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Topic: Integral membrane protein

Ads by Google Related Topics integral membrane protein G protein coupled receptors Protein kinases protein synthesis integral membrane protein subunit proteins C reactive protein protein electrophoresis      annual report 97 The structural basis for the disulfide-mediated dimerization and hexamerization of p58 has been studied by expressing a large set of mutants. It is with great expectations and enthusiam that the staff looks forward to working in this stimulating environment. Progress in Retinal and Eye Research, 16:375-399, 1997 http://www.licr.ki.se/annrep97.html   (7721 words)      The Integral Membrane Protein Snl1p Is Genetically Linked to Yeast Nuclear Pore Complex Function -- Ho et al. 9 (2): ... Nup116-C, Nup100-C, and Nup145-M regions fused to GST are expressed Pom152p and rat Pom121p is separate from the Pom152p homology Snl1p have a stabilizing influence on these particular NPC mutants. http://www.molbiolcell.org/cgi/content/full/9/2/355   (7382 words)      The Localization of the Integral Membrane Protein Cps1p to the Cell Division Site is Dependent on the Actomyosin Ring ... Fluorescence recovery after photobleaching (FRAP) experiments were carried out to study Cps1p dynamics and to find whether Future studies should address if Cps1p is indeed associated sterol-rich Fluorescence recovery after photobleaching experiments have shown that Cps1p does not diffuse freely in the plasma membrane. http://www.molbiolcell.org/cgi/content/full/13/3/989   (6967 words)      Pex3 PEX3 is responsible for CG12 of the peroxisome biogenesis disorders, a group which comprises approximately 1% of all patients in the PBDs (15, 16). Inactivation of the endoplasmic reticulum protein translocation factor, Sec61p, or its homolog, Ssh1p, does not affect peroxisome biogenesis. PEX3 has been identified as an integral membrane protein of the peroxisome in most species in which is has been examined. http://www.peroxisome.org/Scientist/Biogenesis/peroxins/PEX3text.html   (1581 words)      ETH Zurich: Publications Effective rotational correlation times of proteins from NMR relaxation interference. Protein Secondary Structure Determination by NMR - Application with Recombinant Cyclophilin. Membrane protein – lipid interactions in mixed micelles studied by NMR with the use of paramagnetic reagents. http://www.mol.biol.ethz.ch/groups/wider_group/publications   (2471 words)      CHEST: HTI56, An Integral Apical Membrane Protein of the Human Alveolar Type I Cell, Is a Biochemical Marker of Acute ... Although injury to the alveolar epithelial barrier is thought to be of central importance in the pathogenesis of acute lung injury, at the present time (to our knowledge), there are no established biochemical markers for alveolar epithelial injury in human disease. Using this assay, we measured HTI56 in both pulmonary edema fluid and plasma obtained from patients with acute lung injury and from control patients with hydrostatic pulmonary edema. HTI56 in pulmonary edema fluid from 14 patients with acute lung injury (edema fluid protein/plasma protein [is greater than] 0.75) was 4.5X that (p [is less than] 0.0001) of 12 patients with hydrostatic pulmonary edema (clinical history compatible with congestive heart failure, edema fluid protein/plasma protein [is less than] 0.65). http://www.findarticles.com/p/articles/mi_m0984/is_1_116/ai_55332554   (495 words)      Cellular Genomics Awarded U.S. Patent for Integral Membrane Protein-Protein Interaction/Pathway Mapping Technology Terms and conditions, including restrictions on redistribution, apply. "Mapping protein interactions and their biochemical pathways will be critical to understanding mechanisms of disease and, therefore, to identifying optimal targets for drug development. This technology has significance for genomics-based drug discovery as membrane proteins have proven to be a rich source of drug targets that are highly amenable to the development of both small molecule and protein-based therapeutics. http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/06-11-2001/0001511292&EDATE=   (715 words)      An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport Nonetheless, given the dramatic nature of the clustering phenotype, we would still expect to see intensified signal in one location if clustering occurred. The results of a typical experiment are shown in Figure 5B. One of the characteristics that distinguishes integral from peripheral membrane proteins is their relative solubility under different extraction