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Topic: Insulinoma



  
 Insulinoma - Wikipedia, the free encyclopedia
Most patients with benign insulinomas can be cured with surgery.
The definitive management is surgical removal of the insulinoma.
During surgery to remove an insulinoma, an intra-operative ultrasound can sometimes localize the tumour, which helps guide the surgeon in the operation.
http://en.wikipedia.org/wiki/Insulinoma   (725 words)

  
 Ferret Insulinoma FAQ
The proper management of insulinoma without surgery, treating with medication, should keep the ferret relatively free of attacks.
But with unmanaged insulinoma, you may lose the ferret without the surgery.
However, keep in mind that if the tumor is not solitary but spread throughout the pancreas, it may not buy you much time.
http://www.ferretcentral.org/faq/med/insulin.html   (1725 words)

  
 Insulinoma In Ferrets
But because the medical management of insulinoma fails after a period of time, surgery early in the disease is the better option.
About half of the cases of insulinoma can be permanently cured with surgery.
The first line drug of choice is prednisone or prednisolone.
http://www.2ndchance.info/insulinoma.htm   (827 words)

  
 Insulinoma from Medicine, Ob/Gyn, Psychiatry, and Surgery / Oncology
Surgical Care: Because insulinoma resection achieves cure in 90% of patients, it is currently the therapy of choice.
Medical Care: Medical therapy is indicated in patients with malignant insulinomas and in those who will not or cannot undergo surgery.
Simple enucleation is the procedure of choice in insulinomas in the pancreatic head.
http://users3.ev1.net/~drtony/insulnma.htm   (3756 words)

  
 Insulinoma - PetPlace.com
Insulinomas can occur in any breed of dog with mixed breed dogs most commonly affected.
The cause of insulinomas is unknown, and consequently there is no way to prevent development.
Chemotherapy, although it is not very effective for insulinoma
http://www.petplace.com/articles/artShow.asp?artID=27   (623 words)

  
 Insulinoma
Part of the treatment problem with insulinoma, in our experience, is it's randomness in progressing.
There are several drugs used to treat insulinoma.
Recent information from the veterinary community suggests that surgery is now the preferred course of treatment for insulinoma.
http://www.ferret-fact.org/Insulino.htm   (2301 words)

  
 New Hope Animal Hospital - ferret Information
These factors may in some way play a part in the development and expression of insulinoma in the ferret, but as of this writing no research has been conducted to study the significance of these observations.
Owners may observe no symptoms in the very early stages of insulinoma because, at first, the ferret's body tries to control the hypoglycemic periods with counter-regulatory measures of its own.
On the other hand, a geriatric ferret with no other health problems might benefit from insulinoma surgery.
http://www.nhahonline.com/ferretdiseases.htm   (6092 words)

  
 Insulinoma Ferret - Big Ferret Guide
Its important to keep a close eye on a ferret with insulinoma for any changes in behavior that may indicate a need for a dose adjustment (for example, if the...
But with unmanaged insulinoma, you may lose the ferret without the surgery.
VetCentric: What is an Insulinoma in a Ferret?
http://www.bigferretguide.com/insulinoma-ferret.html   (672 words)

  
 Insulinoma Elixer
While we all know that surgery is still the best method to treat insulinoma, there are many, many animals for whom surgery is not an option and require prednisone to control their hypoglycemia.
This mixture is especially helpful in cases where adrenal problems are present and corrective surgery is not an option or has already been done and further surgeries are not desired.
As we have already discussed today, ferrets are a relatively steroid resistant species, which is of benefit in light of the vast numbers of animals on it chronically for IBD, EE, insulinoma, and a number of other conditions.
http://www.miamiferret.org/fhc/elixer.htm   (887 words)

  
 Saddig C, et al. A New Classification Plot for the C-Peptide Suppression Test. JOP. J Pancreas (Online) 2002; ...
This meant that it was less likely to develop a cross-over or even a prospective study design with a sufficient number of patients within an acceptable period of time.
The clinical characteristics of all patients concerning age, gender and body mass index are summarized in Table 1.
Key words C-Peptide (diagnostic use); Hypoglycemia; Insulinoma; Laboratory Techniques and Procedures
http://www.joplink.net/prev/200201/03.html   (3982 words)

