterol. |
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http://www.myholistic.com/glossary/L.php3
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