conditions. http://www.nature.com/cgi-taf/DynaPage.taf?file=/emboj/journal/v20/n15/full/7593915a.html   (7655 words)      An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region -- ... Nuclear envelope breakdown in starfish oocytes proceeds by partial NPC disassembly followed by a rapidly spreading fenestration of nuclear membranes This article has been cited by other articles: SDS-PAGE) of rat liver nuclear envelopes that binds to WGA. http://www.jcb.org/cgi/ijlink?linkType=ABST&journalCode=jcb&resid=122/3/513   (1011 words)      Home Page Thus, we have identified components of the retinal biosynthetic pathway. This system is therefore ideal for exploring the structural features of an integral membrane protein that are critical for its biogenesis, as well as the cellular factors that mediate this process. However, other regions of the protein may play an equal or even more important role, and we are currently trying to identify these regions. http://www.bio.ilstu.edu/Krebs   (600 words)      Integral Membrane Protein P16 of Bacteriophage PRD1 Stabilizes the Adsorption Vertex Structure -- Jaatinen et al. 78 ... Analogous capsid stabilization has been observed in adenovirus, A T5 promoter-based transcription-translation system for the analysis of proteins in vitro and in vivo. Crystallization and preliminary X-ray analysis of receptor-binding protein P2 of bacteriophage PRD1. http://jvi.asm.org/cgi/content/full/78/18/9790   (4563 words)      BCH 4053 Biochemistry I The most commonly studied type of secondary active transport systems use Na The porins are often found associated as trimeric arrangements of 16-stranded These helices are believed to be able to insert into membranes and form a complex assemly that positions the hydrophobic face of the helices towards the apolar lipid environment, and the hydrophilic region towards the center. http://wine1.sb.fsu.edu/BCH4053/Lecture17/Lecture17.htm   (1623 words)      Protein - Open Encyclopedia Proteins can be picky about the environment in which they are found. Proteins can often figure in allergies and allergic reactions to certain foods. The process by which the higher structures form is called protein folding and is a consequence of the primary structure. http://open-encyclopedia.com/Protein   (1833 words)      W0008: Integral Membrane Protein Studied With Static Light Scattering We are using static light scattering to characterize the phase behavior of solutions containing pure detergent and detergent-protein complexes, with the goal of extending the observation that crystals of membrane protein-detergent complexes form near the detergent cloud point. We are using solutions of both protein-detergent complexes and pure detergents in order to assess the relative contributions of the detergent and protein moieties to the overall behavior of the complexes. Integral Membrane Protein Studied With Static Light Scattering. http://www.hwi.buffalo.edu/ACA/ACA99/abstracts/text/W0008.html   (162 words)      Membrane Protein Folding Several proteins, some of which with therapeutic interest are targeted in these studies. Our laboratory is developing new techniques to determine the structures of integral membrane proteins. These methods may now be applied to G-protein-coupled receptors or other integral membrane proteins that have been indentified as potential drug targets. http://www.faculty.virginia.edu/tamm/pages/project_folding.html   (405 words)      NMR structural studies of the integral membrane protein Vpu from HIV-1. NMR structural studies of the integral membrane protein Vpu from HIV-1. coli, were studied in the model membrane environments of dihexanoyl phophatidylcholine (DHPC) micelles and phospholipid bilayers by multidimensional solution and solid-state NMR spectroscopy, respectively. Methodology developments toward structure determination of membrane proteins are also discussed. http://repository.upenn.edu/dissertations/AAI9976449   (232 words)      Lipid-protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR ... Protein Sci., May 1, 2003; 12(5): 1087 - 1096. This article has been cited by other articles in HighWire Press-hosted journals: Lipid-protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy -- Fernández et al. http://www.pnas.org/cgi/content/abstract/99/21/13533   (330 words)      NodeWorks - Encyclopedia: Integral membrane protein Although the structures of thousands of proteins have become known by X-ray diffraction and Nuclear magnetic resonance, the structures of only a few dozens of integral membrane proteins are known at atomic resolution, because