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Topic: Infliximab



  
 infliximab, Primary Sclerosing Cholangitis Literature
Kooros K, Katz AJ 2004 Infliximab therapy in pediatric Crohn's pouchitis.
Date RS, Panesar KJ, Neilly P 2004 Infliximab as a therapy for non-Crohn's enterocutaneous fistulae.
Chan JL, Davis-Reed L, Kimball AB 2004 Counter-regulatory balance: atopic dermatitis in patients undergoing infliximab infusion therapy.
http://www.psc-literature.org/inflix.htm   (9900 words)

  
 Infliximab shows efficacy in treatment of ulcerative colitis
The proportion of patients who were able to discontinue corticosteroids while in clinical remission at week 30 was significantly greater in both Infliximab groups compared with the placebo group (18 percent, 5 mg/kg; 27 percent, 10 mg/kg; 3 percent, placebo; P=0.010 and P 0.001, respectively).
In addition, at week 30, 52 percent of patients in the 5 mg/kg and 51 percent of patients in the 10 mg/kg Infliximab treatment group were in clinical response versus 30 percent of placebo-treated patients (P
Data from the ACT 1 and ACT 2 clinical trials showed Infliximab met primary and secondary endpoints of clinical response, clinical remission and mucosal healing.
http://www.xagena.it/news/medicinenews_net_news/2db9f30839751e6714522e71cdad18b5.html   (935 words)

  
 Patient Education - Drugs - infliximab, Remicade
Gastroenterologists are cautiously excited about infliximab and similar drugs that should be available in the near future.
It ranks drugs from A, where medical studies show no evidence for danger to the fetus or mother, to B, C, D and X, where the medical evidence indicates increasing risk to the fetus which eventually outweighs any benefit to the mother.
Nursing mothers should not receive this drug as its transmission in mother's milk and effect on the baby are unknown.
http://www.gicare.com/pated/infliximab.htm   (849 words)

  
 Drugs for Arthritis -- Infliximab
You will have a chest x-ray and blood tests before starting treatment and then further blood tests while you are on Infliximab to monitor its effects.
Is Infliximab used for any other medical conditions?
If you would like any further information about Infliximab, or if you have any concerns about your treatment, you should discuss this with your doctor or pharmacist.
http://www.poolehos.org/rheum/infliximab.html   (746 words)

  
 Maintenance Infliximab for Fistulizing Crohn Disease - Journal Watch Gastroenterology
Infliximab is effective as maintenance therapy for patients
but none of these were clearly related to infliximab therapy.
response to the infliximab induction regimen, there was no difference
http://gastro.jwatch.org/cgi/content/full/2004/317/1   (367 words)

  
 MedlinePlus Drug Information: Infliximab (Systemic)
Infliximab may cause chest pain, fever, chills, itching, hives, flushing of face, or troubled breathing within a few hours after you receive it.
Inactive tuberculosis infection—Should be treated before starting infliximab therapy.
It is important to have your heart closely checked if you take infliximab, and have existing heart disease, which could worsen while you are on infliximab therapy
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203667.html   (1235 words)

  
 Anti-TNF for ankylosing spondylitis [December 2002; 106-2]
The number needed to treat for one patient to have the outcome at 12 weeks who would not have had it if treated with placebo was 2.3 (95% confidence interval 1.6 to 3.9).
The number needed to treat for one patient to have the outcome at 12 weeks who would not have had it if treated with placebo was 1.4 (95% confidence interval 1.1 to 2.1).
Major improvement in global assessment was experienced by 17/20 patients treated with infliximab, compared with 3/20 experiencing some improvement with placebo.
http://www.jr2.ox.ac.uk/bandolier/band106/b106-2.html   (1361 words)

  
 Infliximab for Crohn's disease - [Medication]
Before starting infliximab treatment, you should be screened with a tuberculin skin test and a chest X-ray.
The long-term effectiveness of this drug still is being studied.
If the skin test is positive or the chest X-ray suggests previous exposure to TB, you will need treatment to prevent active TB.
http://www.bchealthguide.org/kbase/topic/detail/drug/tw2242/detail.htm   (627 words)

