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Topic: Human leukocyte antigen


  
 BioMed Central Full text Effect of human leukocyte antigen heterozygosity on infectious disease outcome: The need for ...
Doherty and Zinkernagel, who discovered that antigen presentation is restricted by the major histocompatibility complex (MHC, called HLA in humans), hypothesized that individuals heterozygous at particular MHC loci might be more resistant to particular infectious diseases than the corresponding homozygotes because heterozygotes could present a wider repertoire of antigens.
Vaccine designers have begun to take account of the HLA genotypes of potential recipients in choosing antigens for inclusion in a vaccine [15], and it has been suggested that HLA genotype be considered in designing samples for inclusion in epidemiologic studies of anti-HIV immune response [12].
To demonstrate allele-specific overdominance for specific infections in human populations, improved analytic tools and/or larger studies (or studies in populations with limited HLA diversity) are necessary.
http://www.biomedcentral.com/1471-2350/4/2   (5254 words)

  
 Mediastinal Fibrosis Is Associated With Human Leukocyte Antigen-A2 -- Peebles et al. 117 (2): 482 -- Chest
Mediastinal Fibrosis Is Associated With Human Leukocyte Antigen-A2
Mediastinal Fibrosis Is Associated With Human Leukocyte Antigen-A2 -- Peebles et al.
Maffei, A, Papadopoulos, K, Harris, PE (1997) MHC class I antigen processing pathways.
http://www.chestjournal.org/cgi/content/full/117/2/482   (2066 words)

  
 Human Leukocyte Antigen-DRB1 Position 11 Residues Are a Common Protective Marker for Sarcoidosis -- Foley et al. 25 ...
Genetic factors, in particular human leukocyte antigens (HLAs) are important determinants of susceptibility to sarcoidosis,
Human Leukocyte Antigen-DR Alleles Influence the Clinical Course of Pulmonary Sarcoidosis in Asian Indians
the role of HLA in sarcoidosis we determined HLA-DR and -DQ alleles
http://ajrcmb.atsjournals.org/cgi/content/full/25/3/272   (3463 words)

  
 Association between Human Leukocyte Antigen Polymorphism and Human Papillomavirus 16-positive Vulval Intraepithelial ...
HLA-A and HLA-B; DNA-based techniques: 144 for HLA-DRB1 and
Association between Human Leukocyte Antigen Polymorphism and Human Papillomavirus 16-positive Vulval Intraepithelial Neoplasia in British Women -- Davidson et al.
Association between Human Leukocyte Antigen Polymorphism and Human Papillomavirus 16-positive Vulval Intraepithelial Neoplasia in British Women
http://cancerres.aacrjournals.org/cgi/content/full/63/2/400   (2567 words)

  
 Markers of activity in clinically recovered human leukocyte antigen-DR17-positive sarcoidosis patients -- Planck et al. ...
Markers of activity in clinically recovered human leukocyte antigen-DR17-positive sarcoidosis patients -- Planck et al.
Markers of activity in clinically recovered human leukocyte antigen-DR17-positive sarcoidosis patients
Keywords: bronchoalveolar lavage, follow-up studies, human leukocyte antigen-DR-antigens, sarcoidosis, T-lymphocytes
http://erj.ersjournals.com/cgi/content/full/21/1/52   (2457 words)

  
 Human Leukocyte Antigen-Associated Susceptibility to Pulmonary Tuberculosis: Molecular Analysis of Class II Alleles by ...
processed antigens by alveolar macrophages may be affected in
Rajalingam, R, Mehra, NK, Jain, RC, et al (1996) Polymerase chain reaction-based sequence-specific oligonucleotide hybridization analysis of HLA class II antigens in pulmonary TB: relevance to chemotherapy and disease activity.
However, studies performed in humans and laboratory animals
http://www.chestjournal.org/cgi/content/full/115/2/428   (2857 words)

  
 Human Leukocyte Antigen Class II Amino Acid Epitopes . Susceptibility and Progression Markers for Beryllium ...
In vitro reactivities of blood lymphocytes from symptomatic and asymptomatic pigeon breeders to antigen and mitogens.
antigen Tri r 2 (30), where a response to peptide 5 is associated
Departments of Medicine and Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; and Laboratory of Human Biology and Genetics, Democritus University of Thrace, School of Medicine, Alexandroupolis, Greece
http://ajrccm.atsjournals.org/cgi/content/full/165/6/788   (4975 words)