they tend to denature on removal from the membrane, under which condition they are impossible to analyze. This is the most common type of IMP. There are many types of IMPs with wildly different structures. http://pedia.nodeworks.com/I/IN/INT/Integral_membrane_protein   (421 words)      Size Comparisons among Integral Membrane Transport Protein Homologues in Bacteria, Archaea, and Eucarya -- Chung et al. ... Over 20 families of these systems have been identified (10). and secondarily on the individual proteins within that family. Phosphate permeases of Saccharomyces cerevisiae: structure, function and regulation. http://jb.asm.org/cgi/content/full/183/3/1012   (3337 words)      Integral membrane protein biosynthesis: why topology is hard to predict -- Ott and Lingappa 115 (10): 2003 -- Journal ... of synaptobrevin was not affected by membrane depletion of the ); however, some proteins use more complex processes. to the translocon, an aqueous pore in the ER membrane responsible http://jcs.biologists.org/cgi/content/full/115/10/2003   (4650 words)      Structural details of an interaction between cardiolipin and an integral membrane protein -- McAuley et al. 96 (26): ... the proteins involved may be agonists that interact with membrane-bound Although the reaction center is structurally well characterized, being one of the most heavily studied integral membrane proteins, Stereo views of the model of cardiolipin at the surface of the AM260W reaction center. http://www.pnas.org/cgi/content/full/96/26/14706   (4905 words)      .: Department of Biology: Max Summers Our studies also demonstrate that sorting of a viral envelope protein to the INM is mediated by a specific INM-sorting motif (INM-SM). Our studies now provide evidence that the co-translational integration and sorting of viral envelope proteins is a protein-facilitated and protein-regulated multistep process which may also be utilized during sorting of cellular INM directed proteins. This is important because mutations in a number of inner nuclear membrane proteins correlate with several human diseases including muscular and lipid dystrophies. http://www.bio.tamu.edu/FACMENU/faculty/summers.htm   (1031 words)      7TM receptor Detailed structural information is based on analogy to bacteriorhodopsin, a 7TM receptor whose structure has been determined by both electron and X ray-based crystallography. The name derives from the proteins' structure or membrane topology, which exhibits seven membrane-spanning elements or transmembrane helices. G protein-coupled receptor), such as the receptors of the olfactory epithelium that bind odorants and the receptors of the neurotransmitter serotonin in the mammalian brain. http://encycl.opentopia.com/term/7TM_receptor   (134 words)      Biological Membranes Hormone receptors signal physiological conditions to the cell interior. Used to make bile acids: a biological 'detergent' used to solubilize fats in the small intestine. Destroys the phase transition of pure lipid membranes, thereby keeping the membranes fluid. http://www.nitorig.net/lec25.html   (288 words)      Efficient biosynthetic incorporation of tryptophan and indole analogs in an integral membrane protein -- Broos et al. ... into a protein can facilitate its structural analysis by spectroscopic of the protein environment on the Trp analog spectrum. Articles by Broos, J. Articles by Strambini, G. Protein Science (2003), 12:1991-2000. http://www.proteinscience.org/cgi/content/abstract/12/9/1991   (359 words)      An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport -- Kops and Guthrie 20 ... Three proteins required for early steps in the protein secretory pathway also affect nuclear envelope structure and cell cycle progression in fission yeast This article has been cited by other articles: Brr6p is located adjacent to the nuclear pore and interacts http://embojournal.npgjournals.com/cgi/content/abstract/20/15/4183   (284 words)      Access of Antibody or Trypsin to an Integral Outer Membrane Protein (P66) of Borrelia burgdorferi Is Hindered by Osp ... Protease treatment of intact spirochetes cleaved P66 and Osp proteins Liang, F. T., Philipp, M. Analysis of Antibody Response to Invariable Regions of VlsE, the Variable Surface Antigen of Borrelia burgdorferi. Rathinavelu, S., de Silva, A. Purification and Characterization of Borrelia burgdorferi from Feeding Nymphal Ticks (Ixodes scapularis). http://iai.asm.org/cgi/content/abstract/67/6/2874   (1020 words)      Articles - Membrane protein Membrane proteins can be classified into two groups, based on their attachment to the