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Topic: Intracellular



  
 Stimulation of the Plasma Membrane Na+/H+ Exchanger NHE1 by Sustained Intracellular Acidosis: EVIDENCE FOR A NOVEL ...
Intracellular acidosis activates the ERK pathway in a time-dependent manner in neonatal rat ventricular myocytes.
ERK pathway in response to sustained intracellular acidosis.
Sustained intracellular acidosis stimulates sarcolemmal NHE activity in neonatal rat ventricular myocytes.
http://www.jbc.org/cgi/content/full/278/34/31676   (4867 words)

  
 Imaging of intracellular calcium stores in single permeabilized lens cells -- Churchill and Louis 276 (2): 426 -- AJP - ...
Data are from a single experiment representative of response observed in 599 of 911 cells in 49 experiments in which 49 cultures were used.
Data are from a single experiment representative of response observed in 73 of 134 cells in 11 similar experiments in which 11 cultures were used.
Data are from a single experiment representative of responses observed in 7 similar experiments in which 7 cultures were used, and 35 of 88 cells showed a juxtanuclear thapsigargin-insensitive Ca
http://ajpcell.physiology.org/cgi/content/full/276/2/C426   (4456 words)

  
 Journal of Bone and Joint Surgery: Intracellular Staphylococcus aureus: A mechanism for the indolence of osteomyelitis
Our aim therefore was to document the fate of the intracellular bacteria after a more natural cause of death of osteoblasts, creating a process which reflected the clinical situation more closely.
Journal of Bone and Joint Surgery: Intracellular Staphylococcus aureus: A mechanism for the indolence of osteomyelitis
This method, however, does not mimic the natural process of the death of osteoblasts.
http://www.findarticles.com/p/articles/mi_qa3767/is_200308/ai_n9239126   (1103 words)

  
 Fluoromicroscopic Studies of Bleomycin-induced Intracellular Oxidation in Alveolar Macrophages and Its Inhibition by ...
The mechanism of bleomycin-induced fibrosis is not yet clear, but studies suggest that the generation of oxygen radicals by the bleomycin-Fe complex may play an important role in the initiation of the fibrotic process.
The therapeutic value of this drug is greatly limited by its association with the development of pulmonary fibrosis.
These results indicate that the fluoromicroscopic method is sensitive for the determination of intracellular oxidation caused by oxygen radicals.
http://ehp.niehs.nih.gov/members/1994/Suppl-10/bhat-full.html   (4799 words)

  
 Diabetes: Intracellular pH plays a critical role in gluco... @ HighBeam Research
In a HC[O.sub.3.sup.-]-buffered medium, however, both exchangers are effective, resulting in overcompensation for the [Ca.sup.2+]-induced acidification and stabilizing the intracellular pH at a higher point (8).
To explore this possibility, we monitored glucose-induced priming in KRBH under conditions of intracellular alkalinization.
In studies on rat islets, Best et al.
http://highbeam.com/library/doc0.asp?DOCID=1G1:82320710&...   (5591 words)

  
 Use of Aminoglycosides in Treatment of Infections Due to Intracellular Bacteria -- Maurin and Raoult 45 (11): 2977 -- ...
Several techniques have been used to assess the intracellular penetration and concentration of antibiotics within eukaryotic
Mackaness, G. The action of drugs on intracellular tubercle bacilli.
Physicochemical conditions prevailing within each parasitophorous vacuole have been defined for only a few intracellular residing
http://aac.asm.org/cgi/content/full/45/11/2977   (5446 words)

  
 Intracellular Trafficking of Angiotensin II and its AT1 and AT2 Receptors: Evidence for Selective Sorting of Receptor ...
Intracellular Pathways of Ang II and AT 1a
that the intracellular trafficking pathways of FITC-Ang II and
To measure changes in intracellular calcium levels under conditions
http://mend.endojournals.org/cgi/content/full/11/9/1266   (5545 words)