  
 Transmission of Parentally Shared Human Leukocyte Antigen Alleles and the Risk of Preterm Delivery -- Li et al. 104 ...
Sharing of human leukocyte antigens in couples with unexplained infertility affects the success of in vitro fertilization and tubal embryo transfer.
the important role that immunology and human leukocyte antigen
shared alleles did not seem to be related to any specific HLA
http://www.greenjournal.org/cgi/content/full/104/3/594   (3377 words)

  
 Human Leukocyte Antigen Class I Alleles and the Disease Course in Sarcoidosis Patients -- Grunewald et al. 169 (6): 696 ...
Distribution of the most commonly detected human leukocyte antigen-a, human leukocyte antigen-b, and human leukocyte antigen-cw alleles in scandinavian sarcoidosis patients and healthy control subjects
on the outcome of disease by human leukocyte antigen (HLA) class
same clinical behavior and the same pattern of HLA alleles as
http://ajrccm.atsjournals.org/cgi/content/full/169/6/696   (4779 words)

  
 Predictive Value of Human Leukocyte Antigen Class II Typing for the Development of Islet Autoantibodies and ...
of susceptible HLA alleles (DR3, DR4), 92% of patients with
of susceptible HLA alleles (DR3, DR4) with islet autoantibody
human leukocyte antigen (HLA) DR3- and DR4-containing haplotypes,
http://jcem.endojournals.org/cgi/content/full/84/7/2342   (3505 words)

  
 Presence of the Human Leukocyte Antigen Class II Gene DRB1*1101 Predicts Interferon {gamma} Levels and Disease ...
Meningioma: Is There an Association with Human Leukocyte Antigens?
Surveillance Committee for Human Subjects Research and the Office
In this study, patients with early-stage melanoma who had clinically
http://www.annalssurgicaloncology.org/cgi/content/full/9/6/587   (3020 words)

  
 A Peptidomimetic that Specifically Inhibits Human Leukocyte Antigen DRB1*0401-restricted T Cell Proliferation -- Woulfe ...
proliferation of human peripheral blood lymphocytes derived from
has been well characterized in vitro in humans and both in vitro
A, representative experiment; B, release of inhibitor from RBC-loaded
http://jpet.aspetjournals.org/cgi/content/full/281/2/663   (3841 words)

  
 eMedicine - HLA-B27 Syndromes : Article by A Luisa Di Lorenzo, MBBCh
The third theory suggests that the T-cell antigen is the true susceptibility factor, and a fourth theory implicates an innate etiology unrelated to HLA.
Synonyms and related keywords: acute unilateral alternating nongranulomatous iridocyclitis, seronegative spondyloarthropathies, acute anterior uveitis, AAU, human leukocyte antigen
The first human leukocyte antigen (HLA) haplotype association with inflammatory disease was discovered in 1972 correlating HLA-B27 with ankylosing spondylitis.
http://www.emedicine.com/oph/topic721.htm   (4156 words)

  
 Human Leukocyte Antigen Test Principal Health News
You are here: Home > Health A to Z > Human Leukocyte Antigen Test
This test may have to be postponed if the patient has recently undergone a transfusion.
Certain HLA types have been linked to diseases, such as rheumatoid arthritis, multiple sclerosis, serum lupus erythematosus, and other autoimmune disorders.
http://www.principalhealthnews.com/topic/topic100586957   (689 words)

  
 AllRefer Health - HLA-B27 Antigen (Human Leukocyte Antigen B27) - Test/Medical Exams/Tests
AllRefer Health - HLA-B27 Antigen (Human Leukocyte Antigen B27) - Test/Medical Exams/Tests
Many HLA antigens exist, but some are of special interest since they are more common in certain autoimmune diseases.
For example, HLA-B27 is found in 80-90% of people with ankylosing spondylitis and Reiter's syndrome.
http://health.allrefer.com/health/hla-b27-antigen-info.html   (469 words)

  
 Acquisition of intact allogeneic human leukocyte antigen molecules by human dendritic cells -- Russo et al. 95 (11): ...
DCs from an HLA-A2-negative individual were cocultivated with PHA-activated human lymphocytes expressing the HLA-A2 allele (right panels).
Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens.
to the treatment of human cancer has been recently confirmed.
http://www.bloodjournal.org/cgi/content/full/95/11/3473   (3661 words)

