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| | Prof. Enrico Smeraldi - Official site |
 | | Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality. | | | Allelic variation, in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. | | | Non-linear association between the serotonin transporter promoter polymorphism and neuroticism: a caution against using extreme samples to identify quantitative trait loci. |
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http://www.enricosmeraldi.com/pubblications_3_2.html
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| | Untitled Document |
| | The article goes on to talk about the amygdala, the part of the brain responsible for feelings of anxiety, which is a part of the brain that the study focused on though the news article doesn’t make a reference to the study when discussing the amygdala. | | | Thus those who have less of the serotonin transporter will consequently have less serotonin uptake, which will result in heightened levels of anxiety. | | | The Inquirer makes it clear throughout the article that SLC6A4 is a behavior related gene and not the singular reason for anxiety. |
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http://www.bio.davidson.edu/courses/genomics/2002/Toran/ptanxiety.html
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| | Serotonin transporter (5-HTT) gene variants associated with autism? -- Klauck et al. 6 (13): 2233 -- Human Molecular ... |
| | The implications for genetic variants of the serotonin transporter in the etiology of autism and possible subgroups of patients, therefore, needs clarification in further studies with other and larger patient samples. | | | In a recent study the short variant of the 5-HTTLPR was found to be associated with autism and haplotype analysis of both polymorphisms in a multiallelic TDT underlined the significance of the locus (19). | | | This is in contrast to the study of the US group using 86 trios for association analysis (21), who presented preferential transmission of the short allele of the 5-HTTLPR. |
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http://hmg.oxfordjournals.org/cgi/content/full/6/13/2233
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| | NIH News Release--Gene May Bias Amygdala Response to Frightful Faces--07/18/2002 |
| | NIMH and NIAAA are part of the National Institutes of Health (NIH), the Federal Government's primary agency for biomedical and behavioral research. | | | Earlier studies by Dennis Murphy, M.D., NIMH, and colleagues, found that the variants accounted for three to four percent of the variance in anxiety traits. | | | A few other studies using behavioral measurements have since turned up similar results, but the research has remained controversial due to the relatively small effect sizes. |
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http://www.nih.gov/news/pr/jul2002/nimh-18.htm
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| | Anger Gene |
| | Although this report did acknowledge that research in this area is still early, it is claimed that those who are more prone to anger can be identified based upon this particular genetic characteristic. | | | This figure was generated based upon information presented by Ohara et al. | | | According to Dr. Redford’s Williams’ research, central nervous system (CNS) serotonin function is involved in the regulation of potentially health damaging behavioral characteristics such as anxiety, depression, hostility and social isolation. |
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http://www.bio.davidson.edu/Courses/genomics/2004/Cobain/angergene.html
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| | Mutant Gene Linked to Obsessive Compulsive Disorder - |
| | NIMH, NIDA, an NIAAA are part of the National Institutes of Health (NIH), the Federal Government's primary agency for biomedical and behavioral research. | | | Transporters are important sites for agents that treat psychiatric disorders. | | | Analysis of DNA samples from patients with obsessive compulsive disorder (OCD) and related illnesses suggests that these neuropsychiatric disorders affecting mood and behavior are associated with an uncommon mutant, malfunctioning gene that leads to faulty transporter function and regulation. |
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http://www.specialneeds.net/disabilities/mutant-gene-linked-to-obsessive-compulsive-disorder.html
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| | Gene Mutation Linked to Obsessive Compulsive Disorder |
| | Murphy's team, which included Norio Ozaki of Jujita Health University School of Medicine in Japan and other scientists, analyzed DNA from 112 unrelated individuals with OCD and 271 patients with other psychiatric disorders or no disorders at all. | | | The fact that the OCD patients have two changes in the same gene may explain why their illnesses and those of their siblings have been so severe and resistant to treatment. | | | The individuals who do have OCD also have other conditions including tic disorder, anorexia nervosa, Asperger's syndrome, alcohol problems, social phobia and depression. |
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http://www.genomenewsnetwork.org/articles/11_03/ocd.shtml
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| | BBC NEWS Health Compulsion linked to faulty gene |
| | Dr Thomas Insel, director of the National Institute of Mental Health, said: "This is a new model for neuropsychiatric genetics, the concept of two or maybe more within-gene modifications being important in each affected individual." | | | Researchers from the US National Institute of Mental Health carried out the study which they say could lead to more treatments for the illness. | | | Some people with OCD are treated with drugs that reduce the binding of serotonin to transporters such as selective serotonin reuptake inhibitors, (SSRIs), but the researchers say people with the hSERT gene defect do not seem to respond to them. |
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http://news.bbc.co.uk/1/hi/health/3205239.stm
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| | Serotonin (5-HT) - transporter gene variant - mental health - more |
| | The results may offer a plausible physiological mechanism underlying the association between 5-HTTLPR genotype, behavioral traits, and mood states. | | | The results indicate that the C178T variation in the HTR3A has a critical influence on the amygdaloid activity and on human face processing, probably through regulation of the receptor expression. | | | Serotonin (5-HT) - transporter gene variant - mental health - more |