  
 Antitumorigenic and Antiinsulinogenic Effects of Calcitriol on Insulinoma Cells and Solid {beta}-Cell Tumors -- ...
Effective chemotherapy of patients who are not cured by surgery
Schott M, Scherbaum WA, Feldkamp J 2000 Drug therapy of endocrine neoplasms.
primary cultures of a human benign insulinoma and isolated human
http://endo.endojournals.org/cgi/content/full/143/10/4018   (7085 words)

  
 Critters Library: Common Ferret Diseases
Above all else, you must be aware that it is unlikely surgery will cure an insulinoma.
Our observations are that ferrets that undergo surgery live longer than ferrets treated only with medication.
Your vet will tell you how to determine when you need to increase the dose of medication and when you need to bring the ferret to the hospital.
http://www.animalnetwork.com/critters/library/diseases/dis_ins.asp   (663 words)

  
 Insulinomas in Dogs
I have no personal experience to draw from and can not help with deciding who is right (the vets who think it works or the ones who think it doesn't).
removed insulinomas in our practice and the surgery itself is not all that
Surgery increases the lifespan of affected dogs because it helps to reduce
http://www.vetinfo.com/dinsulomas.html   (1056 words)

  
 VHJOE - Insulinoma Unmasked by Bariatric Surgery
This is the first case report that we are aware of in which an insulinoma was unmasked by gastric bypass surgery.
Although some subjects with insulinoma have normal body habitus (3), hyperphagia can result from the patient’s attempts to alleviate symptomatic hypoglycemia.
This suggests to us that the insulinoma had been effectively palliated by the patient through overeating, and only when her caloric intake was curtailed, did she suffer the effects from her tumor.
http://www.vhjoe.com/Volume1Issue4/1-4-4.htm   (987 words)

  
 Ferret cancer
Most ferrets respond well to the surgery, and although insulinoma is not likely to be cured by surgery, the ferret's life (and well-being) may be extended almost to the outer range of its normal life span by a successful surgery.
Non-Surgical Approaches to Treating a Ferret with Insulinoma
One problem with surgery as an option for treating insulinoma is that by the time of diagnosis, the insulinoma has probably spread.
http://nv.essortment.com/ferretscancer_rrij.htm   (1401 words)

  
 Ferret Universe-Ferret Insulinoma
Unfortunately, there is no absolute cure for this disease, however with carefully supervised treatments consisting of surgery, diet control and medicines, a ferrets life span can be increased by 3 years or more.
Please contact the webmaster with any comments or concerns.
sensitive to sugar, that giving sugar may even cause insulinoma's (perhaps for genetic reasons, some are more sensitive than others).
http://www.ferretuniverse.com/health/insulinoma.asp   (1179 words)

  
 Insulinoma Clinical Trials Listings and Information at ClinicalTrialsSearch.org
A clinical trial or clinical study is a research project with human volunteer subjects.
Clinical Trials Search.org is a site devoted to listing clinical research studies in human subjects.
Insulinoma Clinical Trials and other clinical trials allow volunteers to have medical treatment options before they are available to the masses.
http://www.clinicaltrialssearch.org/insulinoma_clinical_trials.html   (284 words)

  
 Ultrarapid delayed rectifier current inactivation in human atrial myocytes: properties and consequences -- Feng et al. ...
Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel.
Length of excitation wave and susceptibility to reentrant atrial arrhythmias in normal conscious dogs.
http://ajpheart.physiology.org/cgi/content/full/275/5/H1717   (5015 words)

  
 Care and Feeding of Ferrets
As with any major disease problem in the ferret, insulinoma is a problem that should be addressed by a veterinarian familiar with ferrets, their diseases and with significant experience performing surgery on ferrets.
Insulinoma is treated with a combination of medical and surgical therapy and, in some cases dietary changes.
As many as 25% of all ferrets may develop this form of cancer.
http://drexotic.com/care_ferrets_insulinoma.htm   (1503 words)

  
 Diabetes: Glucose and insulin treatment of insulinoma cel... @ HighBeam Research
The results of our experiments in insulinoma cells can now be used to measure responses to primary islets in culture, both rodent and human.
Isolation of pure [beta]-cells from isolated islets raises additional concerns regarding the conditions of preparation, so every method has its limitations.
Despite those omissions, our current studies are confirming and extending the previous findings, such as Egr1, and highlighting the use of microarray to assess similarities of treatments (e.g., glucose and insulin) and to identify signaling pathways activated by those treatments.
http://www.highbeam.com/library/doc0.asp?DOCID=1G1:117865249&refid=holomed_1   (6891 words)

