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| | Cutaneous Biology Research Center at MGH |
 | | Primary keratinocytes are easily grown in large numbers, and their differentiation can be induced under well-defined culture conditions, with a rapid and homogeneous response amenable to careful biochemical analysis. | | | We use primary keratinocytes and skin as our main experimental model system, and are assessing how the regulatory mechanisms elucidated in this system apply to specific types of human epithelial tumors. | | | More specifically, we will be examining the functional integration of signals that control keratinocyte cell/cell adhesion, growth and differention, with particular emphasis on E-cadherin adhesion complexes, Src/Fyn tyrosine kinases and small GTPases of the Rho family. |
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http://www.massgeneral.org/cbrc/pages/cbrc_Dotto.htm
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| | Epidermal Growth Factor Receptor-dependent Control of Keratinocyte Survival and Bcl-xL Expression through a ... |
| | Induction of apoptosis in HaCaT keratinocytes by conditional expression of a dominant negative AKT construct. | | | Induction of apoptosis in HaCaT keratinocytes by conditional expression of a dominant negative MEK1 construct. | | | Expression and Impairs Keratinocyte Survival-- To target the MEK/MAPK pathway specifically, we used a dominant interfering MEK construct that has no kinase activity (11). |
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http://www.jbc.org/cgi/content/full/276/9/6320
(5100 words)
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| | Cascade Biologics: Human Keratinocyte Growth Supplement |
| | A sterile set of solutions intended for use with EpiLife® medium or Medium 154 to culture human epidermal keratinocytes. | | | A sterile, concentrated (100X) solution intended for use with EpiLife® medium or Medium 154 to culture human epidermal keratinocytes. | | | Asia-Pacific customers, please contact one of our distributors. |
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http://www.cascadebio.com/index.cfm?fuseaction=home.Content&CID=488
(162 words)
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| | Psoriasis and Psoriatic Arthritis OnLine Toolbox: List O'Links |
| | This research group studies the molecular pathways of psoriasis through a combination of clinical research studies using immune-modulating therapies and large scale gene expression studies. | | | Their web site provides general details about the group's research endeavors, and presents new information about the roles of T-Cell, dendritic cell and keratinocyte activation in psoriasis. | | | The acronym "CRISP" stands for "Computer Retrievel of Scientific Projects". |
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http://pso.webwillow.com/links.html
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| | Keratinocyte - Wikipedia, the free encyclopedia |
| | This page was last modified 03:19, 8 May 2006. | | | The time of transit from basal layer to shedding is approximately one month although this can be accelerated in conditions of keratinocyte hyperproliferation such as psoriasis. | | | This layer forms an effective barrier to the entry of foreign matter and infectious agents into the body and minimises moisture loss. |
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http://en.wikipedia.org/wiki/Keratinocyte
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| | Keratinocyte |
| | Derrangements may lead to several disease states including cancer. | | | Estimation of size of clonal unit for keratinocytes in normal human skin. | | | To estimate the territory or surface area covered by a single stem-cell-derived KC population in human skin, clonal skin maps were created from 3 healthy adult women and from normal skin of a psoriatic patient. |
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http://www.thedoctorsdoctor.com/bodysites/skin_keratinocyte.htm
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| | FGF7 - fibroblast growth factor 7 (keratinocyte growth factor) |
| | In the present study, we compared the immunohistochemical localization of KGF and KGFR/FGFR-2 in the normal and cancerous pancreas using specific antibodies that recognize KGF and KGFR/FGFR-2 and examined the expression of KGF, KGFR, and FGFR-2 in human pancreatic cancer by in situ hybridization with the corresponding riboprobes. | | | In this study, we investigated the effects of KGF on PTHrP secretion and expression by normal human foreskin keratinocytes (NHFK) and the effects of PTHrP on KGF secretion and expression by normal human dermal fibroblasts (NHDF) in vitro. | | | FGF1, FGF7, FGF9, FGF10, FGF11, and FGF18 were also expressed in the pancreas at varying time points and levels, as well as FGF receptor forms FGFR1b, FGFR1c, FGFR2b, FGFR2c, FGFR3b, and FGFR4. |
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http://www.ihop-net.org/UniPub/iHOP/gg/88198.html
(5738 words)
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| | Palifermin (Keratinocyte Growth Factor) Information Page |
| | KGF stimulates the growth of cells in tissues such as the skin and the surface layer of the mouth, stomach, and colon. | | | Palifermin is believed to work by stimulating the cells of the lining of the mouth. | | | Palifermin is a modified version of a naturally occurring human protein called keratinocyte growth factor (KGF) that is manufactured in a laboratory. |
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http://www.fda.gov/cder/drug/infopage/palifermin/paliferminQA.htm
(560 words)
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| | Ask A Scientist - Skin cells |
| | When a moisturizer claims to be able to "restore" and "rejuvenate" these cells, the claim probably refers to its ability to add to the lipid component in between the cells, which plumps the skin up a bit and takes away the crusty look. | | | The only keratinocytes that "grow" in the epidermis are found in the basal layer, next to the basal membrane that separates the dermis from the epidermis. | | | These cells still have a nucleus and are "alive," but they have committed to differentiate, so can no longer divide. |
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http://www.hhmi.org/cgi-bin/askascientist/highlight.pl?kw=&file=answers/general/ans_017.html
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| | Holistic Health Encyclopedia - E |
| | The epidermis is the most superficial layer of the skin and provides the first barrier of protection from the invasion of foreign substances into the body. | | | The epidermis is subdivided into five layers or strata, the stratum germinativum (SG), the stratum spinosum(SS), the stratum granulosum(SGR), the stratum lucidum(not seen in this photomicrograph) and the stratum corneum(SC) in which a keratinocyte gradually migates to the surface and is sloughed off in a process called desquamation. | | | The organ attached to the testicle that consists of a very long and highly coiled tube that thickens to form the vas through which the sperm travels. |
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http://www.myholistic.com/glossary/E.php3
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| | The World's Healthiest Foods: Feeling Great |
| | A study of ECGC's effects on keratinocytes (the major type of epidermal or skin cell) found that this green tea compound has yet another means of correcting cancer—that of turning on the genes that direct the cancer cell to return to normal. | | | EGCG has even been found to work as a pro-oxidant or free radical, but just inside cancer cells, where it causes so much damage that the cancer cells' self-destruct mechanisms are triggered. | | | Green tea's anticancer effects include its ability to inhibit the overproduction of the enzyme cyclooxygenase (COX)-2, a protein whose overproduction has been implicated as a factor in many diseases, including arthritis and cancer. |
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http://www.worldshealthiestfoods.com/genpage.php?tname=foodspice&dbid=146
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| | Psoriasis Connections: Psoriasis Resource Library |
| | Presents the theory that psoriasis is a disease of abnormal keratinocyte proliferation induced by T cells. | | | Recent Advances in Psoriasis: The Role of the Immune System by Barbara S. Baker, Imperial College Press, 2000. |
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http://www.psoriasisconnect.com/resources/resource_library.jsp
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| | Annual Report 1997 |
| | Shimizu A, Kato M, Nakao A, Imamura T, ten Dijke P, Heldin C-H, Kawabata M, Shimada S and Miyazono K. Identification of receptors and Smad proteins involved in activin signaling in a human epidermal keratinocyte cell line. | | | Röijer E, Miyazono K, Åström A-K, Geurts van Kessel A, ten Dijke P and Stenman G. Chromosomal localization of three human genes encoding members of the TGF-b superfamily of type I serine/threonine kinase receptors. |
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http://www.licr.uu.se/annual_reports/report97.html
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