  
 Treatment of Complicated Sarcoidosis with Infliximab Anti-Tumor Necrosis Factor-{alpha} Therapy -- Yee and Pochapin 135 ...
Conclusions: Infliximab therapy was successful in a patient
infliximab therapy, and the serum albumin level also improved.
Treatment of Complicated Sarcoidosis with Infliximab Anti-Tumor Necrosis Factor-{alpha} Therapy -- Yee and Pochapin 135 (1): 27 -- Annals of Internal Medicine
http://www.annals.org/cgi/content/abstract/135/1/27   (628 words)

  
 Arch Ophthalmol -- Abstract: A Prospective Trial of Infliximab Therapy for Refractory Uveitis: Preliminary Safety and ...
A Prospective Trial of Infliximab Therapy for Refractory Uveitis
Arch Ophthalmol -- Abstract: A Prospective Trial of Infliximab Therapy for Refractory Uveitis: Preliminary Safety and Efficacy Outcomes, July 2005, Suhler et al.
of 14 patients enrolled for 1 year continued infliximab therapy
http://archopht.ama-assn.org/cgi/content/abstract/123/7/903   (302 words)

  
 Rheumatoid arthritis - etanercept and infliximab (No. 36)
A decision to continue therapy should therefore be based on how the patient’s condition is progressing and how well the drugs are working.
There is currently no evidence to support treatment with etanercept or infliximab for more than 4 years.
There is no evidence to suggest that these drugs should be used one after the other, and so this is not recommended.
http://www.nice.org.uk/page.aspx?o=35993   (299 words)

  
 Infliximab - Wikipedia, the free encyclopedia
Case studies have been done into other uses of infliximab, such as to treat skin diseases.
The most promise lies in those diseases that have increased amounts of TNF-alpha in the cutaneous lesions, such as psoriasis." (Gupta and Skinner, 2004 literature review article)
Infliximab (Remicade®) is a powerful drug used to treat auto-immune disorders like Crohn's disease and rheumatoid arthritis.
http://en.wikipedia.org/wiki/Infliximab   (326 words)

  
 Cutaneous nocardiosis complicating management of Crohn's disease with infliximab and prednisone -- Singh et al. 171 ...
The patient failed to respond to the minocycline therapy, and
experience with infliximab and with corticosteroids has demonstrated
to receive further infliximab infusions (at weeks 12 and 18
http://www.cmaj.ca/cgi/content/full/171/9/1063   (1027 words)

  
 Hospital Practice: Crohn's Disease
The advent of infliximab, however, offers a new therapeutic option for patients with refractory disease.
Hanauer is Professor of Medicine and Clinical Pharmacology, Section of Gastroenterology, University of Chicago Medical Center, Chicago.
Infliximab, a potent inhibitor of tumor necrosis factor-alpha, has been shown to be effective in inducing remission in patients refractory to other therapies.
http://www.hosppract.com/issues/1999/08/dmmhan.htm   (3799 words)

  
 infliximab (Remicade) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
DRUG INTERACTIONS: The interaction of infliximab with other drugs has not been studied.
There are two other injectable drugs that block TNF alpha--infliximab (Remicade) and etanercept (Enbrel).
infliximab (Remicade) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
http://www.medicinenet.com/infliximab/article.htm   (830 words)

  
 Prospective Study of TNF{alpha} Blockade with Infliximab in Anti-Neutrophil Cytoplasmic Antibody-Associated Systemic ...
Infliximab is a promising new therapy for vasculitis both as
The in vitro studies suggest that infliximab may be a more effective
of infliximab as adjuvant therapy in both acute flares (study
http://www.jasn.org/cgi/content/full/15/3/717   (3253 words)

  
 Arthritis Research Campaign Anti-TNF therapy (etanercept, infliximab and adalimumab)
Anti-TNF therapy (etanercept, infliximab and adalimumab) for rheumatoid arthritis
Your rheumatology department can provide further information about the administration of these drugs.
Anti-TNF is a name given to a new class of drugs available for the treatment of severe rheumatoid arthritis.
http://www.arc.org.uk/newsviews/anti_tnf.htm   (559 words)

  
 Infliximab - Drugs & Vitamins - Drug Library - DrugDigest
You will receive infliximab in a clinic setting.
Check with your health care professional before stopping or starting any of your medicines.
Infliximab may worsen the symptoms of heart failure in some patients.
http://www.drugdigest.org/DD/DVH/Uses/0,3915,772Infliximab,00.html   (559 words)