  
 Intracellular PO2 decreases with increasing stimulation frequency in contracting single Xenopus muscle fibers -- ...
There is currently some controversy regarding the manner in which skeletal muscle intracellular P
These results clearly demonstrate that, under the conditions of the present study, intracellular P
Therefore, this study investigated the relationship between intracellular
http://jap.physiology.org/cgi/content/full/91/2/632   (3266 words)

  
 Intracellular and Intraalveolar Localization of Surfactant Protein A (SP-A) in the Parenchymal Region of the Human Lung ...
in an intracellular site other than the lamellar bodies (32).
The aim of the present study was therefore to analyze
Only some of the lamellar bodies (LB) are weakly labeled, mainly at their outer membranes (B).
http://ajrcmb.atsjournals.org/cgi/content/full/26/1/91   (4769 words)

  
 Microcystic Cyanobacteria Extract Induces Cytoskeletal Disruption and Intracellular Glutathione Alteration in ...
These findings suggest that intracellular GSH plays an important role in MCE-induced cytotoxicity and cytoskeleton changes in primary cultured rat hepatocytes.
Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news on the impact of the environment on human health.
Center for Environmental and Occupational Health, Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
http://ehp.niehs.nih.gov/docs/2000/108p605-609ding/abstract.html   (406 words)

  
 BCL-2 Expression or Antioxidants Prevent Hyperglycemia-induced Formation of Intracellular Advanced Glycation ...
The observed association between increased ROS and intracellular AGE formation could simply reflect the fact that transition
of oxidant pathways prevents intracellular AGE formation have
These changes can revert to normal when hyperglycemia is abolished,
http://www.jci.org/cgi/content/full/97/6/1422   (4593 words)

  
 Identification of Linked Legionella pneumophila Genes Essential for Intracellular Growth and Evasion of the Endocytic ...
for intracellular growth and evasion of the endocytic pathway,
it likely that this lesion is responsible for the intracellular
The six mutants which were most defective for intracellular growth and failed to evade the endocytic pathway were chosen for
http://iai.asm.org/cgi/content/full/66/3/950   (6050 words)

  
 CBER Research - OVRR - Karen Elkins, PhD, Immunity to Intracellular Bacteria
Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis LVS.
Invited speaker, ASM Biodefense Research meeting, in session entitled "Host/Pathogen Regulatory Networks," March 2004.
The research in Dr. Elkins' laboratory concerns the fundamental mechanisms of protective immunity to intracellular pathogens, particularly intracellular bacteria.
http://www.fda.gov/cber/research/elkins.htm   (684 words)

  
 Intracellular cholesterol transport -- Maxfield and Wüstner 110 (7): 891 -- Journal of Clinical Investigation
The intracellular trafficking pathways of cholesterol in hepatocytes
Intracellular trafficking of cholesterol monitored with a cyclodextrin.
Intracellular cholesterol transport -- Maxfield and Wüstner 110 (7): 891 -- Journal of Clinical Investigation
http://www.jci.org/cgi/content/full/110/7/891   (5933 words)

  
 A crucial role for profilin-actin in the intracellular motility of Listeria monocytogenes -- Grenklo et al. 4 (5): 523 ...
A crucial role for profilin-actin in the intracellular motility of Listeria monocytogenes -- Grenklo et al.
A crucial role for profilin–actin in the intracellular motility of Listeria monocytogenes
http://emboreports.npgjournals.com/cgi/content/abstract/4/5/523   (227 words)

  
 Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (Nramp1) ...
Immunogenetics in the analysis of resistance to intracellular pathogens.
Phagosomal acidification is mediated by a vacuolar-type H+-ATPase in murine macrophages.
Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections.
http://www.jem.org/cgi/content/full/188/2/351   (6827 words)

  
 Spectra Cell
This detailed nutritional information opens a "window on intracellular function" and enables clinicians to develop appropriate interventions for patients who are pursuing lasting health.
Our company is the industry's leading provider of Functional Intracellular Analysis™ (FIA™), patented tests for assessing the function of specific vitamins, minerals, antioxidants and other essential micronutrients within an individual's white blood cells (lymphocytes).
Unlike traditional serum, hair, and urine tests, it provides a complete picture of an individual's functional intracellular nutritional status.
http://www.spectracell.com   (399 words)