  
 Insulinoma
When frequent feedings and supplements no longer control the clinical signs of insulinoma, drug therapy must start.
Either surgery, medications, or both will extend the life of your ferret about 2 years.
Insulinoma is a progressive disease requiring constant monitoring and care, as well as adjustments in medications.
http://www.texasferret.org/news/199708.shtml   (1864 words)

  
 Ferret News #50 - Insulinoma in Ferrets
Most vets consider the best first course of treatment of insulinoma to be surgery.
See below for information on this common and *treatable* condition.
Another medication that is used in treating insulinoma is Proglycem (diazoxide).
http://www.ferretnews.com/issues/ferret-news-50.html   (1205 words)

  
 Glucose Transporter Proteins in Human Insulinoma -- Boden et al. 121 (2): 109 -- Annals of Internal Medicine
present in human insulinoma is unknown and was, therefore, the
which are derived from a radiation-induced rat insulinoma, expressed
We studied five patients with the clinical insulinoma syndrome.
http://www.annals.org/cgi/content/full/121/2/109   (2433 words)

  
 Functional Changes in Potassium Conductances of the Human Neuroblastoma Cell Line SH-SY5Y During In Vitro ...
expression in Xenopus oocytes of a human insulinoma and islet
http://jn.physiology.org/cgi/content/full/79/2/648   (3980 words)

  
 Forty-Eight-Hour Fast: The Diagnostic Test for Insulinoma -- Hirshberg et al. 85 (9): 3222 -- Journal of Clinical ...
Our data are in good agreement with studies of insulinoma patients
responsiveness in insulinoma patients that is reversible (12).
1999 Neuroglycopenic and other symptoms in patients with insulinomas.
http://jcem.endojournals.org/cgi/content/full/85/9/3222   (2872 words)

  
 VetMedCenter - Consumer - Article Details
Surgical removal of the tumor is an option and helps animals with insulinoma have a longer lifespan than if they do not have surgery.
The most important aspect of treatment for insulinoma is diet.
Signs may or may not be related to eating, excitement, or exercise.
http://consumer.vetmedcenter.com/Consumer/display.asp?id=26126&dt=p   (528 words)

  
 Insulinomas
They also help rule out metastatic disease to the lung or other organs before surgery is preformed.
There are no gender or breed predilections in dogs and cats but ferrets are usually male.
Insulinomas are malignant tumors with most have metastases either microscopically or grossly by the time clinical signs are present.
http://www.gcvs.com/imaging/ultrasound/insulinoma.htm   (508 words)

  
 Identification and functional importance of IL-1 receptors on rat parietal cells -- Schepp et al. 275 (5): 1094 -- AJP ...
of cultured rat pancreatic islets (10, 34, 47), insulinoma
Effects of cytokines on rat insulinoma INS-1 cells.
http://ajpgi.physiology.org/cgi/content/full/275/5/G1094   (5949 words)

  
 Insulinoma
The average survival time in dogs is 16-19 months but this can be increased if surgery is successful in removing obvious cancers.
In the early stages when symptoms are mild, an insulinoma’s effects can be controlled medically.
Insulinomas, like many cancers, have no known cause.
http://www.kvh.com.au/Insulinoma.html   (499 words)

  
 INSULINOMA (HYPOGLYCEMIA)
Another medication which can be useful is diazoxide (Proglycem), although it is expensive and response varies.
Treatment recommendations for insulinomas may vary, but I believe insulinomas initially are best treated by surgical exploration and removal if possible.
With carefully supervised treatment consisting of surgery, diet control, and medications an affected ferret's lifespan can be increased by up to three years.
http://www.ferretnews.org/insulinoma.html   (590 words)

  
 Possible functional regression of insulinoma with prolonged octreotide -- Craig and Gallen 78 (924): 623 -- ...
Metabolic remission with octreotide in patients with insulinoma.
On the use of a new somatostatin analogue in the treatment of hypoglycaemia in patients with insulinoma.
Possible functional regression of insulinoma with prolonged octreotide -- Craig and Gallen 78 (924): 623 -- Postgraduate Medical Journal
http://pmj.bmjjournals.com/cgi/content/full/78/924/623   (959 words)