  
 Definition of human leukocyte antigen - NCI Dictionary of Cancer Terms
human lymphocyte antigen, human papillomavirus, human T-cell leukemia virus type 1, humidifier, Hycamtin
Definition of human leukocyte antigen - NCI Dictionary of Cancer Terms
These antigens vary from person to person, and an HLA test is done before organ transplantation to find out if tissues match between a donor and a recipient.
http://www.cancer.gov/Templates/db_alpha.aspx?print=1&cdrid=386210   (98 words)

  
 Tissue Type Test
If you have bleeding or clotting problems, or if you take blood-thinning medication, tell your health professional before your blood is drawn.
Having an antigen pattern only associated with a certain disease does not mean that the disease is present or will definitely develop.
Antigens on the surface of body cells and tissues can tell the difference between normal body tissue or foreign tissue (for example, tissue from another person's body).
http://www.webmd.com/hw/health_guide_atoz/hw40261.asp   (1247 words)

  
 Electrostatic Potential on Human Leukocyte Antigen: Implications for Putative Mechanism of Chronic Beryllium Disease
Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news on the impact of the environment on human health.
The pathobiology of chronic beryllium disease (CBD) involves the major histocompatibility complex class II human leukocyte antigen (HLA).
Although occupational exposure to beryllium is the cause of CBD, molecular epidemiologic studies suggest that specific HLA-DPB1 alleles may be genetic susceptibility factors.
http://ehponline.org/txg/members/2003/6327/6327.html?section=toxicogenomics   (6006 words)

  
 Cerner Corporation: PathNet Human Leukocyte Antigen (HLA)
PathNet HLA applications are an integral component of the Cerner Millennium® architecture, with features designed to streamline processes, reduce turnaround times and costs, improve access to pertinent patient information, and improve the quality of patient care.
It also supports diagnostic testing for HLA antigens and their disease associations.
The PathNet® Human Leukocyte Antigen (HLA) solution fully automates clinical, financial, and managerial processes associated with HLA typing, antibody screening, crossmatching and recipient-donor matching for the purposes of organ transplant.
http://www.cerner.com/public/millenniumsolution.asp?id=799   (144 words)

  
 Human Histocompatibility Leukocyte Antigen (HLA)-G Molecules Inhibit NKAT3 Expressing Natural Killer Cells -- Münz ...
A class I antigen, HLA-G, expressed in human trophoblasts.
The human amnion is a site of MHC class Ib expression:evidence for the expression of HLA-E and HLA-G. Immunol.
The non-classical MHC molecule HLA-G protects human muscle cells from immune-mediated lysis: implications for myoblast transplantation and gene therapy
http://www.jem.org/cgi/content/full/185/3/385   (4276 words)

  
 GenomicsActivities2004 AccomplishmentsInfectious Disease
A better understanding of the role of various genetic factors in the outcome of infectious diseases will lead to development of novel therapies and better prevention efforts.
Maternal verses paternal inheritance of HLA class I alleles among HIV-infected children: consequences for clinical disease progression.
In 2004, the GWG hired a Career Development fellow, who has significant experience in human genetics, to support genetic investigations and provide technical guidance on study design and data analysis for investigators in NCID and other centers.
http://www.cdc.gov/genomics/activities/ogdp/2004/cocid.htm   (7119 words)

  
 Human leukocyte antigen - Wikipedia, the free encyclopedia
Scientists think that people with certain types of HLA antigens are more likely to develop certain autoimmune diseases, such as SLE (Lupus erythematosus), Myasthenia Gravis, and Sjögren's Syndrome.
HLA types are inherited, and some of them are connected with autoimmune disorders and other diseases.
Besides functional HLA antigens, there are two additional HLA antigens in humans, HLA-DM and HLA-DO, which are important in loading the antigenic peptides generated from pathogens onto the HLA molecules of antigen-presenting cell.
http://en.wikipedia.org/wiki/Human_Leukocyte_Antigen   (495 words)