  
 Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious ...
Brucella abortus evades interactions with late compartments of the endocytic degradative pathway and promotes interactions of its vacuole with the host endoplasmic reticulum (ER) to generate an ER-derived organelle that is permissive for replication.
The focus of our research is to understand the molecular mechanisms by which intracellular bacterial pathogens circumvent host defense mechanisms and, in particular, survive and replicate within mammalian cells.
Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases (NIAID), NIH
http://www.niaid.nih.gov/dir/labs/licp/tularemia.htm   (655 words)

  
 Differential Distribution of Intracellular Glutamate Receptors in Dendrites -- Rubio and Wenthold 19 (13): 5549 -- ...
The objective of the present study was to analyze the intracellular
In the analysis of intracellular pools, we find that
Glutamate receptors are synthesized in the cell body and transported in intracellular compartments to the target synapse.
http://www.jneurosci.org/cgi/content/abstract/19/13/5549   (631 words)

  
 BIGpedia - Biology - Encyclopedia and Dictionary Online
A group of organisms is said to have common descent if they have a common ancestor.
There is also a series of intracellular "parasites" that are progressively less alive in terms of being metabolically active:
These domains reflect whether cells have nuclei or not as well as differences in cell exteriors.
http://www.bigpedia.com/encyclopedia/Biology   (2516 words)

  
 Activation of Neurotransmitter Release in Hippocampal Nerve Terminals During Recovery From Intracellular Acidification ...
Our results suggest that changes in intracellular pH
A number of pathological conditions, such as anoxia and ischemia,
Role of intracellular and extracellular pH in the chemosensitive response of rat locus coeruleus neurones
http://jn.physiology.org/cgi/content/abstract/81/6/2627   (563 words)

  
 Movements of vaccinia virus intracellular enveloped virions with GFP tagged to the F13L envelope protein -- Geada et ...
Visualization and Characterization of the Intracellular Movement of Vaccinia Virus Intracellular Mature Virions
This article has been cited by other articles:
Human Cytomegalovirus Labeled with Green Fluorescent Protein for Live Analysis of Intracellular Particle Movements
http://vir.sgmjournals.org/cgi/content/abstract/82/11/2747   (914 words)

  
 The Organizing Potential of Sphingolipids in Intracellular Membrane Transport -- Holthuis et al. 81 (4): 1689 -- ...
Eukaryotes are characterized by endomembranes that are connected by vesicular transport along secretory and endocytic pathways.
A fundamental problem currently being addressed in cell biology is how the Golgi is organized to perform its vital tasks and
signaling molecules that function not only as intracellular second
http://physrev.physiology.org/cgi/content/full/81/4/1689   (10052 words)

  
 Regulation of AE2-mediated Cl- Transport by Intracellular or by Extracellular pH Requires Highly Conserved Amino Acid ...
AE1-like phenotype, whether in response to changing pH
and 342–347 were not stimulated by intracellular alkalinization.
displayed similar lack of stimulation by intracellular alkalinization.
http://www.jgp.org/cgi/content/full/120/5/707   (7219 words)

  
 Intracellular Cytokine Staining
Table 2: Human Cytokine Intracellular Staining Quick Guide
A modification of the basic immunofluorescence staining and flow cytometric analysis protocol can be used for the simultaneous analysis of surface molecules and intracellular cytokines at single-cell level.
In contrast to detection of secreted cytokines by ELISA, for detection of intracellular cytokines, it is necessary to block secretion of cytokines with reagents such as Monensin or Brefeldin A during the last few hours of the stimulation.
http://www.ebioscience.com/ebioscience/appls/FCI.htm   (833 words)

