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Topic: Ketone bodies



  
 University of Miami School of Medicine - Glossary - Ketonuria
Ketone bodies are a byproduct of this process.
Related words include "ketogenesis" (production of ketone bodies), "ketosis" or "ketonemia" (the presence of ketone bodies in the blood) and "ketotic" (adjective describing conditions involving ketone bodies).
Ketone Bodies: What They Are, How They Accumulate
http://www.med.miami.edu/glossary/art.asp?articlekey=12478   (710 words)

  
 HEALTH AND FITNESS GLOSSARY AND DEFINITIONS: K
The accumulation of ketone bodies in the body, accompanied by a state of acidosis.
The ability of individuals to feel where their bodies are in relation to space; a body awareness.
Under these conditions acetoacetate is formed, which may convert then convert into one of two other ketone bodies, 3-hydroxybutarate, or acetone.
http://www.1-fitness.com/glossary.asp?page=K   (330 words)

  
 Use Of Ketone Bodies Diabetic-Network.com Use Of Ketone Bodies
Various tissues in the body, especially muscle, can use ketone bodies as a source of energy.
Explain how the use of ketone bodies by the brain...
This allows heart and skeletal muscle to use ketone bodies...
http://www.diabetic-network.com/diabetes/use-of-ketone-bodies.html   (307 words)

  
 Welcome to Parrillo Performance
Ketones can also be excreted by the body when not used, therefore not being converted to bodyfat.
This process is termed "ketogenesis"ó which simply means the manufacture of ketones.
Coupled with MCTs ability to spare glycogen, the conversion of MCTs into ketones represents an additional source of energy for the exercising body.
http://www.parrillo.com/sngdetails.asp?sng=tsb&id=3   (1322 words)

  
 LowCarbSite :: View topic - ketosis article
In 1967, the streamline health sciences developed a so-called enzymatic method of analysis of acetoacetate and 3-hydroxybutyrate, which led to the dramatic finding that the human brain, while in the condition of prolonged starvation, was able to use ketone bodies.
The body gets rid of it through the lungs; this is where the sweet smell on the breath during ketosis comes from.
It's the body's way of saying "Whoa, we haven't used what we have yet!" and then figuring out what to do with the excess.
http://www.lowcarbsite.com/forum/ptopic3703.html   (4541 words)

  
 Ketogenic Diet Overview
Playing another major physiological role, ketone bodies act as the principle source of energy during early postnatal development.
Clearly, many questions remain about the physiological relevance and the practical utility of monitoring ketone bodies in the ketogenic diet.
The purpose of this review is to update neurologists by highlighting key issues and controversies pertaining to this important diet-based therapy for epilepsy.
http://www.charliefoundation.org/noframes/diet/overview.php   (2840 words)

  
 ketone bodies - General Practice Notebook
Ketonaemia, ketones in the bloodstream, is a physiological consequence of lipid metabolism.
Ketones are a valuable energy source for tissues such as the brain and muscle.
Ketogenesis is the normal pathway by which ketones are formed in the liver.
http://www.gpnotebook.co.uk/medwebpage.cfm?ID=-147521478   (814 words)

  
 [No title]
The quantitative monitoring of blood ketone bodies is the standard means of evaluating therapeutic progress in ketoacidosis in the clinical setting.
Monitoring levels of ketone bodies is an essential aspect of sick-day management.
Thus an accurate quantitative assessment of ketone bodies in the blood provides a much more valuable insight in determining current metabolic status and treatment strategy.
http://www.mdspharm.co.il/files/bioscanner-keton.doc   (3130 words)

  
 MedlinePlus Medical Encyclopedia: Serum ketones
A normal test result would be "negative", meaning there are no ketone bodies in the blood.
Acetone bodies; Ketones - serum; Nitroprusside test; Ketone bodies - serum
The only risks are those associated with the venipuncture.
http://www.nlm.nih.gov/medlineplus/ency/article/003498.htm   (695 words)

  
 Free fatty acids, but not ketone bodies, protect diabetic rat hearts during low-flow ischemia -- King et al. 280 (3): ...
nor ketone bodies were detrimental to the normal rat heart during
alone or with ketone bodies, had functional recoveries 50% lower
not detrimental, the ketones did not improve the recovery of contractile
http://ajpheart.physiology.org/cgi/content/full/280/3/H1173   (5078 words)

  
 Epi-Center E-Newsletter December 2004 - Happy Holidays!
The first step in the no-carb or extremely low-carb pathway to death is called ketosis.
It also doesn't mean you can't do something good for your body.
This range can be between 7.0 and 7.8 in extreme conditions.
http://www.firstfitnessoforlando.com/December_2004.htm   (1337 words)