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http://www.webmedtoday.com/hotpapers/MedRes/HPMR0508005.htm
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| | WHGD Topics from the Director's Report, September 1997 |
| | CPE could play a role in the sorting of peptide precursors into the regulated secretory pathway, and the absence of CPE in the Cpefat/Cpefat mice causes mis-sorting which then alters the processing. | | | Although the physiologic role of the serotonin transporter in normal human placenta remains to be established, these data suggest a possibility that the placental serotonin transporter may be involved in the maintenance of serotonin levels in the intervillous space and thereby optimize utero placental blood flow. | | | Ganapathy and his research team has recently published reports that demonstrate that tyrosine phosphorylation is an essential component in the signaling pathways participating in the regulation of the human serotonin transporter gene expression. |
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http://www.nida.nih.gov/WHGD/WHGDDirRep9.html
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| | Gene found for obsessive disorder - Genetics - MSNBC.com |
| | Some anxiety drugs and antidepressants target serotonin, but the researchers said patients with the mutations are not helped by these drugs. | | | A specific mutation in the hSERT gene was seen in two patients with OCD and their families, but not in other patients. | | | The researchers analyzed DNA from 170 people, including 30 patients with obsessive-compulsive disorder, 30 with eating disorders such as anorexia and 30 with seasonal affective disorder — which can cause depression and other symptoms in dark winter months. |
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http://www.msnbc.msn.com/id/3341620
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| | PowerPoint Presentation |
| | Serotonin [5- hydroxytryptamine, (5-HT)] function influences normal fear as well as pathological anxiety, behaviors critically dependent on the amygdala in animal models and in clinical studies. | | | Weinberger1*
A functional polymorphism in the promoter region of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of neuroticism and psychopathology, especially anxiety traits, but the predictive value of this genotype against these complex behaviors has been inconsistent. | | | Serotonin Transporter Genetic Variation and the Response of the Human Amygdala
Ahmad R. Hariri,1 Venkata S. Mattay,1 Alessandro Tessitore,1 Bhaskar Kolachana,1 Francesco Fera,1 David Goldman,2 Michael F. Egan,1 Daniel R. |
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http://www-personal.umich.edu/~moje/ppt/ciera2004/CIERAinstituteJuly2004_files/slide0062.htm
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| | Jahrbuch-CD der MPG 2003 - Allelic variants of the functio |
| | The LD may serve as endophenotype in human serotonin research. | | | Allelic variants of the functional promoter polymorphism of the human serotonin transporter gene is associated with auditory cortical stimulus processing | | | The results are consistent with the reported association between 5-HTT genotype and serotonin transport capacity in lymphoblasts, and indicate that auditory stimulus processing is associated with genetic variants of the brain serotonergic system. |
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http://www.mpg.de/forschungsergebnisse/wissVeroeffentlichungen/archivListenJahrbuch/2003/15/publZIM91.html
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| | INDEED! THERE'S HOPE FOR US! GENE FOR OCD FOUND! |
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Some = anxiety=20 drugs and antidepressants target serotonin, but the
researchers said = patients with the mutations are not helped by these
drugs. | | | =
A=20 specific mutation in the hSERT gene was seen in two patients with =
OCD and=20 their families, but not in other patients. | | | Dennis Murphy of the National
Institute of Mental Health, who = worked on=20 the study. |
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http://www.talkaboutsupport.com/group/alt.support.ocd/messages/97895.html
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| | Genes for OCD |
| | They interviewed relatives of the patients and found 6 of the 7 people with the mutation had an obsessive-compulsive disorder, and some also had anorexia, Asperger's syndrome, which is a form of autism, social phobia or were abusers of alcohol. | | | This new finding of similar serotonin mechanism is encouraging and hopefully a pharaceutical or other means of modify these sites will be forthcoming. | | | The gene is called the human serotonin transporter gene (hSERT) and helps dictate how the body uses the neurotransmitter serotonin. |
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http://cognews.com/1067237932/index_html
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| | Publications 1998 |
| | Lesch KP, Heils A, Bengel D (1998) Genetics of the 5-HT transporter: allelic variation in functional expression affects anxiety- and depression-related personality traits and susceptibility to affective disorders. | | | Lesch KP (1998) Serotonin transporter and psychiatric disorders: listening to the gene. | | | Mössner R, Lesch KP (1998) Role of serotonin in the immune system and in neuroimmune interactions. |
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http://www.uni-wuerzburg.de/nervenklinik/psychobiologie/pub1998.html
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| | A novel allele in the promoter region of the human serotonin transporter gene |
| | The human serotonin transporter (hSERT) gene is a promising candidate for mediating the genetic susceptibility for various psychiatric conditions such as mood | | | serotonin transporter; polymorphism; (5-HTTLPR); allelic variation; Libyan Jews; association studies; psychiatric disorders | | | The LJ allele was found in individuals of Libyan and Tunisian Jewish origin but not in Moroccan or Ashkenazi Jews. |
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http://www.nature.com/cgi-taf/DynaPage.taf?file=/mp/journal/v4/n1/abs/4000449a.html
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