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| | Inotrope - Wikipedia, the free encyclopedia |
 | | The term is often used in reference to the way various drugs affect the strength of contraction of heart muscle (myocardial contractility). | | | The drug of choice in any given clinical scenario is often contoversial and in practice, many situations will benefit from any inotrope and the argument is moot. | | | Remains controversial though.), dobutamine (cardiac support), adrenaline (inotropic and vasoconstriction) and enoximone (post cardiac surgery where tachycardia undesirable). |
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http://en.wikipedia.org/wiki/Inotrope
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| | (S-37) INTERACTION OF PROTAMINE WITH ISOFLURANE IN RAT MYOCARDIUM |
| | The goal of this experimental study was to assess the inotropic and lusitropic responses to the association of protamine and isoflurane in rat myocardium. | | | M on the inotropic response to both protamine and isoflurane was also investigated. | | | of 0.5 mmol/l, the positive inotropic effect of protamine was probably related to an interaction with calcium channels. |
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http://www.iars.org/abstracts/abstracts/S25/s37.htm
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| | Optimizing Treatment of Patients with Advanced Heart Failure: Currents: UI Health Care |
| | Before the initiation of inotropic therapy, patients undergo invasive hemodynamic monitoring. | | | Optimizing conventional therapy, patient education, and frequent follow-up by a multidisciplinary CHF management team are other ways to avoid inotropic therapy. | | | Even though short-term intermittent infusion in unstable patients may not always be such a case, the uncertainties surrounding this approach make the selection of appropriate candidates for this therapy critical. |
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http://uihealthcare.com/news/currents/vol1issue3/congestiveheartfailure.html
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| | CHFpatients.com - IV Heart Failure Drugs |
| | The doctors use outpatient IV inotropic therapy with caution in carefully selected patients; mostly patients who have extremely low blood pressure. | | | Inotropes are drugs that make your heart beat more strongly. | | | Side effects were roughly the same from each drug but headaches happened more often with levosimendan, while chest pain and irregular heart rhythm happened more often with dobutamine. |
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http://www.chfpatients.com/inotropes.htm
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| | British Journal of Pharmacology - Ca2+-sensitizing effect is involved in the positive inotropic effect of troglitazone |
| | The positive inotropic effect of troglitazone is not mediated via the cyclic AMP-PKA pathway or the PLC-PKC pathway. | | | Although troglitazone cannot be used clinically at present, clarification of the mechanism of its unique beneficial effects on the cardiovascular system might lead to the development of new inotropic agents and a novel pharmacological approach to treat heart failure. | | | The reasons for the discrepancy between our results and those of previous reports are not clear, however, one explanation may be the different species used in these studies. |
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http://www.nature.com/bjp/journal/v133/n8/full/0704212a.html
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| | Inotropic Support of the Failing Heart |
| | In practice, none of the newer inotropes has been shown to be more effective than epinephrine and, if we are to practice evidence based medicine, this is the drug of choice until proved otherwise. | | | I will consider these drugs individually and discuss the comparisons that have been published with personal views on their use as inotropes for the failing heart. | | | Alpha-adrenergic agonists: There is no evidence that this group of drugs has any inotropic activity but they may be useful to increase the SVR. |
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http://www.euroanesthesia.org/education/rc_vienna/04rc2.HTM
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| | [No title] |
| | The performance of the multiple-drug closed-loop system was evaluated intraoperatively in cardiac surgical patients who required simultaneous treatment with more than one vasoactive or inotropic drug. | | | Patients: The performance of the multiple-drug closed-loop system was evaluated during cardiac surgery in 30 patients who required treatment with more than one vasoactive or inotropic drug. | | | Automated infusion of vasoactive and inotropic drugs to control arterial and pulmonary pressures during cardiac surgery |
