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Topic: Interleukin 12

Ads by Google Related Topics interleukin 2      Response of human intestinal lamina propria T lymphocytes to interleukin 12: additive effects of interleukin 15 and 7 ... Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. Data are the mean of six representative experiments; horizontal bars indicate 1 SD. and microscopically unaffected areas of 12 surgical specimens http://gut.bmjjournals.com/cgi/content/full/43/5/620      Therapy with a Combination of Low Doses of Interleukin 12 and Chloroquine Completely Cures Blood-Stage Malaria, ... The role of interleukin 12 in the immune response, disease and therapy. Pooled parasitemia data represent mean ± SEM from 9 to 12 individual mice studied in two (A) or three (B) experiments. Successful therapy of chronic, nonhealing murine cutaneous leishmaniasis with sodium stibogluconate and gamma interferon depends on continued interleukin-12 production. http://iai.asm.org/cgi/content/full/67/2/513      Interleukin 12: Basic Biology and Potential Applications in Cancer Treatment -- Robertson and Ritz 1 (1): 88 -- The ... B7-1 and interleukin 12 synergistically induce effective antitumor immunity. Multiple effects on peripheral hematology following administration of recombinant human interleukin 12 to nonhuman primates. Immunomodulatory effects of interleukin 12 on human tumorinfiltrating lymphocytes. http://theoncologist.alphamedpress.org/cgi/content/full/1/1/88      Interleukin-12 from Intrinsic Cells Is an Effector of Renal Injury in Crescentic Glomerulonephritis -- TIMOSHANKO et ... 1.2 ± 0.1 c/gcs; sham chimeras, 1.1 ± 0.05 c/cgs) Trinchieri G: Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Macrophages and monocytes produce IL-12 as an early response http://www.jasn.org/cgi/content/full/12/3/464      Arch Otolaryngol Head Neck Surg -- Abstract: Cure of an Established Nonimmunogenic Tumor, SCC VII, With a Novel ... From the Departments of Otolaryngology–Head and Neck Surgery (Dr Mandpe) and Surgery (Drs Tsung and Norton), University of California, San Francisco, and the Surgical Service Veterans Affairs Medical Center, San Francisco (Drs Mandpe, Tsung, and Norton). However, interleukin 12 treatment provided immunity to second 12 were successfully cured, and all cured mice resisted subsequent http://archotol.ama-assn.org/cgi/content/abstract/129/7/786      Interleukin Materials and Methods: Sixty-one CHC patients who were treated by fixed protocol of IFN therapy (IFN [alpha] 9-10 mega U/day for 2 weeks followed by 3 times/week for 22 weeks) and showed similar clinical activities were carefully chosen from 542 IFN-treated CHC and enrolled in this study. Identification of the underlying regulatory factors may lead to new therapeutic approaches in the treatment of these diseases. The aim of this study was determine the immunoregulatory functions of Interleukin 12 (IL-12) with regard to local cytokine production in human liver. http://www.hepatitis-c.de/interleu.htm      Interleukin-10 Inhibits Interleukin-12 p40 Gene Transcription by Targeting a Late Event in the Activation Pathway -- ... B was observed in other studies ( 3, 10 - 12, 47). Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway. http://mcb.asm.org/cgi/content/full/24/6/2385      Endogenous Interleukin-12 Is Not Required for Resolution of Chlamydophila abortus (Chlamydia psittaci Serotype 1) ... Trinchieri, G. Interleukin 12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Acquired resistance but not innate resistance to Mycobacterium bovis bacillus Calmette-Guérin is compromised by interleukin-12 ablation. thus preventing their fusion with lysosomes ( 12). http://iai.asm.org/cgi/content/full/69/8/4808      Regulation of Allergic Mucosal Sensitization by Interleukin-12 Gene Transfer to the Airway -- Stämpfli et al. 21 ... of allergy and asthma later in life ( 12, 13), it has been Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression. Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions. http://ajrcmb.atsjournals.org/cgi/content/full/21/3/317      Intranasal Interleukin-12 Treatment Promotes Antimicrobial Clearance and Survival in Pulmonary Francisella tularensis ... Treatment of tularemia in humans includes the use of aminoglycosides, daily therapy, with relapses and failure rates up to 33% ( 12). Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: a novel pathway of autocrine macrophage activation. http://intl-aac.asm.org/cgi/content/full/48/12/4513      T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated ... Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn’s disease T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease -- Matsuoka et al. http://www.gutjnl.com/cgi/content/abstract/53/9/1303      The Role of Interleukin 12 in the Development of Atherosclerosis in ApoE-Deficient Mice -- Lee et al. 19 (3): 734 -- ... Interleukins in Atherosclerosis: Molecular Pathways and Therapeutic Potential The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP -lpr/lpr mice. The Role of Interleukin 12 in the Development of Atherosclerosis in ApoE-Deficient Mice http://atvb.ahajournals.org/cgi/content/full/19/3/734      Adenovirus-Mediated Expression of Interleukin-12 Induces Natural Killer Cell Activity and Complements ... Application of interleukin 12 to antitumor cytokine and gene therapy. The effect of interleukin 12 desensitization on the antitumor efficacy of recombinant interleukin 12. Antitumor activity of interleukin 12 in preclinical models. http://www.ajrcmb.org/cgi/content/full/20/5/935      Interleukin-12 may induce remission in NHL patients, IL-12 - Lymphoma-net.org news US researchers have called for further investigation into interleukin (IL)-12 - an immune molecule sometimes used as a drug therapy - to treat non-Hodgkin's lymphoma (NHL), after an early-stage study showed that the treatment induces remission in some patients. Interleukin-12 may induce remission in some NHL patients Anas Younes, from The University of Texas MD Anderson Cancer Center in Houston, Texas, and colleagues conducted a study to evaluate the effectiveness and toxicity of artificially produced human IL-12 in patients with relapsed and unresponsive NHL and Hodgkin's disease (HD). http://lymphoma-net.org/newshtml/27908.cfm      Liste des titres (notices ISI) The effect of interleukin 12 desensitization on the antitumor efficacy of recombinant interleukin 12. Immunomodulation by Quillaja saponaria adjuvant formulations: In vivo stimulation of interleukin 12 and its effects on the antibody response. Interferon alpha/beta and interleukin 12 responses to viral infections: Pathways regulating dendritic cell cytokine expression in vivo. http://www.inist.fr/ChercheursIllustres/Resultats/titresISITrinchieriG.html      [No title] The 12 ponse induced by locoregional, low-dose interleukin-2 (IL-2) therapy. Patients receive bolus interleukin-2 on days 1-5 and 8-12. http://www.ugr.es/~oncoterm/csdata/i_ileuki.txt      Interleukin 12 induces crescentic glomerular lesions in a high IgA strain of ddY mice, independently of changes in IgA ... Department of Cardiovascular Medicine, Kyoto University, Graduate School of Medicine, Interleukin 12 induces crescentic glomerular lesions in a high IgA strain of ddY mice, independently of changes in IgA deposition -- Nogaki et al. Interleukin 12 induces crescentic glomerular lesions in a high IgA strain of ddY mice, independently of changes in IgA deposition http://ndt.oupjournals.org/cgi/content/full/15/8/1146      Arch Otolaryngol Head Neck Surg -- Abstract: Combination Nonviral Interleukin 2 and Interleukin 12 Gene Therapy for ... and polymer-formulated murine interleukin 12 (mIL-12) gene therapy Effects of Combined Therapy With Interleukin 2 and Interleukin 12 Gene-Transfected Tumor Vaccine for Head and Neck Carcinoma Combination Nonviral Interleukin 2 and Interleukin 12 Gene Therapy for Head and Neck Squamous Cell Carcinoma http://archotol.ama-assn.org/cgi/content/abstract/127/11/1319      [Frontiers in Bioscience 2, d12-26, January 1, 1997] M.N. Manoussakis, G.K. Papadopoulos, A.A. Drosos and H.M. Moutsopoulos: Soluble interleukin 2 receptor molecules in the serum of patients with autoimmune diseases. Overproduction of IL-6 by fibroblasts cultured from affected skin sites of patients with scleroderma. Better understanding of the pathways regulated by cytokines will allow the identification and/or development of agents for improved modulation of the inflammatory response for the treatment of autoimmune, infectious, and neoplastic diseases. http://www.bioscience.org/1997/v2/d/feghali1/htmls/12-26.htm      Phase I Trial of Concurrent Twice-Weekly Recombinant Human Interleukin-12 Plus Low-Dose IL-2 in Patients With Melanoma ... Gollob JA, Mier JW, Veenstra K, et al: Phase I trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: Ability to maintain IFN-gamma induction is associated with clinical response. Update on the Role of Interleukin 2 and Other Cytokines in the Treatment of Patients with Stage IV Renal Carcinoma Rosenberg SA, Yang JC, Topalian