  
 Mechanism of ketosis, ketogenesis, gluconeogenesis, ketone bodies
The other ketone bodies are formed from it.
This is then exported via the blood to the rest of the body, including the heart, muscles and brain, which seem to love this semi-digested form of fat!
A large amount of energy is released during this process, which can be used for muscle contraction and all of the other activities in the cell and, ultimately, in the body.
http://academic.sun.ac.za/med_physbio/med_physiology/dept/footnote.htm   (396 words)

  
 Fatty Acid Metabolism
This pathway leads to the formation of ketone bodies.
Fatty acid breakdown however must still occur for ATP generation and acetyl-CoA will need to be processed through an alternative pathway.
The production of ketone bodies under these conditions is an important survival mechanism used by cells under such conditions.
http://www.np.edu.sg/~dept-bio/biochemistry/aab/topics/aab_lipid.htm   (881 words)

  
 APStracts 7:0630H, 2000.
Diabetic rat hearts perfused with glucose alone or with ketone bodies, had functional recoveries 50% lower than those of the control hearts, but palmitate restored recovery to control levels.
In control rat hearts, neither palmitate nor ketone bodies altered the recovery of contractile function.
In parallel with the functional recoveries, palmitate prevented the 54% faster loss of ATP in the diabetic, glucose-perfused rat hearts during ischemia, but had no effect on the rate of ATP depletion in control hearts.
http://www.uth.tmc.edu/apstracts/2000/heart/December/630h.html   (307 words)

  
 Ketosis Myths and Facts on the Low-Carbohydrate Diet.
Carbohydrate is not a requirement for any body function.
The condition is never present in a non diabetic on a low-carbohydrate diet, where beneficial ketosis is achieved.
The body experiences a new condition when a person goes on the low-carbohydrate diet.
http://www.biblelife.org/ketosis.htm   (1850 words)

  
 Copper-y smell?
The rest of her body does, too, but not as intensely as her hands.
"Without trying to be too technical I think you can probably say that this ketone body smell is a consequence of fat metabolism.
It is different from an ammonia- like smell that might result from muscle (protein) breakdown.
http://www.medhelp.org/forums/Diabetes/messages/74a.html   (663 words)

  
 Post-exercise ketosis, ketone bodies
(Remember that ketone bodies are produced as a consequence of the gluconeogenic process.
If it were not for ketone bodies most of us would be unconscious after 48 hrs of fasting!
The ketone bodies have a distinctive smell, which can be detected in the breath.
http://academic.sun.ac.za/med_physbio/med_physiology/dept/ketosis.htm   (1735 words)

  
 Fatty acid oxidation and ketone bodies
This allows the heart and skeletal muscles primarily to use ketone bodies for energy, thereby preserving the limited glucose for use by the brain.
The human body produces carnitine through an enzymatically catalyzed
Ketone bodies are utilized by extrahepatic tissues through the conversion of
http://www.med.unibs.it/~marchesi/fatox.html   (2711 words)

  
 Ketone bodies - Wikipedia, the free encyclopedia
Ketone bodies can also be used for energy.
The three ketone bodies are acetoacetate, beta-hydroxybutyrate and acetone.
The brain gets its energy from ketone bodies in starvation (when there's no glucose).
http://en.wikipedia.org/wiki/Ketone_bodies   (441 words)

  
 Report on Research on Rare Diseases in Children: FY 2000 to FY 2005 - National Institute on Alcohol Abuse and ...
Ketone bodies also reduce the free NADP +,which is the major source of the detoxification of free radicals.
High-ketone diet therapy may therefore become a practical method for lifelong treatment of these patients.
The clinical phenotype of FRDA patients is indistinguishable from the phenotype of patients with familial -tocopherol (vitamin E) deficiency, and is different from patients with iron overload.
http://rarediseases.info.nih.gov/html/reports/fy2000child_ht/niaaa.html   (2221 words)

  
 [No title]
Instead, the liver uses ketone bodies to get the energy of the acetyl CoA out to the peripheral tissues, where it can be processed and turned into energetically useful forms.
concentration of acetone is very low, generally not a problem for the body.
Ketone Bodies Characteristics of ketone bodies Three compounds known as ketone bodies: acetoacetic acid, (-hydroxy butyric acid, acetone Normally don’t hurt cells in any way heart tissue prefers ketone bodies to carbohydrate Ketone bodies are produced in the presence of high acetyl CoA concentration.
http://www.uhmc.sunysb.edu/som/students/2003/Lectures/cell31.doc   (2432 words)