membrane. Peripheral proteins easily dissociate following treatment with a polar reagent, such as a solution with an elevated pH or high salt concentrations. Integral membrane proteins are firmly attached to the membrane. http://www.gaple.com/articles/Membrane_protein   (278 words)      [No title] Protein Structures (Require CHIME browser plug-in; see below): This crystal structure was determined from an antibody complex: Where is the antibody? CHIME Plug-In to your Browser (allows on-line viewing of 3D protein structures) http://bio.classes.ucsc.edu/bmb100c   (323 words)      MeSH-D terms associated to GO integral plasma membrane protein (component) The number indicates the strength of the association of the corresponding term to integral plasma membrane protein (component). MeSH-D terms associated to GO integral plasma membrane protein (component) http://www.bork.embl-heidelberg.de/g2d/go2d.pl?0005887:resolved   (63 words)      Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link. For a journal article, please see the Resource Relation field. A biophysical study of integral membrane protein folding http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=800572   (123 words)      Signals and structural features involved in integral membrane protein targeting to the inner nuclear membrane -- ... Deletion mutant of FGFR4 induces onion-like membrane structures in the nucleus Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle normally located in the inner nuclear membrane, however, does not inhibit http://www.jcb.org/cgi/content/abstract/130/1/15   (1442 words)      The integral membrane protein p16.7 organizes in vivo{phi}29 DNA replication through interaction with both the terminal ... Moreover, we provide evidence that the ability of p16.7 to form The integral membrane protein p16.7 organizes in vivo{phi}29 DNA replication through interaction with both the terminal protein and ssDNA -- Serna-Rico et al. The integral membrane protein p16.7 organizes in vivo http://embojournal.npgjournals.com/cgi/content/abstract/22/9/2297   (308 words)      [No title] SCI7.05c, possible integral membrane transport protein, len: 298aa; similar to many eg. TR:O51924 (EMBL:AF012836) inner membrane protein, MalF from the trehalose/maltose transport system of the hyperthermophilic archaeon Thermococcus litoralis (300 aa) fasta scores; opt: 681, z-score: 814.3, E(): 0, (37.5% identity in 285 aa overlap). Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component and Prosite match to PS00402 Binding-protein-dependent transport systems inner membrane comp sign. http://www.sanger.ac.uk/Projects/S_coelicolor/SCO_html/SCO1887.html   (70 words)      VMA21 - Vacuolar ATPase assembly integral membrane protein VMA21 Our findings suggest that Vma21 p is required for assembly of the integral membrane sector of the V-ATPase in the endoplasmic reticulum and that the unassembled 100-kDa integral membrane subunit present in delta vma21 cells is rapidly degraded by nonvacuolar proteases. Vma21 p is a yeast membrane protein retained in the endoplasmic reticulum by a di-lysine motif and is required for the assembly of the vacuolar H(+)-ATPase complex. VMA21 - Vacuolar ATPase assembly integral membrane protein VMA21 http://www.pdg.cnb.uam.es/UniPub/iHOP/gi/33303.html   (106 words)      Lipids, Membranes & Vesicle Trafficking - Virtual Library of Biochemistry & Cell Biology Kinesin Function: Vesicle Transport and Organelle Movement - Information on the role of kinesin in vesicle transport (from the Kinesin Home Page). See also the Discussion Groups section of the General Biochemistry and Cell Biology page. CYTONET/bionet.cellbiol.cytonet - Usenet newsgroup for investigators researching the cytoskeleton, plasma membrane, and plant and fungal cell walls. http://www.biochemweb.org/lipids_membranes.shtml   (362 words)      At2g01770 - integral membrane family protein These synonyms are used for gene At2g01770 (integral membrane family protein): T8O11.6. At2g01770 is a homologue of CCC1 (CCC1 protein) from Saccharomyces cerevisiae. http://www.pdg.cnb.uam.es/UniPub/iHOP/gg/140.html   (33 words)      At2g26350 - zinc-binding peroxisomal integral membrane protein (PEX10) At2g26350 - zinc-binding peroxisomal integral membrane protein (PEX10) These synonyms are used for gene At2g26350 (zinc-binding peroxisomal integral membrane protein (PEX10)): T9J22.2, T9J22.2 T1D16.1. At2g26350 is a homologue of PEX10 (Peroxisome assembly protein 10) from Homo sapiens. http://www.ihop-net.org/UniPub/iHOP/gg/2556.html   (82 words)

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