  
 Infliximab (Remicade). DermNet NZ
Patients receiving infliximab require close supervision and monitoring throughout treatment.
Infliximab should also be used with caution in the following situations:
However, recent clinical trials of infliximab for the treatment of psoriasis and psoriatic arthritis are proving it to be an effective treatment for these conditions.
http://www.dermnetnz.org/treatments/infliximab.html   (443 words)

  
 Anti-TNF-{alpha} therapy for sight threatening uveitis -- Lindstedt et al. 89 (5): 533 -- British Journal of ...
Repeat infusions were given based on clinical response.
Patients were treated with 200 mg (approximately 3 mg/kg) infliximab
Results: Infliximab treatment resulted in an effective suppression
http://www.bjophthalmol.com/cgi/content/abstract/89/5/533   (172 words)

  
 Treatment of Sarcoidosis With Infliximab -- Doty et al. 127 (3): 1064 -- Chest
We report our experience using infliximab to treat such patients.
Methods: A group of patients in whom traditional sarcoidosis
Key Words: corticosteroids • infliximab • sarcoidosis • therapy
http://www.chestjournal.org/cgi/content/abstract/127/3/1064   (263 words)

  
 INFLIXIMAB
If Infliximab is being used to treat rheumatoid arthritis, and the patient is on concomitant methotrexate therapy, providers should include the following information in block 19 of Form HCFA-1500 or the equivalent field on electronic claims: concomitant methotrexate therapy.
Coverage will be provided for Infliximab used in the treatment of ulcerative colitis only if the patient is severely symptomatic, to the extent that colectomy is being considered, despite aggressive conventional medical therapy (e.g., aminosylicylates, corticosteroids, etc.).
Infliximab is indicated in the treatment of moderately to severely active Crohn's disease for the reduction of signs and symptoms in patients who have had an inadequate response to conventional therapy; or
http://www.gamedicare.com/Policies/318.1.htm   (1138 words)

  
 Arch Neurol -- Abstract: The Pathogenesis and Treatment of Optic Disc Swelling in Neurosarcoidosis: A Unique ...
infliximab maintained functional vision in her right eye.
Arch Neurol -- Abstract: The Pathogenesis and Treatment of Optic Disc Swelling in Neurosarcoidosis: A Unique Therapeutic Response to Infliximab, March 2003, Katz et al.
From the Department of Neurology and Neuroscience, New York Presbyterian Hospital–Weill Medical Center of Cornell University, New York, NY.
http://archneur.ama-assn.org/cgi/content/abstract/60/3/426   (160 words)

  
 Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNF{alpha} therapy ...
therapy (infliximab) in rheumatoid arthritis is associated with clinical improvement
Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNF{alpha} therapy (infliximab) in rheumatoid arthritis is associated with clinical improvement -- Alessandri et al.
Objective: To investigate the effect of infliximab treatment
http://www.annrheumdis.com/cgi/content/abstract/63/10/1218   (453 words)

  
 Remicade Side Effects, and Drug Interactions - Infliximab - RxList ...
Additionally, the observed incidence of antibody positivity in an assay may be influenced by several factors including sample handling, timing of sample collection, concomitant medication, and underlying disease.
Antibody development was lower among rheumatoid arthritis and Crohn’s disease patients receiving immunosuppressant therapies such as 6-MP/AZA or MTX.
Serum infliximab concentrations appeared to be unaffected by baseline use of medications for the treatment of Crohn’s disease including corticosteroids, antibiotics (metronidazole or ciprofloxacin) and aminosalicylates.
http://www.rxlist.com/cgi/generic3/infliximab_ad.htm   (2029 words)

  
 Anti-tumour necrosis factor (TNF) {alpha} treatment of rheumatoid arthritis (infliximab) selectively down regulates the ...
and laboratory variables during infliximab therapy are shown
Table 1 Clinical and laboratory variables (mean (SEM)) of RA patients during treatment with infliximab
to infliximab treatment, which seems to be independent of an
http://ard.bmjjournals.com/cgi/content/full/61/8/723   (1978 words)