  
 BioCarta - Charting Pathways of Life
Ketone bodies are transported to other tissues such as brain, muscle or heart where they are converted back to acetyl-CoA to serve as an energy source.
In the metabolic condition called ketosis, ketone bodies are produced faster than they are consumed by tissues and the smell of acetone can be detected on a person's breath.
The brain normally uses only glucose for energy, but during starvation ketone bodies can become the main energy source for the brain.
http://www.biocarta.com/pathfiles/ketonebodiesPathway.asp   (183 words)

  
 Ch438_Bioch Review
Under what conditions will "ketone bodies" be formed (instead of complete oxidation).
answer: High [ATP] with continued breakdown of FA's, therefore need to form ketone bodies to recycle CoA.
Know reactions by which ketone bodies are synthesized and degraded.
http://www.humboldt.edu/~rap1/C438.S04/C438Review/Wk14_review.html   (547 words)

  
 Glossary of genetic disorders.
A condition of having ketone bodies build up in body tissues and fluids.
Ketones that build up in the body for a long time lead to serious illness and coma.
The body can also rid itself of one type of ketone, called acetone, through the lungs.
http://aspin.asu.edu/geneinfo/glos-k.htm   (405 words)

  
 Fatty Acids -- Overview
It is considered to be physiologically equivalent to one because it and acetoacetate are readily interconverted in the body.
These are the compounds known as ketone bodies.
Notice that beta-hydroxybutyrate is not chemically a ketone.
http://www-medlib.med.utah.edu/NetBiochem/FattyAcids/10_1.html   (51 words)

  
 APStracts 2:0115C, 1995.
Lbthe references were done using reference manager utilization and preferred metabolic pathway of ketone bodies for lipid synthesis by isolated rat hepatoma cells.
The results are discussed in terms of the known and proposed metabolic pathways for lipid synthesis from ketone bodies, particularly that from 3-hydroxybutyrate.
Subcellular distribution studies indicated accumulation and compartmentation of 3-hydroxybutyryl CoA primarily in the cytoplasm of hepatoma cells incubated with either ketone body.
http://www.uth.tmc.edu/apstracts/1995/cell/March/115c.html   (212 words)

  
 Ketone Bodies in the Treatment of Disease - Office of Rare Diseases
A metabolic control analysis of th actions of ketones bodies in perfused heart
Ketone Bodies in the Treatment of Disease - Office of Rare Diseases
Panel on Preparation of Ketone Bodies and Precursors
http://rarediseases.info.nih.gov/html/workshops/workshops/ketone2003.html   (141 words)

  
 NATIONAL ACADEMY OF CLINICAL BIOCHEMISTRY
 The test should not be used to monitor the course of therapy since levels of ACAC and AN may rise as levels of BHBA fall during successful therapy(2-8).  Blood ketone determinations that measure BHBA specifically are useful for both diagnosis and ongoing monitoring of DKA(7,16-18).
Blood ketone determinations that rely on the nitroprusside reaction should be used with caution for diagnosis of DKA as results do not quantify BHBA the predominant ketone in DKA).
Recommendation: Ketones should be measured in urine by both patients with diabetes and in the clinic/hospital setting as an adjunct for the diagnosis of diabetic ketoacidosis.  Only specific determinations of beta-hydroxybutyrate in blood should be used to establish a definitive diagnosis of diabetic ketoacidosis and to facilitate ongoing monitoring of ketoacidosis.
http://www.nacb.org/temporary/ketone.htm   (443 words)

  
 Arwen's Journal - The Book of Arwen » Ketone Bodies
During days 1-5, energy levels can flucuate from average to well below average (Feeling light headed, at times, is not uncommon).
In the absence of food (Energy), Ketone bodies are produced by the body as an alternate energy source.
Starvation, is the point where the body has used up all of its non-essential tissues (Reserves),and begins to break down its own essential tissues.
http://www.arwensloft.com/journal/index.php?p=132   (862 words)

  
 Ketone body production and disposal in diabetic ketosis. A comparison with fasting ketosis -- Fery and Balasse 34 (4): ...
10-12 mM, which correspond to the highest ketone body levels encountered
study are the following: the kinetics of ketone bodies are comparable in
process, represents a general characteristic of ketone body metabolism that
http://diabetes.diabetesjournals.org/cgi/content/abstract/34/4/326   (305 words)

  
 Lipid Catabolism
catalyzes inter-conversion of the ketone bodies acetoacetate and
Acetyl-CoA then is converted in liver mitochondria to ketone bodies,
Ketone bodies are transported in the blood to other tissue cells, where they are converted back to acetyl-CoA for catabolism in Krebs cycle (see p.
http://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb2/part1/fatcatab.htm   (1147 words)