  
 Intracellular pH homeostasis during cell-cycle progression and growth state transition in Schizosaccharomyces pombe -- ...
We can find no evidence for cell-cycle-related changes in intracellular
This method allows for accurate intracellular pH measurements
Intracellular pH homeostasis during cell-cycle progression and growth state transition in Schizosaccharomyces pombe -- Karagiannis and Young 114 (16): 2929 -- Journal of Cell Science
http://jcs.biologists.org/cgi/content/abstract/114/16/2929   (279 words)

  
 Multiple T Cell Subsets Control Francisella tularensis LVS Intracellular Growth Without Stimulation Through Macrophage ...
in vivo immune responses to the intracellular bacterium Francisella
The Journal of Experimental Medicine, Volume 198, Number 3, 379-389
Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852
http://www.jem.org/cgi/content/abstract/198/3/379   (429 words)

  
 Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation -- Fluckiger et ...
Taken together, our data suggest that Btk family kinases uniquely
A study with the Ca endoplasmic reticulum-ATPase inhibitor thapsigargin.
While there was little effect on intracellular calcium release,
http://embojournal.npgjournals.com/cgi/content/full/17/7/1973   (8023 words)

  
 A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid ...
family facilitates bud formation, endocytosis and affects intracellular
the intracellular transport of sterols and these other processes.
The autoradiograph of intracellular glycoproteins represented a longer exposure than that showing secreted extracellular glycoproteins.
http://jcs.biologists.org/cgi/content/full/117/14/2983   (7758 words)

  
 Computational Model of Intracellular Pharmacokinetics of Paclitaxel -- Kuh et al. 293 (3): 761 -- Journal of ...
of drug in extracellular fluid) on intracellular drug accumulation.
have been shown to affect intracellular drug accumulation, their
Interdependent Effect of P-Glycoprotein-Mediated Drug Efflux and Intracellular Drug Binding on Intracellular Paclitaxel Pharmacokinetics: Application of Computational Modeling
http://jpet.aspetjournals.org/cgi/content/abstract/293/3/761   (491 words)

  
 Intracellular Recordings - Research Application
The most common intracellular recording techniques use sharp or blunt (Patch Clamp) electrodes.
The Intracellular Recording System provides a complete solution for researchers performing intracellular techniques and includes:
DC resistances of the microelectrodes ranged from 50 to 80 M?.
http://www.adinstruments.com/research/rapps/intracellular.html   (857 words)

  
 Lawrence S. B. Goldstein
Previous work revealed that most intracellular movement in neurons is generated by motor proteins such as kinesin, dynein, or myosin.
Summary: Lawrence Goldstein is interested in understanding the molecular mechanisms of intracellular movement in neurons and the role of transport failure in neurodegenerative diseases.
My laboratory is interested in understanding the logic and molecular mechanisms of these neuronal transport systems, with the related goal of elucidating the likely role of transport failure in neurodegenerative diseases.
http://www.hhmi.org/research/investigators/goldstein.html   (940 words)

  
 Interdependent Effect of P-Glycoprotein-Mediated Drug Efflux and Intracellular Drug Binding on Intracellular Paclitaxel ...
Interdependent Effect of P-Glycoprotein-Mediated Drug Efflux and Intracellular Drug Binding on Intracellular Paclitaxel Pharmacokinetics: Application of Computational Modeling -- Jang et al.
Intracellular concentration of paclitaxel is determined by the
Articles by Jang, S. Articles by Au, J. Interdependent Effect of P-Glycoprotein-Mediated Drug Efflux and Intracellular Drug Binding on Intracellular Paclitaxel Pharmacokinetics: Application of Computational Modeling
http://jpet.aspetjournals.org/cgi/content/abstract/304/2/773   (346 words)

  
 Measurement of Intracellular Calcium -- Takahashi et al. 79 (4): 1089 -- Physiological Reviews
of this method is that the intracellular environment (e.g., viscosity,
changes in intracellular environment might result in the measured
As might have been predicted, the interests of many researchers shifted from [Ca ] analysis at the cellular level to that of the subcellular level.
http://physrev.physiology.org/cgi/content/full/79/4/1089   (9506 words)