SL, et al: Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2. http://www.jco.org/cgi/content/full/21/13/2564      World J Gastroenterol Continuous release of interleukin 12 from microencapsulated engineered cells for colon cancer therapy Interleukin 12 gene transfer into skin distant from This result also showed that the approach for local and sustained release of interleukin 12 could induces both innate and adaptive antitumor immune responses resulting in significant growth suppression and metastases of tumor[29-31]. http://www.wjgnet.com/1007-9327/9/951.asp      Clinical Trial: Interleukin-12 Gene Therapy in Treating Patients With Skin Metastases PROJECTED ACCRUAL: A total of 12 patients (6 per treatment group) will be accrued for this study. Group A: Patients receive interleukin-12 gene intratumorally over 5 minutes on days 1, 3, and 5. Group B: Patients receive IL-12 gene intratumorally over 5 minutes on days 1, 3, 5, 8, 10, and 12. http://clinicaltrials.gov/show/NCT00028652      Two Main Control Elements are Responsible for the Activation of the Murine Interleukin 12 p40 Promoter: Studies Reveal ... The heterodimeric cytokine Interleukin 12 (IL-12) is critical for T-helper 1 responses. (1994) "Impaired interleukin 12 production in human immunodeficiency virus-infected patients" J. Exp. Med. Two Main Control Elements are Responsible for the Activation of the Murine Interleukin 12 p40 Promoter: Studies Reveal C/EBPb and C/EBPd To Have Trans-Activation Functions http://www.jyi.org/volumes/volume3/issue1/articles/zaki.html      Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate ... Prostate Cancer Gene Therapy: Comparison of Adenovirus-mediated Expression of Interleukin 12 with Interleukin 12 plus B7-1 for in Situ Gene Therapy and Gene-modified, Cell-based Vaccines Phase I Study of the Intratumoral Administration of Recombinant Canarypox Viruses Expressing B7.1 and Interleukin 12 in Patients with Metastatic Melanoma Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression http://www.pnas.org/cgi/content/full/94/20/10889      Synergistic Therapeutic Effects of a Tumor Targeting Antibody Fragment, Fused to Interleukin 12 and to Tumor Necrosis ... Copyright © 2003 by the American Association for Cancer Research. Synergistic Therapeutic Effects of a Tumor Targeting Antibody Fragment, Fused to Interleukin 12 and to Tumor Necrosis Factor Synergistic Therapeutic Effects of a Tumor Targeting Antibody Fragment, Fused to Interleukin 12 and to Tumor Necrosis Factor {alpha} -- Halin et al. http://cancerres.aacrjournals.org/cgi/content/abstract/63/12/3202      Human Cytokine Data Sheets (Interleukin 12) available through Research Diagnostics Inc Not for use in diagnostic or therapeutic procedures. Human Cytokine Data Sheets (Interleukin 12) available through Research Diagnostics Inc http://www.researchd.com/cytokines/rdi212.htm      Normal Human Lung Fibroblasts Differently Modulate Interleukin-10 and Interleukin-12 Production by Monocytes . ... is a potent inhibitor of human interleukin 12 production. Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils. Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers. http://ajrcmb.atsjournals.org/cgi/content/full/25/5/592      Interleukin 12 and autoimmune diabetes - Nature Genetics Overall, these results point to several mediators and effector mechanisms that contribute to T1D (ref. 12), and it is likely that the genetic absence of IL-12 or IFN- Interleukin 12 and autoimmune diabetes - Nature Genetics This finding has potential implications for the prediction of at-risk individuals and, perhaps, for the implementation of prevention strategies relevant to several autoimmune diseases. http://www.nature.com/ng/journal/v27/n2/full/ng0201_131.html      Methods for inducing interleukin-12 and a type1/Th1 T-cell response (US6517839) Heinzel, F.P. et al., "Recombinant Interleukin 12 Cures Mice Infected with Leishmania major," Journal of Experimental Medicine, May 1993, 177:1505-9. Zhang, Ming et al., "Interleukin 12 at the Site of Disease in Tuberculosis," The Journal of Clinical Investigation, Apr. 1994, 93:1733-9. D'Andrea, Annalisa et al., "Production of Natural Killer Cell Stimulatory Factor (Interleukin 12) by Peripheral Blood Mononuclear Cells," The Journal of Expreimental Medicine, Nov. 1992, 176:1387-98. http://www.delphion.com/details?pn=US06517839__      Horst Ibelgaufts'COPE: Cytokines Online Pathfinder Encyclopaedia Anderson R et al Construction and biological characterization of an interleukin 12 fusion protein (flexi 