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http://www.sopami.hpg.ig.com.br/artigo14.htm
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| | A New Milrinone Analog: Role of Binding to A1 Adenosine Receptor in its Positive Inotropic Effect on Isolated Guinea ... |
| | Endoh, M.: Correlation of cyclic AMP and cyclic GMP levels with changes in contractile force of dog ventricular myocardium during cholinergic antagonism of positive actions of histamine, glucagon, theophillin and papaverine. | | | Miller, R. Palomo, A. Brandon, T. Hartley, C. and Quinones, M. Combined vasodilator and inotropic therapy of heart failure: Experimental and clinical concepts. | | | Because antagonism toward endogenous adenosine has been suggested as one of the mechanisms responsible for the positive inotropic |
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http://jpet.aspetjournals.org/cgi/content/full/283/2/541
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| | EFFECTS OF NEONATAL HYPOXIA IN THE RAT ON INOTROPIC STIMULATION OF THE ADULT HEART |
| | A similar impairment of the LVP and +dP/dtmax response to isoproterenol was found (n=5 each condition). | | | Clinically this might limit the ability of individuals hypoxemic in early life to initiate rapid autonomically mediated adjustments in ventricular function and might also become significant following cardiac surgery if pharmacologic inotropic support is required. | | | We have asked whether a transient period of hypoxia neonatally (FiO2=0.12,days 1-10 of life) in the rat has long-lasting effects on inotropic stimulation of the heart. |
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http://www.pulsus.com/ccc2003/abs/a776.htm
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| | HGSA Medical Policy: I-13C - Intermittent Intravenous Inotropic Therapy |
| | Rather, it addresses one aspect of the management of chronic (end stage) cardiac failure: intermittent inotropic infusions outside of a hospital inpatient setting. | | | HGSA Medical Policy: I-13C - Intermittent Intravenous Inotropic Therapy | | | Kaan, RN, CTCNC Sydney, Australia; Continuours Home Ambulatory Intravenous Inotropic Drug Therapy in Severe Heart Failure: Safety and Cost Efficacy, American Heart Journal, Vol 134 No 5 Part 1, Nov 1997 |
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http://www.hgsa.com/professionals/policy/i13c.html
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| | APStracts 7:0163R, 2000. |
| | In the isolated perfused rat heart preparation, intracoronary infusion of AM (0.03 and 1 nmol/l) and ET-1 (0.08 and 1 nmol/l) for 30 min induced a dose-dependent, gradual increase in developed tension, the maximal responses being equal. | | | This depressed response was more than overcome by concomitant administration of l-NAME. | | | The inotropic response to combined administration of low doses of AM and ET-1 is substantially suppressed by endogenous NO, whereas the individual effects of the peptides at these doses are not the subject of secondary modulation by NO. |
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http://www.uth.tmc.edu/apstracts/2000/regulatory/May/163r.html
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| | Myocardial Blood Flow, Metabolism, and Inotropic Reserve in Dogs with Dysfunctional Noninfarcted Collateral-Dependent ... |
| | Myocardial Blood Flow, Metabolism, and Inotropic Reserve in Dogs with Dysfunctional Noninfarcted Collateral-Dependent Myocardium -- Gerber et al. | | | Myocardial Blood Flow, Metabolism, and Inotropic Reserve in Dogs with Dysfunctional Noninfarcted Collateral-Dependent Myocardium | | | Jean-Louis J. Vanoverschelde, MD Division of Cardiology and PET Laboratory, University of Louvain Medical School, Brussels, Belgium |
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http://jnm.snmjournals.org/cgi/content/abstract/43/4/556
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| | human * SchumannHeink the Last of the... |
| | The BetaAdrenergic Pathway in the Failing Human Heart Implications for Inotropic Therapy. | | | Ionizing Radiation Part 1 X and Gammaradiation, and Neutrons IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. |
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http://www.bookauthors.de/bookuuuhuman.html
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| | CIGNA Medicare DMERC Dialogue, External Infusion Pump and Inotropic Drugs |