  
 Kiger, John Andrew (1968-05-20) The transcription of simple and complex DNAs by the RNA polymerase of Escherichia coli. ...
This heterogeneity is believed to be of the same nature as the heterogeneity revealed by renaturation studies of eucaryote DNA.
Part II of this thesis is a study of the structure and replication of intracellular phage lambda DNA.
The structure and replication of intracellular bacteriophage lambda DNA.
http://etd.caltech.edu/etd/available/etd-09242002-102646   (732 words)

  
 ANTI-MICROBIAL TARGETING FOR INTRACELLULAR PATHOGENS
The use of the specific targeting molecules will allow more effective antimicrobial therapy against certain intracellular parasites such as M. tuberculosis.
Therefore, adverse side effects will be less likely and effective killing of the pathogen will be more likely.
Typically, parasites in the intracellular compartment, or phagosome, receive a much lower concentration of the antibiotic than what is administered systemically.
http://www.research.ucla.edu/tech/ucla95-579.htm   (224 words)

  
 Intracellular Transport, Assembly, and Degradation of Wild-Type and Disease-linked Mutant Gap Junction Proteins -- ...
in intracellular processing can be associated with separate disease
One possibility consistent with the phenotypic variation observed in CMTX patients is that different defects in Cx32 lead
In the current study, we present the first integrated analysis of the intracellular transport, assembly, and degradation of
http://www.molbiolcell.org/cgi/content/full/11/6/1933   (8900 words)

  
 Akt as a possible intracellular mediator for decidualization in human endometrial stromal cells -- Yoshino et al. 9 ...
Akt as a possible intracellular mediator for decidualization in human endometrial stromal cells
Akt as a possible intracellular mediator for decidualization in human endometrial stromal cells -- Yoshino et al.
we examined the presence of Akt, an emerging intracellular mediator
http://molehr.oupjournals.org/cgi/content/abstract/9/5/265   (529 words)

  
 Intracellular definition - Medical Dictionary definitions of popular medical terms
Intracellular definition - Medical Dictionary definitions of popular medical terms
In contrast to extracellular, meaning outside a cell.
Please consult your healthcare provider before beginning any course of supplementation or treatment.
http://www.medterms.com/script/main/art.asp?articlekey=24383   (201 words)

  
 Intracellular - Wikipedia, the free encyclopedia
In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".
It is used in contrast to extracellular (outside the cell).
http://en.wikipedia.org/wiki/Intracellular   (101 words)

  
 On the Biological Actions of Intracellular Angiotensin -- Re 35 (6): 1189 -- Hypertension
term intracrine on the basis of extensive studies of the intracellular
Intracellular actions of angiotensin II in vascular smooth muscle cells.
The concept of intracellular peptide hormone action, ie, intracrine
http://hyper.ahajournals.org/cgi/content/full/35/6/1189   (1304 words)

  
 Magnesium Deficiency, Cardiac Risk Screening using Scanning Electron Microscopy: IntraCellular Diagnostics' EXAtest for ...
EXA™ Test is a reliable method allowing you, the practitioner, to monitor and screen cellular mineral balance objectively and repeatedly as you follow your patient's metabolic physical status.
Extensive reserach of the buccal cell smear used by Intracellular Diagnostics, Inc. indicate high correlations between altered mineral levels and pathophysiological conditions in the following body systems:
IntraCellular Diagnostics, Inc. is a CLIA approved and California State Licensed laboratory.
http://www.exatest.com   (238 words)

  
 Casein Binds to the Cell Membrane and Induces Intracellular Calcium Signals in the Enteroendocrine Cell: A Brief ...
sensory mechanisms and the intracellular signal pathway in the
Casein Binds to the Cell Membrane and Induces Intracellular Calcium Signals in the Enteroendocrine Cell: A Brief Communication -- Hira et al.
Casein Binds to the Cell Membrane and Induces Intracellular Calcium Signals in the Enteroendocrine Cell: A Brief Communication
http://www.ebmonline.org/cgi/content/abstract/228/7/850   (223 words)