  
 Remicade infliximab side effects, tuberculosis lawyer
Around 150,000 people worldwide have received Remicade (infliximab) infusions since the drug's approval in 1998.
Remicade (Infliximab), an immune-suppressing drug used to treat rheumatoid arthritis and Crohn's disease, has been linked to causing 70 reported cases of tuberculosis (TB) among US patients.
The revised labeling states that patients should be tested and treated for inactive, or latent, TB prior to infliximab therapy.
http://www.remicade-side-effects.com   (265 words)

  
 Infliximab Treatment of Rheumatoid Arthritis and Crohn's Disease -- Nahar et al. 37 (9): 1256 -- The Annals of ...
Infliximab is contraindicated for patients with a clinically
: Infliximab is an effective new agent for the treatment
when considering infliximab for individuals who have chronic
http://www.theannals.com/cgi/content/abstract/37/9/1256   (585 words)

  
 Infliximab Treatment of Sarcoidosis -- Serio 37 (4): 577 -- The Annals of Pharmacotherapy
Infliximab Treatment of Sarcoidosis -- Serio 37 (4): 577 -- The Annals of Pharmacotherapy
relevant to the use of infliximab in the treatment of sarcoidosis was
in the literature to support the use of infliximab in the treatment of
http://www.theannals.com/cgi/content/abstract/37/4/577   (236 words)

  
 Remicade Drug Description - Infliximab - HealthScout
We subscribe to the HONcode principles of the Health On the Net Foundation
Infliximab binds specifically to human tumor necrosis factor alpha (TNFa) with an association constant of 1010 M-1.
Infliximab is produced by a recombinant cell line cultured by continuous perfusion and is purified by a series of steps that includes measures to inactivate and remove viruses.
http://www.healthscout.com/rxdetail/1/118/1/main.html   (240 words)

  
 Infliximab
4 / 555 patients on infliximab in the Rheumatoid studies
In those patients who have ANF positive there is no contraindication to use.
However, these diseases are associated themselves with this disease and there is no direct causative association with the drug.
http://www.arthritis.co.za/infliximab.html   (1040 words)

  
 CCFA.org: Infliximab Approved for Ulcerative Colitis
The decision to use infliximab for this disease is complex and will be based on a number of factors, including a patient's response to other therapies.
Therefore, CCFA urges patients with colitis to discuss the risks and benefits of infliximab therapy with their IBD physician before making the decision to try the new treatment.
FDA Approves Infliximab (Remicade®) as the First Biologic Treatment for Ulcerative Colitis
http://www.ccfa.org/about/news/infliximabforuc   (514 words)

  
 TNF-{alpha}neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal ...
in our experiments has similar characteristics to infliximab,
These effects may clearly be related to the
that the ability of infliximab to induce apoptosis in circulating
http://www.pnas.org/cgi/content/full/100/14/8366   (3457 words)

  
 Infliximab
Infliximab would be used in patients with severe Crohn's disease.
If you have an allergy to any mouse proteins, infliximab, or any other part of the medicine.
Infliximab will be given in a clinic or hospital setting under close observation.
http://www.umm.edu/altmed/ConsDrugs/Infliximabcd.html   (659 words)

  
 Infliximab
Infliximab is only used to reduce the inflammation of the intestines in severe Crohn& when other treatment has been ineffective.
It is only used when treatment with disease modifying antirheumatic drugs (DMARDs, eg sulfasalazine, methotrexate) has proved ineffective.
You may be given medicines such as hydrocortisone, paracetamol or an antihistamine before the infusion to prevent allergic reactions.
http://www.tiscali.co.uk/lifestyle/healthfitness/health_advice/netdoctor/archive/100004617.html   (1112 words)

  
 Newly Approved Drug Therapies (703): Remicade (infliximab), Centocor
Newly Approved Drug Therapies (703): Remicade (infliximab), Centocor
The most common adverse events observed in clinical trials included (but are not limited to) the following:
Infliximab neutralizes the biological activity of TNFa by binding with high affinity to the soluble and transmembrane forms of TNFa and inhibits binding of TNFa with its receptors.
http://www.centerwatch.com/patient/drugs/dru703.html   (505 words)

  
 Infliximab - Product Approval Information - Licensing Action
Indication for Use: Treatment of moderately to severely active Crohn's disease for the reduction of the signs and symptoms in patients who have an inadequate response to conventional therapies; and treatment of patients with fistulizing Crohn's disease for the reduction in the number of draining enterocutaneous fistula(s)
Infliximab - Product Approval Information - Licensing Action
http://www.fda.gov/cder/biologics/products/inflcen082498.htm   (55 words)