  
 Forum Message: 'A: insulinoma'
Good Luck and please keep me informed on how the little one does...
From what you are saying it doesn't sound like insulinoma.
Pawing at the mouth can be a lot of different things, such as not liking the medications.
http://www.practical-pet-care.com/ferret_question.php?ID=2.462384533   (542 words)

  
 Role of tyrosine phosphorylation in leptin activation of ATP-sensitive K+ channels in the rat insulinoma cell line ...
) channels was examined in the rat CRI-G1 insulinoma cell line.
Alternatively, the basal phosphorylation state of target proteins (or channels) and the number or type (tyrosine) of possible phosphorylation sites may be important.
Under current clamp conditions, application of the broad-spectrum protein kinase inhibitor H-7 (10 µM) had no effect on the resting membrane potential or slope conductance of CRI-G1 insulinoma cells and did not occlude the actions of leptin.
http://jp.physoc.org/cgi/content/full/510/1/47   (7374 words)

  
 Differential translocation of protein kinase C isozymes by phorbol esters, EGF, and ANG II in rat liver WB cells -- ...
Similar results were obtained in 3 separate experiments.
As previously observed in mouse neuroblastoma × rat glioma (NG 108-15) cells (3) and insulinoma
Identification and subcellular characterization of protein kinase-C isoforms in insulinoma
http://ajpcell.physiology.org/cgi/content/full/274/4/C974   (4824 words)

  
 MedlinePlus Medical Encyclopedia: Insulinoma
Calling your health care provider Return to top
Call your health care provider if symptoms of insulinoma develop.
The person's blood may be tested while fasting (not eating).
http://www.nlm.nih.gov/medlineplus/ency/article/000387.htm   (550 words)

  
 Insulinoma. Halder PJ, Hafeezunnisa P, Pai R, Samsi AB J Postgrad Med
The clinical presentation of insulinomas being bizarre, misdiagnoses such as seizure disorder, transient ischaemic attach, brain tumours, hysteria, depression, schizophrenia, etc[1],[2],[3],[4] may be made.
In patients with insulinoma this ratio is greater than 1.0[5].
A case of insulinoma who had episoic bizarre behaviour is presented here.
http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1992;volume=38;issue=4;spage=202;epage=4,198;aulast=Halder   (1196 words)

  
 Misdiagnosis of Insulinoma - CureResearch.com
About misdiagnosis: When checking for a misdiagnosis of Insulinoma or confirming a diagnosis of Insulinoma, it is useful to consider what other medical conditions might be possible misdiagnoses or other alternative conditions relevant to diagnosis.
These alternate diagnoses of Insulinoma may already have been considered by your doctor or may need to be considered as possible alternative diagnoses or candidates for misdiagnosis of Insulinoma.
Use of this site is subject to our TERMS OF USE.
http://www.cureresearch.com/i/insulinoma/misdiag.htm   (323 words)

  
 Insulinoma
An insulinoma may cause the body to make extrainsulin, leading to hypoglycemia.
http://www.health-database.com/diabetes/insulinoma-.htm   (21 words)

  
 Symptoms of Insulinoma - WrongDiagnosis.com
Furthermore, symptoms of Insulinoma may vary on an individual basis for each patient.
This symptom information has been gathered from various sources, may not be fully accurate, and may not be the full list of symptoms of Insulinoma.
General information about symptoms of Insulinoma: The symptom information on this page attempts to provide a list of some possible symptoms of Insulinoma.
http://www.wrongdiagnosis.com/i/insulinoma/symptoms.htm   (195 words)

  
 * Insulinoma - (Disease): Definition
Calcitonin may also be elevated in other tumors such as insulinomas, VIPomas, and lung cancer...
The health care provider may suggest a calcitonin test when he/she suspects medullary thyroid cancer.
Hypoglycemia may be caused by tumors in the pancreas called insulinomas.
http://www.bestknows.com/disease/insulinoma.html   (208 words)

  
 Insulinoma in Chronic Renal Failure: A Case Report -- Basu et al. 87 (11): 4889 -- Journal of Clinical Endocrinology & ...
case seems to be the second report of a patient with insulinoma
operation for insulinoma contained no patients with concomitant
attributable to insulinoma may occur in persons with renal failure.
http://jcem.endojournals.org/cgi/content/full/87/11/4889   (1782 words)