  
 Intracellular penetration and bactericidal activity of the novel des-fluoro(6) quinolone, BMS-284756 -- Kolek et al. 48 ...
and cefepime (negative control) for intracellular uptake into
Intracellular penetration and bactericidal activity of the novel des-fluoro(6) quinolone, BMS-284756 -- Kolek et al.
Intracellular penetration and bactericidal activity of the novel des-fluoro(6) quinolone, BMS-284756
http://jac.oxfordjournals.org/cgi/content/full/48/3/445   (600 words)

  
 Relationship of intracellular calcium to dependence on nerve growth factor in dorsal root ganglion neurons in cell ...
These findings support the hypothesis that trophic factor dependence of neurons may be inversely related to levels of intracellular calcium.
It has been hypothesized that, in sympathetic neurons, intracellular levels of calcium are related to trophic factor dependence.
Without NGF, immature sensory, i.e., dependent, neurons survived in the presence of high extracellular potassium, a condition that produces elevated intracellular calcium.
http://www.arclab.org/medlineupdates/abstract_1727434.html   (254 words)

  
 Cell (biology) - Wikipedia, the free encyclopedia
Prokaryotes also lack most of the intracellular organelles and structures that are characteristic of eukaryotic cells (an important exception is the ribosomes, which are present in both prokaryotic and eukaryotic cells).
Prokaryotes are distinguished from eukaryotes on the basis of nuclear organization, specifically their lack of a nuclear membrane.
Most of the functions of organelles, such as mitochondria, chloroplasts, and the Golgi apparatus, are taken over by the prokaryotic plasma membrane.
http://en.wikipedia.org/wiki/Cell_(biology)   (3668 words)

  
 Novel role of the Ca2+-ATPase in NMDA-induced intracellular acidification -- Wu et al. 277 (4): 717 -- AJP - Cell ...
Intracellular pH Response to Anoxia in Acutely Dissociated Adult Rat Hippocampal CA1 Neurons
therefore suggest that Ca -ATPase is involved in NMDA-induced intracellular acidosis in
We also provide new evidence that NMDA-evoked intracellular
http://ajpcell.physiology.org/cgi/content/abstract/277/4/C717   (326 words)

  
 Intracellular Localization of Phosphatidylinositide 3-kinase and Insulin Receptor Substrate-1 in Adipocytes: Potential ...
Another level of specificity may be derived from the intracellular location of different signaling molecules.
specificity at the level of intracellular compartmentation, thus
The present studies focus on the regulation of glucose metabolism by insulin.
http://www.jcb.org/cgi/content/full/140/5/1211   (8785 words)

  
 Regulation of Intracellular Ca2+ Stores by Multiple Ca2+-Releasing Messengers -- Cancela and Petersen 51 (Supplement ...
Berridge MJ, Bootman MD, Lipp P: Calcium: a life and death signal.
Addition to the intracellular solution of, for example,
intracellular infusion of glucose, which inhibited the response
http://diabetes.diabetesjournals.org/cgi/content/full/51/suppl_3/S349   (6162 words)

  
 Journal of Cerebral Blood Flow & Metabolism - Abstract of article: Extracellular-Intracellular Distribution of ...
Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, Minnesota, U.S.A. Correspondence: Josef Pfeuffer, PhD, Center for Magnetic Resonance Research, University of Minnesota Medical School, 2021 Sixth Street S.E., Minneapolis, MN 55455, U.S.A. Received 13 September 1999; Revised 17 December 1999; Accepted 20 December 1999.
The detection of a glucose signal at large diffusion weighting provided direct experimental evidence of intracellular glucose in the rat brain.
0.06) was consistent with a substantial fraction of glucose and lactate signals being intracellular.
http://www.nature.com/jcbfm/journal/v20/n4/abs/9590930a.html   (390 words)

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