| | All initial claims for inotropic therapy must be accompanied by a copy of the patient's medical records substantiating the need for the inotropic drugs. | | | If the medical records do not substantiate that criteria for inotropic therapy are met, initial and subsequent claims for inotropic therapy will be denied as not medically necessary. | | | This documentation requirement is in addition to the current requirement that initial claims include a copy of the order and suggested data collection form (or other form developed by the supplier) that summarizes the medical information used to determine coverage. |
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http://www.cignamedicare.com/dmerc/dlog/Q1_1999/Q1_99_External_Infusion_Pump_and_Inotropic_Drugs.html
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| | Inotropic / chronotropic drugs: |
| | The drug is the most useful 'general purpose' sympathomimetic amine. | | | The clinical effects of the drug are to increase contractility, blood pressure and afterload and to lower the pulse rate. | | | In practice, it is difficult to separate the negative chronotropic and inotropic effects of the beta blockers. |
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http://www.manbit.com/PAC/chapters/P34.cfm
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| | Article #2203, Intraoperative Regional Myocardial Acidosis Predicts the Need for Inotropic Support in Cardiac Surgery |
| | PH (corrected to 37 degrees C, pH(37C)) during surgery was compared in patients who needed INO versus those who did not. | | | Which Patients Can Be Weaned From Inotropic Support Within 24 Hours After Cardiac Surgery? | | | Inotropic support (INO) was defined as requiring one or more of norepinephrine/epinephrine/amrinone/dobutamine/>2.5 mug/kg/min dopamine, for at least 45 minutes intraoperatively, and intraoperative or postoperative IAB use. |
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http://www.perfusion.com/cgi-bin/absolutenm/anmviewer.asp?a=2203&z=3
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| | Cardiac Inotropic Drugs & the Treatment of Heart Failure |
| | Future therapies will most likely involve therapeutic strategies that prevent or minimize the remodeling processes in the heart and vasculature, and thereby arrest the the syndrome at early stages of cardiac dysfunction | | | Acute pulmonary edema in dysfunction resulting from acute myocardial infarction may be alleviated by treatment with nitroprusside, nitroglycerin, or nifedipine | | | Cardiac Inotropic Drugs & the Treatment of Heart Failure |
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http://www.md.huji.ac.il/mirror/netpharm/inotrope.htm
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| | Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations |
| | Acetylcholine, cardiovascular response, species variation negative inotropic response. | | | Species differences in the negative inotropic effect of acetylcholine may be caused by differences in the coupling between myocardial muscarinic receptors and the ion channels that mediate negative inotropy. | | | There was no correlation between the species differences in the negative inotropic effect of acetylcholine in atria and the density or affinity of acetylcholinesterase or muscarinic receptors. |
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http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=166860
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| | AGING AND EXERCISE |
| | Venous filling is impaired by poor peripheral venous tone, varicosities, and a slow relaxation of the ventricular wall. | | | Reduced sensitivity to catecholamines blunts the inotropic increase of myocardial contractility during vigorous exercise. | | | After-loading of the ventricle also rises more than in a younger individual, in part because of hypertension and a loss of arterial elasticity, and in part because weakened skeletal muscles must contract at a larger fraction of their peak voluntary force. |
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http://www.sportsci.org/encyc/agingex/agingex.html
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| | Assessment of myocardial perfusion and contractile function by inotropic stress Tc-99m sestamibi SPECT imaging and ... |
| | Department of Cardiovascular Medicine, Northwick Park and St Mark's Hospitals NHS Trust and Institute of Medical Research, Watford Road, Harrow, Middlesex HA1 3UJ, UK Correspondence to: Dr Lahiri. | | | The assessment of both myocardial perfusion and contractile function by simultaneous inotropic stress MIBI imaging and echocardiography | | | Keywords: multivessel disease; inotropic stress; SPECT imaging; echocardiography |
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http://heartjnl.highwire.org/cgi/content/abstract/79/3/274
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