  
 The Renal Cell Carcinoma-associated Antigen G250 Encodes a Human Leukocyte Antigen (HLA)-A2.1-restricted Epitope ...
Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX
Copyright © 1999 by the American Association for Cancer Research.
Diverse CD8+ T-Cell Responses to Renal Cell Carcinoma Antigens in Patients Treated with an Autologous Granulocyte-Macrophage Colony-Stimulating Factor Gene-Transduced Renal Tumor Cell Vaccine
http://cancerres.aacrjournals.org/cgi/content/abstract/59/21/5554   (902 words)

  
 Bioline International Official Site (site up-dated regularly)
Previous work showed an association of the hemorrhagic form with human leukocyte antigens (HLA), suggesting a role of genetic factors in disease susceptibility.
Nevertheless, data on HLA association with the classical form of the disease is scarce in literature.
Sixty-four patients and 667 normal individuals, living in the state of Paraná, Southern Brazil, were used as test and control group, respectively.
http://www.bioline.org.br/abstract?id=oc04118   (291 words)

  
 Howstuffworks "How Your Immune System Works"
AIDS (Acquired Immune Deficiency Syndrome) is a disease caused by HIV (the Human Immunodeficiency Virus).
There are also all kinds of human ailments that are caused by the immune system working in unexpected or incorrect ways that cause problems.
Why doesn't a white blood cell attack every cell in the body?" There is a system built into all of the cells in your body called the Major Histocompatibility Complex (MHC) (also known as the Human Leukocyte Antigen (HLA)) that marks the cells in your body as "you".
http://health.howstuffworks.com/immune-system.htm/printable   (5631 words)

  
 Northern California's Comprehensive Thalassemia Center at at Children's Hospital Oakland
Human leukocyte antigens (HLA) are proteins that are present on the surface of our bodies' cells.
An individual's HLA type is inherited from his or her parents at the time of conception.
If there is not a good match, this new immune system may recognize the recipient's body as 'foreign' and attack various organs and tissues.
http://www.thalassemia.com/hla.html   (316 words)

  
 Essential Role of Human Leukocyte Antigen-encoded Proteasome Subunits in NF-kappa B Activation and Prevention of Tumor ...
Essential Role of Human Leukocyte Antigen-encoded Proteasome Subunits in NF-
and LMP10 subunits in rodent and human cells.
Essential Role of Human Leukocyte Antigen-encoded Proteasome Subunits in NF-kappa B Activation and Prevention of Tumor Necrosis Factor-alpha -induced Apoptosis -- Hayashi and Faustman 275 (7): 5238 -- Journal of Biological Chemistry
http://www.jbc.org/cgi/content/abstract/275/7/5238   (484 words)

  
 Glossary: human leukocyte antigen (HLA)
the six "markers" on each of your cells that enable your body to tell the difference between your own cells and foreign ones; there are over 100 different human leukocyte antigens.
http://www.med.umich.edu/trans/transweb/journey/recip_journey/glossary/blue/hla.html   (31 words)

  
 A Combination of Human Leukocyte Antigen DQB1*02 and the Tumor Necrosis Factor {alpha} Promoter G308A Polymorphism ...
HLA area responsible for our previous findings in type 1/2 patients.
A Combination of Human Leukocyte Antigen DQB1*02 and the Tumor Necrosis Factor {alpha} Promoter G308A Polymorphism Predisposes to an Insulin-Deficient Phenotype in Patients with Type 2 Diabetes -- Li et al.
leukocyte antigen (HLA) class II locus may affect the phenotype
http://jcem.endojournals.org/cgi/content/abstract/88/6/2767   (570 words)

  
 Proving Paternity—Human Leukocyte Antigen Test
The HLA polymorphic genetic system is extremely powerful in determining the probability of paternity.
Thus, the HLA system of the blood of the child, mother, and putative father are tested and the probability of paternity is calculated.
The human leukocyte antigen (HLA) blood test is based on antigens (a substance that will stimulate the production of antibodies) found on the white blood cells.
http://www.astm.org/JOURNALS/FORENSIC/PAGES/106.htm   (153 words)