  
 Ketosis - Wikipedia, the free encyclopedia
Ketosis, which is one of the body's processes for the metabolism of body fat, should not be confused with ketoacidosis, a medical condition induced by diabetes, that is usually accompanied by dehydration, hyperglycemia, and insulin deficiency.
During the initial stages of starvation the brain does not burn ketones, since they are an important substrate for lipid synthesis in the brain.
Ketosis (key-toe-sis) is a stage in metabolism occurring when the liver has been depleted of stored glycogen and switches to a fasting mode such as occurs during sleep, during dieting, and during the body's response to starvation.
http://en.wikipedia.org/wiki/Ketosis   (495 words)

  
 Fatty Acids -- Ketone Bodies: Answer
Ketone bodies are used by most aerobic tissues, particularly heart and muscle.
Ketone bodies are synthesized in the liver mitochondria, which is where HMG CoA lyase is expressed.
Hence the liver is a net exporter of ketone bodies.
http://www-medlib.med.utah.edu/NetBiochem/FattyAcids/faq/1_11a.html   (104 words)

  
 Life Enhancement:: Ketone Bodies in Energy, Neuroprotection, . . .
They also suggest that ketones might be a beneficial treatment for elderly patients or others suffering from oxidative damage to mitochondria.
found that d-beta-hydroxybutyrate, a ketone naturally found in rat and human metabolism, protected neurons in cell-culture models of Alzheimer’s and Parkinson’s diseases.
Ketone bodies, natural metabolites produced from fatty acids, are sources of energy that can be used when there is insulin deficiency (which may be pathological, as in diabetes, or as a result of consuming low dietary carbohydrate) or mitochondrial senescence.
http://www.life-enhancement.com/article_template.asp?ID=885   (794 words)

  
 The metabolism of ketone bodies in developing human brain: development of ketone-body-utilizing enzymes and ketone ...
The metabolism of ketone bodies in developing human brain: development of ketone-body-utilizing enzymes and ketone bodies as precursors for lipid synthesis.
http://www.arclab.org/medlineupdates/abstract_1206409.html   (60 words)

  
 Ketone bodies Ask the Dietician vhi.ie
Ketone bodies are derived from fat and are the main source of energy used by the brain during starvation.
Remember, vital organs such as the heart and kidneys are made of muscle tissue.
This has the effect of sparing the body's muscle and organ tissue which otherwise would quickly become depleted and would dramatically reduce survival time during starvation.
http://www.vhihealthe.com/experts/diet/diet_q071.jsp   (252 words)

  
 Role of glucose and ketone bodies in the metabolic control of experimental brain cancer
Our results in a mouse astrocytoma suggest that malignant brain tumours are potentially manageable with dietary therapies that reduce glucose and elevate ketone bodies.
This contrasts with normal brain tissue that can derive energy from both glucose and ketone bodies.
Role of glucose and ketone bodies in the metabolic control of experimental brain cancer
http://www.nature.com/cgi-taf/dynapage.taf?file=/bjc/journal/v89/n7/abs/6601269a.html   (288 words)

  
 Ketone Bodies Terms and Definitions at www.MedicalGlossary.org
The ketone bodies can be used as fuels by muscle and brain tissue.
Home > Chemicals and Drugs > Organic Chemicals > Ketones > Ketone Bodies Terms and Definitions
acetonemia, acetonuria, ketonemia & ketonuria go here; ketogenesis is probably KETONE BODIES /biosyn
http://www.medicalglossary.org/ketones_ketone_bodies_definitions.html   (197 words)

  
 PR Newswire: BTG Acquires Shimizu Pharmaceuticals' Ketone Bodies Technology: Potential New Products for Stroke, Head ...
BTG Acquires Shimizu Pharmaceuticals' Ketone Bodies Technology: Potential New Products for Stroke, Head Trauma and Neurodegenerative Disorders.
PR Newswire: BTG Acquires Shimizu Pharmaceuticals' Ketone Bodies Technology: Potential New Products for Stroke, Head Trauma and Neurodegenerative Disorders.@ HighBeam Research
http://www.highbeam.com/library/doc0.asp?DOCID=1G1:69841810&refid=ip_encyclopedia_hf   (123 words)

  
 Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission -- Thio et al. 54 (2): ...
According to one hypothesis, ketone bodies have anticonvulsant
OBJECTIVE: To determine the effect of the ketone bodies ß-hydroxybutyrate
Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission
http://www.neurology.org/cgi/content/abstract/54/2/325   (259 words)