  
 BioMed Central Articles which cite: Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis ...
Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept.
Articles which cite: Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept.
http://www.biomedcentral.com/search/citedby/12823852   (126 words)

  
 Articles - Rheumatology
Most rheumatic diseases are treated with analgesics, NSAIDs (anti-inflammatory drugs), steroids (in serious cases), DMARDs ("steroid-sparing" agents) and monoclonal antibodies, such as the recently introduced infliximab and etanercept.
Cytology and chemical pathology of fluid aspirated from affected joints (e.g.
http://www.1-electric.com/articles/Rheumatology   (192 words)

  
 MedlinePlus Medical Encyclopedia: Arthritis
Such medications, including etanercept (Enbrel), infliximab (Remicade) and adalimumab (Humira), are administered by injection and can dramatically improve your quality of life.
http://www.nlm.nih.gov/medlineplus/ency/article/001243.htm   (1802 words)

  
 The utility of tumour necrosis factor blockade in orphan diseases -- Keystone 63 (Supplement 2): ii79 -- Annals of the ...
have been shown to improve with infliximab but not with etanercept.
mechanism(s) of action of the two antagonists with infliximab
These results lend further support for the concept of differential
http://www.annrheumdis.com/cgi/content/abstract/63/suppl_2/ii79   (256 words)

  
 News - FDA Approves Remicade (Infliximab) for Psoriatic Arthritis
An immune-mediated inflammatory disease, psoriatic arthritis affects approximately one million men and women in the U.S. and is often characterized by the complex symptoms of joint inflammation (arthritis) and skin lesions (psoriasis).
MALVERN, PA -- May 17, 2005 -- Centocor, Inc. announced today that the U.S. Food and Drug Administration (FDA) has approved Remicade® (infliximab) to reduce the signs and symptoms of active arthritis in patients with psoriatic arthritis.
Click here if this is not your Personal Edition
http://www.docguide.com/news/content.nsf/news/8525697700573E188525700400751ABC   (1902 words)

  
 FDA Grants REMICADE® (Infliximab) Fast Track Designation for Active Ulcerative Colitis
Centocor, Inc, announced today that REMICADE® has received a Fast Track Designation from the U.S. Food and Drug Administration (FDA) for the treatment of active ulcerative colitis (UC), a chronic and debilitating disease of the colon, or large intestine, that affects nearly a half million people in the United States.
Please send any medical news or health news press releases to:
FDA Grants REMICADE® (Infliximab) Fast Track Designation for Active Ulcerative Colitis
http://www.medicalnewstoday.com/medicalnews.php?newsid=17983&nfid=mnf   (1125 words)

  
 PRESS RELEASE FDA Grants REMICADE(R) (Infliximab) Fast Track Designation for Treatment of Active Ulcerative Colitis
The FDA's Fast Track regulations, based upon the FDA Modernization Act of 1997, are designed to assist in the development of products that may treat serious or life-threatening diseases and address an unmet medical need.
FDA Grants REMICADE(R) (Infliximab) Fast Track Designation for Treatment of Active Ulcerative Colitis
PRESS RELEASE FDA Grants REMICADE(R) (Infliximab) Fast Track Designation for Treatment of Active Ulcerative Colitis
http://www.marketwire.com/mw/release_html_b1?release_id=77840   (1071 words)

  
 BioMed Central Articles which cite: How does infliximab work in rheumatoid arthritis?
Articles which cite: How does infliximab work in rheumatoid arthritis?
http://www.biomedcentral.com/search/citedby/12110154   (97 words)

  
 Autologous haematopoietic stem cell transplantation in juvenile idiopathic arthritis -- Wedderburn et al. 88 (3): 201 ...
Myers A, Clark J, Foster H. Tuberculosis and treatment with infliximab.
http://adc.bmjjournals.com/cgi/content/full/88/3/201   (3117 words)

  
 Arch Dermatol -- Abstract: Potential of Tumor Necrosis Factor Inhibitors in Psoriasis and Psoriatic Arthritis, February ...
the TNF inhibitors etanercept and infliximab in psoriasis and
http://archderm.ama-assn.org/cgi/content/abstract/140/2/218   (292 words)

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