  
 Identification of multiple HIV-1 cytotoxic T-cell epitopes presented by human leukocyte antigen B35 molecules.
Identification of multiple HIV-1 cytotoxic T-cell epitopes presented by human leukocyte antigen B35 molecules.
OBJECTIVE: To identify HIV-1 cytotoxic T lymphocyte (CTL) epitopes presented by human leukocyte antigen (HLA)-B35 molecules that are associated with the accelerated progression of AIDS using a reverse immunogenetic approach.
These multiple epitopes will be useful in studies for immunopathogenesis of AIDS.
http://www.aegis.com/aidsline/1997/mar/M9730814.html   (518 words)

  
 human leukocyte antigen - definition of human leukocyte antigen by the Free Online Dictionary, Thesaurus and ...
human leukocyte antigen is not available in the general English dictionary and thesaurus.
This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.
human leukocyte antigen - definition of human leukocyte antigen by the Free Online Dictionary, Thesaurus and Encyclopedia.
http://www.thefreedictionary.com/human+leukocyte+antigen   (90 words)

  
 A Feasibility Study of Human Leukocyte Antigen (HLA) Typing for Dried Bloodstains
antigen systems, forensic science, genetic typing, human leukocyte antigen
A Feasibility Study of Human Leukocyte Antigen (HLA) Typing for Dried Bloodstains
This paper constitutes a feasibility report on the use of the human leukocyte antigen (HLA) system for the typing of dried bloodstains.
http://www.astm.org/JOURNALS/FORENSIC/PAGES/351.htm   (224 words)

  
 Immunization with class I human histocompatibility leukocyte antigen can protect macaques against challenge infection ...
The state of the art may have changed since the publication date.
METHODS: HLA class I antigens were immunopurified from a human B-lymphoblastoid cell line.
CONCLUSIONS: This demonstration of partial protection, together with our previous work reporting that vaccination with allogenic cynomolgus lymphocytes can protect against challenge infection with SIV grown in simian cells, suggests that allogenic immune response induced before or during establishment of HIV infection may have important implications for AIDS disease progression.
http://www.aegis.com/aidsline/1995/sep/M9591005.html   (484 words)

  
 HLA-B27: At a Glance
This test is sometimes ordered to help assess the likelihood that you have an autoimmune disorder that is associated with the presence of HLA-B27.
To determine whether you have human leukocyte antigen B27 (HLA-B27) on the surface of your cells.
http://www.labtestsonline.org/understanding/analytes/hla_b27/glance.html   (119 words)

  
 Bioline International Official Site (site up-dated regularly)
The results showed no cationized ferritin and UEA I lectin in any parasitophorous vacuole membrane, however, the Class I HLA molecule labeling was observed in some endocytic vacuoles containing parasite until 1 h of interaction with T.
In order to analyze which components of the endothelial cell plasma membrane are internalized and become part of the parasitophorous vacuole membrane, the culture of endothelial cells was labeled with cationized ferritin or UEA I lectin or anti Class I human leukocytte antigen (HLA) before or after infection with T.
Anionic Sites, Fucose Residues and Class I Human Leukocyte Antigen Fate During Interaction of
http://www.bioline.org.br/abstract?id=oc02098   (209 words)

  
 fig001nmn: Gene map of the human leukocyte antigen (HLA) region
cytotoxic T lymphocyte function and mediate immune responses against ‘endogenous’ antigens and virally infected targets, whereas HLA class II molecules are involved in the presentation of ‘exogenous’ antigens to T helper cells.
Gene map of the human leukocyte antigen (HLA) region.
Gene map of the human leukocyte antigen (HLA) region
http://www-ermm.cbcu.cam.ac.uk/03005969h.htm   (171 words)

  
 Title 22 - §851. Human Leukocyte Antigen Screening Fund
The Human Leukocyte Antigen Screening Fund, referred to in this section as the "fund," is established as a nonlapsing fund to support bone marrow screening by individuals and organizations determined to be eligible according to rules adopted by the department under subsection 2.
Money in the fund must be expended as allocated by the Legislature for the purposes of the fund and may be invested as provided by law.
Chapter 250-A: HUMAN LEUKOCYTE ANTIGEN SCREENING FUND (HEADING: PL 1999, c.
http://janus.state.me.us/legis/statutes/22/title22sec851.html   (201 words)

  
 AllRefer Health - Medical Encyclopedia - H
Human Chorionic Gonadotrophin - Qualitative Serum (HCG - Qualitative - Serum)
Human Chorionic Gonadotrophin - Quantitative Serum (HCG - Quantitative)
http://health.allrefer.com/health/health-topics-h.html   (623 words)

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