  
 Alcoholic ketoacidosis at autopsy. Pounder DJ, Stevenson RJ, Taylor KK . 1998;43(4): 812-816.
Three of 12 diabetics had extreme elevations of femoral blood ketone bodies: 87.5, 20.4, and 17.4 mM/L. Measurement of ketone bodies in vitreous humour or pericardial fluid using clinical laboratory methodologies is recommended in unexplained deaths in chronic alcoholics as well as diabetics.
This opens up the possibility of using simpler clinical laboratory methodologies which cannot be applied to autopsy blood due to hemolysis.
Vitreous ketone levels showed good correlation with blood and pericardial fluid levels, suggesting that vitreous could be used as an alternative autopsy specimen for this analysis.
http://www.astm.org/jforensicsci/PAGES/2836.htm   (258 words)

  
 Word List
Kartagener's Syndrome *KS* - a condition where the heart is located on the right side of the body in patients with Immotile Cilia Syndrome
transer of a kidney from the body of one person to another
chemical test used to detect the presence of ketone bodies in the urine; if positive, fats are being utilized by the body instead of carbohydrates, which occurs in starvation or an unstable diabetic state
http://www.angelfire.com/wv/MT/klist.html   (482 words)

  
 diabetic ketoacidosis - definition of diabetic ketoacidosis in the Medical dictionary - by the Free Online Medical ...
Decreased pH and bicarbonate concentration in the body fluids caused by accumulation of ketone bodies in uncontrolled diabetes mellitus.
http://medical-dictionary.thefreedictionary.com/diabetic+ketoacidosis   (92 words)

  
 abstract
Under conditions of fasting or caloric restriction (CR), however, brain cells can also derive energy from ketone bodies (acetoacetate and beta-hydroxybutyrate).
Seizure susceptibility, body weights, and the levels of plasma glucose were measured once a week over a ten-week treatment period in each diet group.
Glucose uptake into the brain is greater during epileptic seizures than during most other brain activities suggesting a key role for glucose in the initiation and spread of seizure activity.
http://www.hscbklyn.edu/http://Alumni/kingsbrook/seyfried.html   (423 words)

  
 Kelp, Ketone bodies, Ketosis, Kidneys
When severe, ketosis is known as ketoacidosis, because the body becomes over-acidified due to the acidity of two of the ketone bodies.
In all these cases the body is forced to use fat as an alternative energy source, and free fatty acids in the circulation are converted to ketone bodies in the liver.
Conditions leading to ketosis are fasting or starvation, a shortage of carbohydrate, or uncontrolled diabetes mellitus which results in the body's inability to utilize carbohydrate as an energy source.
http://www.health-diets.net/healthsearch/kelp.htm   (275 words)

  
 Ketone Bodies, Serum
-hydroxybutyrate (unmeasured) but treatment of ketoacidosis results in increased acetoacetate (measured) and thus a more positive "acetone&; reaction, before ketone bodies decrease.
Determining the presence of ketone bodies is useful when isopropanol ingestion is suspected.
Thus, as ketoacidosis is treated, an apparent positive Acetest® is found while there is an actual reduction of total plasma ketone body concentration.
http://www.labcorp.com/datasets/labcorp/html/chapter/mono/sc000100.htm   (376 words)

  
 Ketone bodies - urine - A Medical Reference Article
Ketone bodies - urine - A Medical Reference Article
A resource with information on over 10,000 medical topics including: Ketone bodies - urine
http://www.umm.edu/dwp/003988.htm   (33 words)

  
 Ketones - [Medical Test]
Some medications can cause the test to indicate that ketones are present when they are not.
Dehydration may concentrate ketones in the urine, causing a falsely high result.
Therefore, specific blood tests are generally done to more accurately measure ketones.
http://www.peacehealth.org/kbase/topic/medtest/hw7738/factors.htm   (100 words)

  
 Fatty Acid Metabolism
•For cells which rely primarily or solely (such as the brain) on carbohydrate metabolism, ketone bodies represent a major energy source during times of starvation.
•Ketone bodies are produced from  condensation and degradation of acetyl-CoA molecules.
http://www.cameron.edu/~teds/5fats_files/slide0022.htm   (57 words)

  
 Ch438_Lec_36
The limiting factor in using ketone bodies then becomes the ability of the liver to synthesis them, which requires the induction of the enzymes required for acetoacetate biosynthesis.
In the peripheral tissues the ketones must be reconverted to acetyl CoA in the mitochondria:
's for both are similar, the CNS doesn't begin to use ketone bodies in preference to glucose until their concentration exceed's the concentration of glucose in the serum.
http://www.humboldt.edu/~rap1/C438.S04/C438Notes/C438nLec36.htm   (1113 words)

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