  
 NFWS - What you should know about ferret insulinoma
Because insulinoma usually affects ferrets in middle age, it is often not noticed by the ferret's owner as soon as it could be, since he or she attributes symptoms such as lethargy to part of the natural ageing process just like I did.
She was very understanding and to my surprise said that she had come across two cases of ferrets with insulinoma in her last practice.
The accuracy of the blood test can be affected by various factors such as the stress of undergoing an anaesthetic or the fact that he had had "nil by mouth" before the anaesthetic.
http://homepage.ntlworld.com/ferreter/insulinoma.htm   (1725 words)

  
 Leptin Rapidly Suppresses Insulin Release from Insulinoma Cells, Rat and Human Islets and, In Vivo, in Mice -- Kulkarni ...
treated clonal insulinoma cells with leptin, and a dose-dependent
The effect of leptin on mouse and rat insulinoma cells was investigated.
Therefore, in this study, we investigated the effect of recombinant
http://www.jci.org/cgi/content/full/100/11/2729   (5679 words)

  
 Free Insulin Test: Insulinoma Diabetes Insulin Testing for Hypoglycemia Free Insulin Test.
In a number of conditions, notably insulinoma and diabetes, this relationship is impaired.
Insulin tends to circulate at inappropriately high levels in patients with insulin-secreting pancreatic tumors; such tumors can thus be a cause of hypoglycemia.
Accordingly, insulin immunoassays - used sometimes in connection with provocative doses of tolbutamide or calcium - play an essential role in the identification (and localization) of insulinomas.
http://www.liposcience.com/control.cfm?id=18   (374 words)

  
 Diabetes: A Case of Insulinoma Diagnosed by Arterial Stim... @ HighBeam Research
An ASVS technique can be safe and useful for diagnosis of insulinoma when a series of conventional challenge test reveal no clear diagnosis and localizing sources of hyperinsulinism not detected with preoperative morphologic studies.
A Case of Insulinoma Diagnosed by Arterial Stimulation Venous Sampling: Value of the Calcium Intraarterial Stimulation Test When Findings of Other Preoperative Studies Are Negative.(Abstract)
A solitary insulinoma (diameter, 10 mm) was diagnosed at the tail of pancreas after surgery.
http://www.highbeam.com/library/doc0.asp?DOCID=1G1:62893019&refid=holomed_1   (373 words)

  
 A Novel Six-nucleotide Insertion in Exon 4 of the MEN1 Gene, 878insCTGCAG, in Three Patients with Familial Insulinoma ...
A Novel Six-nucleotide Insertion in Exon 4 of the MEN1 Gene, 878insCTGCAG, in Three Patients with Familial Insulinoma and Primary Hyperparathyroidism -- Okamoto et al.
http://jjco.oxfordjournals.org/cgi/reprint/32/9/368   (34 words)

  
 Forum Message: 'A: insulinoma'
If he does have an insulinoma, you can discuss medications and dosages with your vet, and explain how happy he seems on a lower dose.
They will be able to do some blood work and possibly x-rays.
It sounds like he should be seen by a vet to determine if he really has an insulinoma.
http://www.practical-pet-care.com/ferret_question.php?ID=2.592630864   (491 words)

  
 Insulinoma
Whipple's triad is the basis for the clinical diagnosis of insulinomas.
They are usually very small with 70% measuring less than 1.5 cm.
Pancreatic beta cells secrete both insulin and C-peptide
http://www.5mcc.com/Assets/SUMMARY/TP0485.html   (267 words)

  
 Regulation of {beta} cell glucokinase by S-nitrosylation and association with nitric oxide synthase -- Rizzo and Piston ...
Glucokinase is concentrated in insulin-secretory granules of pancreatic B-cells.
Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase.
http://www.jcb.org/cgi/content/full/161/2/243   (3852 words)

  
 Islet Cell Autoantigen of 69 kDa Is an Arfaptin-related Protein Associated with the Golgi Complex of Insulinoma INS-1 ...
MIN6 insulinoma cells were cultured and processed as described
Confocal microscopy for ICA69 (pseudored), markers of the Golgi complex and SGs in rat insulinoma INS-1 cells (pseudogreen).
Islet Cell Autoantigen of 69 kDa Is an Arfaptin-related Protein Associated with the Golgi Complex of Insulinoma INS-1 Cells -- Spitzenberger et al.
http://www.jbc.org/cgi/content/full/278/28/26166   (4722 words)

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