12): delivery to acute myeloid leukemic blasts using adeno associated virus. Bigda J et al Interleukin 12 augments natural killer-cell mediated cytotoxicity in hairy cell leukemia. Journal of Experimental Medicine 178: 413-8 (1993); Kiniwa M et al Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes. http://www.copewithcytokines.de/cope.cgi?005130      IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its ... Interleukin 18 Gene Transfer Expands the Repertoire of Antitumor Th1-type Immunity Elicited by Dendritic Cell-based Vaccines in Association with Enhanced Therapeutic Efficacy In this study, we analyzed the effects of murine IGIF on the activation of Interleukin (IL)-18 Promotes the Development of Chronic Gastrointestinal Helminth Infection by Downregulating IL-13 http://www.jimmunol.org/cgi/content/short/158/4/1541      IL-12 gene transfer alters gut physiology and host immunity in nematode-infected mice -- Khan et al. 281 (1): 102 -- ... Synergism between interleukin 1 beta and 6 on noradrenergic nerves in rat myenteric plexus. McKenzie, GJ, Bancroft A, Grencis RK, and McKenzie ANJ A distinct role for interleukin-13 in Th2 cell mediated immune responses. Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. http://ajpgi.physiology.org/cgi/content/full/281/1/G102      Interleukin 12 p40 Production by Barrier Epithelial Cells during Airway Inflammation -- Walter et al. 193 (3): 339 -- ... (references 4, 5, 7, 9, 10, and 12 and unpublished observations). /ß- and interleukin 12-mediated pathways in promoting T cell interferon Plevy, S.E., Gemberling, H.M., Hsu, S., Dorner, A.J., and Smale, S.T. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. http://www.jem.org/cgi/content/full/193/3/339      National Cancer Institute - Clinical Trials (PDQ®) Biopsy-proven residual disease at least 12 weeks after myeloablative therapy Recurrent disease, evidenced by any of the following: Cohort A: Patients receive interleukin-12 (IL-12) IV over 5-15 seconds on days 1, 3, 5, 8, 10, and 12. http://www.nci.nih.gov/clinicaltrials/NANT-2001-01      Combination Therapy with AG-490 and Interleukin 12 Achieves Greater Antitumor Effects than Either Agent Alone -- ... Combination Therapy with AG-490 and Interleukin 12 Achieves Greater Antitumor Effects than Either Agent Alone Combination Therapy with AG-490 and Interleukin 12 Achieves Greater Antitumor Effects than Either Agent Alone -- Burdelya et al. Articles by Burdelya, L. Articles by Yu, H. Cancer Research http://mct.aacrjournals.org/cgi/content/full/1/11/893      Interleukin-12 (IL-12) Production in Whole Blood Cultures From Human Immunodeficiency Virus-Infected Individuals ... Chehimi J, Paganin C, Frank I, Chouaib S, Starr SE, Trinchieri G: Interleukin-12 in the pathogenesis and therapy of HIV disease. Denis M, Ghadirian E: Dysregulation of interleukin 8, interleukin 10, and interleukin 12 release by alveolar macrophages from HIV type 1-infected subjects. Meyaard L, Hovenkamp E, Otto SA, Miedema F: IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses. http://www.bloodjournal.org/cgi/content/full/89/2/570      IL-12 and IL-18 act in synergy to clear vaccinia virus infection: involvement of innate and adaptive components of the ... in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. Changes in body weight are expressed as the relative body weight at each time-point in reference to the weight observed at day 0. upon combined stimulation with interleukin (IL) 12 and IL-18: A novel pathway of autocrine macrophage activation. http://vir.sgmjournals.org/cgi/content/full/84/8/1961      Negative Regulation of Interleukin-12 Production by a Rapamycin-Sensitive Signaling Pathway: A Brief Communication -- ... The regulation and biological activity of interleukin 12. Inherited interleukin 12 deficiency in a child with Bacille Calmette-Guérin and Salmonella enteritidis disseminated infection. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. http://www.ebmonline.org/cgi/content/full/228/9/1023      BBC NEWS Health Vaccine 'may stop heart disease' Professor Packard said the main problem with vaccines was that they targeted the immune system, which is already thought to be involved in triggering the inflammation process seen in heart disease. It targets a chemical messenger called interleukin 12, thought to play an important part in the inflammation process. Scientists at Leiden University in the Netherlands recently reported a breakthrough in their search for a vaccine. http://news.bbc.co.uk/go/newsFeedXML/moreover/-/1/hi/health/4115223.stm      Reduced production of interleukin 12 by interferon gamma primed alveolar macrophages from atopic asthmatic subjects -- ... Interleukin (IL)-12 is a heterodimeric cytokine critical for driving This study is the first to show reduced IL-12 p70 production by AMs from asthmatic subjects. Lane 1 = molecular weight marker, lanes 2-6 = normal subjects, lanes 7-11 = asthmatic subjects, lane 12 = negative control, lane 13 = no RT control. http://thorax.bmjjournals.com/cgi/content/full/55/10/842      High Plasma Osteopontin Level and Its Relationship with Interleukin-12-mediated Type 1 T Helper Cell Response in ... Correlation between plasma OPN and interleukin (IL)-12 in patients with pulmonary tuberculosis. OPN concentrations correlated significantly with those of interleukin In a recent study, we provided evidences in support of this http://ajrccm.atsjournals.org/cgi/content/full/167/10/1355      Feline Leukemia Virus DNA Vaccine Efficacy Is Enhanced by Coadministration with Interleukin-12 (IL-12) and IL-18 ... ( 12), and their utility in the prophylaxis of retroviral infections, DNA vaccination trials have been conducted in cats. a variety of animal disease models ( 12, 47), relatively few http://jvi.asm.org/cgi/content/full/75/18/8424      Prostaglandin E2 is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive ... Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production. Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection. Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12. http://www.bloodjournal.org/cgi/content/full/97/11/3466      Blockade of endogenous interleukin 12 results in suppression of murine streptococcal cell wall arthritis by enhancement ... The goal of this study was to investigate the role of endogenous interleukin 12 (IL12) in acute murine streptococcal cell Interleukin 12 (IL12), originally described as cytotoxic lymphocyte maturation factor and natural killer cell stimulatory Blockade of endogenous interleukin 12 results in suppression of murine streptococcal cell wall arthritis by enhancement of interleukin 10 and interleukin 1Ra -- Joosten et al. http://www.annrheumdis.com/cgi/content/full/59/3/196      Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12 -- Becher et al. 110 (4): 493 -- ... Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy. Segal, B.M., Dwyer, B.K., and Shevach, E.M. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. Steinman, L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. http://www.jci.org/cgi/content/full/110/4/493      Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury -- Schwacha et al. ... Multiple roles for IL-12 in a model of acute septic peritonitis. Interleukin (IL)-12 is a heterodimeric cytokine produced primarily by antigen-presenting cells such as macrophages, monocytes, Animal models of sepsis and shock: a review and lessons learned. http://ajpcell.physiology.org/cgi/content/full/282/2/C263      CD47 Ligation Selectively Downregulates Human Interleukin 12 Production -- Armant et al. 190 (8): 1175 -- The Journal ... CD47 Ligation Selectively Downregulates Human Interleukin 12 Production CD47 Ligation Selectively Downregulates Human Interleukin 12 Production -- Armant et al. The Journal of Experimental Medicine, Volume 190, Number 8, October 18, 1999 1175-1182 http://www.jem.org/cgi/content/full/190/8/1175      INTERLEUKIN 12 (IL-12) antibodies available through Research Diagnostics Inc Not responsible for any patent infringements with the use or derivation of these products. INTERLEUKIN 12 (IL-12) antibodies available through Research Diagnostics Inc Please inquire for other applications or types of antibodies not listed below. http://www.researchd.com/cytokines/il12ab.htm      Interleukin-12 (IL-12) and IL-18 Are Important in Innate Defense against Genital Herpes Simplex Virus Type 2 Infection ... Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Humoral response to herpes simplex virus is complement dependent. http://jvi.asm.org/cgi/content/full/75/14/6705      Activation of the Murine Interleukin-12 p40 Promoter by Functional Interactions between NFAT and ICSBP -- Zhu et al. ... Interleukin (IL)-12 is a heterodimeric cytokine that is critical cells were cultured for an additional 12 h. Antibodies to NFAT and IRF family members caused supershift or inhibition of complex II, among which NFATc1, NFATc2, NFATc4, IRF-4, and ICSBP ( lanes 6, 7, 9, 10, and 12) are identified as components. http://www.jbc.org/cgi/content/full/278/41/39372

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